Infection - Curetis
Transcript of Infection - Curetis
Curetis GmbH | Max-Eyth-Str. 42 | 71088 Holzgerlingen | Germany
Tel.: +49 (0)7031 49195 10 | Email: [email protected] |
Unyvero is designed to expandwith your growing needsA single test handles one patient sample,
analyzes around 100 DNA analytes and delivers reliable results within just 4-5 hours
Unyvero’s sample-to-answer platform provides rapid results for severe infectious diseases in hospitalized patientsPowerful multiplex PCR technology combined with
the broadest range of microorganism and resistance
targets sets the Unyvero System apart.
The Unyvero System consists of:
00585 Rev 3.0 © Curetis GmbH
Caution – Investigational Device. Limited by Federal US Law to investigational Use. Not available for Sale in the United States.
www.curetis.com
Fast & Simple Syndromic Testing for Severe Infections - Improving Patient Outcomes
Lysator to lyse and process a variety of native samples
Cockpit to manage testing process, display, store, and transmit results
Analyzer to perform DNA testing with random-access, multiplex PCR
Unyvero L4 Lysator Unyvero C8 Cockpit Unyvero A50 Analyzer
Urinary TractInfection
DNA purifi cation
PCR set-up
Multiplex PCRwith array detection
Applications for severe infections:
Blood Culture – BCU
Hospitalized Pneumonia – HPN
Intra-Abdominal Infection – IAI
Implant & Tissue Infection – ITI
Urinary Tract Infection – UTI
Working time 30 seconds
30 minutes lysis in Lysator
Assembling Unyvero Cartridge with Sample and Master Mix Tube
B
Working time 60 seconds
Transfer patient sample to Unyvero Sample Tube
A
Working time 20 seconds
Scanning and inserting the Unyvero Cartridge in the A50
(Max. 2 cartridges simultaneously)
C
EasyWorkfl ow
Unyvero Urinary Tract Infection (UTI) Cartridge
Workfl ow of the Unyvero SystemUnyvero
Uropathogens can be detected in 4-5 hours using the Unyvero solution
Staphylococcus aureus
Coagulase negative staphylococci
Staphylococcus saprophyticus
Streptococcus agalactiae
Enterococcus spp.
Enterococcus faecalis
Enterococcus faecium
Corynebacterium urealyticum
Enterobacteriaceae
Citrobacter freundii / koseri
Klebsiella aerogenes (E. aerogenes)
Enterobacter cloacae complex
Escherichia coli
Klebsiella oxytoca
Klebsiella pneumoniae
Klebsiella variicola
Proteus spp.
Providencia spp.
Bacteroides spp. /Prevotella spp.
Acinetobacter baumannii complex
Pseudomonas aeruginosa
Detection of prokaryotic genetic sequence
Candida spp.
Candida albicans
Candida auris
Candida glabrata
Gram-positive bacteria Enterobacteriales Non-fermenting
bacteria
Anaerobic bacteria
Universal Bacteria
Fungi
GeneResistance
Faster detection enables earlier optimization of therapy
Urinary tract infections (UTIs) account for a major part of clinical
workloads in microbiology laboratories.
UTIs are among the most prevalent hospital-acquired infections,
and are the second most common cause of bacteremia in
hospitalized patients.2
Mortality rates for patients with urosepsis range from 25 to 60%.3
The number of UTIs caused by antibiotic-resistant bacteria
is increasing.4
The Unyvero UTI Application simultaneously identifi es a large panel of bacteria,
fungi, and antibiotic resistance genes directly from urine samples.
UTIs are among the most common hospital-acquired
Annual cost for UTIs in France is €58 million.5
1 Point prevalence survey: Acute care hospitals 2011-2012.
2 WHO. Prevention of hospital acquired infections: A practical guide. 2nd edition. 2002.
3 Paech B. et al., Risk Factors for Urosepsis in Older Adults: A Systematic Review. 2016. 2:1–7.
4 English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) Report 2017.
5 François M. et al., The economic burden of urinary tract infections in women visiting general practices in France: a cross-sectional survey. BMC Health Serv Res. 2016;16(a):365.
Multiple Sample Types
24/7Results
mecA
vanAvanB
ctx-M
impkpcndmoxa-23oxa-24oxa-48vim
mcr-1
qnrBqnrS
sul1
3rd generation Cephalosporins
Glycopeptides
Fluoroquinolones
Sulfonamide
Carbapenem
Polypeptides / polymyxins
Oxacillin
Catheter-associated urinary tract infections
Complicated cystitis
Urosepsis
Pyelonephritis
Unyvero UTI can be used for diagnosis of complicated urinary tract infection and their consequences:
Results displayed in Cockpit – PDF export, LIS connection
D
4 to 5 hour analysis process