1.1 Recognition of self molecules by immune system is important for A. Activation of natural killers involved in innate immunity B. Binding and identification of consequences of the future cooperation x C. Induction of TCR and BCR expression on the self molecules D. Stimulation of binding with E. Activation of processes leading to kill the cell presenting self molecules 1.2 NK natural killer identifie the abnormalities on cells by detecting the amount of A. MHC I molecules x B. Non self molecules C. PAMP pathogen-associated molecular patterns D. PRR pattern recognition receptors E. SGR somatically generated cell surface receptors 1.3 PRR pattern recognition receptors can bind A. B and T lymphocytes B. Host-cell molecules C. MHC I molecules D. NK cells E. PAMP 1.4 SGR (e.g. BCR resp TCR) on B and T lymphocytes are A. Bound only to MHC I molecules B. Encoded to recognise PAMP C. First to be produced after exposition to foreign molecule D. Of the same specificity in everybody E. Randomly generated during intrauterine development

x

x

1.5 Immunological memory deals with A. Activation of phagocyting cells leading to ingestion of mibrobial invaders B. Changes of adaptive immunity after repeated exposition to the antigen of the same microbe x C. Stability of innate immunity reaction to reexposition to the same microbe D. Recognition of PAMP via PRR E. Stimulation of defective host cell with reduced amount of MHC molecules to do the apoptosis 1.6 Which of below mentionned structures on microbes are recognised by human immune system molecules. A. MHC I molekuly B. MHC II molekuly C. PAMP x D. PRR E. SGR 2.1 Synthetic molecule that bind the receptors on B cells, but does not stimulise their production of specific antibodies unless it is conjugated with bigger immunogenic molecules is A. adjuvans

B. C. D. E.

carrier hapten immunogen tolerogen

x

2.2 Which of below mentioned molecules induce the strongest specific immune reaction in man A. 250 000 Da self plasmatic protein B. 150 000 Da toxin produced by bacterium x C. 500 Da plasmatic protein from monkey D. 400 Da molecule from foreign man E. 200 Da molecule of carbohydrate that is the same in all biological species 2.3 During early stages of lymphocyte development the receptor-epitop binding can results in inactivation or death of the lymphocyte, or unresponsivness. The epitop is A. hapten B. immunogen C. tolerogen x D. carrier E. adjuvans 2.4 Natural killers induce lysis of infected cell, that has the decreased exposition of MHC I molecules. NK cells do this by activation of receptors: A. receptors for complement B. Fc receptors C. KAR killer activation receptors x D. KIR killer inhibition receptros E. TCR 2.5 Antibodies mediated accumulation of macrophages in the site of pathogen arises thanks to A. Receptors for complement B. Fc receptors x C. KIR killer activation receptors D. PRR pattern recognition receptors E. TLR toll like receptors 2.6 A. B. C. D. E. Allergic reaction is induced by adjuvans hapten immunogen tolerogen no of answer is correct

x

2.7 Binding of epitop on Fab portion of molecule before its Fc fragment anchors in target structure is not required for A. molecule of the carrier B. conjugate of hapten-carrier C. hapten

D. E.

IgE IgG

x

2.8 Immunocompetent cells lymphocytes are stimulated by binding of antigens to the surface receptors. This activity is influenced by: A. A single and the only receptor per cell B. A single type of receptor found on all cells C. Integration of several signals generated by multiple receptors on single cells x D. Multiple receptors that bind soluble ligands only E. Nonspecific receptors binding a wide spectrum of ligands

3.1 Vaginal candidosis (infection produced by funguses microbes) after ATB therapy is caused by:A. B. C. D. E. The ammount of secreted lysosyme in vagina The ammount of secreted mucus in vagina Changes in physiological flora pH in vagina changes of function of epitelial cells x

3.2 Repeated pneumoniae infectious inflamation of lungcaused by oportunistic pathogens in patient with impaired cilliated epitelium of bronchuses is conditioned by:A. B. C. D. E. decreased IgA antibodies production changes in total antibodies production decrease of pH decrease of nonspecific immune reactions impairement of specific immune mechanism

x

3.3 Permanent uretral catheter as one of the cause of cystitis (inflamation of urine bladder) results inA. production of conditions favorable for changes of molecules between epitelium and environment B. introduction of microorganisms in urethra x C. secretion of mucus from epithelial cells D. changes of pH of urine E. all possibilities are correct

3.4 Which of mentionned possibilities is the example of physiological barrier inhibiting colonisation by microorganismsA. B. C. D. E. respiratory tract with pH - 9,0 11,0 skin - pH around 8,0 stomac - pH 1,0 3,0 upper part of GIT pH - 6,5 7,5 vagina pH around 7,0 x

3.5 Which of the mentionned possibilities is the cause of microbicidal activity in respiratory tractA. Lysosyme that degrades 1,4 glycosidical binding of bacteria x B. Saliva that break IgA molecules pn mucous membrane C. Fatty acids of commensal bacteria degrading the peptidoglycan of pathogens D. Tears enabling ingestion of microbes by phagocytes E. Lysosyme degrading DNA and RNA produced by pathogenic microbes. 4.1 Which of mentioned cells are present on the place of infection by worms A. basofils B. eosinofils x C. lymphocytes D. monocytes E. neutrofils 4.2 A. B. C. D. E. NK cells natural killers - belong to: basofils eosinofils lymphocytes monocytes neutrofils

x

4.3 In microscopic smear of the pus from bacterial infection site there will be mostly present A. bazofils B. eozinofils C. lymphocytes D. monocytes E. neutrofils x 4.4 A. B. C. D. E. Which of mentionned cells are leading cells in allergic reactions basofils dendritic cells lymphocytes monocytes neutrofils x

4.5 Which of mentionned cells engulf extracellular bacterial antigens and are not antigen presentig cells A. basofils B. dendritic cells C. eosinofils D. macrophages E. neutrofils x 4.6 A. Red blood cells arise from granulocyte line

B. C. D. E. 4.7 A. B. C. D. E.

lymfocyte line monocyte line myeloid line trombocyte line

x

Which of bellow mentionned cells undergo differenciation in thymus basofils eosinofils lymfocytes x monocytes neutrofils

4.8 Predominant form of leucocytes in the blood of patient with longlasting pyogenic bacterial infection are A. B lymphocytes B. Juvenil and inmature neutrofils x C. Monocytes a macrophages D. Natural killers E. T lymphocytes 4.9 A. B. C. D. E. 5.1 A. B. C. D. E. Cells of lymphoid line Are most frequent leucocyte population Is formed by T, B, and NK cells Contain cytoplasmatic granules Differentiat from precursors of myeloid cells Phagocyte rests of foreign cells. PAMP pathogen-associated molecular patterns Enable lymphocytes to recognise microbes and disrupt them Are cystein-rich peptides of leucocytes Are recognised by PRR receptors of innate immunity Are proteins on the surface of infected cell Induce secretion of interferons

x

x

5.2 Primary immunity to Gram negative bacterium involves A. Nonspecific stimulation of complement B. Production of specific somatically generated receptors C. Productin and secretion of specific antibodies D. Production of specific cytokines by lymphocytes E. Stimulation of KIR on NK cells 5.3 A. B. C. D. E. Nonspecific immune mechanisms do not include chemokines complement defenzines memory cells Interferon type 1

x

x

5.4 Which of below mentionned molecules are expressed on the surfaces of human infected cells or abnormal cells and are recognised as stress molecules by NK cells A. Alfa or beta defensines B. C3 convertase and properdine C. Cytokines and chemokines D. Interferon and/or interferon beta E. MICA and MICB x 5.5 A. B. C. D. E.6.1

Alternative pathway of complement is activated by Cell surface molecules, that are largely recognised as foreign for host x Mannose containing rests of glycoproteins on some microbes Stimulation of KAR on NK cells Immunocomplexes of antigen and antibodies TLR receptors binding PAMP In cytoplasma and/or on membrane bound proteins In plasma, lympha other body fluids On surface of plasmatic cells As transmembrane polypeptides In lipid bilayer of nucleusAntibody (immunoglobulin) Epitop-specific receptors on T lymfocytes (TCR) are present

A. B. C. D. E. A. B. C. D. E.

x

6.2

Is synthesised and secreated by B and T cells Binds several different epitop at once Contains 4 different polypeptids of light chains Recognises specific epitopes and self molecules Recognises antigens that lead to destruction of the antigens

x

6.3 Constant regions of heavy chains in molecules of immunoglobulin influence

A. B. C. D. E.

Epitope Fab fragment Isotype Idiotype Antigentic specificity

x

6.4 The cleavage of the immunoglobulin molecule by pepsin results in production of

A. B. C. D. E.

Separated heavy and light chains Inhibition of antigen binding 2 individual antigen binding fragments In cold crystalising structures Dimer of antigen binding molecules

x

6.5 In patient with allergy the cross binding of the allegen molecule with Fab fragment of immunoglobulin will activate degranulation of mediators:

A. B. C.

IgA IgE IgG

x

D. E.6.6

Histamin Mastocytes Activation of C1 Cleavage and activation of C4, C2 and C3 IgA binding to specific epitop Production of Membrane Attack Complex Production of C3 convertaseClassical complement pathway is activated by

A. B. C. D. E.

x

6.7.

The role of classical complement pathway is to:

A. B. C. D. E. A. B. C. D. E. A. B. C. D. E.6.8

Cleave to immunoglobulin molecules on Fc fragments Lyse microbe Recognise specific epitops on microbes To start degranulation of histamin Inhibit degranulation of histamin All cells with nucleus Antigen presenting cells on erytrocytes on mastocytes on T cellsMHC II molecules are expressed on

x

x

6.9

The structure of TCR is formed by

heterodimer of ab (gd) bound on membrane of T cell complex of heavy and light chains molecules CD3 a CD247 on the membrane of T cell complex of MHC with peptid (pMHC) soluble IgM molecule

x

6.10 Migration of B lymfocyte to a specific place (e.g. lymphatic node) depend on production of

A. B. C. D. E.6.11

antibodies CD8 molecule CD3 molecule complement Selectins CD4 CD8 GlyCAM-1 IgA IgG

x x

A. B. C. D. E. A. B. C.

Which of mentioned molecules is present on every mature T helper cell

7.1

TCR receptor on CD8+T cells - recognises fragments of peptid bound in

CD3 molecule CD4 molecule MHC I molecule

x

D. E.7.2

MHC II molecule MHC III molecule That is specific for 2 to10 different antigens In phagosome and cytoplasma In membrane complex containing CD3 On their surface membrane Only before leaving bone marrowB lymphocytes exprime the molecule of immunoglobulin

A. B. C. D. E.

x

7.3 A. B. C. D. E.7.4

Primary lymfoid organs are those in which Specific immunity is activated Filtration of cell debrits are performed Circulating leucocytes communicate mutually Lymphocytes undergo the basical differenciation PRRs bind antigensThymus is the place of primary differenciation of

x

A. B. C. D. E.7.6

B cells T cells Erytrocytes Heamtopoetic stem cells Neutrofils BCR CD1d CD3 CD8 CD19Which of molecules is present on CD4+ T cell

x

A. B. C. D. E. A. B. C. D. E.

x

7.7

Positive selection of T cell:

Is done in bone marrow Means production of specific TCR Is the migration of stem cells to tymus Is programmed death of autoreactive T cells Recognition of self MHC by double positive thymocytes Bone marrow Lymphatic node Peyers plaques Spleen TonsilsWhich are primary lymfoid organs

x x

7.8

A. B. C. D. E. A. B. C. D.

7.9

White pulpe of spleen is rich on

erytrocytes CD4+CD8+T cells double positive NK cells Plasmatic cells

x

E. 8.1 A. B. C. D. E. 8.2 A. B. C. D. E.

Precursores of B cells . Changes of IgM to IgE is enabled by the process: Immunity maturation Allel exclusion Isotype switch Junction diversity somatic hypermutation

x

Existence of BCR and TCR specific only for one antigen is enabled by: rearrangemet of genes for variable part of immunoglobulin molecule x maturation of immunity exclusion of allels Isotype swich Junction diversity

8.3 Presence of only mothers or only fathers genes for V chains is enabled by A. Exclusion of allels x B. Antibody diversity C. Isotype switch D. Junction diversity E. Random rearrangement of VD and VDJ 8.4 A. B. C. D. E. Antibody specificity is produced by Recombination of V, D and J genes Rearrangemet of VD and J segments for heavy chains Affinity maturation for antigen caused by mutation Recombination of CL with CH1, CH2, CH3 or CH4 domens x

Transport of VL allel from mothers on fathers chromosome

8.5 During restimulations of memory B cells the minor mutation in DNA encoding variable part of light and heavy chains will result in A. Isotype swich B. Decrease of antigenic specificity C. Exclusion of allels D. Specificity maturation E. .apoptosis of the cell x 9.1 A. B. C. D. E. Which of problems is typical for patients with aplasia of tymus problems of B cells development only inactivation of complement system dysfunction of NK cells dysfunction of cellular immunity dysfunction in T lymphocyte differenciation and B cell mediated immunity x

9.2 Negative selection of T cells is produced in A. periferal blood circulation B. bone marrowi C. lymphatic node D. spleen E. thymus 9.5 A. B. C. D. E. T cell can recognise many different antigens has surface membrane markers characteristic for NK cells changes to memory cells during reexposition to an antigen migrates mostly to respiratory organs, skin and peritoneal cavity produces slowlier answer to antigen than NK cells do

x

x

9.6 NKT cells A. are usually CD8 pocitive B. bind with pMHC II C. have TCR D. synthesise immunoglobulin E. present Ig on their surface 9.8 A. B. C. D. E. B-1 B cells when compared with B-2 B cells arise later in development are more important for innate immunity mechanisms have IgD than IgM molecules recognise more antigens require T cell cooperation for activation

x

x

10.1 T cells recognise epitop to which they are exposed for the first time by A. randomly generated TCRs x B. MHC molecule C. Ig molecule D. One of many molecule on the surfacei E. PRR 10.2 Which of below mentioned bind peptid to MHC II A. CD4+ T B. CD8+ T C. Dendriticcells D. gd T cells E. neutrofils 10.3 A. B. C. D. E. Fragments of intracelular pathogen are presented to T cell by activation of PRR on the cell surface by pinocytosis to gd T cells by molecules of MHC I to CD8+ T cells by molecules of MHC II to CD8+ T cell by molecules of MHC II to CD4+ T cell

x

x

10.4 Imunological synapsis is A. binding of PAMP to PRR B. Restriction of CD4+ T cells for MHC I molecule C. Selective anergy of T cells D. Recognition of free peptides by T cells E. Contact between APC and T cell 10.5 CD4+ T respnding to intracellular aggregation of phagocyting cells are A. APC B. CTL - cytotoxic T lymphocytes C. Th0 cells D. NK cells th1 E. Th2 cells pathogen by activation

x and

x

10.6 Presence of lipopolysaccharid from bacterial cell wall in the tissue stimulates (nonspecific stimulation) A. APC cells to cytokines secretion B. Release of cytokines to activate leucocytes C. Stimulation and sectretion of IFN- g that activate leucocytes D. Th0 cells differentiate to Th1 cells E. All answere are correct x 10.7 A. B. C. D. E. Formation of pMHC I on infected cell Results in BCRs cross binding and signalisation to the nucleus CD4+ T cell secretion of IL-4 CD8+ T cell killing of infected cell Naive Th1 cell secretion of cytokines Th0 cells differentioate to Th2 cell

x

10.8 Activation of B cell results in A. Presentation of MHC I by dendritic cells B. Recognition of epitop by surface IgD and IgM C. Transmission of signal from BCR and CD4+ T cell to the nucleus D. Isotypte switch E. Lysis of antigen by proteasomes

x

11.1 Production of of visible aggregates to identify blood groupes by binding IgM with apropriate A or B antigens is: A. aglutination x B. complement aktivation C. neutralisation D. opsonisation E. precipitation 11.2 C3b is able to bind on a microbe that will make it more attractive for phagocytosis. This process is A. agglutination

B. C. D. E.

complement activation neutralisation opsonisation precipitation

x

11.3 Test (diffusion in agar) that identifies production on not soluble complexes of soluble antigen with antibody is the example of A. agglutination B. complement activation C. neutralisation D. opsonisation E. precipitation x 11.4 Antigen antibody binding that will result in incapability of microbe to bind on target cells is: A. agglutination B. complement activation C. neutralisation x D. opsonisation E. precipitation 11.5 Which of mentione izotypes of antbodies activate complemet cascade if bound to antigen A. IgA and IgD B. IgA and IgE C. IgA and IgM D. IgE and IgG E. IgG and IgM x 12.1 State of unresponsivness of T lymphocytes that exists after production of immunological synapsis is sa nazva A. allergy B. apoptosis C. anergy x D. autoimmunity E. hypersensitivity 12.2 Which of mentioned cells are the source of the 2nd signal to T cell after immunological synapsis is produced A. APC x B. Anergised T cell C. CD4+T cells D. B cells E. Naive T cells-thymocytes

12.3 Which of mentioned cells need cooperation of pMHC with costimulatory 2nd signals from APC to be activated. A. anergised T cells B. B cells C. Mastocytes D. Nave T cells x E. Natural killers 13.4 Whicb of mechanisms are/is responsible for repeated infection with influenza virus A. Neutralisation antibodies are short living B. Low stimulation of CD4+ T cells to produce memory cells C. Intracellular localisation disable stimulation of immune system D. Hypersensitivity type 1 is present only in second exposition E. Variability of viral antigens x 13.6 Molecule of acute phase of infection synthesised in liver during bacterial and viral infection is A. CRP x B. Chemokin C. Complement D. Immunoglobulin E. Interleukin 13.7 Which of mentioned isotype is consistent with mucous membrane immunity A. IgA x B. IgD C. IgE D. IgG E. IgM 13.8 A. B. C. D. E. Which of characteristic is consistent with mucous membrane immunity Rapid answer against all molecules Chronical inflammation producing unfavourable conditions form microbes IL-2 and IFN-g produce favourable environment for TH1 Secretion of IgG is more important than secretion of IgA Tolerance to foreign antigens is more regular than exceptional x

13.9 Even unvaccinated child can be protected against some of vaccination preventable diseases because of A. Herd immunity x B. Genetical predisposition C. Antigenic shift D. Imunity escape E. Tolerance 13.10 Herd effect is not possible

A. B. C. D. E.

if more than 85 % are vaccinated for tetanus and rabies diphtheria, pertussis, haemophilus meningitis measles, rubeolla, mumps poliomyelitis, variola small pox

x

13.11 Which of mentioned type of vaccine will elicit the most protective immunity A. attenuated live virus vaccine x B. DNA vakcine C. Killed virus in vaccine D. Rekombinant vaccine E. Subunit vaccine 14.1 Patient with symptoms of sneezing, congestion in nose, respiratory problems becoming worse when he enters his house that is wet and molds are present on the walls and with skin tests for hypersensitivity positive has: A. Contact dermatitis B. DTH C. Hypersensitivity type I x D. Hypersensitivity type II E. Hypersensitivity type III. 14.2 Patient with history of PNC allergy was given the dose in PNC injection. In minutes the symptoms of hypotension, tachycardia, diffuse exanthema arised. She suffered from: A. Anaphylactic reaction x B. Anergy C. ADCC D. Ashtma E. Contact hypersensitivity 14.3 Which of mentione reaction is induced by interaction of host cell membrane with IgM or IgG antibodies A. Arthus reaction B. Serum disease C. hypersenzitivity I type D. hypersensitivity II type x E. hypersensitivity IV type 14.4 A patient with known allergy ate unconsciously the cake with peanuts that resulted in diffus exanthema, respiratory distress and diffuse lung symptoms This is typical for: A. hypersensitivity I. Type x B. arthus reaction C. serum disease D. IgG binding on extraceluluar matrix in respiratory tract mucous membrane E. IgM dependent disease from immunocomplexes 14.5 Contact dermatitis example of

A. B. C. D. E. 14.6 A. B. C. D. E.

hypersensitivity I type mediated by CD4+T cells hypersensitivity I type mediated by CD8+T cells hypersensitivity II type mediated by CD8+T cells hypersensitivity III type mediated by CD4+T cells hypersensitivity IV type mediated by CD4+T cells Glomerulonefritis can be caused by: hypersensitivity I type mediated by CD4+T cells hypersensitivity II type mediated by IgM antibodies hypersensitivity III type mediated by free IgG molecules hypersensitivity IV type mediated by B cells hypersenzitivitu IV typu mediated by IgG or IgM i

x

x

14.7 Patient treated by PNC with symptoms of dyspnoe, hypotnesion, tachycardia, malaise with positivity of antibodies against PNC present on erytrocytes are typical for: A. hypersensitivity I type mediated by IgG B. hypersensitivity II type mediated by IgG x C. hypersensitivity III type mediated by IgG D. hypersensitivity III type mediated by IgG and IgM E. hypersensitivity IV type mediated by CD4+T cellsi 15.1 A. B. C. D. E. 15.2 A. B. C. D. E. 15.3 A. B. C. D. E. Imunodeficiency caused by genetic or innate impairment is primary secondary always lethal not detectable all answers are correct Secondary immunodeficiency is not consistent with Di Geoerge sy malnutrition HIV infection Immunosupresive therapy All answers are correct Deficiency in lymphoid line is presented by Impairment in specific humoral immunity Impairment in non-specific cellular immunity Impairment in ADCC Impairment in DTH All answers are correct

x

x

x

15.4 Deficiency in T cell immunity is presented by A. Mild specific humoral immunity impairment B. Non-specific cellular immunity impairment C. Impairement in ADCC

D. E. 15.5 A. B. C. D. E. 15.6 A. B. C. D. E.

DTH impairement All answers are correct|||| Deficiency in B cells line is presented by Problems in specific humoral immunity Problemsin non-specific cellular immunity Problems in ADCC Problems with DTH Several possibilities are correct (if yes which) x x x

x

Problems with ingestion and degradation of antigen is the deficit fo phagocyting cells NK cellsk T cells B cells All answers are correct

15.7 Deficiency in complement system will be presented by important impairment of A. opsonization B. bacterial lysis C. inflammation generation D. non-specific immunity E. all answers are correct x

16.1 of A. B. C. D. E. 16.2 A. B. C. D. E.

Deficiency to inactivate and eliminate of autoreactive cells is the result autoimmunity positive selection negative selection tolerance supression x

Deficiency of immune system to recognise epitop and eliminate it is autoimmunity positive selection negative selection tolerance x supression

16. 3 Inativation and destructon of lymphocytes bearing the BCR or TCR recognising self molecules results in A. autoimmunity B. positive selection C. negative selection x D. tolerance E. supression

16.4 Molecular mimicry is resulting from reaction against self structures produced by A. cross reacting antibodies x B. loss of toleranie C. loss of negative selection D. loss of anergy of immunologicall priviledged organs E. loss of central tolerance 16.5 Central tolerance is produced A. in primary lymphoid organs in utero x B. v secondary lymphoid organs in utero C. v primary lymphoid organs after birth x D. v secondary lymphoid organs after birth E. by not existence of the 2nd signal to activate T lymphocytes after immunological synapsis is produced 16.6 Periferal tolerance is produced A. in primary lymphoid organs in utero B. in primary lymphoid organs after birth C. by regulatory inhibition of autoreactive cells D. not existence of the 2nd signal to activate T lymphocytes after formation of immunological synapsis E. C and D is correctvetci monosti s sprvne x 16.7 Reumatoid factor is A. IgM antibody bound on Fc fragment IgG B. Diagnostical for reumatic feve C. Both are correct 16.8 A. B. C. D. E. Immunologically privileged organs or tissues are cornea placenta lumen of tubules of testes brain all are correct x

x

16.9 Autoimmune disease is characterised by A. production of antibodies against self structures B. production of specific T cells against self structures x C. reactions (cellular and humoral immunity) against self structures 17.1 A. B. C. D. E. 17.2 Transplantation success depend on Family relationship Genetical match imunosupresive therapy ABC is correct BC is correct Transplantat from the genetically identical twin is

x

A. B. C. D. E. 17.3 A. B. C. D. E. 17.4 A. B. C. D. E. 17.5 A. B. C. D. E.

autotransplantat isotransplantat allotransplantat heterotransplantat idiotransplantat Transplantat from parents is Autotransplantat Isotransplantat Allotransplantat Heterotransplantat idiotransplantat

x

x

Transplantat of skin from of animal given to man is Autotransplantat Isotransplantat Allotransplantat Heterotransplantat x idiotransplantat MHC I and II genes are characterised Codominancy Heterozygocy Multiple locusesi Autosimale dominant transmission Several answers are correct (which) by x x x

17.5 A. B. C. D. E. 17.6 A. B. C. D. E. 17.7 A. B. C. D.

Acute reaction to graft is characterised by rejection Within minutes Resulting from activity of existing sensibilised T cells Resulting from production of new reaction to nonself antigens in graft x Resulting from preexisting antibodies Resulting from the lost of tolerance Chronical reaction to graft is characterised by rejection Within minutes Resulting from activity of existing sensibilised T cells Resulting from production of new reaction to nonself antigens in graft x Resulting from preexisting antibodies Resulting from the lost of tolerance Accelerated reaction to graft is characterised by rejection Within minutes Resulting from activity of existing sensibilised T cells x Resulting from production of new reaction to nonself antigens in graft Resulting from preexisting antibodies

E. 17.8 A. B. C. D. E. 17.9 A. B. C. D. E.

Resulting from the lost of tolerance Hyperaccute reaction to graft is characterised by Within minutes Resulting from activity of existing sensibilised T cells Resulting from production of new reaction to nonself antigens in graft Resulting from preexisting antibodies x Resulting from the lost of tolerance Host versus graft reaction is Typical for reaction after transplantation of bone marrow Typical for reaction in second transplantation Characterised by rising success in direction auto, iso, allo, xeno Characterised by existence of memory cells All answers are correct x

17.10 Graft versus host reaction is F. Typical for reaction after transplantation of bone marrow x G. Typical for reaction in second transplantation H. Characterised by rising success in direction auto, iso, allo, xeno I. Characterised by existence of preformed antibodies J. All answers are correct

2. A. B. C. D. E. 3. A. B. C. 4. a. b. c. d. e.

Vaccination against small pox was experimentaly described by Edward Jenner x Louis Pasteur Ramzes I Ali Mao Malin Robert Koch Antigen react with antibodies Only in vivo Only in vitro In vivo and in vitro

x

Antibodies of acute phase of infection are IGD IgM x IgE IgA IgG

5. A. B. C. 6. A. B. C. D.

Significant for infection is decrease in titer increase in titer x change from positivity to negativity and 4 fold increase of titer Detection o acute phase inflamation in serum of patient is to detect Specific cell immunity pecific humoral immunity Non specific cell immunity Non specific humoral immunity x

7. Activation of complement immediatly after the secopnd exposition to antigen is done by A. B. C. Alternative path Classical path MBL path x

18. Cells of lymphoid system i. Produce immunoregulative cytokins ii. Do not influence other part of immune system iii. Do not influence specific immunity 19. Bactericidal activity of serum is test of a. quantitative to detect specific immunity b. qualitative to detect specific immunity c. quantitative to detect nonspecific imunity d. qualitative to detect non specific immunity

x

20. Serologica reactions are reactions of F. antigen with antibody to detect specific immunity G. antigen with antibody to detect nonspecific immunity H. antigen with complement to detect nonspecific immunity I. antigen with complement to detect specific immunity

x

1. In vaccination against variola small pox the attenuated annimal virus was used to prevent human virus infection (antigenic similarity and cross reacting immunity). Similar principle is used in vaccination against A. tuberculosis B. tetanus C. measles D. poliomyelitis E. pertussis

2. A. B. C. D.

Specific passive immunity naturally acquired is From transplacentarly transmitted antibodies from mother x After disease After vaccination After aplication of specific immune serum

3. Inactivation of serum is done by heating the fresh serum to 37 C for 3O (min.) A. correct B. Wrong x 4. A. B. C. D. 5. A. B. The antigen can be bound for better visualisation of aglutination on: Other corpuscular antigen or body erytrocyete latex particules all answers are correct x To detect dynamics of total antibodies we need one sample at least 2 samples x

6. By detecting the concentration of C3, C4 components of complement in serum of patient we detect: a. Specific cell immunity b. Specific humoral immunity c. Non specific cellular immunity d. Non specific humoral immunity x 7. F. G. H. I. Biological properties of complement are: Lysis of cell (formation of MAC) Opsonisation Stimulation of fagocytosis chemotaxis of leucocytes All answers are correct x

1. Substance that resemble toxin, that has its antigenic and immunogenic properties but not toxic properties is called A. antitoxin B. toxoid x C. toxin D. antibody E. hapten 2. F. G. H. Complete antigen: hapten semihapten imunogen

x

3. A. B. 4. A. B. C. D. 5. A. B. C. D. 6. A. B. C. D. E. F.

CH50 is a Specific immunity function Nonspecific immunity function Serotypisation is the method to detect Specific immunity Nonspecific immunity Antibody titer Antigenic structure of microbe

x

x

Detection of concentration of lysosyme is samples from patient we use: M. lysodeicticus E. coli Precipitation Agglutination Titer is Dilution of serum x Indicating the amount of antibodies in not diluted serum For ex. 1:124 Indicate the number of vial in witch the reaction is positive Is to detect precipitation Is used to detect nonspecific immunity

7. Antibodies connected with innate (maternally derived) immunity of newborne baby is A. IgM B. IgG x C. IgE D. IgA E. IgD 12. Vaccination can produce autoimmune disease., is not needed because the disease against that they protect are eradicated no more present of the world. These statements are A. true based on immunological and epidemiological studies B. correct - based on immunological surveys C. flase and presented by antivaccination activitists D. are not well studied and that is why they can be tolerated E. are well studied and should be propagated 13. To detect corpuscular antigen we use mostly: A. agglutination methods B. precipitation methods C. diffusion method 14. In serotypisation we detect A. antigenic structure of bacteria antibodies B. specific immunity with the help of antigens with x

the x

help

of

15. Titer is indicating A. dilution of antigen B. dilution of antibodies C. quanitative value of specific serological reaction D. qualitative value of specific serological reaction

x

16. Mean number of phagocyted elements by 1 PMNL is indicated by: a. Fagocyting activity b. Index of fagocytosis x 17. Part of nonspecific cell immunty function is detected by a. Concentration of lysosyme b. Bactericidal activity of serum c. Phagocyting activity d. Number of lymphocytes 18. Antigen presenting cells (APC): a. Are not in lymph nodes b. Can phagocyte c. Do not present antigen to T cells 20.To myeloid line are not involved: a. Eozinofils b. NK cells c. Macrophages 14. The first vaccination was directed against A. Rabies B. measels C. tetanus D. small pox E. chicken pox 15. CH50 is a F. detection of hemolytical activity of complement G. Specific immunity function qualitative test H. Nonspecific immunity function qualitative test

x

x

x

x

x

16 .Measurement of C3, C4 complementu molecules in seurm of patient detect: e. pecific cell immunity f. pecific humoral immunity g. Nonspecific cell immunity h. Nonspecific humoral immunity x 17 . To detect dynamics of total antibodies we need

A. B.

one sample at least 2 samples

x

18. . Bactericidal activity of serum is test: e. quantitative to detect specific immunity f. qualitative to detect specific immunity g. quantitative to detect nonspecific imunity qualitative to detect non specific immunity i. I. J. K. L. M. N. Titer is

x

Dilution of serum Indicating the amount of antibodies in not diluted serum x For ex. 1:124 Indicate the number of vial in witch the reaction is positive Is to detect precipitation Is used to detect nonspecific immunity Antibodies connected with innate intrauterine x

ii. disease of newborne baby is h. IgM i. IgG j. IgE k. IgA l. IgD

16. Activation of complement after the 1st exposition to antigen is done by A. Alternative way B Classical way C MBL way D All answers are correct E A and C is correct

x

17. To detect soluble molecules toxin for ex. Which test can be use: A. agglutination B. precipitation x C. diffusion D. B and C is correct 18. Which of mentioned way is correct to indicate the titer of antigodies: A. 16O B. 1: 16O x C. 1 x16O 19. Serotypisation is to detect: A. specific humoral immunity B. specific cellular immunity

C.

antigenic structure of microbe

x

20, Number of phagocyting PMNL in % indicates: A. phagocytic activity x B. Index of phagocytosis 1. On the surface of cytotoxic T cells is a) IgG b) CD 4 c) CD 8 d) p 24 2. Ddetetion of lysosyme is the test of a) specific cellular immunity b) non-specific cellular immunity c) specific humoral immunity d) non-specific humoral immunity e) bactericidal activity of saliva

x

x

2. Discrimination of immunocompetent cells of specific immunity is possible based on a) Morpfological signs b) Specific surface molecules c) Spontaneous production of cytokines d) Presence of granules 5. Presentation of extraceluluar bacteria to T cells is enabled by molecules on APC a) MHC I b) MHC II x c) IgG d) TcR 6. Number of polypeptid chains is the biggest in a) IgG b) IgM c) IgE x d) IgD 7. MHC II molecule is active in a) Recognision of antigens b) Presentation of antigens c) Neutralisation of antigens d) Stimulation of cytotoxic immunity

x

8. Complement fixation reaction is a) in vivo reaction to detect activity of complement b) reaction detectiong concentration of complemnt molecules in serum of patient c) is serological reaction x d) is reaction in vitro to detect 50% of hemolytical activity of complement 9. Result 1: 160 of serological reaction a) is the titer of antibodies b) is the highest dilution with positive reaction of Ag + Ab c) is the lowest dilution with positive Ag+Ab reaction d) is negative result of serological reaction 11: Molecule of T cell receptore (TCR) is parallel to a) Fab fragment of IgG x b) Fc fragment of IgG c) MHC I d) MHC II 12. a) b) c) d) 15. a) b) c) d) Exotoxn Is immunogenic Is the synonyme to toxoid Is neutralised by anatoxin Is a part of vaccine against tetanus x

x

Imunoglobuline other than monomeric structure is IgG, IgE, IgD IgG, IgA, IgD, IgE IgM, IgA, x IgG, IgE

16. Specific IgM antibodies in serum from the blood taken from umbilical cord is indicating a) Intrauterine infection of the fetus b) Transplacentarly transmitted antibodies from mother c) Perinatal infection x d) Postnatal infection