INFLUENCE OF PHYSICS OF TABLET COMPRESSION Small-Scale
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DRAFTINFLUENCE OF PHYSICS OF
TABLET COMPRESSION
Small-Scale Presenter: Alberto Cuitino
November 3rd, 2010
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DRAFTDesign Pharmaceutical Solids
-12-10 -8 -6 -4 -2 0 2 4
-1000-800-600-400-200
0200
Die Filling Compression Breakup DissolutionMixing
EXPERIMENTS
MODELING & SIMULATIONS
Integrated
Integrated
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DRAFTDie Filling – Feed frame
EXPERIMENTS
initial
exit 1 exit 2
exit 3
152.3mmAB
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DRAFTDie Filling – Feed frame
Void/porous MicrostructureIMPACTS
STRENGTH and DISSOLUTION
MODELING & SIMULATIONS Smaller ParticlesMore Surface Area
Larger ParticlesLess Surface Area
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DRAFT
Pressure (MPa)
Den
sity
(g/m
l)
0 5 10 15 20 250
0.5
1
1.5
Sample InfoMass = 0.4 gSize = 996.1 mm3
Composition = 55% (D),15%(S2), 15%(S3)15%(S4)
Expected solid density =1.68 g/ml
Long-range prediction
Pressure (MPa)
Den
sity
(g/m
l)
0 0.5 1 1.5 2 2.50
0.5
1
1.5
predictexpt1expt2
0
2
4
6
8
10
0
2
4
6
8
Z
0
2
4
6
X Y
Z
dens
1.251.21.151.11.0510.950.90.85
Density distribution
0
2
4
6
8
10
0
2
4
6
8
Z
0
2
4
6
X Y
Z
Szz
-0.53-0.55-0.57-0.59-0.61-0.63-0.65-0.67
Pressure distribution
0
2
4
6
8
10
0
2
4
6
8
Z
0
2
4
6
X Y
Z
dens
1.251.21.151.11.0510.950.90.85
Density distribution
0
2
4
6
8
10
0
2
4
6
8
Z
0
2
4
6
X Y
Z
Szz
-0.53-0.55-0.57-0.59-0.61-0.63-0.65-0.67
Pressure distribution
Micro-structure from X-ray CT
ConsolidationMODELING & SIMULATIONS
EXPERIMENTSMultiscale Modeling – Concurrent particle-continuum description
Tablet Compaction Model:
– Multiscale– Preserves local heterogeneous
structure of the powder bed– Predicts macroscopic trends
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DRAFT
Displacement fields in a uniaxially loaded tablet during the formation of a crack.
Bonding-DebondingEXPERIMENTS
Crack
Non-uniform fields
Fracture dominated by weakest regions
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DRAFT-12 -10 -8 -6 -4 -2 0 2 4
-1000
-800
-600
-400
-200
0
200
Bonding-DebondingMODELING & SIMULATIONS
0
20
40
60
80
100
120
0 5 10 15 20 25 30 35
Time
Bon
ding
Str
engt
h
σ A – contact area
-8
-7
-6
-5
-4
-3
-2
-1
0
1
2
0 2 4 6 8 10 12 14 16 18 20
Separation
Forc
e an
d Po
tent
ial
Inter-particle Kernel
development ofhistory dependent inter-particle bonding
Microscopic
Compact StrengthEvolving Force Field
force
TABLET
Macroscopic
Displacement
COMPRESSION
TENSION
Non-uniform fields
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DRAFTStructure “carried” downstream
DissolutionMODELING & SIMULATIONS
EXPERIMENTS
VALIDATION
0
20
40
60
80
100
0 20 40 60 80Time (min)
% D
rug
Rel
ease
Blend 6 640rpmBlend 3 160rpmModel Tablet Blend 6 640rpmModel Tablet Blend 3 640rpm
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DRAFT• A ballistic deposition technique is used to simulate die-filling.
• Powder composition• Particle size distribution• Powder cohesion
Die Filling
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DRAFT• Individual particles are
dropped from the top of the container, falling until they reach a stable position.
• Multiple powders can be considered with different size distributions and physical properties.
Multicomponents
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DRAFT• Particle cohesivity determines the stability of structures in the powder bed.• Cohesion is considered through the critical angle, at which a particle will start
rolling.
Cohesion
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DRAFTNo cohesion Cohesion
Cohesion
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DRAFTParticle Rearrangement
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DRAFT• Once the particles are closely packed, further increases in pressure lead to
particle deformation as the only mechanism available for volume reduction.• The compaction stage is modeled using a mixed discrete-continuum
approach.• The particle motion is constrained by a grid with dimensions of the same
order as the size of the system.• Standard Finite Element techniques are utilized to generate a grid, with the
motion of each simulated particle described in terms of the behavior of the vertexes of the grid’s nodes. Inter-particle interactions are modeled using local constitutive relations.
Compaction
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DRAFT23
2 34
R
ERF
• The particle interactions during the compaction process have a strong influence on the mechanical properties of solid product. The types of interactions include contact forces (elastic, elastic-plastic, fully plastic) as well as tensile forces. •In the current implementation of the numerical method, the elastic contact is modeled using a Hertzian law.
2
22
1
21
21
111,111EEERRR
where
Ei and νi are the Young’s moduli and Poisson ratios of the particles in contact and Ri are their radii. The plastic regime following the elastic response is modeled using a power law, characterized by a hardening exponent.
Compaction Forces
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DRAFTparticle-particle distance
inte
ract
ion
pote
ntia
lR
α
θH
d
Where γ is the liquid surface tension
• Caused by the formation of liquid bridges – as liquid vapors from the ambient gas phase condensate on the particle surfaces, a liquid meniscus forms, bonding particles to each other.
dHRF
/1cos2
Compaction Forces
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DRAFT 2
212
221
2
221
221
221
221 ln22
6 rrRrrR
rrRrr
rrRrrA
21 rrR
• Van der Waals forces – short range forces, usually dominant for either small particles or during the particle fragmentation stages of compaction.
particle-particle distance
inte
ract
ion
pote
ntia
lΔ – the distance between the particles.
Compaction Forces
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DRAFTTertiary MixtureD and S2, S3, S4
0
2
4
6
8
10
0
2
4
6
8
Z
0
2
4
6
X Y
Z
dens
1.251.21.151.11.0510.950.90.85
Density distribution
0
2
4
6
8
10
0
2
4
6
8
Z
0
2
4
6
X Y
Z
Szz
-0.53-0.55-0.57-0.59-0.61-0.63-0.65-0.67
Pressure distribution
Initial configuration
Configuration after rearrangement
Pressure (MPa)
Den
sity
(g/m
l)
0 5 10 15 20 250
0.5
1
1.5
Sample InfoMass = 0.4 gSize = 996.1 mm3
Composition = 55% (D),15%(S2), 15%(S3)15%(S4)
Expected solid density =1.68 g/ml
Long-range prediction
Pressure (MPa)
Den
sity
(g/m
l)
0 0.5 1 1.5 2 2.50
0.5
1
1.5
predictexpt1expt2
Mass (g) Dimensions (mm)
Number ofParticles
ExpectedSolid Density
(g/ml)0.4 9×9×6.1 33,764 1.68 0.75
V
Filling/Rearrangement/Compaction
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DRAFT• PressterTM tablet press simulator
• Set to mimic Stokes B2 press• Tooling
• Oval, deep cut• i.e., tablets are oval with domelike top and
bottom surfaces• Presster data:
• Upper compression force• Tablet x-section area • Tablet thickness • Tablet weight • radial die wall force, ejection forces, stage speed …
Presster™ Studies
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DRAFTPresster data collected at different compaction forces (10kN, 15kN, and 20kN )
Presster™ Studies
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DRAFT• The model can be used to simulate the evolution of the configuration of the powder bed with time as well as monitor the values of various quantities indicative of its mechanical properties. • Several different powders have been considered, both individually and in a blend to demonstrate the versatility of the method.
• Each blend can be mapped to granulation parameters by:
• Simulations vs. PressterTM Data• Error minimization
Identification of critical blend properties from 500 simulations
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DRAFTSmall-Scale Study
• Provides mechanistic parameters for granulations
• The parameters can be used for generating SIMULATED surface response models for conditions other than tested using models