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Institute of Microbiology Institute of Microbiology
Chinese Academy of Chinese Academy of
SciencesSciences•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
International Advisory Panel
National Advisory Panel
Academic Committee
Academic Degree Committee
Development Committee
Culture Collect. Center
Microbial Analy. Center
High-throughputScreening Platform
Tech. Support Platform
Information Center
Administrative System
Center for Microbial Resources
State Key Lab of Microbial Resources
CAS Key Lab of Syst. Mycol. & Lichenol.
Center for Microbial Genome Research
Co-op with BeijingGenomics Inst., CAS
National Microbial Engineering Center
Center for Molecular Immunology
Center for Molecular Virology
Center for Agri. Biotech.Co-op with Inst. Genetics & Develop
. Biol., CAS
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Energy & Industrial Biotechnology
Developmental StrategyDevelopmental Strategy Construct Modern
Biotechnology Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operationBroad International Co-operationBroad International Co-operationBroad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
European Commission Fifth Framework RTD ProgrammeQuality of Life and Management of Living ResourcesKey Action 3: The Cell FactoryRTD Priority 3.3.4: Identification and Sustainable Use of Metabolic and Genetic Diversity as a Source of New Valuable Products
Review of FP5 Review of FP5 in IMCASin IMCAS
Review of FP5 Review of FP5 in IMCASin IMCAS
MultiGenome Access Technology for Industrial CatalystsAn EU – China Collaboration
Objectives• Obtain material from a range of unique Chinese hypersaline and
thermal sites• Survey microbial biodiversity, and establish and archive a
collection of novel microbes• Develop methods for the efficient isolation and recovery of
microbial genes from these sites • Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for commercial exploitation
Overview
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These Chinese extreme environments are of outstanding significance as microbial ecosystems with unique chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the identification and production of valuable new enzymes for sustainable applications in biotechnological processes and consumer products. This special collaboration, which is the first microbial biotechnology collaboration between the EU and China, will provide substantial opportunities for the development of European and Chinese biotechnology.
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management of Living Resources
Key Action 3 : The Cell Factory
RTD Priority 3.3.4 : Identification and Sustainable Use of Metabolic and Genetic Diversity as a Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Hydrothermal outbreak, upper site small poolRehai thermal area
Pearl Spring – Rehai thermal area
Sampling algal mat at large basinLangpu geothermal area
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province (Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially processed on site . There has been good progress with the isolation of DNA from geothermal sites visited during the first sampling expedition and we have begun to generate bacterial gene libraries derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic resources derived from these expeditions and technologies.
The Consortium
•Prof. Bill Grant- University of Leicester, UK
•Prof. Antonio Ventosa- University of Sevilla, Spain
•Prof. Don Cowan- University of the Western Cape, South Africa
•Prof. Ma Yanhe- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones- Genencor International BV, The Netherlands
极 端 微 生 物 实 验 室
Contacts Coordinator: Prof. Bill Grant, EU Scientific Officer: Dr. Indridi Benediktsson University of Leicester, UK [email protected] [email protected]
The Sampling Team
Hydrothermal outbreak poolRehai thermal area
Extremozyme genes
• DNA library• Metagenomic
DNA Libraries• cDNA Library
-Mannanase -Amylase -Xylanase Lipase Catalase …….
High thoughput screening
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating Water Management for the Valorisation of Agric
ultural Wastes in Paper Industry
An EU - China Collaboration
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Review of FP4 Review of FP4 in IMCASin IMCAS
Review of FP4 Review of FP4 in IMCASin IMCAS
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating W
ater Management for the Valorisation of Agricultural Wastes in Paper Industry
Activities:
To achieve these objectives, the proposed project has been constructed with an integrated multidisciplinary approach combining complementary Chinese and European industrial partners including small enterprises in close association with academics originating from both countries.
Objectives:
1.Water pollution prevention: Development of a fungal enzyme process using mainly laccases for improving annual plant kraft pulp bleachability.
2.Water pollution treatment and recycling: Design of a fungal process for effluent detoxification and decolourization in order to facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme Thematic Programme : Basic Natural Resources Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot Institut National De La recherche Agronomique [email protected]
The Consortium: -DR.GUIGAN FANG CHINESE ACADEMY OF FORESTRY -DR.HEINZ JELLER ANDRITZ AG, AUSTRIA -DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Ongoing International Cooperative ProjectsOngoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the long-term cooperation with EU
An EU – China Collaboration
An EU – China Collaboration
Thank YouThank You