I.Right lung, superior lobe. II.Right lung, middle lobe. III.Right lung, inferior lobe.
ICY THERAPY spot treats CANCER in the lung 1. Evaluating Cryoablation of Metastatic Lung/Pleura...
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Transcript of ICY THERAPY spot treats CANCER in the lung 1. Evaluating Cryoablation of Metastatic Lung/Pleura...
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ICY THERAPYspot treats
CANCERin the lung
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Evaluating Cryoablation of Metastatic Lung/Pleura Tumors In Patients –
Safety and Efficacy
de Baere T1 ; Woodrum D2 ; Abtin F3 ; Littrup P4 ; Farouil G1
1. Institut de Cancerologie Gustave Roussy, VILLEJUIF Cedex, France 2. Mayo Clinic, Rochester, MN, United States3. Unv. of California-Los Angeles, Los Angeles, CA, United States4. Karmanos Cancer Institute, Detroit, MI, United States
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1. Dr. Thierry de BeareInstitut de Cancerologie Gustave Roussy, VILLEJUIF Cedex, France
2. Dr. David WoodrumMayo Clinic,
Rochester, MN, United States3. Dr. F Abtin
Unv. of California-Los Angeles, Los Angeles, CA, United States
4. Dr. Peter LittrupKarmanos Cancer Institute,
Detroit,MI, United States
Multicenter, prospective, single arm study
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Objective
Assess the role of CT guided cryoablation in targeted treatment of small to medium
metastatic tumors in the lung
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Why Ablation versus Surgery
• Many of the patients are not surgical candidates
• Cryoablation usually requires only an overnight stay in the hospital
• Shorter recovery time
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• Pulmonary metastatic disease
• Up to 5 pulmonary metastases (≤3.5
cm) with no more than 3 on one side.
Inclusion Criteria
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• Primary NSLC lung cancer
• Inability to lie flat or respiratory distress at rest
• Uncontrolled coagulopathy or bleeding disorders
Exclusion Criteria
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Demographics
BMI
Max: 44Min: 15 Avg: 27
Age
Max: 83Min: 26 Avg: 6319
12
72
Subjects Enrolled (n=40)
IGRMayoUCLAKarmanos
60%
40%
Gender
MaleFemale
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Primary Cancer Diagnosis
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Procedure Data
10Confidential
Bilateral20%
Unilateral80%
Tumor Locations
Tumor Size (cm)
Max: 3.2 Min: 0.3 Avg: 1.4
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Procedure Data
11Confidential
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12Confidential
Side EffectsCTCAE Grade
PneumothoraxPleural EffusionPain: Chest/BackHemorrhageCough
Adverse Event Number Rate Per Procedure
2410643
50%21%13%8%6%
Top Five
• Non-Cardiac Chest Pain• Pneumothorax requiring VATS• AV Fistula thrombosis requiring thrombectomy
Grade 3 Events
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Response Rate100% 100%95%
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Lung CryoablationAxial Probe Placement
Coronal Probe Placement
NeedlesIn
TumorLung Tumor
Ice BallEdge
Freezing
Lung Metastasis
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• Cryoablation of lung tumors mets ≤3.5 cm appears safe and efficacious
• Preliminary short-term results offer promising local tumor control
• Larger experience and longer follow-up is necessary
Take Home Points