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Slide 60 IgA nephropathy: Schemati ed dra!ingo" a glomer#l#$ $ho!ing prominent electronden$e depo$it$ immediately %eneath the

parame$angial %a$ement mem%rane a$$ociated!ith me$angial hypercell#larity&

S60 ' IgA nephropathy:

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Slide 6( Idiopathic IgA nephropathy: )a$$ontrichrome $tain demon$trating $egmentally*aria%le hypercell#larity that i$ e+cl#$i*elyme$angial in $ome $egment$ ,on right-

%#t mani"e$t$ a$ more comple+ endocapillaryhypercell#larity !ith $light o%literation o" capillaryl#men$ el$e!here ,on le"t-&

S6( ' Idiopathic IgAnephropathy:

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Slide 6. Idiopathic IgA nephropathy: Inten$eme$angial $taining "or IgA&

S6. ' Idiopathic IgAnephropathy:

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Slide 6/ Idiopathic IgA nephropathy: )e$angialelectron den$e depo$it$ o" IgA&

S6/ ' Idiopathic IgAnephropathy:

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Slide 6 Idiopathic IgA nephropathy pl#$ ac#tet#%#lar necro$i$& A .'year'old man de*eloped arapidly progre$$i*e renal "ail#re to a $er#mcreatinine concentration o" 1&. mg2dl !ith gro$$

hemat#ria o*er (3 day$& Renal %iop$ydoc#mented me$angial proli"eration$ !ith $trong$taining "or IgA and !ea4 5/& Erythrocyte$ lledmany t#%#le$ ,A7O8 $tain-&

S6 ' Idiopathic IgAnephropathy pl#$ ac#tet#%#lar necro$i$&

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Slide 6 a Idiopathic IgA nephropathy pl#$ ac#tet#%#lar necro$i$& In the a%o*e ca$e9 erythrocyte$!ere al$o "o#nd in the cytopla$m o" t#%#lar cell$9

a phenomenon termed erythrophagocyto$i$&Erythrocyte$ !ere noted %oth in the ape+ ,arro!-and %a$e ,arro!head- o" t#%#lar cell$ ,H E-&

S6 a ' Idiopathic IgAnephropathy pl#$ ac#tet#%#lar necro$i$&

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Slide 63 Idiopathic IgA nephropathy pl#$ ac#tet#%#lar necro$i$& In the ca$e de$cri%ed a%o*e9erythrocyte ca$t$ !ere a$$ociated !ith $ign$ o"

t#%#lar necro$i$ incl#ding den#dation ,arro!- andr#pt#re ,arro!head- o" the t#%#lar %a$ementmem%rane ,A7O8 $tain-&

S63 ' Idiopathic IgAnephropathy pl#$ ac#tet#%#lar necro$i$&

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Slide 63a Idiopathic IgA nephropathy pl#$ ac#tet#%#lar necro$i$& Erythrocyte ca$t$ !ere noted inthe #rinary $ediment in the $ame ca$e %y pha$econtra$t micro$copy&

S63a ' Idiopathic IgAnephropathy pl#$ ac#tet#%#lar necro$i$&

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Slide 63% Idiopathic IgA nephropathy pl#$ ac#tet#%#lar necro$i$& In the $ame ca$e9 electronmicro$copy $ho!ed #rinary erythrocyte ca$t$ in*arying degree$ o" hemoglo%in degradation9 $omeappearing a$ empty $hell$&

S63% ' Idiopathic IgAnephropathy pl#$ ac#tet#%#lar necro$i$&

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