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IHS-link Seminar No.1
The Life Question
141021Kaito Kikuchi
Brief Introduction
Kaito Kikuchi
1st year Master’s student
Research Keywords: Microbiology/Quantitative Biology/Bioinformatics
Twitter: @kickingkite
Website: www.kaito.co
I. Lifecommon, extraordinary, diverse, complex.
What is Life?
What is Life?
Extraterrestrial Life?
Complexity
organism cell
II. Life Sciencetackling the life question
“Life Science”
“Life Science”
The Cell: Foundation for Life
organism cell
Single-Cell Biology
Cells Cell
Why Single?
population
cell
orange
homogenous
yellow red
heterogenous
orange
Single Cell Biophysics
• Physical Laws
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• Aim to establish a Law of Living Systems
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• Precise measurement of single cell parameters
Pressure Volumex = Constant
Viscosity Cell Sizex = Growthe.g.
ViscosityCell SizeGrowth
Single Cell Microscopy
E. coli culture
slide glass
microscopesingle cell imaging
Single Cell Imaging
15sec x 300 images = 1hour 15min GFP-tagged protein shown diffusing
III. Relationshipour standing point
Life as a focal pointMathematics
Physics Chemistry
Philosophy
Computer Science
Arts
BiologySociology
Huge public implications
• GMO, Ebola, iPS, Abortion, STAP…
• Life-related issues have huge implications in society
• Insufficient mutual understanding between scientists and the general public
• Common yet remote nature of Life Sciences
Need for cooperative efforts
• Life-related issues demand interdisciplinary attention and cooperation
• Example: brain death ethics
• Remarkable progress in diagnosis technologies,but its accuracy does not yield an answer to
Brain Death = Human Death?
Conclusion
• Life Scientists: try to answer the Life Question
• The cell is the shared basis of life→Single-cell Biophysics
• Life-related issues demand interdisciplinary efforts
• How can we unite forces to address these issues?