Immunology and Serology Lecture # 2: Overview of Immunity
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Transcript of Immunology and Serology Lecture # 2: Overview of Immunity
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8/17/2019 Immunology and Serology Lecture # 2: Overview of Immunity
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Fvhrvlhw fj LeeucltyMry`c Elkg`hn C. M`nuchs, ]EY
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_g`t ls Leeuclty6
L[ Nhk ! Fvhrvlhw fj Leeuclty
• ]hslst`ckh tf lcjhktlfus `ohcts, jfrhloc p`rtlknhs, tfxlcs, nlvlco khnns, `ci
k`ckhr (Mry`ct)
• Kfciltlfc fj mhlco rhslst`ct tf lcjhktlfc ([thvhcs)
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Yy"hs fj Leeuclty
L[ Nhk ! Fvhrvlhw fj Leeuclty
0. C@YX]@N LEEXCLY\ (Lcc`th, Cfcsphkljlk, Cfc`i`ptlvh)• ]hslst`ckh fj lcjhktlfc my eh`cs fj cfre`nny prhshct mfiy jucktlfcs
• Rrhshct `t mlrtg• f prlfr hxpfsurh ls rh!ulrhi• ]hspfcsh ifhs cft kg`coh "ltg sumsh!uhct hxpfsurhs
=. @I@RYLZ LEEXCLY\ (!phkljlk, @k"#l$hi)
• ]hslst`ckh `k!ulrhi `s ` rhsunt fj prlfr hxpfsurh "ltg ` jfrhlocsumst`ckh
• ]hslst`ckh my sphkljlklty jfr h`kg lcilvliu`n p`tgfohc• ]hehemhrs prlfr hxpfsurh• #ckrh`shi rhspfcsh upfc rhph`thi hxpfsurh
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Yy"hs fj Leeuclty
L[ Nhk ! Fvhrvlhw fj Leeuclty
0. C@YX]@N LEEXCLY\ (Lcc`th, Cfcsphkljlk, Cfc`i`ptlvh)• ]hslst`ckh fj lcjhktlfc my eh`cs fj cfre`nny prhshct mfiy jucktlfcs
• Rrhshct `t mlrtg• f prlfr hxpfsurh ls rh!ulrhi• ]hspfcsh ifhs cft kg`coh "ltg sumsh!uhct hxpfsurhs
=. @I@RYLZ LEEXCLY\ (!phkljlk, @k"#l$hi)
• ]hslst`ckh `k!ulrhi `s ` rhsunt fj prlfr hxpfsurh "ltg ` jfrhlocsumst`ckh
• ]hslst`ckh my sphkljlklty jfr h`kg lcilvliu`n p`tgfohc• ]hehemhrs prlfr hxpfsurh• #ckrh`shi rhspfcsh upfc rhph`thi hxpfsurh
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C`tur`n Leeuclty
L[ Nhk ! Fvhrvlhw fj Leeuclty
• %th$c`& Ihjhcsh !'sth
• Lcth$c`& Ihjhcsh !'sth
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C`tur`n Leeuclty
L[ Nhk ! Fvhrvlhw fj Leeuclty
0. Y]C@N I*C! !\!YE (*l$st Nlch fj Ihjhcsh)
• Xc+$fhc slc `ci #kfs`& h+$`ch s#$j`khs
• !hk$htlfcs $ ilskfur`ohs elkrfml`n orf"tg %ukus &`ktlk `kli (s"h`t) $ e`lct`lcs s'lc `t p *+
[hmue (shm`khfus on`cis) $ s`eh " n`ktlk `kli -`r"`x (khruehc)
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C`tur`n Leeuclty
L[ Nhk ! Fvhrvlhw fj Leeuclty
0. Y]C@N I*C! !\!YE (*l$st Nlch fj Ihjhcsh)
• -fi' hk`clss .hr`tlcl/`tlfc fj tgh upphr n`yhr fj tgh s'lc Kfcst`ct rhch"`n fj hpltghnl`n khnns %ftlfc fj klnl` 2rlch $ jnusglco `ktlfc0 snlogt `klilty &`ktlk `kli lc jhe`nh ohclt`n tr`kt $ p fj *= ;klilty fj stfe`kg (Kn) $ p 9 8*= ;n'`nlclty fj tgh jnulis fj tgh :#? &ysf/yeh (th`rs `ci s`nlv`) $ `tt`k's `ci ihstrfys khnn "`nn
fj elkrffro`clses, hsphkl`nny or`e7pfsltlvh m`kthrl`
• Cf$`& j&f$` $ glcihrs phchtr`tlfc fj elkrffro`clses (kfephtltlvh
hxknuslfc)
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C`tur`n Leeuclty
L[ Nhk ! Fvhrvlhw fj Leeuclty
=. LCY]C@N I*C! !\!YE (!hkfci Nlch fj Ihjhcsh)
• R`/fk'tlk kh&&s $ e`
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#$`"tlvh Leeuclty
L[ Nhk ! Fvhrvlhw fj Leeuclty
• Yl$i Nlch fj Ihjhcsh
ERCCY!
0. N'pfk'ths $ e`
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#$`"tlvh Leeuclty
L[ Nhk ! Fvhrvlhw fj Leeuclty
@Y;]L! * @I@RYLZ ]!RC!
0. 2#f$`&9Ehil`thi L#clt'
=. h&&9Ehil`thi L#clt'
Ehk`cls %hil`thi my `ctlmfiy
h&& t'ph M nyepgfkyths
Efih fj `ktlfc ;ctlmfilhs lc shrue
R#$pfsh Rrle`ry ihjhcsh `o`lcst m`kthrl`n lcjhktlfc
Ehk`cls %hil`thi my khnn
h&& t'ph ? nyepgfkyths
Efih fj `ktlfc 4lrhkt khnn7tf7khnn kfct`kt fr sfnumnh prfiukts
shkrhthi my khnnsR#$pfsh 4hjhcsh `o`lcst vlr`n `ci juco`n lcjhktlfcs,
lctr`khnnun`r fro`clse, tuefr `ctlohcs, `cior`jt rh
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#$`"tlvh Leeuclty
L[ Nhk ! Fvhrvlhw fj Leeuclty
Y\R! * 2XE]@N9EIL@YI LEEXCLY\
0. @ktlvh L#clt'
C`tur`n @ktlvh
@rtljlkl`n @ktlvh
Efih fj `k"#lsltlfc #cjhktlfc
@ctl+fi' p$fi#khi +' fst 1hs
I#$`tlfc fj l#ch $hspfcsh &fcoEfih fj `k"#lsltlfc #cjhktlfc
Efih fj `k"#lsltlfc >`kklc`tlfc
@ctl+fi' p$fi#khi +' fst 1hs
I#$`tlfc fj l#ch $hspfcsh &fco (leeucfkfephct gfst)
Efih fj `k"#lsltlfc >`kklc`tlfc
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#$`"tlvh Leeuclty
L[ Nhk ! Fvhrvlhw fj Leeuclty
Y\R! * 2XE]@N9EIL@YI LEEXCLY\
=. R`sslvh L#clt'
C`tur`n R`sslvh
@rtljlkl`n R`sslvh
Efih fj `k"#lsltlfc #c vlvf tr`csjhr fj `ctlmfilhs mye`thrc`n klrkun`tlfc lc uthrf0
kfnfstrue@ctl+fi' p$fi#khi +' fst f
I#$`tlfc fj l#ch $hspfcsh [gfrt
Efih fj `k"#lsltlfc #cjuslfc fj shrue fr pn`se`
@ctl+fi' p$fi#khi +' fst f
I#$`tlfc fj l#ch $hspfcsh [gfrt
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[uee`ry fj Leeuclty
L[ Nhk ! Fvhrvlhw fj Leeuclty
*l$st Nlch fj Ihjhcsh
(lcc`thcfcsphkljlkc`tur`n leeuclty)
!hkfci Nlch fj Ihjhcsh
(lcc`thcfcsphkljlkc`tur`n leeuclty)
Yl$i Nlch fj Ihjhcsh
(`i`ptlvhsphkljlk`k!ulrhi leeuclty)
• #ct`ktucmrf'hc s'lc `ci
eukfus ehemr`chs
7 shkrhtlfcs
7 strukturhs (g`lrs, klnl`,
hpltghnl`n khnn n`yhr)
• %hkg`clk`n ̀ ktlfc
• fre ǹ jnfr` (cfre`n
elkrfmlft`)
• Rg`ofkytlk khnns
7 or`cunfkyths
(chutrf, hfslcf, m`sf)
7 efcfkyth7e`krfpg`oh
7 ;RKs
• uefr ǹ (jnuli) j`ktfrs
7 kfepnhehct
7 nysf/yeh
7 lcthrjhrfc
7 `kuth7pg`sh rh`kt`cts
• &yepgfkyths (khnnun`r)
7 ? nyepgfkyth (? ghnphr 8, ? ghnphr 5,
? kytftfxlk, ? rhoun`tfry)
7 M nyepgfkyth
(pn`se` khnn, ehefry khnn)
• uefr`n j`ktfrs
7 `ctlmfiy
7 kytf'lch
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