Infra-slow oscillations & consciousness. Infra-slow oscillations Slow fluctuations in the frequency...
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Transcript of Infra-slow oscillations & consciousness. Infra-slow oscillations Slow fluctuations in the frequency...
![Page 1: Infra-slow oscillations & consciousness. Infra-slow oscillations Slow fluctuations in the frequency range of 0.01Hz -0.1 Hz Prominent during sleep Present.](https://reader036.fdocuments.net/reader036/viewer/2022062309/5697c01b1a28abf838ccf798/html5/thumbnails/1.jpg)
Infra-slow oscillations & consciousness
![Page 2: Infra-slow oscillations & consciousness. Infra-slow oscillations Slow fluctuations in the frequency range of 0.01Hz -0.1 Hz Prominent during sleep Present.](https://reader036.fdocuments.net/reader036/viewer/2022062309/5697c01b1a28abf838ccf798/html5/thumbnails/2.jpg)
Infra-slow oscillations
Slow fluctuations in the frequency range of 0.01Hz -0.1 Hz
Prominent during sleep
Present in awake brain?
Infra-slow activity fluctuations in fMRI BOLD signal
Task specific / Resting state networks
Vanhatalo, Palva et al., PNAS 2004
![Page 3: Infra-slow oscillations & consciousness. Infra-slow oscillations Slow fluctuations in the frequency range of 0.01Hz -0.1 Hz Prominent during sleep Present.](https://reader036.fdocuments.net/reader036/viewer/2022062309/5697c01b1a28abf838ccf798/html5/thumbnails/3.jpg)
Somatosensory detection task
8 subjects
Weak, constant-current electrical stimuli at the threshold of detection
ISI 3-6 s
TASK: indicate detected stimuli with thumb twitch
Detection rate ~40 %
Direct current (DC) electrodes
EMG to detect thumb switches
![Page 4: Infra-slow oscillations & consciousness. Infra-slow oscillations Slow fluctuations in the frequency range of 0.01Hz -0.1 Hz Prominent during sleep Present.](https://reader036.fdocuments.net/reader036/viewer/2022062309/5697c01b1a28abf838ccf798/html5/thumbnails/4.jpg)
The clustering of Hit probability
The clustering of HITs and MISSES
![Page 5: Infra-slow oscillations & consciousness. Infra-slow oscillations Slow fluctuations in the frequency range of 0.01Hz -0.1 Hz Prominent during sleep Present.](https://reader036.fdocuments.net/reader036/viewer/2022062309/5697c01b1a28abf838ccf798/html5/thumbnails/5.jpg)
The clustering of Hit probability
Non-random performance
Detections are clustered
Detection ”runs” between 18-72 seconds more prominent than expected
![Page 6: Infra-slow oscillations & consciousness. Infra-slow oscillations Slow fluctuations in the frequency range of 0.01Hz -0.1 Hz Prominent during sleep Present.](https://reader036.fdocuments.net/reader036/viewer/2022062309/5697c01b1a28abf838ccf798/html5/thumbnails/6.jpg)
The correlation of infra-slow oscillations & behaviour
![Page 7: Infra-slow oscillations & consciousness. Infra-slow oscillations Slow fluctuations in the frequency range of 0.01Hz -0.1 Hz Prominent during sleep Present.](https://reader036.fdocuments.net/reader036/viewer/2022062309/5697c01b1a28abf838ccf798/html5/thumbnails/7.jpg)
Hit probability is correlated with the phase of infra-slow oscillations
Detection is more probable in the rising than falling phases of infra-slow oscillations
Detection is not depended on the amplitude nor on the real part of the infra-slow oscillations
![Page 8: Infra-slow oscillations & consciousness. Infra-slow oscillations Slow fluctuations in the frequency range of 0.01Hz -0.1 Hz Prominent during sleep Present.](https://reader036.fdocuments.net/reader036/viewer/2022062309/5697c01b1a28abf838ccf798/html5/thumbnails/8.jpg)
Phase-locking of infra-slow oscillations in individual subjects
In every subject, the detection is more probale in the rising than in the falling phase
The presence of alternating task-specific and resting state networks?
![Page 9: Infra-slow oscillations & consciousness. Infra-slow oscillations Slow fluctuations in the frequency range of 0.01Hz -0.1 Hz Prominent during sleep Present.](https://reader036.fdocuments.net/reader036/viewer/2022062309/5697c01b1a28abf838ccf798/html5/thumbnails/9.jpg)
Correlation of higher frequencies with the infra-slow oscillations
All frequencies from 1.25 Hz to 40 Hz are nested with the infra-slow oscillations
Amplitude is high during the rising phase of infra-slow oscillation
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Results and Implications
The phase of infra-slow oscillations correlates with the detection of weak threshold level somatosensory stimuli
The alternation between task-specific and resting state networks determine the fate of the stimulus
Amplitude does not correlate with detection
No gross excitability changes
Higher frequencies are nested into infra-slow oscillations
Co-operation between all frequencies facilitate detection,
Network excitability
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Acknowledgements
Systems Neuroscience and Informatics Group @ Neuroscience Center, University of Helsinki
J. Matias Palva
Tomi Maila
Simo Monto
Shrikanth Kulashekhar
Santeri Rouhinen