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![Page 1: Infant feeding in the context of HIV International evidence and recommendations WHO Guidelines on HIV and Infant feeding. 2010.](https://reader035.fdocuments.net/reader035/viewer/2022070400/56649f115503460f94c240cf/html5/thumbnails/1.jpg)
Infant feeding in the context of HIV
International evidence and recommendations
WHO Guidelines on HIV and Infant feeding. 2010
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National (or sub-national) health authorities should decide whether health services will principally counsel and support mothers known to be HIV-infected to:
- breastfeed and receive ARV interventions, or, - avoid all breastfeeding,
as the strategy that will most likely give infants the greatest chance of HIV-free survival.
This decision should be based on international recommendations and consideration of the socio-economic and cultural contexts of the populations served by Maternal and Child Health services, the availability and quality of health services, the local epidemiology including HIV prevalence among pregnant women and main causes of infant and child mortality and maternal and child under-nutrition
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Mothers known to be HIV-infected (and whose infants are HIV uninfected or of unknown HIV status) should exclusively breastfeed their infants for the first 6 months of life, introducing appropriate complementary foods thereafter, and continue breastfeeding for the first 12 months of life.
Breastfeeding should then only stop once a nutritionally adequate and safe diet without breast milk can be provided.
Which breastfeeding practices and for how long?
… in settings where national authorities decide to promote and support BF and ARVs …
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National (or sub-national) health authorities should decide whether health services will principally counsel and support mothers known to be HIV-infected to:
- breastfeed and receive ARV interventions, or, - avoid all breastfeeding,
as the strategy that will most likely give infants the greatest chance of HIV-free survival.
This decision should be based on international recommendations and consideration of the socio-economic and cultural contexts of the populations served by Maternal and Child Health services, the availability and quality of health services, the local epidemiology including HIV prevalence among pregnant women and main causes of infant and child mortality and maternal and child under-nutrition
![Page 5: Infant feeding in the context of HIV International evidence and recommendations WHO Guidelines on HIV and Infant feeding. 2010.](https://reader035.fdocuments.net/reader035/viewer/2022070400/56649f115503460f94c240cf/html5/thumbnails/5.jpg)
HIV free survivalThe number of infants born HIV-infected mothers who are
both uninfected and alive … at 18 months(in the absence of ARVs to prevent HIV transmission through BF)
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HIV free survivalThe number of infants born HIV-infected mothers who are
both uninfected and alive … at 18 months(in the absence of ARVs to prevent HIV transmission through BF)
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HIV free survivalThe number of infants born HIV-infected mothers who are
both uninfected and alive … at 18 months(in the absence of ARVs to prevent HIV transmission through BF)
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0
50%
100%
6 mth 12 mth 18 mth
HIV free survivalThe number of infants born HIV-infected mothers who are
both uninfected and alive … at 18 months
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Measuring 'success' in PMTCT
• Policy, interventions and programmes should be judged on their ability to promote HIV free survival among all children and the health and survival of mothers
• Preventing HIV transmission is not enough
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WHO guideline development• Rigorous, independent assessment of available research evidence
– GRADE process– Systematic reviews consolidated into tables
• Consideration of impact, feasibility, implications beyond immediate recommendations and cost
• Equity – ensuring that recommended interventions provide benefit to all sections of the population – particularly important
• Guideline development groups include academic experts, programme manager, civil society and community representatives– Declarations of interest
• Publication of all evidence included and rationale behind recommendations
• Allocation of strength of recommendation
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Strength of a recommendation
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Implications of a strong recommendation
• Patients: Most people in this situation would want the recommended course of action and only a small proportion would not
• Clinicians: Most patients should receive the recommended course of action
• Policy makers: The recommendation can be adapted as a policy in most situations
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Revised WHO Recommendations on the use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants (2010)
• Eligibility criteria for ART– CD4 count <350, irrespective of clinical stage– Clinical stage 3 or 4, irrespective of CD4 count
• The 2010 recommendations … provide two alternative options for women who are not on ART and breastfeed:
– A) daily NVP for infants from birth until the end of the breastfeeding period. or
– B) continued regimen of triple ARV therapy to the mother until the end of the breastfeeding period.
• ARV prophylaxis …. should continue until one week after all exposure to breast milk has ended.
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National (or sub-national) health authorities should decide whether health services will principally counsel and support mothers known to be HIV-infected to:
- breastfeed and receive ARV interventions, or, - avoid all breastfeeding,
as the strategy that will most likely give infants the greatest chance of HIV-free survival.
Mothers known to be HIV-infected (and whose infants are HIV uninfected or of unknown HIV status) should exclusively breastfeed their infants for the first 6 months of life, introducing appropriate complementary foods thereafter, and continue breastfeeding for the first 12 months of life.
Breastfeeding should then only stop once a nutritionally adequate and safe diet without breast milk can be provided.
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• What is the evidence base in support of the main revisions?– Efficacy and safety of ARVs to prevent HIV transmission through BF– The risks associated with not BF– The optimal duration of BF by HIV-infected mothers– Maternal health considerations
• Why WHO recommends that national authorities promote a single infant feeding strategy for all HIV-infected mothers and their infants?
• What are the 'opportunities' and 'challenges' of adopting and implementing the revised recommendations?
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Timing of Mother-to-Child HIV Transmission - No ARVs
Early Antenatal(<36 wks)
Late Antenatal(36 wks to
labour)
Late Postpartum
(6-24 months)
Early Postpartum
(0-6 months)
Adapted from N Shaffer, CDC
5-10% 10-15% 5-20%
Labour and Delivery
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MTCT in 100 HIV+ Mothers by Timing of Transmission – no ARVs
0
20
40
60
80
100
# uninfected
# infected during BFfor 2 yrs
# infected duringdelivery
#infants infectedduring pregnancy
63
uninfected
15
157
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HIV transmission and feeding practices(no interventions to prevent HIV transmission)
7
19.9
24.528
32.336.7
3.1
9.713.2
15.918.2 20.5
0
5
10
15
20
25
30
35
40
Birth 6 weeks 14 weeks 6 months 12 months 24 months
Breastfed Exclusive formula
Nduati. 2000. JAMA 283:1167-74
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Exclusive breastfeeding reduces HIV transmissionHR p 95% CI
EBF 1.0
BM + fluid/food 1.56 0.308 0.66-3.69
BM + solids 10.87 0.018 1.51-78.00
BM+FF (@12wks) 1.82 0.057 0.98-3.36 Coovadia H. Lancet 2007. 369:1107-1116
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Maternal ARV prophylaxis studies antepartum and postpartum (Dual or triple ARVs/ART)
Between age 4-6 weeks and 6-7 months HIV transmission rates
0.6% 0.9% 0.6%1.1%
0%
2%
4%
6%
8%
10%
DREAM (CROI 2008) Mitra Plus (IAS 2007) Amata (IAS2007) KIBS (CROI 2008)
% T
R at
6 m
onth
s
4 non-randomized-controlled studies show reduced HIV breastfeeding transmission
6 mo EBF 6 mo EBF 6 mo EBF 6 mo EBF
Courtesy: Lynne Mofenson
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Kesho Bora:All infants:
HIV infections
Triple ShortEvents (cum) /at risk
Rate (95% CI)
Events (cum) /at risk
Rate (95% CI)
Reduc-tion
Birth 7/395 1.8 (0.8, 3.7) 9/401 2.2 (1.2, 4.3) 18%
6 weeks 13/376 3.3 (1.9, 5.6) 19/373 4.8 (3.1, 7.4) 31%
6 months 19/337 4.9 (3.1, 7.5) 33/329 8.5 (6.1, 11.8) 42%
12 months 21/275 5.5 (3.6, 8.4) 36/249 9.5 (6.9, 13.0) 42%
Log rank test p = 0.039 (stratified on centre and intention to BF)
0 1 2 3 4 5 6 7 8 9 10 11 12
Age (in months)0.
750.
800.
850.
900.
951.
00
Pro
po
tio
n n
ot
infe
cted
Infant HIV-free rates to 12 months of age.RCT, by study stratum
ShortTriple
RCT in Kenya, Burk. Faso and SA
2 arms - AZT + 3TC + LPV/r until
•Delivery only (Short) then nil Or
•End of BF ~6mths (Triple)2.5% cumulative transmission @12m in those with effective viral suppression
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Triple ShortEvents (cum) /at risk
Rate (95% CI)
Events (cum) /at risk
Rate (95% CI)
Reduc-tion
Birth 11/400 2.7 (1.5, 4.9) 11/403 2.7 (1.5, 4.9) 0 %
6 weeks 19/377 4.8 (3.1, 7.4) 24/376 6.0 (4.1, 8.8) 20 %
6 months 33/347 8.3 (6.0, 11.5) 50/334 12.6 (9.7, 16.3) 34 %
12 months 40/278 10.4 (7.7, 13.9) 62/252 16.3 (12.9, 20.5) 36 %
Log rank test p = 0.022(stratified on centre and intention to BF)
0 1 2 3 4 5 6 7 8 9 10 11 12
Age (in months)0.
750.
800.
850.
900.
951.
00
Pro
po
rtio
n a
live
an
d n
ot
infe
cted
Infant HIV-free survival rates to 12 months of age.RCT, by study stratum
ShortTriple
Kesho Bora:All infants:
HIV-free survivalRCT in Kenya, Burk. Faso and SA
2 arms - AZT + 3TC + LPV/r until
•Delivery only (Short) then nil Or
•End of BF ~6mths (Triple)
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Mma bana study
2 randomised arms and one observationalMothers not eligible for ART received either: lopinavir/ritonavir and combivir } for 6mor abacavir/AZT/3TC } while BFMothers eligible for ART – outcomes observed
Viral suppression >92% all groups
Infa
nt H
IV t
rans
mis
sion
%
0123456789
10
Mothers not eligible forART
Observational
LPV/r + combivirAbacavir/AZT/3TCObservational
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Infant Age
Pro
ba
bilit
y o
f H
IV-1
In
fec
tio
n
1wk 9wk 6mo 9mo 12mo 15mo 18mo 24mo
0.0
00.0
50.1
00.1
50.2
00.2
50.3
0ControlExtended NVPExtended NVP+ZDV
Age1 wk
6 wks
9 wks
14 wks
6 mos
9 mos
12 mos
15 mos
18 mos
24 mos
Estimates (%)
Control 0.3 5.1 7.4 8.4 10.1 10.6 11.5 12.4 13.9 14.5
Extended NVP 0.1 1.7 2.6 2.8 4.0 5.2 7.0 7.8 10.1 11.2
Extended NVP+ZDV 0.2 1.6 2.4 2.8 5.2 6.4 8.1 8.7 10.2 12.3
Probability of HIV-1 Infection in Infants Uninfected at Birth by Treatment Arm: PEPI-Malawi
3 arms:
•Control
•NVP to infants for 14 wks
•NVP and AZT to infants for 14wks
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6.4%
3%
1.8%
0.0
1.0
2.0
3.0
4.0
5.0
6.0
7.0
8.0
9.0
10.0
Transmission at 6 mo
Control
Maternal LPV/rfor 6 mo
Inf NVP for 6mo
Breastfeeding, Antiretroviral and Nutrition(BAN) study (Chasela, IAS 2009)
Infa
nt H
IV t
rans
mis
sion
rat
es %
p=0.001
p=0.003
3 Arms: Control Mothers receive lopinavir/ritonavir for 28 wks throughout BF period Breastfeeding infants received daily NVP for 6 months
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6.4%
3%
1.8%
7.6%
4.7%
2.9%
0.0
1.0
2.0
3.0
4.0
5.0
6.0
7.0
8.0
9.0
10.0
Transmission at 6 mo Death at 6 mo
Control
Maternal LPV/rfor 6 mo
Inf NVP for 6mo
Breastfeeding, Antiretroviral and Nutrition(BAN) study (Chasela, IAS 2009)
Infa
nt H
IV t
rans
mis
sion
and
m
orta
lity
rate
s %
p=0.001
p=0.003
3 Arms: Control Mothers receive lopinavir/ritonavir for 28 wks throughout BF period Breastfeeding infants received daily NVP for 6 months
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• High quality evidence that …– ARV interventions to infants or mothers significantly
reduce HIV transmission through breastfeeding• No evidence of diminished protection over time
– No evidence of significant drug-related adverse events• No increased adverse events with prolonged ARV intervention. • NVP adverse events occur within first few weeks and do not
accumulate with longer exposure• Dose of NVP given to infants as prophylaxis is less than that
routinely given as ART for infected infants
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Risks associated with not breastfeeding
• Non breastfeeding from birth• Early cessation of BF
HIVtransmission
Morbidity/mortality
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Effect of breastfeeding on infant and child mortality due to infectious diseases in less developed countries: A pooled analysis – WHO, Lancet 2000
< 2 mths 2-3 mths 4-5 mths 6-8 mths 9-11 mths
Odd ratio 5.8 4.1 2.6 1.8 1.4
Protection provided by breastmilk
< 6 mths 6-11mths
Diarrhoea 6.1 2.4
ARI 1.9 2.5
Breastfeeding recognised as the single most
important intervention to prevent child deaths
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Higher Early Mortality (7 Months) in Formula-Fed than Breastfed Infants
Thior I et al. JAMA 2006;296:794-805
4.3%
1.5%
9.3%
4.9%
10.7%
8.5%
0
2
4
6
8
10
12
1 month 7 months 18 months
Formula fedBreastfed
Predominant causes infant death: Diarrhoeal diseases and pneumonia
% M
orta
lity
p=0.005
p=0.003p=0.21
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Higher mortality in HIV-exposed infants whose mothers chose to give formula feeds
• 94 deaths amongst 1034 infants started on EBF• 73 of these children were HIV-infected• Overall HIV-free survival was 75.41% at 6 months
(i.e. 223 deaths or infections amongst 1037 infants)
• 8 deaths amongst 101 infants on RF from birth• Deaths occurred in first 3 months of life
Cumulative mortality according to initial infant feeding type
Feeding type N 1m 2m 3m 4m 5m 6m
EBF 1037 1.92% 3.69% 6.12% 8.02% 9.07% 10.1%
RF 101 4.22% 9.90% 15.12% - - -
Coovadia H. Lancet 2007. 369:1107-1116
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J Acquir.Immune.Defic.Syndr. 2010;53(1):28-35
Decreased survival among infants who stopped BF early or who were never BF.
AHR = 6.19; (95% CI 1.41–27.0, P = 0.015)
97% infants were tested at 6 wks – none infected.
Difference was independent of maternal health or if receiving ART
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Programmatic experiences
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Replacement feeding in PMTCT sites
• Sample of milk collected from bottles (n=94) being offered to infants brought by mothers to PMTCT clinic follow-up visits– 63% heavily contaminated with E.coli– 28% diluted (based on protein concentration)
In spite of– All mothers having completed
12 years of education– 72% having fridges– All received good counselling on IFP
Bergstrom. Acta Paeds 2007
• 15-20% mothers reported free FF being used for something other than index child
– Sold– Exchanged
• 50-75% reported running out– Mainly because of clinic
supply
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Knowledge of nurses and counsellors about risk of BF transmission
0
20
40
60
80
100
120
140
160
0 - 20 20 - 40 40 - 60 60 - 80 80 - 100 Don't Know
Number of infants infected
Num
ber o
f res
pond
ents Response to question: If 100 HIV-infected
women breastfeed until their children are two years old how many children will be infected at 2 years of age? (mother and child do not receive any antiretroviral medicines)
Chopra and Rollins, Arch. Dis. Child. 2008
Correct answer ~14
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Feeding at some PMTCT sites in SA
0102030405060708090
100
RietvleiRural
ZeerustRural
ShongweRural
COSHRural
DurbanUrban
PmbUrban
BFFF
The quality of infant feeding counselling translated into HIV free survival of infants
Woldenbeset. IAS 2009
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Cost of scenarios - 10,000 HIV mothers (US$)Assume eligibility criteria for ART <350
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Why does WHO recommends that national authorities promote a single infant feeding strategy
for all HIV-infected mothers and their infants?
• High quality evidence that ARVs very significantly reduces the risk of HIV transmission through breastfeeding
• Documented evidence of increased mortality when replacement feeds are given inappropriately in the context of HIV
• Even with good protocols and training, difficult to assure high quality counselling and support for all infant feeding practices
• Cost effective interventions are available that improve survival of mothers and infants and reduce transmission
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Guidance to countries
• Review position/policies– Review the evidence – Assess type of epidemic– Assess contribution of infectious diseases and malnutrition to infant
mortality and potential impact of safer BF on HIV-free survival– Assess quality and coverage of PMTCT/ART services– Consider financial and human resource costs of options– Formulate national infant feeding and HIV strategy
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Adoption of WHO 2010 guidelines on HIV and Infant feeding
• Angola• Burundi• Cameroon• Central African Republic• Chad• Congo• DRC• Equatorial Guinea• Eritrea• Ethiopia• Gabon• Ghana
• Kenya• Lesotho• Madagascar• Malawi• Mozambique• Namibia• Rwanda• Senegal• Swaziland• Tanzania• Uganda• Zambia• Zimbabwe
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Why does WHO recommends that national authorities promote a single infant feeding strategy for all HIV-infected
mothers and their infants?
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Guidance to countries
• Review position/policies– Review the evidence – Assess type of epidemic– Assess contribution of infectious diseases and malnutrition to infant
mortality and potential impact of safer BF on HIV-free survival– Assess quality and coverage of PMTCT/ART services– Consider financial and human resource costs of options– Formulate national infant feeding and HIV strategy
• Plan implementation– Advocacy to health care workers, health professionals and communities to
gain confidence for support in implementation– Training, commodities, – Local prototypes and plan for scale-up– Identify what national materials need to be revised– Funding applications e.g. Global fund
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What will influence the way mothers will feed their infants?
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Breastfeeding is not just nutrition
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Natal Witness 4th February 1999
Baby cries, mum killed “An Ermelo man who allegedly whipped a woman to death with a
sjambok was arrested on Tuesday, Mpumalanga police said yesterday. The 33-year-old man allegedly whipped Ellen Nkosi to death at about midnight on Monday. Police said he shouted at her for not breastfeeding her baby to make it stop crying, and then whipped her” – Sapa
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With leadership, and,
common purpose and perspectives among health workers and communities alike,
HIV-infected mothers and their infants have the best chance of improved health and survival since the beginning of the HIV epidemic.
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Acknowledgements
• Colleagues at WHO Departments of CAH, MPS and HIV• The many researchers who have worked to understand these risks
and opportunities• The mothers, infants and families who have been part of the research
studies
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Effective interventions
Risk factors
What wins?
Health system issues
Gerry Boon
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Mma bana study
2 randomised arms and one observationalMothers not eligible for ART received either: lopinavir/ritonavir and combivir } for 6mor abacavir/AZT/3TC } while BFMothers eligible for ART – outcomes observed
Infa
nt H
IV
tran
smis
sion
%
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10
Mothers not eligible forART
Observational 1248 pregnant women referred to study sites. After counselling about study interventions, 110 (8.8%) declined enrolment as preferred to give formula feeds.