Indeterminate Leprosy

• earliest and mildest form of the disease• few numbers of hypopigmented macules

(cutaneous lesions) • loss of sensation is rare. • most cases progress into a later form,

although patients with strong immunity may either clear the infection on their own or persist in this form without progressing.

Tuberculoid Leprosy

• one large red patch with well-defined raised borders or a large hypopigmented asymmetrical spot

• lesions become dry and hairless • loss of sensation may occur at site of some lesions • tender, thickened nerves with subsequent loss of

function are common • spontaneous resolution may occur in a few years or

it may progress to borderline or rarely lepromatous types

Tuberculoid Leprosy

• organisms present at low to undetectable levels• low infectivity• granulomas and local inflammation• peripheral nerve damage• normal serum immunoglobulin levels• normal T – cell responsiveness• specific response to M. leprae antigens

Borderline Tuberculoid Leprosy

• similar to tuberculoid type except that lesions are smaller and more numerous

• cutaneous lesions are numerous and less well defined

• anesthesis is less severe• disease may stay in this stage or convert back

to tuberculoid form, or progress

Borderline Tuberculoid Leprosy