Imaging Findings of Various Calvarial Bone Lesions with a Focus … · 2016-01-18 · 44 Imaging...
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Pictorial EssaypISSN 1738-2637 / eISSN 2288-2928J Korean Soc Radiol 2016;74(1):43-54http://dx.doi.org/10.3348/jksr.2016.74.1.43
INTRODUCTION
In this article, we reviewed our institutional database and ra-diology department database of images taken from 2005 to 2013 and retrieved the records of 256 patients who underwent brain CT or MRI and were later diagnosed with tumorous or nontumorous calvarial lesions (122 malignant neoplasms, 115 benign neoplasms, 19 non-neoplastic lesions). The majority of patients either had multiple myelomas (n = 108, 42.2%) or be-nign osteomas (n = 99, 38.7%) (Table 1). Though calvarial me-
tastases are the most common malignant lesions, multiple my-eloma is more common in our database because of errors in coding and also because our institution is renowned for treating hematologic malignancies. We retrospectively reviewed the im-aging findings of CT and MRI for these calvarial lesions, and, using a categorical imaging approach, we briefly described and illustrated the imaging findings of representative osteolytic cal-varial lesions. The Institutional Review Board approved this retrospective review, and the requirement of informed consent was waived.
Imaging Findings of Various Calvarial Bone Lesions with a Focus on Osteolytic Lesions다양한 두개골 병변의 영상소견: 골용해성 병변을 중심으로
Younghee Yim, MD1, Won-Jin Moon, MD1*, Hyeong Su An, MD1, Joon Cho, MD2, Myung Ho Rho, MD3
Departments of 1Radiology, 2Neurosurgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea3Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
In this review, we present computed tomography (CT) and magnetic resonance im-aging (MRI) findings of various calvarial lesions on the basis of their imaging pat-terns and list the differential diagnoses of the lesions. We retrospectively reviewed 256 cases of calvarial lesion (122 malignant neoplasms, 115 benign neoplasms, and 19 non-neoplastic lesions) seen in our institutions, and classified them into six cat-egories based on the following imaging features: generalized skull thickening, focal skull thickening, generalized skull thinning, focal skull thinning, single lytic lesion, and multiple lytic lesions. Although bony lesions of the calvarium are easily identi-fied on CT, bone marrow lesions are better visualized on MRI including diffusion-weighted imaging or fat-suppressed T2-weighted imaging. Careful interpretation of calvarial lesions based on pattern recognition can effectively narrow a range of possible diagnoses.
Index termsSkullNeoplasmsMagnetic Resonance ImagingTomography, X-Ray ComputedDiagnosis, DifferentialRetrospective StudiesBone DiseaseBone Marrow Disease
Received April 14, 2015Revised June 16, 2015Accepted July 19, 2015*Corresponding author: Won-Jin Moon, MDDepartment of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul 05030, Korea.Tel. 82-2-2030-5544 Fax. 82-2-2030-5549E-mail: [email protected]
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distri-bution, and reproduction in any medium, provided the original work is properly cited.
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Imaging Findings of Various Calvarial Bone Lesions with a Focus on Osteolytic Lesions
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CATEGORICAL APPROACH TO IMAGING DIAGNOSIS
With increasing frequency, CT and MRI have been incorpo-rated into the basic imaging tools for evaluating calvarial le-sions. Therefore, it is useful to categorize diagnostic features of images taken not by conventional radiography but by CT and MRI (1, 2). It is possible to categorize 8 different types of cal-varial lesions based on 4 key features: thickening or thinning of calvarial bone, sclerosis or lysis of bone, focal or generalized le-sions, and, finally, singularity or multiplicity of lesions. On CT and MRI, sclerotic lesions appear as thickening of calvarial bone (either the inner/outer tables, or bone marrow, or both). Accord-
ingly, we can simplify the classification system into six categories based on three main features. We suggest that calvarial lesions are classified into calvarial thickening, thinning, and lytic lesion. When the calvarial lesions fall into the ‘thickening’ or ‘thinning’ categories, they can be further subdivided into focal or general-ized lesions. The lytic category can be subdivided into either sin-gle or multiple lesions. Furthermore, we can expect to get addi-tional information about matrix characteristics with contrast enhancement and diverse advanced MR sequences such as dif-fusion-weighted imaging (DWI) (3), perfusion-weighted imag-ing, and MR spectroscopy. A flowchart for a systematic approach to imaging diagnosis of calvarial lesions is provided in Table 2.
Single or Multiple Osteolytic Lesions
Multiple Myeloma
Multiple myeloma is characterized as multiple osteolytic le-sions due to the malignant proliferation of osteoclast-activating factors triggered by myeloma. Plain radiography of multiple myeloma patients is characterized by a subcortical circular or elliptical radiolucent shadow, and the axial skeleton is the pre-dominant site of the abnormality. CT shows punched-out le-
Table 1. Calvarial Lesions from Our Institution Database (n = 256) Calvarial Lesions No. of Cases (%)
Malignant neoplasm 122 (47.7)
Multiple myelomaMetastasisLymphomaRhabdomyosarcomaMesenchymal chondrosarcomaLangerhans cell histiocytosis
10873112
Benign neoplasm 115 (44.9)
OsteomaFibrous dysplasiaMeningiomaOsseous hemangiomaPlexiform neurofibromaDesmoplastic fibromaInflammatory myofibroblastic tumorLipomaChordoid tumor
9954211111
Non-neoplastic lesion 19 (7.4)
Epidermoid/dermoid cystCephalhematomaSkull thinning due to arachnoid cystBenign parietal thinningParry Romberg syndromeAtertic meningocephaloceleInterparietal foraminaGorham diseasePhenytoin induced hyperostosisDepressed fractureAcromegalyExostosisPeripheral low-flow vascular malformation
3322111111111
Data are presented as numbers of patients with percentages in parentheses.
Table 2. Categories and Pathologies Based on Involvement Pattern of Calvarial Lesions
Category LesionsLytic
Single Histiocytosis-X, osseous hemangioma, epidermoid and demoid cyst, desmoplastic fibroma, aretic meningocele, gorham disease, osteosarcoma/chondrosarcoma, osteomyelitis, arachnoid granulation, intraosseous meningioma, fibrous dysplasia, neurofibromatosis type 1, burr-hole
Multiple Multiple myeloma, metastasis, lymphomaThickening
Diffuse Acromegaly, shunted hydrocephalus, phenytoin induced hyperostosis, Paget's disease, chronic hemolytic anemia
Focal Metastasis, osteoma, fibrous dysplasia, meningioma, chronic calcified hematoma, hyperostosis frontalis interna
Thinning
Generalized Prominent convolutional marking, craniosynostosis, lacunar skull, long-stnding hydrocephalus, normal parietal thinning
Focal Secondary thinning due to benign tumor, Parry Romberg syndrome
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sions with soft tissue masses and fractures. On MRI, multiple myeloma presents with low-to-intermediate signal intensity on T1-weighted images, high signal intensity on T2-weighted im-ages, and high signal intensity on DWI (4). The lesions enhance strongly following contrast administration. Four different imag-ing patterns may appear: normal-looking marrow, a micro nodu-lar pattern (also described as variegated or salt and pepper le-sions), a focal pattern, or a diffuse pattern (Fig. 1) (1, 2).
Osteolytic Metastases
Metastases take various forms; they can be seen as either os-teoblastic or osteolytic lesions on plain radiograph. When ap-pearing as single or multiple lytic lesions, metasteses are usually seen as one or more relatively circumscribed intraosseous lesions
or sometimes as diffusely destructive on bone algorithm CT (2). Hypointense infiltrating foci are seen on T1-weighted images as metastases replace hyperintense normal yellow marrow. Most skull metastases are hyperintense compared to bone marrow on T2-weighted images and appear clearly on fat-saturated con-trast-enhanced T1-weighted images (Fig. 2). DWI is helpful for the detection of bone marrow involvement of the calvarium (3).
Langerhans Cell Histiocytosis
Langerhans cell histiocytosis (LCH) is an uncontrolled mono-clonal proliferation of abnormal Langerhans cells involving any organ. When LCH involves the skull, it manifests as a small soft tissue calvarial mass with lytic defect and beveled edge more on the inner table than the outer table on plain radiograph and CT
Fig. 1. A 70-year-old male with multiple myeloma. On lateral skull radiograph (A) and axial CT (B), multiple punch-out osteolytic lesions in the skull (salt and pepper) are seen, a pathognomonic finding of multiple myeloma.
A B
Fig. 2. A 70-year-old female with renal cell carcinoma.A. On contrast-enhanced CT, two huge osteolytic soft tissue masses with extreme enhancement in right parietooccipital and left frontotemporal bone are seen (arrows).B. On lateral skull radiograph, two huge osteolytic lesions (arrows) are seen.C. On MRI, huge soft tissue metastatic tumors show heterogeneous signal intensity on diffusion-weighted imaging (arrows).
A B C
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scans. It is often seen as bilateral soft tissue masses with bone destruction. On MRI, LCH presents as an enhancing soft tissue mass on contrast-enhanced T1-weighted images with vivid en-hancement of the pituitary infundibulum and stalk thickening (Fig. 3) (5-7).
Osseous Hemangioma
Osseous hemangiomas are benign skull lesions composed of predominantly vascular entities. On plain radiographs and CT scans, they present as sharply defined expansile lesions, which may include a periosteal reaction and be surrounded by a thin peripheral sclerotic rim, as is the case approximately 30% of the
time. They show intact inner and outer tables; the outer table tends to be more expanded than the inner table. Trabecular th-ickening with radiating spicules is also commonly seen. MRI sig-nal strength depends on the quantity of slow-moving venous blood, the proportion of red to fatty marrow, and hypointense trabeculae (8). Osseous hemangiomas are typically hyperintense on T1-weighted images and heterogeneously hyperintense on T2-weighted images. They enhance intensely, heterogeneously, or minimally on contrast-enhanced CT or MRI (Fig. 4) (8, 9).
Epidermoid and Dermoid Cysts
Epidermoid and dermoid cysts are ectodermal inclusion cysts
Fig. 4. A 45-year-old male with osseous hemangioma. A. On lateral skull radiograph, a small osteolytic lesion (arrow) is seen in the right parietal skull.B, C. A focal mass is detected with non-enhancing low signal intensity (arrow) on coronal gadolinium-enhanced T1-weighted MR image (B) and high signal intensity (arrow) on coronal T2-weighted MR image (C).
A B C
Fig. 3. A 4-year-old girl with Langerhans cell histiocytosis.A. On lateral skull radiograph, a focal osteolytic lesion (arrow) is visible. B. Non-contrast CT shows a localized osteolytic lesion with beveled edges in the right frontal bone (arrow). C, D. On MRI, the osteolytic mass shows heterogeneous signal intensity on a T2-weighted image (arrow) (C) and marked enhancement with fo-cal cystic change on the gadolinium-enhanced T1-weighted image (arrow) (D).
A B C D
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lined by epithelium. They occur inside the orbit, in the calvarial diploic space, and intracranially (9). They typically appear as en-capsulated unilocular cystic lesions with a signal intensity that depends on their components (1). On plain radiograph and CT scans, epidermoids appear as intradiploic, expansile, osteolytic lesions with smooth sclerotic margins while dermoids appear as expansile, osteolytic midline lesions. On CT, dermoids contain a soft-tissue component extending to overlying skin and intracra-nial areas. Usually epidermoids have a fluid-like signal intensity on MRI. Dermoids have a heterogeneous appearance with var-ied signal intensities depending on their various compositions. Since dermoids contain fatty tissue, they show low attenuation on CT and high signal intensity on T1-weighted images (Fig. 5) (1, 6, 9). Enhancement is generally absent although mild pe-ripheral enhancement can be seen in about 25% of cases.
Intraosseous Meningioma
When a meningioma invades overlying bone, it can create an osteolytic bone lesion. Infrequently, meningioma arises initially in the calvarium. It is thought that trapping of ectopic menin-
gocyte or arachnoid cap cells in the cranial sutures may cause primary intraosseous meningiomas (10). Approximately 68% of primary extradural meningiomas involve the calvarium (11). Pri-mary extradural meningiomas typically present with slow scalp swelling and do not show any neurologic symptoms or signs, unless the lesion extends through the inner table and compresses intracranial structures (12). On plain radiograph and CT, well-defined radiolucent, osteolytic lesions can be seen. On MRI, me-ningiomas are usually hypo- to isointense on T1-weighted im-ages and iso- to hyperintense or sometimes heterogeneously intense on T2-weighted images. Contrast enhancement generally enhances evenly and often produces a dural tail (Fig. 6) (2).
Fibrous Dysplasia
Fibrous dysplasia is characterized as the replacement of nor-mal cancellous bone with abnormal fibrous tissue (13). On plain radiograph, they appear as ground-glass sclerotic lesions or cystic lesions commonly crossing bony sutures. They may involve mul-tiple calvarial bones (14), tending to cause the outer table to bulge while conserving the shape of the inner table (15). CT scans
Fig. 5. A 13-year-old boy with epidermoid cyst of the skull.Lateral skull radiograph (A) and axial CT (B) show a large lucent area with well-defined sclerotic margin (arrow) in the right parietal bone. The le-sion shows heterogeneous bright signal intensity on coronal T2-weighted image (arrow) (C), and shows thin wall enhancement on non-contrast (arrow) (left in D) and contrast-enhanced T1-weighted images (arrow) (right in E).
A B C D E
Fig. 6. A 58-year-old female with intracalvarial meningioma. A. A small well-defined radiolucent lesion (arrow) is seen on lateral skull radiograph. B. The pre-contrast CT scan shows a well-defined mildly expansile osteolytic meningioma (arrow) on the right parietal bone. C, D. This mass shows iso-signal intensity (C) on T2-weighted image (arrow) and contrast enhancement (arrow) (D) when gadolinium is applied.
A B C D
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show a degree of hazy and intradiploic density. On T1-weighted images, they are usually hypointense, but more fibrous areas can be isointense. On T2-weighted images, they show various sig-nals, depending on their cellularity: those that are more fibrous with fewer bony trabeculae and less cellularity exhibit relatively high signal intensities, while more osseous and cellular matrices can show relatively low signal intensities (16). Contrast enhance-ment produces a variable range of intensities depending on le-sion stage; there can be homogeneous, central or peripheral en-hancement (Fig. 7).
Lymphoma
Malignant lymphoma may originate in the skull and extend to outside the cranium (17). Presenting as nonspecific osteolytic lesions on plain radiograph, on CT scans they instead appear as extra-intra cranial isodense lesions in the cranial vault or ho-mogenous masses with sharp margins. On MR, most reported
cases of skull lymphomas produced isointense signals on pre-contrast T1-weighted images with intense enhancement with contrast. However, MR imaging does not diagnose lymphoma accurately because it can mimic metastatic carcinoma, osteomy-elitis, or in some cases, meningioma (Fig. 8) (18).
Desmoplastic Fibroma
Desmoplastic fibroma is a rare benign bone tumor which orig-inates from fibrous tissue, and a majority of cases are seen in those younger than 30 years of age. Desmoplastic fibroma most commonly occurs in the metaphyses of the long bones, the man-dible, and the pelvis, whereas the maxilla, calvaria, sternum, and vertebrae are less frequently affected. Simple radiographs show an expansile, osteolytic lesion with a trabeculated or bubbly ap-pearance. At times, the tumor may have a very aggressive radio-graphic appearance with bone destruction, cortical erosion, or soft-tissue invasion (19, 20). The dense connective tissue and hy-
Fig. 7. A 35-year-old male with fibrous dysplasia.A. On non-contrast CT, an expansile lesion (arrow) with internal ground-glass opacity emerging from the occipital bone is seen.B, C. On coronal T1-weighted image (B) and T2-weighted image (C), the lesion shows iso signal intensity (arrow) and mixed signal intensity (ar-row), respectively. D. It shows heterogeneous but marked enhancement (arrow) when gadolinium is added.
A B C D
Fig. 8. A 59-year-old male with skull lymphoma.A. On axial gadolinium-enhanced T1-weighted MR images, multiple homogeneous enhancing mass lesions are seen in both parietal bones (arrow in right parietal bone lesion).B, C. The lesions show hyperintensity on diffusion-weighted imaging (arrow) (B) and iso signal intensity on the T2-weighted image (arrow) (C).
A B C
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percellular regions have intermediate signal intensity on T1-wei-ghted images and heterogenous signal intensity on T2-weighted images (Fig. 9) (19).
Atretic Meningocehalocele
Atretic cephalocele is composed of dura, fibrous tissue, and dysplastic brain tissue. Oval or elongated defects are observable on plain skull radiographs. On CT scans, a subgaleal soft tissue mass with “spinning top” configuration is seen. On MRI, a sub-cutaneous scalp mass with intracranial extension through skull and dura may be seen as having heterogeneous signals on T1-
weighted images and high signals on T2-weighted images and heterogeneous enhancement after contrast injection. On MR ve-nography, a vertically positioned straight sinus equivalent (per-sistent falcine vein) is seen (Fig. 10) (21).
Gorham Disease
Gorham disease is an intraosseous neoplastic proliferating dis-ease of hemangiomatous or lymphagiomatous tissue with pro-gressive massive osteolysis. The first stage involves vascular pro-liferation in connective tissue; in the second stage, fibrous tissue replaces the absorbed bone without regeneration of the bone
Fig. 9. A 1-year-old girl with desmoplastic fibroma.A. A focal osteolytic lesion with sclerotic border (arrow) is seen near the right coronal suture on non-contrast CT. B, C. The lesion shows prominent enhancement on the gadolinium-enhanced T1-weighted image (arrow) (B), but shows low signal intensity rel-ative to brain parenchyma on diffusion-weighted imaging (arrow) (C).
A B C
Fig. 10. A 45-year-old man with atretic cephalocele and persistent falcine sinus.Coronal plain radiograph (A) shows a well-defined bony defect (arrow) in the interparietal region. On a T2-weighted image (B), a U-shaped hy-pointense subscalp lesion (arrows) which extends to a congenital bony defect is detected. Anomalous persistent falcine sinus is noted as well (open arrow). On contrast-enhanced MR venograph, marked stenosis (arrow) of the persistent falcine sinus (open arrow) at the junction of the falcine and superior sagittal sinuses is noted (C). Reprinted from Cho J, Kim MY, Roh HG, Moon WJ. MR images of spontaneously involuted atret-ic cephalocele concomitant with persistent falcine sinus in an adult. J Korean Soc Magn Reson Med 2006;10:117-120; with permission.
A B C
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matrix. On CT scans, radiolucent foci in the intramedullary or subcortical regions are seen and the gradual disappearance of bone may be apparent. MR imaging of Gorham disease involv-ing the calvaria has not been widely reported, but a reticular pat-tern on a contrast enhanced fat-suppressed T1-weighted image was reported (16).
Burr Hole
Burr holes appear as well-defined defects in the inner and out-er tables of the skull vault on CT or simple radiograph. On con-trast-enhanced MR images, the margins of the burr hole usually show enhancement, and in some cases, diffuse enhancement with a filling of the plunge defect may be seen. Defects caused by plunging may show high signal intensity on T2-weighted images, which is referred to as a “mushroom sign” (22).
Others
Skull OsteosarcomaSkull osteosarcomas show nonspecific radiological features,
for example, they can be either osteolytic, osteoblastic, or mixed in involvement pattern. However, spicular calcification tends to be seen, and a sun burst appearance exists in 25% to 31% of cases (23). Bone destruction and mineralization of the tumors may in-dicate an osteogenic sarcoma (24).
OsteomyelitisOsteomyelitis of the calvarium may occur as a consequence of
trauma or as a complication of sinus sepsis. Pus in the bone can spread either into the cranium or outward into subgaleal or sub-cutaneous planes where it can form abscesses, visible as osteo-lytic lesions on CT (25).
Arachnoid GranulationArachnoid granulations usually present as sharply marginat-
ed, lucent, occipital bone lesions adjacent to the transverse sinus. They generally appear as hypointense or isointense relative to the brain parenchyma on T1-weighted images and hyperintense on T2-weighted images and show minimal heterogeneous contrast enhancement (26, 27).
Neurofibromatosis Type 1Neurofibromatosis type 1 is a multisystem neurocutaneous
disorder that is one of the most common inherited autosomal dominant central nervous system disorders. The radiographic spectrum includes focal areas of abnormal signal intensity in deep grey or white matter, optic nerve glioma, progressive sphe-noid wing dysplasia, lambdoid suture defects, dural calcifica-tion at the vertex, buphthalmos, and in rare cases, the Moyam-oya phenomenon (28).
Focalized or Generalized Thickening of the Calvarium
Osteoblastic Metastasis
Osteoblastic metastases arise from hematogenous spread from primary cancers. In such instances, they are often seen without benign sclerotic borders. On CT scans, metastatic lesions are usually seen as enhancing masses centered in bone with osseous destruction and most are lytic, though a few are sclerotic (e.g., prostate lesions). Osteoblastic metastases appear as hypointense lesions on both T1-weighted and T2-weighted images without significant enhancement and appear positive on DWI (2, 29).
Osteoma
Osteomas are benign, slow-growing tumors usually found in-cidentally (30). They are the most common benign osseous tu-mors in the calvarium, and are mainly found in the outer table of the skull (31). They appear as dense oval lesions on radiographs. On CT images, they appear as very hyperdense sclerotic masses with clear-cut outlines that grow from, and attach to, the external aspect of the cortical bone. They are homogeneously hypointense on T1-weighted images, heterogeneously hypointense on T2-weighted images, and do not show contrast enhancement (2).
Fibrous Dysplasia
Fibrous dysplasia can be seen as calvarial thickening because it tends to cause the outer table to bulge while conserving the shape of the inner table (15).
Meningioma
Usually benign, meningiomas arising from the dura can cause hyperostosis. On plain radiograph and CT, 75% of cases appear as round or smoothly lobulated masses that are hyperdense com-
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pared to the cerebral cortex. 25% of cases demonstrate calcifica-tion. Hyperostosis on bone algorithm CT is often seen (32).
Acromegaly
Growth hormone hypersecretion can manifest as generalized thickening of the skull. Bony abnormalities associated with gr-owth hormone include sella turcica alterations, prominence and enlargement of frontal and maxillary sinuses, excessive pneuma-tization of the mastoids, prominence of the occipital protuber-ance, thickening or, less commonly, thinning of the cranial vault, enlargement and elongation of the mandible, and widening of the mandibular angle (32).
Others
Shunted HydrocephalusChronic intracranial hypotension or prolonged ventricular
shunting for hydrocephalus can cause diffuse thickening of all bones of the neurocranial vault. This happens because outward pressure needed to expand the cranium is missing, so the inner table of the skull bone grows instead. On simple radiographs and CT scans, the entire cranial vault thickening can be seen (33).
Dilantin TherapyDilatin (Diphenylhydantoin) is widely used for the manage-
ment of patients with epileptic convulsions. Dilatin has recently been shown to stimulate osteoblast proliferation in approximate-ly 34% of patients. The degree of skull thickening is correlated with frontal bossing and degree of facial coarsening (34). The in-crease in the thickness of the calvarium is mainly presented in the diploic space (35).
Paget DiseasePaget disease, also known as osteitis deformans, can cause
chronic metabolic skeletal disorders (2) characterized by bony expansion with variable destruction with or without sclerosis. The characteristics of CT and MR are a loss of normal trabecu-lae from lysis, a disorganized pattern of trabecular thickening, and, finally, sclerosis when the disease is in the blastic phase. Since a majority of cases are seen in the mixed phase, the yellow marrow signal intensity is maintained regardless of the MR se-quence (36, 37).
Chronic Hemolytic AnemiaPatients with hemolytic anemia have red marrow hyperplasia,
causing the widening of the diploic space; the outer table thins or is completely obliterated. Before diploic widening, a coarse granular or stippled pattern can be seen in the upper parietal re-gion. When the hyperplastic marrow perforates or destroys the outer table, new bony spicules perpendicular to the inner table are seen as “hair-on-end” signs (38).
Chronic Calcific CephalhematomaCephalhematoma that is not absorbed within a month begins
to ossify where the periosteum is lifted and the ossification grad-ually covers the surface of the hematoma. The thick band-like ossification mimics doubling of the skull, so it is referred to as a “double skull sign” (39). On CT and radiograph, it appears as a uniform, densely calcified mass located immediately adjacent to the outer table, within the periosteum (1).
Hyperostosis Frontalis InternaHyperostosis frontalis interna is a benign condition which th-
ickens the inner table of the frontal bone. Though the etiology is not clearly known, estrogen signaling is thought to be involved. The hyperostotic bone tends to be less dense on simple radio-graphs or on CT than are normal cortical bones (40, 41).
Focal or Generalized Thinning of the Calvarium
Prominent Convolutional Marking (Copper-Beaten Skull)
Prominent convolutional marking is widely considered to be a reflection of normal brain growth. The growing brain exerts a continuous pulsatile pressure on the cranium, producing a gyral pattern on plain radiographs which is known as the copper-beat-en pattern (42).
Craniosynostosis
Craniosynostosis is a rare, complex condition defined as a premature fusion of one or more of the cranial sutures (43). Pri-mary craniosynostosis is due to a developmental error during embryogenesis, while secondary craniosynostosis is due to me-chanical or metabolic causes (44). In plain radiographs, perisu-tural sclerosis, localized breaking, bony bridging, and absence of the suture are primary signs of craniosynostosis. When raised
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intracranial pressure is maintained over long, fingerprinting and copper beating can be seen (45).
Lacunar Skull
Lacunar skull is characterized as a dysplasia of the membra-nous bone caused by mesenchymal abnormality and is associat-ed with neural tube defects, especially myelomeningocele with Chiari II malformation. It is seen as a well-defined lucent lesion (having a scooped-out appearance) which corresponds to the nonossified fibrous bone (32).
Long-Standing Hydrocephalus
Regardless of the cause of hydrocephalus, increased intracra-nial pressure may result in diffuse calvarial thinning with or wi-thout deformity when it is not treated properly (33).
Normal Parietal Thinning
Parietal thinning is an uncommon condition which can be caused by either non-progressive congenital dysplasia of the di-pole or acquired and progressive diseases such as tumors, diabe-tes, long-standing steroid therapy, or osteoporosis. The bilateral parietal bones show symmetrical thinning (involving the outer tables and diploe) with a scalloped appearance while the inner table is usually intact (46, 47).
Secondary Thinning due to Benign Tumors
Benign tumors or slow growing cysts can result in overlying skull thinning because of a chronic pressure effect. Smooth-mar-gined calvarial thinning without periosteal reaction or new bone formation suggests that the underlying lesion is benign.
Parry Romberg Syndrome
Parry Romberg syndrome is rare neurocutaneous disorder also known as progressive hemifacial atrophy. One side of the face, including the skin, subcutaneous tissue, muscles, cartilage, and underlying bony structures, becomes slowly and progres-sively atrophic. Radiologic findings include bone and soft-tissue atrophy of varying degrees, which do not cross the midline (48).
CONCLUSION
Calvarial lesions vary from clinically insignificant lesions to
life-threatening lesions such as bone metastases. While bony le-sions of the calvarium are easily identified using brain CTs, bone marrow lesions can be visualized better on brain MRIs than on brain CTs. Diffusion-weighted MRI is helpful in detection and diagnosis of bone marrow lesions. The categorical imaging ap-proach presented here will be helpful in narrowing the list of possible diagnoses of calvarial lesions.
Acknowledgments
This study was supported by Konkuk University in 2015 and by a grant of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI12C0713).
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다양한 두개골 병변의 영상소견: 골용해성 병변을 중심으로
임영희1 · 문원진1* · 안형수1 · 조 준2 · 노명호3
이 임상화보의 목적은 다양한 두개골 병변을 병변의 양상에 따라 분류하여 컴퓨터단층촬영과 자기공명영상소견을 보여주
고 감별진단을 제시하는 것이다. 256예의 두개골 병변 증례(122 악성종양, 115 양성종양, 19 비종양성 병변)를 후향적으
로 분석하였으며 이를 다음과 같은 여섯 가지 분류로 나누었다: 전반적 두개골비후, 국소적 두개골비후, 전반적 두개골 위
축, 국소적 두개골 위축, 단발성 용골성 병변, 다발성 용골성 병변. 두개골의 골병변은 컴퓨터단층촬영으로 잘 찾아낼 수
있으나, 골수병변의 진단은 확산강조영상이나 지방억제 T2 강조영상과 같은 자기공명영상이 좀 더 우수하다. 침범패턴에
따른 두개골 병변의 세심한 판독이 감별진단의 범위를 줄이면서 정확한 진단으로 이끌 수 있다.
건국대학교 의학전문대학원 건국대학교병원 1영상의학교실, 2신경외과학교실, 3성균관대학교 의과대학 강북삼성병원 영상의학교실