Immune Responses
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Transcript of Immune Responses
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Immune Responses
A. Innate Defenses (Nonspecific Defenses)1. Inherited defenses2. Attempt to stop all foreign invaders in the
same way (nonspecific)3. Broken down into different categories
A) Mechanical protection1) epidermis2) mucus
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Immune Responses
3) cilia/hair4) lacrimal apparatus5) saliva6) urination, defecation, vomiting, and
diarrheaB) Chemical protection
1) perspiration, lacrimal fluid, sebum, and saliva – lysozymes
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Immune Responses
2) gastric juice, vaginal secretions, bile, and pancreatic juice – alter pH
C) Interferons1) work by inhibiting viral replication in cells2) released from:
a) virus-infected cellsb) lymphocytes & macrophages
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Immune ResponsesD) Natural killer cells
1) present in spleen, lymph nodes, red bone marrow, & blood
2) work by releasing perforins & granzymesE) Phagocytosis
1) neutrophils2) macrophages (monocytes)
a) wanderingb) fixed
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Immune Responses
3) stepsa) leukocytosisb) marginationc) diapedisisd) chemotaxise) adherence/opsonizationf) ingestion
i) phagosome
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Immune Responses
g) phagolysosome formationi) lysosome
(a) lysozymes(b) digestive enzymes
h) digestioni) residual bodies
i) exocytosis
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Immune Responses
F) Inflammation – 3 stages1) increased vasodilation & permeability
a) causes characteristic warmth, redness, pain & swelling
b) aided by a number of chemicals (in response to tissue damage)i) histamine – released by many blood cellsii) kinins – formed in blood
(a) also chemotactic agent
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Immune Responsesiii) prostaglandins – released from damaged
cells(a) intensify effects of histamine and kinins(b) may promote diapedisis
iv) leukotrienes – released by basophils & mast cells(a) promote adherence
2) phagocyte mobilization3) tissue repair
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Immune ResponsesG) Fever
1) caused by pyrogens a) any chemical that causes an increase in
body temperatureb) most often released from WBC, as well
as some bacteria2) promote sequestration of iron & zinc 3) may aid interferon, inhibit microbe growth,
& speed reaction time of defense cells
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Immune Responses
H) Complement System1) a group of at least 20 plasma proteins2) once activated some increase the
inflammatory response while others destroy bacteria directly
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Immune Responses
B. Adaptive Immunity (Specific Defense)1. 3 important aspects
A) antigen-specific1) antigen – any substance that initiates
an immune responseB) systemicC) has memory
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Immune Responses
2. 2 types of adaptive immunityA) cell-mediated immune responseB) antibody-mediated (humoral) immune
response
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Immune Responses
3. Overview of Cell-Mediated ImmunityA) an antigen penetrates body’s nonspecific
defensesB) antigen is taken up by an antigen-
presenting cell (APC) and broken downC) antigen fragments merge with major
histocompatability complex (MHC) proteins on the APC’s membrane
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1) MHC – special protein imbedded in a cell’s membrane; allows for the recognition of self
D) T cell comes into contact with APC, recognizes the “new” MHC protein and becomes active
E) activated T cells divide and differentiate1) cytotoxic (killer) T cells (CD8 cells)
a) rupture antigen’s cell wall/membraneb) secrete lymphotoxin into antigen
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Immune Responses
c) alter antigen DNA causing death2) memory T cells
a) recognize antigens directly (sometimes by their MHC proteins) to speed future responses
3) suppressor T cellsa) suppress the cytotoxic T cells when their
job is complete
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Immune Responses
4) helper T cells (CD4 cells)a) produce a number of interleukins (IL’s)
i) IL-2 – stimulates T cell proliferationii) IL-4 – promotes T cell growth; stimulates
production of IgEiii) IL-5 – promotes the secretion of IgA
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Immune Responses
4. Overview of Antibody-Mediated ImmunityA) cell-mediated response has occurredB) helper T cells activate B cells
1) stimulate B cell division & differentiationa) memory B cellsb) plasma cells
2) enhance antibody production via the production of interleukins
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Immune Responses
C) antibody merges w/ antigen = antigen-antibody complex
D) antibody causes destruction of the antigen1) neutralization
a) bind to toxins or virus rendering them useless
2) immobilizationa) bind to cilia or flagella slowing antigen
movement
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Immune Responses
3) attraction of phagocytes4) facilitating phagocytosis5) stimulating inflammation 6) inhibiting antigen metabolism
5. Antibody StructureA) Consist of 4 polypeptide chains
1) 2 identical chains ~450 amino acids in length known as heavy (H) chains
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Immune Responses
2) 2 identical chains ~220 amino acids in length known as light (L) chains
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Immune Responses
B) The H chain has 5 variations resulting in 5 classes of antibodies (immunoglobulins)1) IgA – found in blood plasma, breast milk,
and mucus membranesa) prevents pathogens from adhering to
epithelia and penetrating tissues
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Immune Responses
2) IgD – integral part of B cell membranea) acts as an antigen presenter
3) IgE – found mainly in tonsils, skin & mucus membranesa) stimulates mast cells to release contents
and attracts eosinophils
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Immune Responses
4) IgG – 75-85% of circulating antibodies in plasmaa) crosses placenta to confer temporary
immunity to the fetus5) IgM – found on the B cell membrane and
circulating in plasmaa) presence indicates a recent infection