Industrial biotechnology, past, present, and future Swedish-African partnerships
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Transcript of Industrial biotechnology, past, present, and future Swedish-African partnerships
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Industrial biotechnology, past, present and future Swedish-
African Partnerships.
Bo Mattiasson
Lund University and Indienz AB
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Sida-supported activities
• BioEARN
• BioInnovate
• Bilateral programs
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BioEARN and to some extent also in BioInnovate
• Enzyme and microbial technology
• Environmental biotechnology
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Projects
• Upgrading fish waste – production of PUFA
• Biogas from industrial waste
• Enzymes for the leather industry
• Wastewater treatment e.g. from leather industry
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Biogas from surplus biomass
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Anaerobic degradation of organic material
ORGANIC MATERIAL
SOLUBLE MONOMERS
EXTRACELLULAR
HYDROLYSIS
VOLATILE FATTY
ACIDS
ACETATE HYDROGEN
CARBON DIOXIDE
ACIDOGENESIS
ACETOGENESIS
METHANOGENESIS
METHANE
CARBON DIOXIDE
Enzymatic degradation
Microbial degradation
BIOGAS
METHANOGENESIS
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How far can one drive on the
bioenergy produced from 1 hectar
(10.000 m2)?
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Project with Tanzania
• Bioenergy carriers from biomass
• Ethanol from wild cassava
• Biogas from residues from starch production
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Biomass can be used for many purposes
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Platform chemcials
• For industry to build on.
• Relatively simple molecules that are converted afterwards
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Sources of biomass
• Waste from traditional farming
• Waste from industrial processing
• Municipal solid waste
• GMO crops specially designed for industrial biotech.
• Algae
• etc
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12
3
Mono-, di-, or tri- glycerate
Glycerol carbonate
Glyceric acid
3-Hydroxypropionic acid
1,3-Propanediol
Propionic acid
3-Hydroxypropionaldehyde
Propanol
Glycerol
Glycidol
DihydroxyacetoneDiglyceraldehyde
Branched polyesters and nylons
1,2-Propanediol
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Malonic acidAcrylic acid
Ethyl-3HP
Methylacrylate
Acrylamide
2
Acrylonitrile
3-Hydroxypropionic acid
Propiolactone
Poly-3HP
1,3-Propanediol
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Enzymes and micororganisms as industrialcatalysts
• Organisms isolated from extreme environments are a good source of enzymes adapted to harsh conditions
• Enzyme properties can be improved using gene technology
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A novel alkaline protease from a novel alkaliphilic microorganism isolated from an alkaline soda lake
Nesterenkonia aethiopica Protease crystals
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New biology to obtain suitable Biocatalysts
RESEARCH APPROACH
Extremophilicorganisms,
Genesisolation
cultivation
Extreme habitats
Cloning, expression & Production
Rational design,Directed evolution
genes
GREENCHEM
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Industrial enzymes
• For food industry
• For leather industry
• For chemical industry
• For cosmetics
• For conversion of biomass
• etc.
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Environmental biotechnology
• Remediation
• Degradation of toxic chemicals
• Bioenergy (mainly biogas)
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The largest biotech process
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The largest biotech process
• Treatment of water
– Wastewater
– Water for consumption
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Heavy metals constitute a serious environmental problem today!
• Polluting water and soil
• HM are taken up by the crops
• Influences ecosystems negatively
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Bioreactors for removal of heavy metal ions
• Sulfate reducing bacteria grown in bioreactor
• Porous glass used as carrier material
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worldwide public
health problem
Microcystins
29
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Collaboration with the private sector?!
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STRATEGY FOR BUILDINGSTRONG BIOTECHNOLOGY
RESEARCH.
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Microbialfermentation
Enzymetechnology
Enzyme µbial
technology
Cloning & molecularbiology
Downstreamprocessing ofbiomolecules
Anaerobic fermentation
Processtechnology
The seven pillars for building competence inIndustrial biotechnology.
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Microbialfermentation
Enzymetechnology
Enzyme µbial
technology
Cloning & molecularbiology
Downstreamprocessing ofbiomolecules
Anaerobic fermentationProcess
technology
Need for adding application oriented work
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Microbialfermentation
Enzymetechnology
Enzyme µbial
technology
Cloning & molecularbiology
Downstreamprocessing ofbiomolecules
Anaerobic fermentationProcess
technology
Need for adding APPLIED RESERCH
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Enzymetechnology
Applied projects for e.g. Master students
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Enzymetechnology
Applied projects for e.g. Master students
Industrial partner
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Enzymetechnology
Applied projects for e.g. Master students
Industrial partner
Fermentationtechnology
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Microbialfermentation
Enzymetechnology
Enzyme µbial
technology
Cloning & molecularbiology
Downstreamprocessing ofbiomolecules
Anaerobic fermentationProcess
technology
Add INDUSTRIALCOLLABORATION
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Course in entrepreneurship in biotechnology
• Make a market survey
• Write a business plan
• To arrange financial support
• IPR
• To meet others who have made the journey and succeeded or failed.
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Why this course?
• Important to discuss project areas that are familiar to the students.
• Important to have concrete objects to work with
• It gives the students the toolbox for starting
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In Lund this has resulted in
• Bioprocess Control AB
• Capsenze HB
• Enviro AB
• Protista Int. AB
• Indienz AB
• Cyclicor AB
• Enza AB
• m.fl.
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Indienz ABworks with a pilot scale biorefinery
• One of the founders now tries to start a daughter company in India
• One founder from Ethiopia is investigating the possibilities to establish activities in Ethiopia.
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Bioprocess Control AB
monitoring and control of anaerobic digestion
• On founder from China is CEO and has started a daughter company there.
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Points to focus on …
• Postdoctoral training
• Industrial contacts
• PhD-programme and postdoc programmes to be introduced gradually
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When starting …
• Collaborate with established companies
• Start with less demanding projects
• Consulting, trouble shooting etc
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Thank you for listening!
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Bo Mattiasson
• www.biotek.lu.se
• +46 70-6059830