ICFTD 2016 Program August 31, 2016 Scientific Program€¦ · 15:42 Embodied Cognition of Dynamic...

ICFTD 2016 Program August 31, 2016

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10th International Conference on

Frontotemporal Dementias

August 31–September 2, 2016 Munich (GERMANY)

Scientific Program

www.icftd2016.de


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12:15–12:30 Opening

Room Lecture Hall

Chairs Janine Diehl-Schmid (Munich/DE), Manuela Neumann (Tuebingen/DE)

12:30–13:50 Session 1: FTLD: current perspectives - future directions

Room Lecture Hall

Chairs Bruce Miller (San Francisco, CA/US), Julie Snowden (Manchester/GB)

12:30 Changing perspectives on frontotemporal dementia

Julie Snowden (Manchester/GB)

12:55 Frontotemporal dementia neuroanatomy: onset, spread, and implications for

treatment

William S. Seeley (San Francisco, CA/US)

13:20 Social and Economic Burden of Frontotemporal Degeneration

O1 James Galvin (Boca Raton/US), David Howard (Atlanta/US), Nadine Tatton, Sharon

Denny (Radnor/US)

13:35 Toward tau PET imaging in FTLD: An update

O2 Brad Dickerson, Scott McGinnis, Sara Makaretz, Christina Caso, Aaron Schultz,

Keith Johnson (Charlestown/US)

14:20–15:55 Session 2: Social cognition and behavior: challenges and interventions

Room Lecture Hall

Chairs Adrian Danek (Munich/DE), Mario Mendez (Los Angeles, CA/US)

14:20 Current concepts of social cognition and assessment in FTD

Bruno Dubois (Paris/FR)

14:45 Empathy and emotional processing in FTD

Katherine Rankin (San Francisco, CA/US)

15:10 An analysis of the trajectories of illness severity measurements in behavioral variant

frontotemporal dementia

O3 Kalyani Kansal, Halima Amjad, Sadhvi Saxena, Chiadi Onyike (Baltimore/US)

15:25 Phenotype, neuropsychology and psychopathology of C9orf72 mutation carriers from

the German FTLD-Consortium

O4 Janine Diehl-Schmid, Carola Rossmeier (Munich/DE), Sarah Straub, Theresia Kelm

(Ulm/DE), Johannes Kornhuber (Erlangen/DE), Klaus Fliessbach (Bonn/DE), Timo

Grimmer (Munich/DE), Alexander Kehl, Markus Otto (Ulm/DE), Matthias L. Schroeter

(Leipzig/DE), German FTLD-Consortium (Ulm/DE)

15:40 Reward deficits in behavioral variant frontotemporal dementia include insensitivity to

negative stimuli

DB1 David Perry, Samir Datta, Virginia Sturm, Kristie Wood, Jessica Zakrzewski, Bruce

Miller, Joel Kramer, Howard Rosen (San Francisco, CA/US)


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15:42 Embodied Cognition of Dynamic Emotion in Frontotemporal Lobar Degeneration

DB2 Charles Marshall, Chris Hardy, Lucy Russell, Camilla Clark, Katrina Dick, Emilie

Brotherhood, Jennifer Nicholas, Jonathan Rohrer, James Kilner, Jason Warren

(London/GB)

15:44 Longitudinal decline in cognitive functioning in presymptomatic frontotemporal

dementia

DB3 Janne Papma, Lize Jiskoot, Elise Dopper, Tom Den Heijer, Reinier Timman, Rick

Van Minkelen, John Van Swieten (Rotterdam/NL)

15:46 The impact of context on emotion decoding in frontotemporal dementia

DB4 Fiona Kumfor (Randwick, Sydney, Sydney/AU), Agustin Ibañez (Buenos Aires,

Santiago/AR), John Hodges, Olivier Piguet (Randwick, Sydney, Sydney/AU)

15:48 Neuropsychological profiles in behavioural variant Frontotemporal Dementia and

Psychiatric disorders

DB5 Everard Vijverberg (Amsterdam, The Hague/NL), Sigfried Schouws, Paul David

Meesters, Sietske Sikkes (Amsterdam/NL), Esmee Verwijk (The Hague/NL), Hannie

Comijs, Philip Scheltens, Max Stek, Yolande Pijnenburg, Annemiek Dols

(Amsterdam/NL)

15:50 Frontotemporal Dementia in Patients of African Descent

DB6 Keith Josephs (Rochester/US), William Hu (Atlanta/US), Argye Hillis (Baltimore/US),

Bradley Dickerson (Boston/US), Neill Graff-Radford (Jacksonville/US), Cameron

Davis (Baltimore/US), Rufus Akinyemi, Adesola Ogunniyi (Ibadan/NG), Nilufer Taner

(Jacksonville/US), Jonathan Graff-Radford (Rochester/US), Amza Ali (Mona/JM),

David Tang-Wai (Toronto/CA), Meredith Wicklund (Gainesville/US), Florence

Pasquier, Florence Lebert (Lille/FR), Julie Snowden (Manchester/GB), Nick Fox

(London/GB), Murray Grossman (Philadelphia/US), Chiadi Onyike (Baltimore/US)

15:55–17:30 Postersession I - Caregiver

Room Ballroom

P35 Spouses' experience of behavioural-variant frontotemporal dementia in the pre-

diagnostic phase

Kirrily Rogers (Parkville/AU), Amy Brodtmann, David Darby (Heidelberg, Box

Hill/AU), Vicki Anderson (Parkville/AU)

P36 Emotional Behavior in Dementia Patients and Spousal Caregivers: Rrelationship with

Caregiver Depression

Alice Verstaen, Anna Sapozhnikova, Sandy Lwi, Marcela Otero, Casey Brown, Dyan

Connelly, Robert Levenson (Berkeley/US)

P37 The Marte Meo-concept as a useful tool in understanding and counseling in FTD

Ursula Becker (Alfter/DE)

P38 Do neuropsychiatric symptoms lead to nursing home placement in bvFTD?

Differences and similarities between community and nursing home residents

Clarissa Giebel (Manchester/GB), Rachel Winson (Norwich/GB), David Knopman

(Rochester/US), Eneida Mioshi (Norwich/GB)

P39 Dimensions and Predictors of Perceived Burden Among Caregivers of Patients with

Frontotemporal Degeneration

James Galvin (Boca Raton/US)


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P40 Unity with Creativity: A new model to leverage rare disease advocacy organization

expertise into high-quality local support for FTD caregivers

Sharon Denny, Bridget Moran (Radnor/US)

P41 Characteristics of caregiver burden among mild frontotemporal lobar degeneration

patients: comparison between behavioral variant frontotemporal dementia and

semantic dementia with right- and left-sided predominant cerebral atrophy.

Asuka Koyama, Ryuji Fukuhara, Yusuke Miyagawa, Maki Hotta, Mamoru Hashimoto,

Manabu Ikeda (Kumamoto/JP)

P42 Family experiences of living with behavioural variant Frontotemporal Dementia

(bvFTD): implications of a qualitative longitudinal research study for coping and

interventions

Jan Oyebode, Jenny LaFontaine (Bradford/GB), Michael Larkin (Birmingham/GB)

P43 An intervention program for caregivers of early-onset dementia patients with frontal

behavioral changes: an explorative study increasing their sense of competence

Flora Gossink, Yolande Pijnenburg, Philip Scheltens, Rikie Kleverwal, Aafke Pera,

Nicole Korten, Max Stek, Rose-Marie Droes, Annemiek Dols (Amsterdam/NL)

P44 Family repercussions as a consequence of the alterations of social cognition present

in a patient diagnosed with frontotemporal dementia - behavioral variant

Daniel Martinez Martinez, Delver Amaury Garzón Muñoz, Johana Andrea Ramírez

Torres, Adelaida Bedoya Salcedo, Milena García García (Bogotá/CO)

P45 Care for people with Young Onset Dementia: A web-based intervention aiming to

support family carers

Susanna Saxl, Helga Schneider-Schelte (Berlin/DE)

P46 Caregivers' Attitudes Toward Family Participation in Frontotemporal Degeneration

Biomarker Research

Courtney Igne (Philadelphia/US), Lauren Massimo (University Park, PA/US), Corey

McMillan, Rachael Langey, Collin York, Kim Firn, Olga Kofman, Amy Halpin, Murray

Grossman (Philadelphia/US)

P47 Service needs in Young Onset Dementia: How ‘closest’ relatives balance being a

carer, being a care manager and meeting their own needs.

Jan Oyebode (Bradford/GB), Bridget Jones (Guildford/GB), Heather Blakey

(Leeds/GB), Sahdia Parveen (Bradford/GB), Christian Bakker (Nijmegen/NL), Joany

Millenaar, Marjolein de Vugt (Maastricht/NL), Alexander Kurz (Munich/DE), Heather

Gage (Guildford/GB)

P48 The CARE Pathway Model for Dementia: Integrating Psychosocial and

Rehabilitative Strategies for Care of Persons with FTD Disorders

Darby Morhardt, Sandra Weintraub, Becky Khayum, Emily Rogalski, Marsel

Mesulam (Chicago/US)

P49 Dissociation of Clinical Diagnostic and Caregiver Distress Neuropsychiatric Features

in FTD

Lydia Hatfield, Jennifer Wynne Taylor, Matthew Harris, Nansi Greger-Holt, Daniel I.

Kaufer (Chapel Hill/US)


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15:55–17:30 Postersession I - Social cognition and behavior

Room Ballroom

P50 In extremis: decision-making deficit in behavioral variant frontotemporal dementia

Guilhem Carle, Nicolas Borderies, Carole Azuar, Aurélie Guignebert, Maeva Camus,

Goeffroy Gagliardi, Raphael Le Bouc, Richard Levy, Mathias Pessiglione (Paris/FR)

P51 Moral judgments in frontotemporal dementia

Ingo Uttner, Lukas Petersdorff, Sarah Anderl-Straub, Elisa Semler, Sarah Böhm,

Dorothée Lulé (Ulm/DE), Heiner Fangerau (Düsseldorf/DE), Markus Otto (Ulm/DE)

P52 Cross frequency coupling during response inhibition in behavioural variant


Laura Hughes, James Rowe (Cambridge/GB)

P53 Prolonged Visual Facial Gaze in Frontotemporal Dementia

Pongsatorn Paholpak (Khon Kaen, Los Angeles/TH), Liang Li-Jung, Drew R. Carr,

Elvira Jimenez, Robin J Barrows, Valeiry Sabodash, Mario F. Mendez (Los

Angeles/US)

P54 Person-Based vs. Generalized Impulsivity Disinhibition in Frontotemporal Dementia

and Alzheimer’s Disease

Pongsatorn Paholpak (Khon Kaen, Los Angeles/TH), Drew R. Carr, Joseph P

Barsuglia, Robin J Barrows, Elvira Jimenez (Los Angeles/US), Grace J Lee (Loma

Linda/US), Mario F. Mendez (Los Angeles/US)

P55 Emotion and Moral Dilemmas in Behavioral Variant Frontotemporal Dementia

Sylvia S. Fong (Los Angeles/US), Carlos D. Navarrete (East Lansing/US), Sean E.

Perfecto, Andrew R. Carr, Elvira E. Jimenez, Mario F. Mendez (Los Angeles/US)

P56 The pitfall of behavioral variant frontotemporal dementia mimics despite

multidisciplinary application of the FTDC criteria

Welmoed Krudop, Annemiek Dols, Cora Kerssens, Piet Eikelenboom, Niels Prins,

Christiane Möller, Siegfried Schouws, Didi Rhebergen, Eric Exel, van, Wiesje Flier,

van der, Sietske Sikkes, Philip Scheltens, Max Stek (Amsterdam/NL)

P57 Neuropsychiatric effects of neurodegeneration of the medial versus lateral ventral

prefrontal cortex in humans

Edward Huey, Seonjoo Lee, Adam Brickman, Masood Manoochehri, Erica Griffith,

D.P. Devanand, Yaakov Stern (New York, NY/US), Jordan Grafman (Chicago, IL/US)

P58 Combined intensity ratings of congruent and incongruent facial emotions highly

discriminate between behavioral-variant frontotemporal dementia and major

depressive disorder

Isabelle Chiu (Basel/CH), Olivier Piguet (Sydney/AU), Janine Diehl-Schmid, Lina

Riedl (Munich/DE), Johannes Beck, Thomas Leyhe, Edith Holsboer-Trachsler

(Basel/CH), Manfred Berres (Koblenz/DE), Andreas U. Monsch, Marc Sollberger

(Basel/CH)

P59 Executive functioning and mental attribution predict environmentally-driven

behaviours in behavioural variant frontotemporal dementia

Emma Flanagan (Norwich/GB), Maxime Bertoux (Norwich, Paris/GB), Bruno Dubois,

Valérie Hahn, Elodie Guichart-Gomez (Paris/FR), Eneida Mioshi (Norwich/GB), Marie

Sarazin (Paris/FR), Michael Hornberger (Norwich/GB)


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P60 Emotion recognition in presymptomatic CHMP2B mutation carriers

Jette Stokholm, Peter Roos, Jørgen E. Nielsen (Copenhagen/DK), Adrian M. Isaacs

(London/GB), Jerry Brown (Cambridge/GB), Peter Johannsen (Copenhagen/DK)

P61 Emotion network breakdown relates to baseline autonomic dysfunction in behavioral

variant frontotemporal dementia

Virginia Sturm, Jesse Brown, Alice Hua, Sandy Lwi, Howard Rosen, Bruce Miller,

Robert Levenson, William Seeley (San Francisco/US)

P62 The Eating Behavior Inventory (EBI): a new clinical tool for the early diagnosis of

frontotemporal dementia.

Carole Azuar, Adriana Amaya, Maeva Camus, Aurelie Funkiewiez, Thomas Mauras,

Richard Levy, Isabelle Le Ber, Bruno Dubois (Paris/FR)

P63 Clinical types of FТD in elderly patients of Alzheimer’s disease outpatients clinic

(clinical-neuropsychological study)

Yana Fedorova, Irina Roshchina, Elena Ponomareva, Igor Kolykhalov, Natalia

Mikhаylova, Svetlana Gavrilova (Moscow/RU)

P64 Functional dissociation between anterior temporal lobe and inferior frontal gyrus in

the processing of dynamic body expressions: Insights from behavioral variant


Jan Jastorff, François-Laurent De Winter, Jan Van Den Stock, Mathieu

Vandenbulcke (Leuven/BE)

P65 Determinants of theory of mind performance in Alzheimer's disease

Siddharth Ramanan (Bangalore/IN), Leonardo Cruz de Souza (Belo Horizonte/BR),

Marie Sarazin (Paris/FR), Antonio Lúcio Teixeira, Paulo Caramelli (Belo

Horizonte/BR), Bruno Dubois (Paris/FR), Michael Hornberger, Maxime Bertoux

(Norwich/GB)

P66 Brain structural correlates of executive and social cognition profiles in behavioral

variant Frontotemporal Dementia and elderly Bipolar Disorder

Teresa Torralva, Sandra Baez, Clara Pinasco, María Roca, Jesica Ferrari, Blas

Couto, Indira Cordero (BUenos Aires/AR), Agustin Ibañez, Indira Cordero (Buenos

Aires/AR), Cruz Francy, Pablo Reyes, Diana Matellana (Bogota/CO), Marcelo

Cetkovich, Facundo Manes (Buenos Aires/AR)

P67 Uncovering the neural bases of cognitive and affective empathy loss in the

behavioural-variant of frontotemporal dementia

Muireann Irish, Nadene Dermody, Stephanie Wong, John Hodges, Olivier Piguet

(Sydney/AU)

P68 Multimodal evidence of interoceptive dimensions in neurodegeneration and stroke

Indira García-Cordero, Lucas Sedeño, Teresa Torralva, Laura de la Fuente, Jessica

Ferrari, Clara Rodriguez, Sandra Baez, Adrian Yoris, Sol Esteves, Margherita

Melloni, Paula Salamone, Facundo Manes, Adolfo Garcia, Agustin Ibañez (Buenos

Aires/AR)

P69 Bilingualism effect on cognitive development in Mongolian children

Delgertsetseg Chuluundorj, Nyamsuren Dorjpalam, Chuluundorj Begz

(Ulaanbaatar/MN)

P70 Multidimensional Apathy and Insight in Frontotemporal Lobar Degeneration and

Alzheimer’s Disease


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Ratko Radakovic, Shuna Colville, Denise Cranley, John Starr, Suvankar Pal, Sharon

Abrahams (Edinburgh/GB)

P71 Do you have a strategy? Multimodal signatures of social bargaining in

neurodegeneration and frontal lesion

Margherita Melloni, Teresa Torralva (BUenos Aires/AR), Pablo Billeke (Santiago/CL),

Sandra Baez, Eugenia Hesse, Laura de La Fuente, Agustina Birba, Indira Garcia

Cordero, Adolfo Garcia, Lucas Sedeño, Facundo Manes, Agustin Ibañez (BUenos

Aires/AR)

P72 Changing the artistic experience in Behavioral variant of Frontotemporal Dementia

Claire Boutoleau-Bretonniere (Nantes, Bron/FR), Cédric Bretonnière, Christelle

Evrard, Laetitia Rocher (Nantes/FR), Audric Mazzietti, Olivier Koenig (Bron/FR),

Martine Vercelletto, Pascal Derkinderen (Nantes/FR), Catherine Thomas-Antérion

(Bron, Lyon/FR)

P73 Distinct neuropsychiatric subtypes of behavioural variant FTD have different

functional profiles

Claire M O'Connor, Lindy Clemson, Cassandra Kaizik, Naomi Daveson, John R

Hodges, Sharpley Hsieh, Olivier Piguet (Sydney/AU), Eneida Mioshi (Norwich/GB)

P74 Neural basis of motivational approach and withdrawal behaviors in

neurodegenerative disease

Shunichiro Shinagawa (Tokyo, San Francisco/JP), Adhimoolam Babu, Virginia

Sturm, Tal Shany-Ur, Parnian Toofanian Ross, Pardis Poorzand, Scott Grossman,

Bruce Miller, Katherine Rankin (San Francisco/US)

P75 Categorization impairment in bvFTD, PSP and AD

Béatrice Garcin, Emmanuelle Volle, Aurelie Funkiewiez, Nicolas Defoor, Bruno

Dubois, Richard Levy (Paris/FR)

P76 So close yet so far: executive contribution to memory processing in behavioural


Maxime Bertoux (Norwich/GB), Siddharth Ramanan (Bangalore, India./IN), Andrea

Slachevsky, Carolina Delgado, Fernando Henriquez, Gada Musa (Santiago,

Chile/CL), Foudil Lamari (Paris, France/FR), Michel Bottlaender (Saclay, France/FR),

Marie Sarazin (Paris, France/FR), Michael Hornberger (Norwich/GB), Bruno Dubois

(Paris, France/FR)

P77 Apathy and Impulsivity in Frontotemporal Lobar Degeneration Syndromes.

Claire Lansdall, Ian T.S. Coyle-Gilchrist, Patricia Vázquez Rodríguez

(Cambridge/GB), Eileen Wehmann (Hamburg, Germany./DE), Alicia Wilcox

(Cambridge/GB), Katrina M. Dick (London/GB), P. Simon Jones, Karalyn Patterson,

James B Rowe (Cambridge/GB)

P78 Fronto-striatal correlates of behavioural disturbances in behavioural-variant


Maxime Bertoux, Emma Flanagan (Norwich/GB), Olivier Piguet, John Hodges

(Sydney, Australia/AU), Michael Hornberger (Norwich/GB)

P79 The Brain Network Abnormalities Underlying Apathy and Impulsivity in

Frontotemporal Lobar Degeneration.


(Cambridge/GB), Eileen Wehmann (Hamburg, Germany./DE), Alicia Wilcox

(Cambridge/GB), Katrina M. Dick (London/GB), P. Simon Jones, Karalyn Patterson,

James B. Rowe (Cambridge/GB)


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P80 Loss of White Matter Connectivity Related to Apathy and Impulsivity in

Frontotemporal Lobar Degeneration Disorders.


(Cambridge/GB), Eileen Wehmann (Hamburg, Germany./DE), Alicia Wilcox, P.

Simon Jones, Karalyn Patterson, James B. Rowe (Cambridge/GB)

P81 Cognitive profile in the C9ORF72 expansion related frontotemporal lobar

degeneration

Noora-Maria Suhonen (Oulu/FI), Ramona M Haanpää, Tuomo Hänninen, Anne M

Remes (Kuopio/FI)

P82 Frontotemporal dysfunction in elderly patients with bipolar disorder

Yaroslav Kalyn, Elena Shipilova, Irina Roshchina, Yana Vologdina, Tatiana Safarova

(Moscow/RU)

P83 Looking but not seeing: Understanding emotional face perception in behavioural-


Rosalind Hutchings (Randwick/AU), Romina Palermo (Crawley/AU), Jason

Bruggemann (Kensington/AU), John Hodges, Olivier Piguet, Fiona Kumfor

(Randwick/AU)

P84 Should I trust you? Learning and memory of socially relevant information in dementia

Stephanie Wong (Randwick/AU), Claire O'Callaghan (Cambridge/AU), Fiona Kumfor

(Randwick/AU), Greg Savage (Sydney/AU), John Hodges, Olivier Piguet

(Randwick/AU), Michael Hornberger (Norwich/GB)

P85 Motivated to remember? Modulation of value-based learning and memory in

dementia

Stephanie Wong (Randwick/AU), Greg Savage (Sydney/AU), John Hodges, Olivier

Piguet (Randwick/AU), Michael Hornberger (Norwich/GB)

P86 The Awareness of Social Inference Test (TASIT): Application of a short version of the

TASIT for the clinical diagnosis of behavioural-variant frontotemporal dementia

Fiona Kumfor (Randwick, Sydney, Sydney/AU), Cynthia Honan (Launceston/AU),

Jessica Hazelton (Randwick, Sydney/AU), John R. Hodges (Randwick, Sydney,

Sydney/AU), Skye McDonald (Sydney/AU), Olivier Piguet (Randwick, Sydney,

Sydney/AU)

P87 Changes in sexual behaviour and intimacy in frontotemporal dementia: impact on

spousal carers.

Cassandra Kaizik (Randwick/AU), Rebekah Ahmed (Randwick, Sydney/AU), Claire

O'Connor (Sydney/AU), Eneida Mioshi (Norwich/GB), Olivier Piguet, John Hodges

(Randwick, Sydney/AU)

P88 Neurodegeneration With Brain Iron Accumulation Can Mimic Frontotemporal

Dementia

Ahmet Evlice, Hacer Bozdemir, Kezban Aslan (Adana/TR)

P89 Behavioral variant frontotemporal dementia can be conceptualized and individually

predicted with meta-analyses & pattern classification of imaging data

Matthias Schroeter, Sebastian Meyer, Jane Neumann (Leipzig/DE), Angela Laird

(Leipzig/US), Karsten Mueller, Markus Otto (Leipzig/DE)


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P90 Neural correlates of verbal and nonverbal memory for item-item and item-location

information: Evidence from semantic dementia and Alzheimer's disease

Marshall Dalton (Sydney, Australia, London, UK/AU), Michael Hornberger , John

Hodges, Olivier Piguet (Sydney, Australia/AU)

P91 A spatial anticipation deficit is revealed by eyetracking metrics in behavioural variant

frontotemporal dementia.

Silvia Primativo, Camilla Clark, Keir Yong, Jason Warren, Jonathan Rohrer,

Sebastian Crutch (London/GB)

P92 Autonomic and Facial Expressive Emotional Responses: Relationships with Disease

Severity and Frontotemporal Dementia Subtypes

Alice Hua, Sandy Lwi (Berkeley/US), Bruce Miller (San Francisco/US), Robert

Levenson (Berkeley/US)

P93 Processing of auditory conflict in frontotemporal dementia

Camilla Clark, Jennifer Agustus, Jennifer Nicholas, Chris Hardy, Catherine

Mummery, Jonathan Schott, Jonathan Rohrer, Sebastian Crutch, Jason Warren

(London/GB)

P94 Expectation and reward in frontotemporal dementia: the case of music

Camilla Clark, Hannah Golden, Oliver McCallion, Jennifer Nicholas, Miriam Cohen,

Catherine Slattery, Ross Paterson, Alexander Foulkes, Catherine Mummery,

Jonathan Schott, Jonathan Rohrer, Sebastian Crutch, Jason Warren (London/GB)

P95 Longitudinal profiles of autobiographical memory retrieval in FTD

Annu Mothakunnel, Sharpley Hsieh, Ramon Landin-Romero, John R. Hodges, Olivier

Piguet, Muireann Irish (Sydney/AU)

P96 PERSONAL SPACE IN FRONTOTEMPORAL DEMENTIA

Sarah Anderl-Straub, Magdalena Nagl, Jens Dreyhaupt, Hans-Peter Müller, Markus

Otto, Ingo Uttner (Ulm/DE)

P97 All is not lost: Positive behaviors in Alzheimer’s disease and behavioral-variant

frontotemporal dementia with disease severity

Akira Midorikawa (Hachioji-shi, Sydney/JP), Cristian Leyton, David Foxe, Ramon

Landin-Romero, John Hodges, Olivier Piguet (Sydney/AU)

P98 Clinical Differentiation of Psychiatric Disorders from Behavioural Variant

Frontotemporal Dementia: A prospective study

Everard Vijverberg (Amsterdam, The Hague/NL), Flora Gossink, Welmoed Krudop,

Sietske Sikkes, Cora Kerssens, Niels Prins, Max Stek, Philip Scheltens, Yolande

Pijnenburg, Annemiek Dols (Amsterdam/NL)

P99 Music defines fMRI signatures of molecular nexopathies

Jennifer L Agustus, Camilla N Clark, Hannah L Golden, Catherine F Slattery, Phillip

D Fletcher, Jonathan D Rohrer, Jason D Warren (London/GB)

P100 Do criteria for behavioural variant frontotemporal dementia capture the cognitive and

behavioural profile of ALS/FTD?

Jennifer Adams, Jennifer Thompson, Matthew Jones, Jennifer Harris, Anna

Richardson, Tobias Langheinrich, David Neary, Julie Snowden (Salford/GB)

P101 Progression in late onset frontal lobe syndrome

Flora Gossink, Everard Vijverberg, Welmoed Krudop, Philip Scheltens, Max Stek,

Yolande Pijnenburg, Annemiek Dols (Amsterdam/NL)


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P102 Body schema processing in frontotemporal dementia

Rebecca Bond, Christopher Hardy, Lucy Russell, Charles Marshall, Camilla Clark,

Sebastian Crutch, Jonathan Rohrer, Jason Warren (London/GB)

P103 Vascular Frontotemporal Disorder

Michael Hoffmann, Fabian Rossi, Ramon Rodriguez Cruz, Annuli Khaki, Khizar Malik

(Orlando, Florida, Orlando/US)

P104 Risk of suicide in patients with behavioral variant Frontotemporal Dementia

Innocenzo Rainero, Milena Zucca, Elisa Rubino, Flora Govone, Alessandro Vacca,

Lorenzo Pinessi (Turin/IT)

P105 Moral processing deficit in behavioral variant frontotemporal dementia is associated

with emotion recognition deficits and both structural and functional lateral orbitofrontal

abnormalities

Jan Van den Stock, François-Laurent De Winter, Dante Mantini, Jan Jastorff, Rik

Vandenberghe, Mathieu Vandenbulcke (Leuven/BE)

P106 Demographic influence in Depression prevalence in frontotemporal dementia (FTD):

A meta-regression perspective

Amir Sepehry, Anita Afshinkia, Ging-Yuek Robin Hsiung (Vancouver/CA)

P107 Boxer’s Dementia with Aggression and Sexual Disinhibition - A Case Series

Viviana Chiappetta, Mohamed Eldefrawi, Sasidhar Gunturu, Monica Babillo, Marlene

Carrillo, Elba Contreras (Bronx/US)

P108 Psychotic symptoms and formal thought disorders in behavioral variant


Flora Gossink, Everard Vijverberg, Welmoed Krudop, Philip Scheltens, Max Stek,

Yolande Pijnenburg, Annemiek Dols (Amsterdam/NL)

P109 Profile of Memory impairment in behavioral variant of the FTD

Milena Garcia Garcia, Cristian Triviño Martinez, José Manuel Santacruz Escudero,

Diana Lucía Matallana Eslava (Bogotá/CO)

P110 Semantic categorization into the variants of FTD

Cristian Triviño Martínez, Milena García García, Hernando Santamaría-García, Diana

Lucía Matallana Eslava (Bogotá/CO)

P111 A longitudinal study of neuropsychiatric and cognitive symptoms in patients with

FTDbv

Milena Garcia Garcia, Cristian Triviño Martinez, José Manuel Santacruz Escudero,

Diana Lucía Matallana Eslava (Bogotá/CO)

P112 Differences in social cognition between behavioral-variant frontotemporal dementia

and depression: preliminary results

Maya Lichtenstein, Nader Fallah, Andrew Howard (Vancouver/CA), Paul Eslinger

(Hershey/US), Howard Feldman (Vancouver, San Diego/US)

P113 Behavioral variant frontotemporal dementia mimicked by right carotid artery stenosis

without observable lesion on MRI.

Yong Bum Kim, Pil-Wook Chung, Heui-Soo Moon, Bum Chun Suh, Won Tae Yoon

(Seoul/KR)


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P114 Neuropsychological Assessment of Medial Frontal Functioning in Frontotemporal

Dementia

Julia MacKinley, Mervin Blair, Kristy Coleman, Sascha Gill, Dhwanil Bhatty

(London/CA), Erin Warriner, Kathy Smolewska (Hamilton/CA), Stephen Pasternak

(London/CA), Mavis Kershaw (Victoria/AU), Elizabeth Finger (London/CA)

P115 Neural Correlates of Reversal Learning Deficits in Behavioral Variant Frontotemporal

Degeneration

Kylie Ternes, Joseph Kable (Philadelphia/US), Joseph McGuire (Boston/US), Katya

Rascovsky, Corey McMillan, Murray Grossman (Philadelphia/US)

P116 Compulsory mental care among patients with a neuropathologically confirmed

dementing disorder

Madeleine Liljegren, Maria Landqvist Waldö, Robert Rydbeck, Elisabet Englund

(Lund/SE)

P117 Qualitative assessment of verbal fluency performance in patients with bvFTD and

PPA

Esther van den Berg, Lize Jiskoot, Marielle Grosveld, John van Swieten

(Rotterdam/NL)

P118 Similar Findings on Clinical and Neuropsychological Measures in Asymptomatic

Mutation Versus Non-Mutation Carriers: Preliminary Data From LEFFTDS

Brad Boeve (Rochester/US), Howard Rosen, Adam Boxer (San Francisco/US),

Giovanni Coppola (Los Angeles/US), Christina Dheel (Rochester/US), Brad

Dickerson (Boston/US), Kelley Faber (Indianapolis/US), Julie Fields (Rochester/US),

Tatiana Foroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US), Nupur Ghoshal

(St. Louis/US), Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US),

Murray Grossman (Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao

(Bethesda/US), Robin Hsiung (Vancouver/CA), Edward Huey (New York/US), David

Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas (San

Francisco/US), David Knopman (Rochester/US), John Kornak, Joel Kramer (San

Francisco/US), Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce

Miller (San Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers

(Jacksonville/US), Katherine Rankin (San Francisco/US), Les Shaw

(Philadelphia/US), Margaret Sutherland (Bethesda/US), Arthur Toga (Los

Angeles/US), John Trojanowski (Philadelphia/US), Ashley Vetor (Indianapolis/US),

Sandra Weintraub (Chicago/US), Zbigniew Wszolek (Jacksonville/US)

P119 Differences on Neuropsychiatric Measures in Asymptomatic (CDR=0) Versus Mildly

Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From LEFFTDS

Howard Rosen (San Francisco/US), Brad Boeve (Rochester/US), Adam Boxer (San

Francisco/US), Giovanni Coppola (Los Angeles/US), Christina Dheel (Rochester/US),

Bradford Dickerson (Boston/US), Kelly Faber (Indianapolis/US), Julie Fields

(Rochester/US), Tatiana Faroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US),

Nupur Ghoshal (St. Louis/US), Jill Goldman (New York/US), Neill Graff-Radford

(Jacksonville/US), Murray Grossman (Philadelphia/US), Hilary Heuer (San

Francisco/US), John Hsiao (Bethesda/US), Ging-Yuek R. Hsiung (Vancouver/CA),

Edward D. Huey (New York/US), David Irwin (Philadelphia/US), Kejal Kantarci

(Rochester/US), Anna Karydas (San Francisco/US), David Knopman

(Rochester/US), John Kornak, Joel Kramer (San Francisco/US), Walter Kukull

(Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US),

Creighton Phelps (Bethesda/US), Rosa Rademakers (Jacksonville/US), Katherine

Rankin (San Francisco/US), Les Shaw (Philadelphia/US), Margaret Sutherland

(Bethesda/US), Arthur Toga (Los Angeles/US), John Trojanowski (Philadelphia/US),


12

Ashley Vetor (Indianapolis/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek

(Jacksonville/US)

P120 Investigating the role of face processing in behavioural variant frontotemporal

dementia

Lucy Russell, Martina Bocchetta, Sophie Harding, Sebastian Crutch, Jason Warren,

Jonathan Rohrer (London/GB)

P121 Neuropsychological profiles in familial frontotemporal dementia

Sophie Leijdesdorff, Esther van den Berg, Lize Jiskoot, Janne Papma, John van

Swieten (Rotterdam/NL)

P122 Longitudinal analysis of cognitive test score trajectories in behavior variant


Kalyani Kansal, Halima Amjad, Sadhvi Saxena, Chiadi Onyike (Baltimore/US)

P123 Social behavioral changes differ in frontotemporal dementia and semantic dementia

Harmony DUCLOS, Serges BELLIARD, Catherine MERCK, Vincent DE LA

SAYETTE, Francis EUSTACHE, Beatrice DESGRANGES, Mickaël LAISNEY

(Caen/FR)

P124 Longitudinal analysis of electronic messages to characterize language decline in

frontotemporal dementia with bulbar amyotrophic lateral sclerosis

Kalyani Kansal, Elsheba Abraham, Ashnaa Rao, Chiadi Onyike (Baltimore/US)

P125 Longitudinal performance of global measures of illness severity in semantic dementia

Kalyani Kansal, Halima Amjad, Sadhvi Saxena, Chiadi Onyike (Baltimore/US)

P126 Neuropsychiatric Symptoms in the Genetic Frontotemporal Dementia Initiative

(GENFI) Cohort

Leila Sellami (Québec/CA), Martina Bocchetta (London, United Kingdom/GB), John

van Swieten (Rotterdam/NL), Barbara Borroni (Brescia/IT), Daniela Galimberti

(Milan/IT), Mario Masellis (Toronto/CA), James B Rowe (Cambridge/GB), Caroline

Graff (Stockholm/SE), Fabrizio Tagliavini (Milano/IT), Giovanni Frisoni (Brescia/IT),

Elizabeth Finger (London Ontario/CA), Alexandre Mendonça (Lisboa/PT), Sandro

Sorbi (Florence/IT), Katrina M Dick, Jonathan D Rohrer (London/GB), Robert Laforce

Jr (Québec/CA)

P127 Differences on Neuropsychological Measures in Asymptomatic (CDR=0) Versus

Mildly Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From LEFFTDS

Joel Kramer (San Francisco/US), Sandra Weintraub (Chicago/US), Brad Boeve

(Rochester/US), Howard Rosen, Adam Boxer (San Francisco/US), Giovanni Coppola

(Los Angeles/US), Christina Dheel (Rochester/US), Brad Dickerson (Boston/US),

Kelly Faber (Indianapolis/US), Julie Fields (Rochester/US), Tationa Faroud

(Indianapolis/US), Ralitza Gavrilova (Rochester/US), Nupur Ghoshal (St. Louis/US),

Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US), Murray

Grossman (Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao

(Bethesda/US), Robin Hsiung (Vancouver/CA), Edward Huey (New York/US), David

Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas (San

Francisco/US), David Knopman (Rochester/US), John Kornak (San Francisco/US),

Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San

Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers



Angeles/US), John Trojanowski (Philadelphia/US), Ashley Vetor (Indianapolis/US),

Zbigniew Wszolek (Jacksonville/US)


13

P128 Depressive symptoms in patients with frontotemporal lobar degeneration

Mamoru Hashimoto, Ryuji Fukuhara, Keiichiro Kaneda, Manabu Ikeda

(Kumamoto/JP)

P129 Virtual reality as an assessment of cognition in behavioural variant Frontotemporal

Dementia: A Feasibility Study.

Emilie Brotherhood, Jason Drummond, David Swapp, Lucy Russell, Silvia Primativo,

Chris Hardy, Anthony Steed, Mel Slater, Jonathan D. Rohrer, Jason Warren,

Sebastian Crutch (London, UK/GB)

P130 Mistakes, I’ve made a few: Intact awareness, but impaired emotional processing of

errors in bvFTD.

Howard Rosen, Carole Scherllng (San Francisco/US), Jessica Zakrzewski (San

Francisco, Gainsville/US), Samir Datta (San Francisco/US), Robert Levenson

(Berkeley/US), Virginia Sturm, Bruce Miller (San Francisco/US)

P131 Misdiagnosis of very early frontotemporal dementia

Florindo Stella (Rio Claro-SP, Brazil, São Paulo - Brazil, Campinas-SP, Brazil/BR),

Lucas Mella, Vítor Marques, Thiago Fontana (Campinas-SP, Brazil/BR), Júlia

Loureiro (São Paulo - Brazil, Campinas-SP, Brazil/BR), Luiz Silva (Campinas-SP,

Brazil/BR)

P132 CLINICAL AND NEUROCOGNITIVE CORRELATES UNDERLYING THE FIRST

SYMPTOMS IN BEHAVIORAL VARIANT OF FRONTO TEMPORAL DEMENTIA

(BVFTD)

Hernando Santamaría García (Bogotá, Buenos Aires/CO), Pablo Reyes

(Bogotá/CO), Sandra Báez (Buenos Aires/AR), Ángela Martínez, José Santacruz

(Bogotá/CO), Mariano Sigman (Buenos Aires/AR), Diana Matallana (Bogotá/CO),

Agustín Ibáñez (Buenos Aires/CO)

P133 Frontotemporal dementia and schizophrenia - whats the connection I? An updated

case series and review of the literature.

Dennis Velakoulis, Samantha Loi (Melbourne/AU)

P134 Neuronal correlates of theory of mind and emotion comprehension during insincere

communication in neurodegenerative disease

Gianina Toller, Tal Shany-Ur, Suzanne Shdo, Laura Bouvet, Clinton Mielke, Scott N.

Grossman, Pardis Poorzand, Bruce L. Miller, Katherine P. Rankin (San

Francisco/US)

P135 Intra-individual variability in cognitive measures as a differential marker of genetic

variant FTD: a neuropsychological perspective

Amir Sepehry, Dana Wittenberg, Pheth Sengdy, Penny Slack (Vancouver/CA), Matt

Baker, Rosa Rademakers (Jacksonville/US), Howard Feldman, Ian Mackenzie, Ging-

Yuek Hsiung (Vancouver/CA)

P136 The Moral Emotions Assessment: a new tool for the early diagnosis of frontotemporal

dementia.

Chloe Daigmorte, Maeva Camus, Thomas Mauras, Aurélie Funkiewiez, Isabelle Le

Ber, Bruno Dubois, Richard Levy, Marc Teichmann, Carole Azuar (Paris/FR)

P137 ECOCAPTURE. A Quantitative Evaluation of Apathy Close to Real Life Situation by

Means of a Multimodal Sensor System Integrated.

Bénédicte BATRANCOURT, Karen LECOUTURIER, Carla ARAUJO (PARIS, F-

75013, Paris, France/FR), Vincent GUILLEMOT (F-75013, Paris, France/FR), Carole

AZUAR, Richard LEVY (PARIS, F-75013, Paris, France/FR)


14

P138 Physical aggressiveness among patients with a neuropathologically confirmed

dementing disorder

Madeleine Liljegren, Maria Landqvist Waldö (Lund/SE), Alexander Frizell Santillo

(Malmö/SE), Elisabet Englund (Lund/SE)

P139 Neuropsychiatric symptoms in patients with Alzheimer's disease and frontotemporal

dementia. Why is it important the night time behaviors and anxiety in the clinical

presentation of the Frontolobar Degeneration dementia?

Adrian Martinez Ruiz, G. Isaac Acosta Castillo, Leonardo Ramirez, Ana Luisa Sosa

Ortiz (Mexico City/MX)

P140 Association between MoCA Subitem Scores and Corresponding Cognitive Test

Performance in Patients with bvFTD

Kristy Coleman (London/CA), Brenda Coleman (Toronto/CA), Julia MacKinley,

Stephen Pasternak, Elizabeth Finger (London/CA)

P141 The differences of characteristics in abnormal eating behaviors in semantic dementia

between right and left predominant temporal lobe atrophy

Ryuji Fukuhara, Mamoru Hashimoto (Kumamoto-city/JP), Shunichiro Shinagawa

(Tokyo/JP), Kazue Shigenobu (Osaka/JP), Hibiki Tanaka, Kazuhiro Kawahara,

Yusuke Miyagawa, Naoko Ichimi, Manabu Ikeda (Kumamoto-city/JP)

P142 Relationship between cognitive declines and independency in the activities of daily

living in patients with frontotemporal dementia.

Maki Hotta, Mamoru Hashimoto, Ryuji Fukuhara, Asuka Koyama, Miki Murata,

Kazuhiro Yoshiura, Tomohisa Ishikawa, Hibiki Tanaka, Manabu Ikeda

(Kumamoto/JP)

P143 Neurobiological Subtract of False-Belief Reasoning: Insights from Frontotemporal

Dementia and Alzheimer’s Disease

Belen Pascual, Sahil Bajaj, Joseph C Masdeu (Houston/US)

P144 Altered Fronto-Thalamic Functional Connectivity and its Association with Emotion

Recognition Deficits in Frontotemporal Dementia

Namita Multani, Cassandra Jessica Anor, David F. Tang-Wai, Ron Keren, Maria

Carmela Tartaglia (Toronto/CA)

P145 Frontal lobe dysfunction in early recovery period of ischemic stroke

Lyudmila Pustokhanova, Elena Morozova (Perm/RU)

P146 Longitudinal neuropsychological evaluation of progranulin (GRN) mutation carriers

Dana Wittenberg, Robin G.Y. Hsiung, Pheth Sengdy (Vancouver/CA), Matthew

Baker, Rosa Rademakers (Vancouver/US), Penny Slack, Howard H. Feldman, Ian R.

Mackenzie (Vancouver/CA)

P147 Cognitive and Behavioral Trajectory of Behavioral-Variant Frontotemporal Dementia

Differs According to Underlying Pathology

Jeffrey Phillips, David Irwin, Katya Rascovsky, Vivianna Van Deerlin, Virginia Lee,

John Trojanowski, Corey McMillan, Murray Grossman (Philadelphia/US)

P148 Variables affecting emotional reactivity to socioemotional stimuli in frontotemporal

dementia

Sylvia Fong, Mario F. Mendez (Los Angeles/US)


15

P149 Patterns of neuropsychiatric symptoms in a Mexican sample diagnosed with

Alzheimer’s disease and frontotemporal dementia (behavioral and language variants)

according to stage of cognitive decline.

Juan Francisco Flores-Vazquez, Gilberto Isaac Acosta-Castillo, Airam Campos-

Jiménez, Loreli Alvarez-Diaz, Adrian Martínez Ruiz, Ana Luisa Sosa-Ortiz (Mexico

City/MX)

P150 Differences on Novel Measures of Social Comportment in Asymptomatic (CDR=0)

Versus Mildly Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From

LEFFTDS

Katherine Rankin, Joel Kramer, Howard Rosen (San Francisco/US), Brad Boeve

(Rochester/US), Adam Boxer (San Francisco/US), Giovanni Coppola (Los

Angeles/US), Brad Dickerson (Boston/US), Christina Dheel, Julie Fields, Ralitza

Gavrilova (Rochester/US), Nupur Ghoshal (St. Louis/US), Jill Goldman (New

York/US), Neill Graff-Radford (Jacksonville/US), Murray Grossman

(Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao (Bethesda/US),

Robin Hsiung (Vancouver/CA), Edward Huey (New York/US), David Irwin

(Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas, John Kornak (San

Francisco/US), David Knopman (Rochester/US), Walter Kukull (Seattle/US), Ian

Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US), Creighton Phelps

(Bethesda/US), Rosa Rademakers (Jacksonville/US), Les Shaw (Philadelphia/US),

Margaret Sutherland (Bethesda/US), Arthur Toga (Los Angeles/US), John

Trojanowski (Philadelphia/US), Ashley Vetor (Indianapolis/US), Sandra Weintraub

(Chicago/US), Zbigniew Wszolek (Jacksonville/US)

P151 Greater facial expressive versus self-reported emotional reactivity correlates with

diminished right posterior insular volume in bvFTD

Peter Pressman (San Francisco, Berkeley/US), James J. Casey, Kuan Hua-Chen

(Berkeley/US), Clinton Mielke, Katherine Rankin (San Francisco/US), Robert W.

Levenson (Berkeley/US)

P152 Frontotemporal dementia and schizophrenia - whats the connection II? A

neuropsychological and social cognition comparison of patients with chronic

schizophrenia and FTD

Dennis Velakoulis, Hui-Minn Chan, Wendy Kelso, Rene Stalky (Melbourne/AU)

P153 The Attribution of Animacy and Agency in Frontotemporal Dementia vs. Alzheimer’s

Disease

Sylvia S Fong, Andrew R Carr, Madelaine Daianu (Los Angeles/US), Mariel B

Deutsch (Los Angeles, New York/US), Elvira E Jimenez, Kevin O Juarez, Michelle M

Mather (Los Angeles/US), Pongsatorn P Paholpak (Los Angeles, Khon Khaen/TH),

Sean E Perfecto, Paul M Thompson, Mario F. Mendez (Los Angeles/US)

P154 Social emotions in behavioral variant frontotemporal (bvFTD) patients. How FTD

patients experience schadenfreude and envy.

Hernando Santamaría García (Bogotá, Buenos Aires/CO), Sandra Baez (Bogotá,

Buenos Aires/AR), Pablo Reyes, Diana Matallana (Bogotá/CO), Agustín Ibáñez

(Buenos Aires/CO)

P155 Cross-cultural Adaptation and Validity of the Brazilian version of the Clinical staging

scale and disease progression in frontotemporal dementia

Thaís Bento Lima da Silva, Valéria Bahia, Mário Amore Cecchini, Luciana Cassimiro,

Viviane Amaral Carvalho, Henrique Cerqueira Guimarães, Paulo Caramelli, Marcio

Balthazar, Benito Damasceno, Cássio Bottino, Sonia Brucki, Leonardo Cruz de

Souza (SAO PAULO/BR), Eneida Mioshi (SAO PAULO/GB), Ricardo Nitrini, Mônica

Yassuda (SAO PAULO/BR)


16

P156 Distinct Patterns of Cognitive Behavioral Change in Emerging FTLD in the Presence

and Absence of MND Support a ‘Bottom-Up’ Model of FTLD Onset.

Claire Flaherty (Hershey/US)

17:30–19:00 Session 3: Genetics of FTLD

Room Lecture Hall

Chairs Peter Heutink (Tuebingen/DE), Christine van Broeckhoven (Antwerp/BE)

17:30 Next generation sequencing approaches in FTD and ALS

Stefan Züchner (Miami, FL/US)

17:55 Identification Of A Novel FTD-MND Gene On Chromosome 16

O5 Carol Dobson-Stone, Agnes Luty (Sydney/AU), Elizabeth Thompson, Peter

Blumbergs (Adelaide/AU), William Brooks, Claire Shepherd (Sydney/AU), Justin

Yerbury (Wollongong/AU), Glenda Halliday, Peter Schofield, John Kwok (Sydney/AU)

18:10 Global initiative to identify genetic modifiers of disease onset and presentation in

patients with progranulin mutations

O6 Cyril Pottier (Jacksonvile/US), Daniel J Serie (Jacksonville/US), Edward D Huey

(New York/US), Manuela Neumann (Tuebingen/DE), Peter Johannsen

(Copenhagen/DK), Jarosław Slawek (Gdańsk/PL), Elizabeth C Finger (London

Ontario/CA), Carol F Lippa (Philadelphia/US), Charles L III White (Dallas/US),

Thomas G Beach (Sun City/US), John B Kwok (Sydney/AU), Sandro Sorbi

(Florence/IT), Bernardino Ghetti (Indianapolis/US), Marsel M Mesulam, Elieen H

Bigio (Chicago/US), Raquel Sanchez-valle (Barcelona/ES), Stuart Pickering-Brown

(Manchester/GB), Amalia Bruni (Lamezia terme/IT), Ekaterina Rogaeva

(Toronto/CA), Jonathan D Rohrer (London/GB), Caroline Graff (Stockholm/SE), Ian R

Mackenzie (Vancouver/CA), Thomas D Bird (Seattle/US), Carlos Cruchaga (Saint

Louis/US), John C van Swieten (Rotterdam/NL), Bruce L Miller (San Francisco/US),

Adolfo Lopez de Munain (San Sebastián/ES), Vivianna M Van Deerlin

(Philadelphia/US), Giacomina Rossi (Milan/IT), Luisa Benussi, Barbara Borroni

(Brescia/IT), Daniela Galimberti (Milan/IT), Roberta Ghidoni (Brescia/IT), Isabelle Le

Ber (Paris/FR), Joanna Biernacka (Rochester/US), Dennis W Dickson

(Jacksonvile/US), Neill R Graff-Radford (Jacksonville/US), Brad F Boeve

(Rochester/US), Rosa Rademakers (Jacksonvile/US)

18:25 Loss of function mutations in dipeptidyl peptidase 6 in Alzheimer disease and

Frontotemporal dementia: a novel pathway in neurodegeneration

DB7 Rita Cacace (Antwerp/BE), Tobi Van den Bossche (Antwerp, Edegem/BE), Jonathan

Lippiat (Leeds/GB), Jonathan Janssens (Antwerp/BE), Greet De Baets (Leuven/BE),

Sebastiaan Engelborghs, Anne Sieben (Antwerp/BE), Mathieu Vandenbulcke

(Leuven/BE), Peter de Rijk, Elise Cuyvers, Caroline Van Cauwenberghe, Caroline

Robberecht, Lubina Dillen, Céline Merlin, Nathalie Geerts (Antwerp/BE), Rik

Vandenberghe (Leuven/BE), Jean-Jacques Martin, Peter P. De Deyn (Antwerp/BE),

Joost Schymkowitz (Leuven/BE), Stuart Maudsley, Marc Cruts, Julie van der Zee,

Kristel Sleegers, Christine Van Broeckhoven (Antwerp/BE)

18:27 Symptom Onset in Genetic Frontotemporal Dementia

DB8 Katrina M Dick (London/GB), Bradley F Boeve (Minnesota, USA/US), Barbara

Borroni (Brescia, Italy/IT), Adam Boxer (San Francisco, California/US), Alexis Brice

(Paris, France/FR), Christopher R Butler (Oxford, UK/GB), Philippe Couratier

(Limoges, France/FR), Bradford C Dickerson (Charlestown, MA, USA/US), Simon

Ducharme (QC, Canada/CA), Elizabeth Finger (London, ON, Canada/CA), Daniela

Galimberti (Milan, Italy/IT), Alexander Gerhard (Manchester, UK/GB), Nupur Ghoshal


17

(MO, USA/US), Caroline Graff, (Stockholm, Sweden/SE), Murray Grossman,

(Philadelphia, PA 19104, USA/US), John R Hodges, (Sydney, Australia/AU), Edward

D Huey (New York, USA/US), Robert Laforce Jr (QC, Canada/CA), Isabelle Le Ber

(Paris, France/FR), Johannes Levin (Munich, Germany/DE), Ian R Mackenzie

(Canada/CA), Mario Masellis (Toronto Canada/CA), Olivier Martinaud (France/FR),

Alexandre Mendonça, (Lisbon, Portugal/PT), Fermin Moreno (San Sebastián,

Spain/ES), Jennifer M Nicholas, (London, London, UK/GB), Chiadi U Onyike (MD,

USA/US), Markus Otto (Ulm, Germany/DE), Erik D Roberson (USA/US), Emily

Rogalski (United States/US), Howard J Rosen (San Francisco, California/US), James

B Rowe (Cambridge, UK/GB), Raquel Sanchez-Valle (Barcelona, Spain/ES), Isabelle

Santana (Coimbra, Portugal/PT), Sandro Sorbi (Florence, Italy/IT), John van Swieten

(Rotterdam, Netherlands/NL), Matthis Synofzik (Tuebingen, Germany/DE), Fabrizio

Tagliavini (Milano, Italy/IT), Rik Vandenberghe (Leuven, Belgium/BE), Jonathan D

Roher (London/GB)

18:29 ATXN2 polyQ intermediate repeats influence Frontotemporal Lobar Degeneration

phenotype

DB9 Elisa Rubino, Cecilia Mancini, Patrizia Ferrero, Marina Ferrone, Stefano Bianca,

Silvia Boschi, Milena Zucca, Laura Orsi, Salvatore Gentile, Lorenzo Pinessi, Alfredo

Brusco, Innocenzo Rainero (Turin/IT)

18:31 Gene-based analysis detects novel loci associated with frontotemporal dementia and

its clinical subtypes

DB10 Aniket Mishra (Amsterdam/NL), Raffaele Ferrari, FTD-GWAS Consortium (London,

UK/GB), Peter Heutink (Tuebingen/DE), John Hardy (London, UK/GB), Yolande

Pijnenburg, Danielle Posthuma (Amsterdam/NL)

18:35 Panel discussion: How do we move from large scale sequencing efforts in genetics to

biology?

Peter Heutink (Tuebingen/DE)

19:30–21:00 Welcome reception

Room Foyer

ICFTD 2016 Program September 1, 2016

18

08:30–10:00 Session 4: Molecular neuropathology of FTLD

Room Lecture Hall

Chairs Manuela Neumann (Tuebingen/DE), Ian Mackenzie (Vancouver/CA)

08:30 Molecular neuropathology of FTLD with focus on C9orf72 mutations

Ian Mackenzie (Vancouver/CA)

08:55 Evidence from human studies for spreading/staging of TDP-43 pathology in FTLD

and ALS

Glenda Halliday (Sydney/AU)

09:20 New Models For Alzheimer's And other Related Tauopathies By Transmission Of

Neuronal And Glial Tau Pathology

O7 John Trojanowski (Philadelphia/US)

09:35 Clinicopathological correlations in early vs. late age-of-onset frontotemporal dementia

and frontotemporal lobar degeneration

O8 Sang Won Seo, Marie-Pierre Thibodeau, David C. Perry, Alice Hua, Manu Sidhu,

Stephanie E. Gaus, Gil Rabinovici, Katherine D. Rankin, Adam L. Boxer, Joel H.

Kramer, Howard J. Rosen, Maria Luisa Gorno-Tempini, Lea T. Grinberg, Eric J.

Huang, Stephen J. DeArmond, John Q. Trojanowski, Bruce L. Miller, William W.

Seeley (San Francisco/US)

09:50 TTBK1/2 hyper-activation drives pTau and pTDP accumulation

DB11 Laura Taylor, Pam McMillan, Nicole Liachko, Aleen Saxton, Tim Strovas, Brian

Kraemer (Seattle/US)

09:52 Cerebrospinal fluid phosphorylated tau levels are associated with post-mortem tau

inclusion burden in frontotemporal lobar degeneration

DB12 David Irwin (Philadelphia/US), Alberto Lleo (Barcelona/ES), Corey McMillan, Felicia

Cooper, David Wolk, Leslie Shaw, Edward Lee, John Trojanowski, Murray Grossman

(Philadelphia/US)

09:54 Testing reversibility of pathology in a new in vitro model for C9orf72 ALS/FTD

DB13 Frederike Riemslagh, Renate Hukema, Santoesha Nanhoe, Charlene den Hollander,

Helen de Boer, John van Swieten, Rob Willemsen (Rotterdam/NL)

09:56 Abundant lower motor neuron RNA foci with perinucleolar studding in C9orf72 FTD-

ALS

DB14 Sarat Vatsavayai, Stephanie Gaus, Ji-Hye Hwang, Bruce Miller, William Seeley (San

Francisco/US)

10:30–12:00 Session 5: Progressive aphasias

Room Lecture Hall

Chairs Marilu Gorno-Tempini (San Francisco, CA/US), Peter Nestor (Magdeburg/DE)

10:30 Apraxia of speech and its rehabilitation

Maya Henry (Austin, TX/US)

10:55 The right hemisphere and its semantics

Peter Garrard (London/GB)


19

11:20 In vivo correlates of pathological diagnosis in clinical variants of primary progressive

aphasia

O9 Edoardo Gioele Spinelli (Milan, San Francisco/IT), Maria Luisa Mandelli, Miguel

Santos (San Francisco/US), Stephen M Wilson (Tucson/US), Federica Agosta

(Milan/IT), John Q Trojanowski (Philadelphia/US), Eric J Huang, Lea T Grinberg (San

Francisco/US), Massimo Filippi (Milan/IT), Bruce L Miller, William W Seeley, Maria

Luisa Gorno-Tempini (San Francisco/US)

11:35 Imaging tDCS effects in primary progressive aphasia

O10 Kyrana Tsapkini, Yenny Webb-Vargas, Andreia Faria, Bronte Ficek, Tushar

Chakravarty, Constantine Frangakis, John Desmond, Martin Lindquist, Argye Hillis

(Baltimore/US)

11:50 Bilingualism in primary progressive aphasia: systematic review and case reports from

two European centers

DB15 Ana Sofia Costa (Braga/PT), Jennifer Wojtala (Aachen/DE), Sofia Rocha (Braga/PT),

Kathrin Reetz (Aachen/DE), Alvaro Machado (Braga/PT)

11:52 Differential binding of AV-1451 tau-PET across variants of primary progressive

aphasia

DB16 Jennifer Whitwell, Nirubol Tosakulwong, Joseph Duffy, Heather Clark, Mary

Machulda, Edythe Strand, Matthew Senjem, Ronald Petersen, Clifford Jack, Val

Lowe, Keith Josephs (Rochester/US)

11:54 Deficits in Rhythm Processing in PPA are linked to SMA atrophy

DB17 Jolien Schaeverbeke, Rose Bruffaerts (Leuven/BE), Manon Grube (Berlin,

Newcastle-upon-Tyne/GB), Veerle Neyens (Leuven/BE), Bruno Bergmans

(Brugge/BE), Eva Dries (Leuven/BE), Tim Griffiths (Newcastle-upon-Tyne/GB), Rik

Vandenberghe (Leuven/BE)

11:56 Anatomo-functional segregation of the mental lexicon: the model of Primary

Progressive Aphasia

DB18 Clara Sanches, Marc Teichmann, Olivier Colliot (Paris/FR), Alexandre Routier

(Paris/FI), Rafaella Miggliaccio (Paris/FR)

12:00–14:00 Postersession II - Genetics

Room Ballroom

P157 C9orf72, does the size matter?

Clemence Fournier, Vincent Anquetil, Agnès Camuzat, Mathieu Barbier (PARIS/FR),

Valérie Buée-Scherrer, Vincent Deramecourt, Nicolas Sergeant, Florence Pasquier

(Lille/FR), GIE NeuroCEB Network (Paris/FR), Bruno Dubois, Charles Duyckaerts

(PARIS, Paris/FR), Alexis Brice (PARIS/FR), Isabelle Le Ber (PARIS, Paris/FR)

P158 RNA metabolism in Frontotemporal dementia.

Vincent Anquetil, Agnès Camuzat, Clemence Fournier, Pierre de la Grange, Mathieu

Barbier (Paris/FR), Valérie Buée-Scherrer, Vincent Deramecourt, Nicolas Sergeant,

Florence Pasquier (Lille/FR), Bruno Dubois, Véronique Sazdovitch, Danielle Seilhean

(Paris/FR), Luc Buée (Lille/FR), Alexis Brice, Charles Duyckaerts, Isabelle Le Ber

(Paris/FR)


20

P159 A cluster of progranulin C157KfsX97 mutations in Southern Italy: clinical

characterisation and genetic correlations

Dario Saracino, Cinzia Coppola, Gianfranco Puoti, Giacomo Lus, Clemente Dato

(Naples/IT), Isabelle Le Ber (Paris/FR), Paola Caroppo, Elena Piccoli, Fabrizio

Tagliavini (Milan/IT), Giuseppe Di Iorio (Naples/IT), Giacomina Rossi (Milan/IT)

P160 Genetic screening of C9orf72 and TBK1 mutations and clinical correlations in

combined FTLD/ ALS phenotypes

Estrella Gómez-Tortosa, María Ruggiero (Madrid/ES), Emilio Franco-Macías

(Seville/ES), Cristina Prieto-Jurczynska, Begoña Venegas, Carlos Ordás, Silvia Gil

Navarro, Rosa Guerrero, Julián Pérez-Pérez, Mª José Sainz (Madrid/ES)

P161 TBK1 mutation frequencies and associated phenotypes in French frontotemporal

dementia and amyotrophic lateral sclerosis cohorts

Agnes Camuzat, Paola Caroppo, Anne De Septenville, Stephanie Millecamps

(PARIS/FR), Philippe Couratier (LIMOGES/FR), Mathieu Barbier (PARIS/FR),

Frederic Blanc (STRASBOURG/FR), Lucette Lacomblez (PARIS/FR), François

Sellal, Marie-Celine Fleury (STRASBOURG/FR), Alexis Brice, Isabelle Le Ber

(PARIS/FR), French Clinical and Genetic Research Network on FT French Clinical

and Genetic Research Network on FT (France/FR)

P162 Clinical features of TBK1 carriers and comparison with Belgian FTD patients carrying

another FTD-TDP causing mutation.

Sara Van Mossevelde (Antwerp, Wilrijk, Edegem/BE), Julie van der Zee, Ilse

Gijselinck (Antwerp, Wilrijk/BE), Sebastiaan Engelborghs (Wilrijk, Antwerp/BE), Anne

Sieben (Antwerp, Wilrijk, Ghent/BE), Tim Van Langenhove (Antwerp, Wilrijk,

Edegem/BE), Jan De Bleecker (Ghent/BE), Jonathan Baets (Antwerp, Wilrijk,

Edegem/BE), Mathieu Vandenbulcke, Koen Van Laere (Leuven/BE), Sarah

Ceyssens (Antwerp, Edegem/BE), Marleen Van den Broeck, Karin Peeters, Maria

Mattheijssens (Antwerp, Wilrijk/BE), Patrick Cras (Wilrijk, Edegem/BE), Rik

Vandenberghe (Leuven/BE), Peter De Jonghe (Antwerp, Wilrijk, Edegem/BE), Jean-

Jacques Martin (Wilrijk/BE), Peter P. De Deyn (Wilrijk, Antwerp/BE), Marc Cruts,

Christine Van Broeckhoven (Antwerp, Wilrijk/BE)

P163 TBK1 loss-of function and dominant-negative mutations in an extended European

cohort of FTD and ALS patients.

Julie van der Zee, Ilse Gijselinck, Sara Van Mossevelde, Federica Perrone,

Sebastiaan Engelborghs (Antwerp/BE), Jan De Bleecker (Ghent/BE), Jonathan Baets

(Antwerp/BE), Ellen Gelpi (Barcelona/BE), Ricardo Rojas-García (Barcelona/ES),

Jordi Clarimón, Alberto Lleó (Barcelona, Madrid/ES), Janine Diehl-Schmid,

Panagiotis Alexopoulos (Munchen/DE), Robert Perneczky (Munchen, London/DE),

Matthis Synofzik, Jennifer Just, Ludger Schöls (Tuebingen/DE), Caroline Graff,

Håkan Thonberg (Stockholm/SE), Barbara Borroni, Alessandro Padovani

(Brescia/IT), Albena Jordanova (Antwerp, Sofia/BE), Stayko Sarafov, Ivailo Tournev

(Sofia/BG), Alexandre de Mendonça, Gabriel Miltenberger-Miltényi, Frederico Simões

do Couto (Lisbon/PT), Alfredo Ramirez (Bonn/DE), Frank Jessen (Bonn,

Cologne/DE), Michael T. Heneka (Bonn/DE), Estrella Gómez-Tortosa (Madrid/ES),

Adrian Danek (Munich/DE), Patrick Cras (Antwerp/BE), Rik Vandenberghe

(Leuven/BE), Peter De Jonghe, Peter P. De Deyn, Kristel Sleegers, Marc Cruts,

Christine Van Broeckhoven, BELNEU consortium, EUEOD consortium

(Antwerp/BE)

P164 Large-scale Whole Genome Sequencing in ALS: Project MinE

Michael van Es (Utrecht/NL)


21

P165 Investigating the genetic impact of TUBA4A in a Belgian cohort of FTD and ALS

patients

Federica Perrone, Hung Nguyen Phuoc, Sara Van Mossevelde (Antwerp/BE), Anne

Sieben (Antwerp, Ghent/BE), Jan De Bleecker (Ghent/BE), Mathieu Vandenbulcke,

Rik Vandenberghe (Leuven/BE), Sebastiaan Engelborghs, Jonathan Baets, Peter De

Jonghe, Patrick Cras, Peter De Deyn, Jean-Jacques Martin, Julie van der Zee,

Christine Van Broeckhoven (Antwerp/BE)

P166 Investigating the role of rare heterozygous CHCHD10 variants in a Belgian cohort of

FTD and ALS patients

Hung Nguyen Phuoc, Federica Perrone, Sara Van Mossevelde (Antwerp/BE), Anne

Sieben (Antwerp, Ghent/BE), Patrick Santens, Jan De Bleecker (Ghent/BE), Rik

Vandenberghe, Mathieu Vandenbulcke (Leuven/BE), Sebastiaan Engelborghs,

Jonathan Baets, Peter De Jonghe, Patrick Cras, Peter De Deyn, Jean Jacques

Martin, Julie Van Der Zee, Christine Van Broeckhoven (Antwerp/BE)

P167 Founder effect of P301L MAPT mutation in families with FTD in Baix Llobregat

County (Barcelona, Spain)

Leire Palencia-Madrid (Vitoria/ES), Sergi Borrego, Oriol Grau-Rivera, Ramon Reñe,

Isabel Hernandez (Barcelona/ES), Consuelo Almenar (Sant Boi de Llobregat,

Barcelona/ES), Anna Antonell, Mircea Balasa, Albert Llado (Barcelona/ES), Ellen

Gelpi (Barcelona/BE), Marian M. de Pancorbo (Vitoria/ES), Raquel Sanchez-Valle

(Barcelona/ES)

P168 ANALYSIS OF GENETIC POLIMORPHISMS AND GENETIC MUTATIONS IN

FRONTOTEMPORAL LOBAR DEGENERATION

María José Gil Moreno (Torrejón de Ardoz, Madrid/ES), María Sagrario Manzano

Palomo (Parla, Madrid/ES), María Luz Cuadrado Pérez, Miguel Calero Lara, Alberto

Rábano Gutiérrez (Madrid/ES)

P169 Impaired LTP-like cortical plasticity and intra-cortical facilitation in presymptomatic

FTLD mutation carriers.

Alberto Benussi, Maura Cosseddu, Ilaria Filareto, Valentina Dell'Era, Silvana Archetti,

Maria Sofia Cotelli (Brescia/IT), Anna Micheli (Bergamo/IT), Alessandro Padovani,

Barbara Borroni (Brescia/IT)

P170 Frontotemporal lobar degeneration spectrum: the first genetic screen in a Greek

cohort

Suzee Lee (San Francisco/US), Eliana Marisa Ramos (Los Angeles/US), Christos

Kroupis, Christos Koros (Athens/GR), Victoria Van Berlo, Kevin Wojta, Qing Wang,

Deepika Dokuru, Mochtar Pribadi (Los Angeles/US), Anastasios Bonakis, Vasiliki

Papastefanopoulou, John Papatriantafyllou (Athens/GR), Bruce Miller (San

Francisco/US), Leonidas Stefanis (Athens/GR), Giovanni Coppola (Los Angeles/US),

Sokratis G. Papageorgiou (Athens/US)

P171 More than two-hundred and fifty FTD patients looking for genes: results from Italian

FTD Network

Antonella Alberici (Brescia/IT), Benedetta Nacmias (Florence/IT), Giancarlo

Logroscino (Lecce/IT), Amalia Bruni (Lamezia Terme, Catanzaro/IT), Fabrizio

Tagliavini (Milan/IT), Roberta Ghidoni (Brescia/IT), Daniela Galimberti (Milan/IT),

Laura Bonanni (Chieti/IT), Annachiara Cagnin (Padua/IT), Marco Bozzali (Rome/IT),

Vincenzo Silani (Milan/IT), Rosanna Turrone (Brescia/IT), Camilla Ferrari, Gemma

Lombardi, Valentina Bessi (Florence/IT), Rosa Capozzo, Chiara Zecca, Simone

Arcuti (Lecce/IT), Chiara Cupidi, Livia Bernardi, Nicoletta Smirne, Francesca

Frangipane (Lamezia Terme, Catanzaro/IT), Giacomina Rossi, Paola Caroppo, Pietro

Tiraboschi (Milan/IT), Luisa Benussi, Giuliano Binetti, Miriam Ciani, Silvia Fostinelli


22

(Brescia/IT), Andrea Arighi, Chiara Fenoglio, Giorgio Fumagalli (Milan/IT), Marco

Onofrj (Chieti/IT), Elio Scarpini (Milan/IT), Sandro Sorbi (Florence/IT), Alessandro

Padovani, Barbara Borroni (Brescia/IT)

P173 TREM2 variant p.His157Tyr in Colombian patients with frontotemporal dementia.

Andrea Lopez-Caceres, Andres Laserna (Bogotá/CO), Cristian Triviño-Martínez,

Elkin Garcia-Cifuentes (Bogota/CO), Juan Carlos Gómez-Vega, Paola Ayala-

Ramírez (Bogotá/CO), Pablo Reyes, Hernando Santamaría-García, Jose Manuel

Santacruz (Bogota/CO), Ignacio Zarante (Bogotá/CO), Diana Matallana (Bogota/CO)

P174 Utilizing FTD-associated MAPT-S305 mutations to develop cell models that express

4R Tau

Kathryn Bowles, Alison Goate (New York/US)

P175 Unraveling the genetic role of SORT1 in the Belgian frontotemporal dementia

population

Stephanie Philtjens, Eline Wauters, Sara Van Mossevelde, Julie van der Zee, Tim

Van Langenhove, Sebastiaan Engelborghs (Antwerp/BE), Mathieu Vandenbulcke

(Leuven/BE), Maarten Versteven, Karin Peeters, Maria Mattheijssens, Marleen Van

den Broeck, Patrick Cras (Antwerp/BE), Rik Vandenberghe (Leuven/BE), Peter P. De

Deyn, Marc Cruts, Christine Van Broeckhoven (Antwerp/BE)

P176 Differences in rate of participation in clinical research studies in asymptomatic

members of families with frontotemporal dementia (FTD)

Ging-Yuek R. Hsiung, Pheth Sengdy, Emily Dwosh (Vancouver/CA), Matt Baker,

Rosa Rademakers (Jacksonville/US), Howard Feldman, Ian R. Mackenzie

(Vancouver/CA)

P177 Right temporal variant frontotemporal dementia with motor neuron disease: a novel

association with the C9orf72 expansion

Ione Woollacott, Katrina Dick, Elizabeth Gordon, Martina Bocchetta, Sophie Harding,

Katie Sidle, Jason Warren, Jonathan Rohrer (London/GB)

P178 VALIDATION OF FRONTOTEMPORAL LOBAR DEGENERATION PEDIGREE

CLASSIFICATION CRITERIA IN A NORTHERN ITALY COHORT: IMPLICATIONS

FOR GENETIC TESTING AND COUNSELING

LUISA BENUSSI, SILVIA FOSTINELLI, MIRIAM CIANI, ROBERTA ZANARDINI,

GIULIANO BINETTI, ROBERTA GHIDONI (BRESCIA/IT)

P179 Molecular mechanism of genetic anticipation in C9orf72 repeat expansion families

Marc Cruts, Ilse Gijselinck, Sara Van Mossevelde, Julie van der Zee, Anne Sieben,

Sebastiaan Engelborghs (Antwerp/BE), Jan De Bleecker (Ghent/BE), Adrian Ivanoiu

(Brussels/BE), Olivier Deryck (Bruges/BE), Bavo Heeman, Veerle Bäumer, Marleen

Van den Broeck, Maria Mattheijssens, Karin Peeters (Antwerp/BE), Peter De Jonghe,

Patrick Cras (Antwerp, Edegem/BE), Jean-Jaques Martin, Peter Paul De Deyn,

Christine Van Broeckhoven (Antwerp/BE)

P180 The genetic landscape of clinical FTD: a systematic whole-exome sequencing study

of 125 consecutive cases

Cornelis Blauwendraat, Carlo Wilke, Iris Jansen, Patrizia Rizzu, Javier Simón-

Sánchez, Peter Heutink, Matthis Synofzik (Tuebingen/DE)

P181 Myelin Oligodendrocyte Basic Protein and Longitudinal Decline in Behavioral-Variant


Lauren Massimo, Lior Rennert, Sharon Xie, Vivianna Van Deerlin, David Irwin, Corey

McMillan, Murray Grossman (Philadelphia/US)


23

P182 Genetic overlap between 4-repeat tauopathies suggests a role for development in the

pathobiology of corticobasal degeneration

Jennifer Yokoyama (San Francisco/US), Chun Fan (San Diego/US), Yunpeng Wang

(Oslo/NO), Naomi Kouri (Jacksonville/US), Raffaele Ferrari (London/GB), Ole

Andreassen (Oslo/NO), John Hardy (London/GB), Adam Boxer, Bruce Miller (San

Francisco/US), Gerard Schellenberg (Philadelphia/US), Dennis Dickson

(Jacksonville/US), Anders Dale (San Diego/US), Rahul Desikan (San Francisco/US)

P183 Effects of multiple genetic loci on age at onset in frontotemporal dementia

Raffaele Ferrari (London/GB), M Grassi, F Graziano, F Palluzzi (Pavia/IT), S Archetti,

E Bonomi (Brescia/IT), AC Bruni, RG Maletta, L Bernardi, C Cupidi, R Colao

(Lamezia Terme/IT), I Rainero, E Rubino, L Pinessi (Torino/IT), D Galimberti, E

Scarpini, M Serpente (Milan/IT), B Nacmias, I Piaceri, S Bagnoli (Florence/IT), G

Rossi (Florence, Milan/IT), G Giaccone, F Tagliavini (Milan/IT), L Benussi, G Binetti,

R Ghidoni (Brescia/IT), A Singleton (Bethesda/US), J Hardy, P Momeni (London/GB),

A Padovani, B Borroni (Brescia/IT)

P184 Epigenetic modification in Italian FTLD patients carrying the C9orf72 repeat

expansion

Irene Piaceri, Andrea Tedde, Gemma Lombardi, Camilla Ferrari, Valentina Bessi,

Sandro Sorbi, Benedetta Nacmias, Silvia Bagnoli (Florence/IT)

P185 NIH EXAMINER as tool for tracking executive dysfunction in carriers of FTLD-

causing mutations within the LEFFTDS Consortium

Howard Rosen, Peter Ljubenkov (San Francisco/US), Brad Boeve (Rochester/US),

Joel Kramer, Adam Boxer (San Francisco/US), Giovanni Coppola (Los Angeles/US),

Christina Dheel, Julie Fields, Ralitza Gavrilova (Rochester/US), Nupur Ghoshal (St.

Louis/US), Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US),

Murray Grossman (Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao

(Bethesda/US), Ging-Yuek R. Hsiung (Vancouver/CA), Edward D. Huey (New

York/US), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna

Karydas (San Francisco/US), David Knopman (Rochester/US), John Kornak (San

Francisco/US), Walter Kukull (Seattle/US), Ian Mackensie (Vancouver/US), Bruce

Miller (San Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers

(Jacksonville/US), Les Shaw (Philadelphia/US), Margaret Sutherland (Bethesda/US),

Arthur Toga (Los Angeles/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek

(Jacksonville/US), Tatiana Faroud, Kelly Faber, Ashley Vetor (Indianapolis/US), John

Trojanowski (Philadelphia/US), Katherine Rankin (San Francisco/US)

P186 TMEM106B polymorphism is associated with lower cortical volumes in a clinically

diagnosed FTD cohort

Sophie R. Harding, Martina Bocchetta, Elizabeth Gordon, Dave M. Cash, M. Jorge

Cardoso, Gary Adamson, Sebastien Ourselin, Jason D. Warren, Simon Mead,

Jonathan D. Rohrer (London/GB)

P187 The genetic correlation between Frontotemporal Dementia (FTD), and

neurodevelopmental diseases, and the convergence in functional pathways.

Erdogan Taskesen, Aniket Mishra, Danielle Posthuma (Amsterdam/NL), Yolande

Pijnenburg (Amsterdam, Londen/NL)

P188 Familial frontotemporal dementia - ALS syndrome by TARDBP gene mutation

Mikel Olabarrieta, Francesc Pujadas, Antonio Palasi (Barcelona/ES), Antoni Turon

(Salt (Girona)/ES), Anna Antonell (Barcelona/ES), Ellen Gelpi (Barcelona/BE),

Raquel Sánchez-Valle (Barcelona/ES)


24

P189 Absence of Differences on Key Measures in Mildly (CDR=0.5) Versus Overtly

(CDR≥1) Symptomatic Mutation Carriers: Preliminary Data From LEFFTDS

David Knopman, Bradley Boeve (Rochester/US), Howard Rosen, Adam Boxer (San


Bradley Dickerson (Boston/US), Kelly Faber (Indianapolis/US), Julie Fields

(Rochester/US), Tatiana Foroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US),


(Jacksonville/US), Murray Grossman (Philadelphia/US), Hillary Heuer (San

Francisco/US), John Hsiao (Bethesda/US), Edward Huey (New York/US), Robin

Hsiung (Vancouver/CA), David Irwin (Philadelphia/US), Kejal Kantarci

(Rochester/US), Anna Karydas, John Kornak, Joel Kramer (San Francisco/US),

Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San

Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers



Angeles/US), John Trojanowski (Philadelphia/US), Sandra Weintraub (Chicago/US),

Zbigniew Wszolek (Jacksonville/US), Ashley Vetor (Indianapolis/US)

P190 The genetic and epidemiology of frontotemporal dementia in Sardinia

Francesca Di Stefano, Giuseppe Borghero, Antonino Cannas, Angela Sanna

(Monserrato/IT), Maria Rita Murru, Daniela Corongiu, Stefania Cuccu, Stefania

Tranquilli, Maria Giovanna Marrosu (Cagliari/IT), Adriano Chiò (Turin/IT), Francesco

Marrosu, Gianluca Floris (Monserrato/IT)

P191 Differences on Clinical Measures in Asymptomatic (CDR=0) Versus Mildly

Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From LEFFTDS

David Knopman, Bradley Boeve (Rochester/US), Howard Rosen, Adam Boxer (San


Bradley Dickerson (Boston/US), Kelly Faber (Indianapolis/US), Julie Fields

(Rochester/US), Tatiana Foroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US),


(Jacksonville/US), Murray Grossman (Philadelphia/US), Hillary Heuer (San

Francisco/US), John Hsiao (Bethesda/US), Robin Hsiung (Vancouver/CA), Edward

Huey (New York/US), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US),

Anna Karydas, Joel Kramer (San Francisco/US), Walter Kukull (Seattle/US), Ian

Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US), Creighton Phelps

(Bethesda/US), Rosa Rademakers (Jacksonville/US), Katherine Rankin (San

Francisco/US), Les Shaw (Philadelphia/US), Margaret Sutherland (Bethesda/US),

Arthur Toga (Los Angeles/US), John Trojanowski (Philadelphia/US), Ashley Vetor

(Indianapolis/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek

(Jacksonville/US)

P192 Estimation of Age of Onset in Presymptomatic Frontotemporal Degeneration

Prerana Vaddi, Elisabeth Mccarty Wood, Vivianna Van Deerlin, David Irwin, Murray

Grossman, Corey McMillan (Philadelphia/US)

P193 Targeted Multi-Gene Panel Sequencing in Korean Patients with Frontotemporal

Dementia: A preliminary result

Eun-Joo Kim (Busan/KR), Young-Eun Kim, Ja-Hyun Jang, Eun-Hae Cho

(Yongin/KR), Jay C. Kwon (Changwon/KR), Ki-Hyeong Park (Incheon/KR), Kyung

Won Park (Busan/KR), Jae-Hong Lee (Seoul/KR), Seong Hye Choi (Incheon/KR),

Soo Jin Yoon (Daejeon/KR), Jee H. Jeong, Byung-Ok Choi, Duk L. Na, Chang-Seok

Ki, Seung Hyun Kim (Seoul/KR)


25

P194 Effect of predictive testing in adult onset neurodegenerative diseases on social and

personal life – a pilot study

Petra Cohn-Hokke (Amsterdam/NL), John van Swieten (Amsterdam, Rotterdam/NL),

Aad Tibben (Leiden/NL), Hanne Meijers-Heijboer (Amsterdam/NL), Anneke Kievit

(Rotterdam/NL)

P195 Gene-group based genetic burden tests reveals additional candidate genes for FTD.

Jeroen van Rooij, Tsz-Hang Wong (Rotterdam/NL), Javier Simón-Sánchez, Cornelis

Blauwendraat, Patrizia Rizzu (Tuebingen/DE), Peter Heutink (Tuebingen,

Amsterdam/DE), Matthis Synofzik (Tuebingen/DE), André Uitterlinden, Joyce van

Meurs, John van Swieten (Rotterdam/NL)

P196 The phenotypic variability of c9orf72 mutations: at the interface between neurology

and psychiatry

Carola Rossmeier, Dieter Edbauer, Janine Diehl-Schmid (Munich/DE)

P197 Anthropometric measures of asymptomatic individuals at-risk for familial


Ging-Yuek Hsiung, Pheth Sengdy (Vancouver/CA), Matt Baker, Rosa Rademakers

(Jacksonville/US), Howard Feldman, Ian Mackenzie (Vancouver/CA)

P198 TMEM106B and APOE as genetic modifiers of FTD-3 in the Danish CHMP2B family

Peter Roos, Nina Rostgaard, Peter Johannsen (DK-2100 København Ø/DK), Jeremy

M. Brown (Cambridge, UK/GB), Adrian M. Isaacs (London, UK/GB), Gunhild

Waldemar, Troels T. Nielsen (DK-2100 København Ø/DK), Jørgen E. Nielsen (DK-

2100 København Ø, Copenhagen, DK/DK)

P199 Probing FTD genetics with a next-generation sequencing gene panel

Carolin Koriath, Gary Adamson, Ron Druyeh, Janna Kenny, Martin Rossor, Jon

Schott, Catherine Mummery, Nick Fox, Jason Warren, John Collinge, Jon Rohrer,

Simon Mead (London/GB)

P200 Reduced disease penetrance of progranulin mutation p.tyr294* - a case report

Linn Öijerstedt (Stockholm, Huddinge, Stockholm/SE), Christin Andersson

(Huddinge, Stockholm/SE), Vesna Jelic, Caroline Graff (Stockholm, Huddinge,

Stockholm/SE)

P201 Prevalence, phenotypic variability and neuropsychological findings of C9orf72

mutations in a Bulgarian dementia cohort

Shima Mehrabian (Sofia/BG), Hakan Thonberg, Bengt Winblad (Stockholm/SE),

Margarita Raycheva (Sofia/SE), Lena Lilius (Stockholm/SE), Katya Stoyanova

(Sofia/BG), Charlotte Forsell (Stockholm/SE), Draga Toncheva (Sofia/BG), Lena

Cavallin, Eric Westman (Stockholm/SE), Latchezar Traykov (Sofia/BG), Caroline

Graff (Stockholm/SE)

P202 Frequency and contribution of variants in 17 dementia related genes in a Bulgarian

dementia cohort

Hakan Thonberg (Stockholm/SE), Shima Mehrabian (Sofia/BG), Bengt Winblad

(Stockholm/SE), Katya Stoyanova (Sofia/BG), Charlotte Forsell (Stockholm/SE),

Margarita Raycheva (Sofia/SE), Lena Lilius (Stockholm/SE), Draga Toncheva,

Latchezar Traykov (Sofia/BG), Caroline Graff (Stockholm/SE)

P203 Double mutations in TREM2 and C9orf72 genes in a Bulgarian individual with

atypical FTD phenotype and rapid progression

Latchezar Traykov, Shima Mehrabian (Sofia/BG), Hakan Thonberg (Stockholm/SE),

Margarita Raycheva (Sofia/SE), Charlotte Forsell (Stockholm/SE), Katya Stoyanova


26

(Sofia/BG), Lena Lilius (Stockholm/SE), Draga Toncheva (Sofia/BG), Mariann

Harangi (Debrecen/HU), Gabor G. Kovacs (Vienna/AT), Bengt Winblad, Caroline

Graff (Stockholm/SE)

P204 Colombian Familial Dementia with Frontotemporal Features Associated with a

Presenilin-1 Mutation

Diana Matallana (Bogotá/CO), Katya Rascovsky (Philadelphia, PA/US), Paola Ayala,

Andrea Lopez, Ignacio Zarante (Bogotá/CO), Corey McMillan, David Irwin, Beth

McCarty-Wood, Viviana Van Deerlin, EunRan Suh, Murray Grossman (Philadelphia,

PA/US)

P205 Sporadic frontotemporal dementia: polygenicity and pleiotropy

Raffaele Ferrari (London/GB), Yunpeng Wang (Oslo/NO), Jana Vandrovcova

(London/GB), Anders M Dale (St. Louis/US), Ole A Andreassen (Oslo/NO), Bruce

Miller, Rahul S Desikan (San Francisco/US)

P206 NeuroX to screen neuro-genes in large FTLD cohort

Raffaele Ferrari, John Hardy (London/GB)

P207 GRN c.708+1_+4delTGAG DELETION IN A LARGE FAMILY DIAGNOSED WITH

FRONTO-TEMPORAL DEMENTIA

Gulsen BABACAN-YILDIZ (Istanbul/TR), Gamze GUVEN, Hasmet HANAGASI,

Basar BILGIC, Hakan GURVIT, Nihan ERGINEL-UNALTUNA (ISTANBUL/TR), Rita

GUEIRREIRO (ISTANBUL/GB), Ebba LOHMANN (ISTANBUL, Tuebingen/DE)

P208 Evaluation of a Novel PCR Technology for the Quantification of C9orf72

Hexanucleotide Repeat Expansions

Eran Bram, Kristen Culp, Nathan Nevitt, Jon Kemppainen, Gary Latham (Austin/US),

EunRan Suh, Kaitlyn Grando, Vivianna Van Deerlin (Philadelphia/US)

P209 CLINICAL AND GENETIC ANALYSES OF FAMILIAL AND SPORADIC

FRONTOTEMPORAL DEMENTIA PATIENTS IN SOUTHERN ITALY ( The

Apulia_FTD_Registry)

Rosa Capozzo (Tricase, Lecce/IT), Celeste Sassi (Bethesda, MD, USA, London,

UK/US), Monia Benahmed-Hammer (Bethesda, MD, USA/US), Simona Arcuti, Chiara

Zecca, Maria Rosaria Barulli, Rosanna Tortelli (Tricase, Lecce/IT), Francesco

Carnicella, Claudia Dell'Aquila (Andria, Italy/IT), Francesco Valluzzi (Monopoli, Italy,

/IT), Francescop Panza (Tricase, Lecce, Bari, Italy/IT), Andrew Singleton (Bethesda,

MD, USA/US), Giancarlo Logroscino (Tricase, Lecce, Bari/IT)

P210 Frontotemporal lobar degeneration spectrum: first genetic screen in a Greek cohort

Eliana Marisa Ramos (Los Angeles, CA, USA/US), Suzee Lee (San Francisco/US),

Christos Kroupis, Christos Koros (Athens/GR), Victoria Van Berlo, Kevin Wojta, Qing

Wang, Deepika Dokuru, Mochtar Pribadi (Los Angeles, CA, USA/US), Anastasios

Bonakis, Vasiliki Papastefanopoulou, John Papatriantafyllou (Athens/GR), Bruce

Miller (San Francisco/US), Leonidas Stefanis (Athens/GR), Giovanni Coppola (Los

Angeles, CA, USA/US), Sokratis G. Papageorgiou (Athens/US)

P211 Psychiatric symptoms in CDR=0 MAPT mutation carriers

Edward Huey, Gayathri Cheran, Jill Goldman, Masood Manoochehri, Sarah Cines

(New York, NY/US), Tim Lynch, Brendan Kelly (Dublin/IE), Sarah Shair, Judith

Heidebrink, Henry Paulson (Ann Arbor/US), Stephanie Cosentino (New York, NY/US)

P212 Investigation of Mutation Related Covariance Pattern in Asymptomatic Carriers of

GRN and C9ORF72 mutations using [F18]-FDG PET


27

Elham Shahinfard, Jessie Fu (Vancouver, B.C./CA), Claudia Jacova (Oregon/US),

Dinelle Katie, Pheth Sengdy, Siobhan McCormick (Vancouver, B.C./CA), Vesna

Sossi (Vancouver, Vancouver, B.C./CA), A. Jonathan Stoessl, Howard Feldman, Ian

Mackenzie, Ging-Yuek Robin Hsiung (Vancouver, B.C./CA)

P213 Results of a diagnostic NGS gene panel for patients with dementia.

Resie Vervenne - van Spaendonk, Fred van Ruissen, Margriet Smit, Daphne van

Beek, Petra Cohn-Hokke, Erik Sistermans, Janneke Weiss (Amsterdam/NL)

P214 Genetic mutations in Frontemporal dementia - report from the memory clinic from

Serbia

Elka Stefanova, Gorana Mandic, Valerija Dobricic, Tanja Stojkovic, Milena Jankovic,

Ivana Novakovic, Vladimir Kostic

P215 Closing the tau loop: the missing tau mutation

Allan McCarthy (Dublin/IE), Roisin Lonergan (Dublin/US), Diana Olszewska, Sean

O'Dowd (Dublin/IE), Gemma Cummins (Cambridge/GB), Brian Magennis, Emer

Fallon, Niall Pender (Dublin/IE), Edward Huey, Stephanie Cosentino (New York,

NY/US), Killian O'Rourke, Brendan Kelly, Martin O'Connell (Dublin/IE), Isabelle Delon

(Cambridge/GB), Michael Farrell (Dublin/IE), Maria Grazia Spillantini

(Cambridge/GB), Lewis Roland, Stanley Fahn (New York, NY/US), Peter Craig,

Michael Hutton (Surrey/GB), Tim Lynch (Dublin/IE)

P216 Bioinformatics and FTD: using genes to untangle molecular underpinnings of disease

Raffaele Ferrari (London/GB)

P217 C9orf72 repeat expansions and TARDBP mutations in two Brazilian Dementia

Research Centers

Leonel Takada, Valeria Bahia (Sao Paulo/BR), Henrique Guimarães, Leonardo

Souza (Belo Horizonte/BR), Thais Costa (Sao Paulo/BR), Thiago Vale (Belo

Horizonte/BR), Roberta Rodriguez, Fabio Porto (Sao Paulo/BR), João Machado,

Rogério Beato (Belo Horizonte/BR), Karolina Cesar, Jerusa Smid, Sonia Brucki,

Jessica Maximino (Sao Paulo/BR), Sarah Camargos (Belo Horizonte/BR), Gerson

Chadi (Sao Paulo/BR), Paulo Caramelli (Belo Horizonte/BR), Ricardo Nitrini (Sao

Paulo/BR)

12:00–14:00 Postersession II - Neuropathology

Room Ballroom

P218 Multiple accumulation of neurodegenerative disease-related proteins in familial

granulin mutation brains

Masato Hosokawa (Tokyo/JP), Tetsuaki Arai (Tokyo, Tsukuba/JP), Hiromi Kondo

(Tokyo/JP), Geidy Serrano, Thomas Beach (Sun City/US), Masato Hasegawa,

Haruhiko Akiyama (Tokyo/JP)

P219 P301L MAPT mutation with globular glial inclusions

Sergi Borrego (Barcelona/ES), Joana Morgado (Lisboa/PT), Oriol Grau

(Barcelona/ES), Consuelo Almenar (Sant Boi de Llobregat/ES), Mircea Balasa, Albert

Lladó, Raquel Sánchez-Valle (Barcelona/ES), Ellen Gelpi (Barcelona/BE)


28

P220 Clinical and neuropathological features of Frontotemporal dementia caused by the

P301L MAPT mutation in Baix Llobregat County (Barcelona, Spain)

Sergi Borrego (Barcelona/ES), Joana Morgado (Lisboa/PT), Oriol Grau

(Barcelona/ES), Ramón Reñé (Hospitalet del Llobregat/ES), Isabel Hernández

(Barcelona/ES), Consuelo Almenar (Sant Boi de Llobregat/ES), Mircea Balasa, Anna

Antonell, Albert Lladó (Barcelona/ES), Ellen Gelpi (Barcelona/BE), Raquel Sánchez-

Valle (Barcelona/ES)

P221 Generation of specific and sensitive antibodies against C9orf72

Petra Frick (Tuebingen/DE), Dieter Edbauer, Elisabeth Kremmer, Regina Feederle

(Munich/DE), Ian Mackenzie (Vancouver/CA), Jeroen Pasterkamp (Utrecht/NL),

Manuela Neumann (Tuebingen/DE)

P222 CLINICAL AND NEUROPATHOLOGICAL CLASSIFICATION OF

FRONTOTEMPORAL DEMENTIA: ANALYSYS OF COMMON AND SPECIFIC

CHARACTERISTICS

María José Gil Moreno (Madrid/ES), María Sagrario Manzano Palomo (Parla,

Madrid/ES), María Luz Cuadrado Pérez, Alberto Rábano Gutiérrez (Madrid/ES)

P223 CEREBROVASCULAR PATHOLOGY IN FRONTOTEMPORAL LOBAR

DEGENERATION: A NEUROPATHOLOGICAL STUDY


Palomo (Parla, Madrid/ES), María Luz Cuadrado Pérez, Alberto Rábano Guitérrez

(Madrid/ES)

P224 ARGYROPHILIC GRAINS PATHOLOGY IN FRONTOTEMPORAL LOBAR

DEGENERATION


Palomo (Parla, Madrid/ES), María Luz Cuadrado Pérez, Alberto Rábano Gutiérrez

(Madrid/ES)

P225 Neuropathology of ALS with Dementia

Eileen Bigio, Yasushi Nishihira, Qinwen Mao, Sandra Weintraub, Nailah Siddique,

Teepu Siddique, M-Marsel Mesulam (Chicago/US)

P226 106 FTD cases with refined neuropathological confirmation.

Anne Sieben (Wilrijk, Gent, Antwerp/BE), Sara Van Mossevelde, Julie van der Zee

(Wilrijk, Antwerp/BE), Joery Goossens (Wilrijk/BE), Peter Paul De Deyn (Wilrijk,

Groningen, Antwerp/BE), Patrick Cras (Wilrijk, Edegem/BE), Sebastiaan

Engelborghs, Christine Van Broeckhoven (Wilrijk, Antwerp/BE), Jean-Jacques Martin

(Wilrijk/BE)

P228 The effect of fetal and perinatal asphyxia on familial frontotemporal dementia gene

transcription as studied in a rat model.

Melinda Barkhuizen (Maastricht, The Netherlands, Potchefstroom, South Africa/NL),

Phyllis van der Ploeg, Fleur van Dijck, Kimberly Cox-Limpens (Maastricht, The

Netherlands/NL), Daniel van den Hove (Maastricht, The Netherlands, Würzburg,

Germany/NL), Harry Steinbusch, Boris Kramer (Maastricht, The Netherlands/NL),

Danilo Gavilanes (Maastricht, The Netherlands, Guayaquil, Equador/NL)

P229 MAPT mutations and sporadic frontotemporal tauopathies: lost in translation?

Shelley Forrest, Jillian Kril (Camperdown/AU), John Kwok (Randwick/AU), Maria

Grazia Spillantini (Cambridge/GB), John Hodges, Glenda Halliday (Randwick/AU)

P230 Targeting the cytoskeleton in frontotemporal dementia

Anna King, Nan Tian, Rachel Atkinson, James Vickers (Hobart/AU)


29

P231 Clinical and pathological study of FTLD-FUS presenting chorea

Ito Kawakami (Tokyo/JP), Tetsuaki Arai (Tokyo, Tsukuba/JP), Zen Kobayashi

(Tokyo/JP), Osamu Yokota (Okayama/JP), Takashi Nonaka, Kazuhiro Niizato,

Kenichi Oshima (Tokyo/JP), Shinji Higashi (Tokyo, Tsukuba/JP), Masato Hosokawa,

Masato Hasegawa, Haruhiko Akiyama (Tokyo/JP)

P232 Clinicopathological correlation of frontotemporal dementia disorders

Christer Nilsson, Christina Elfgren, Karin Nilsson, Ulla Passant, Alexander Frizell

Santillo, Susanna Vestberg, Maria Landqvist Waldö, Danielle van Westen, Elisabet

Englund (Lund/SE)

P233 pThr175 tau is associated with tau pathology in a spectrum of tauopathies

Alexander Moszczynski, Wencheng Yang, Michael Strong (London/CA)

P234 An AAV9 mediated rat model of pThr175 tau protein toxicity

Alexander Moszczynski, Jason Gopaul, Patrick Mccunn, Kathryn Volkening,

Madeline Harvey, Robert Bartha, Susanne Schmid, Michael Strong (London/CA)

P235 pThr175 tau as a toxic phosphoepitope in CTE and ALSci

Alexander Moszczynski (London/CA), Ann McKee (Boston/US), Wendy Strong,

Michael Strong (London/CA)

P236 Selective vulnerability of the locus coeruleus in frontotemporal lobar degeneration

(FTLD) with tau pathology

David Irwin, Mathew Byrne, David Wolk, Edward Lee, Murray Grossman, John

Trojanowski (Philadelphia/US)

P237 Prevalence of Amyloid pathology and PiB positivity in Frontotemporal dementia

Rachel Tan (Randwick, Sydney/AU), Jillian Kril (Sydney/AU), Yue Yang

(Randwick/AU), Olivier Piguet (Randwick, Sydney/AU), Lars Ittner (Sydney/AU), John

Kwok, John Hodges, Glenda Halliday (Randwick, Sydney/AU)

P238 Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in

Niemann- Pick Disease Type C

Stefania Zampieri (Udine/IT), Sonia Canterini (Rome/IT), Kathy Newell (Kansas City,

Kansas/US), Cristiana Stuani (Trieste/IT), Jill Murrell, Bernardino Ghetti (Indianapolis,

Indiana/US), Maria Teresa Fiorenza (Rome/IT), Bruno Bembi (Udine/IT), Emanule

Buratti (Trieste/IT), Andrea Dardis (Udine/IT)

P239 Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal

lysosomal storage pathology

Emma Clayton, Sarah Mizielinska (London/GB), James Edgar (Cambridge/GB),

Troels Tolstrup Nielsen (Copenhagen/DK), Ida Holm (Randers, Aarhus/DK), Peter

Johannsen, Jørgen Nielsen (Copenhagen/DK), Emmanuel Asante, John Collinge

(London/GB), FReJA Consortium (Jutland/GB), Adrian Isaacs (London/GB)

P240 Pathological prediction in behavioral variant frontotemporal dementia

David Perry, Jesse Brown, Katherine Possin, Andrew Trujillo, Anneliese Radke, Anna

Karydas, Ana Sias, Gil Rabinovici, Maria Luisa Gorno-Tempini, Adam Boxer, Mary

De May, Eric Huang, Katherine Rankin, Suzee Lee, Manu Sidhu, Stephanie Gaus,

Jose Vargas, Rik Ossenkoppele, Alainna Brown (San Francisco, CA/US), Giovanni

Coppola (Los Angeles, CA/US), Howard Rosen (San Francisco, CA/US), Daniel

Geschwind (Los Angeles, CA/US), John Trojanowski (Philadelphia, PA/US), Lea

Grinberg, Joel Kramer, Bruce Miller, William Seeley (San Francisco, CA/US)


30

P241 TDP-43 Pre-Inclusions in Primary Progressive Aphasia: Morphology and Distribution

Garam Kim, Zach Parton, Sandra Weintraub, Eileen Bigio, M.-Marsel Mesulam,

Changiz Geula (Chicago/US)

P242 Sporadic FTLD TDP type C is a distinct clinicopathological entity from FTLD types

A/B

G Michael Baer, Matthew Byrne, Felicia Cooper, EunRan Suh, Leo McCluskey,

Lauren Elman, David Wolk, Vivianna M. Van Deerlin, Virginia Lee, Edward Lee,

Murray Grossman, John Trojanowski, David J. Irwin (Philadelphia/US)

P243 Tau aggregation and neurodegeneration predict regional atrophy and intrinsic

connectivity disruption in progressive supranuclear palsy

Salvatore Spina, Jesse A. Brown, Jersey Deng, Alissa Nana Li, Norbert Lee, Ji-Hye

Hwang, Stephanie E. Gaus, Eric J. Huang, Adam Boxer, Howard J. Rosen, Bruce L.

Miller, Lea Grinberg, William W. Seeley (San Francisco/US)

P244 TDP-43 Protein Pathology in Mouse Model's of Alzheimer's Disease

Liam Kaylor (Aurora, Hobart/US)

P245 Disproportionate von Economo neuron and fork cell TDP-43 aggregation is

associated with somatodendritic degeneration in sporadic behavioral variant FTD

Alissa Nana, Manu Sidhu, Stephanie Gaus, Ji-Hye Hwang (San Francisco/US), Libo

Li (San Francisco, Qiqihar/CN), Youngsoon Park, Eun-Joo Kim, Stephen DeArmond,

Lea Grinberg, Eric Huang, Bruce Miller, William Seeley (San Francisco/US)

P246 Utility of Ubiquitin/p62 aggregates screening in granular neurons of the cerebellar

cortex in a Brain Bank: experience of the Neurological Tissue Bank of the Biobanc-

Hospital Clinic-IDIBAPS,Barcelona(Spain)

Rainiero Avila (Sevilla, Barcelona/ES), Oscar Ramos, Oriol Grau, Anna Antonell,

Albert Lladó, Raquel Sanchez-Valle (Barcelona/ES), Ellen Gelpi (Barcelona/BE)

P247 Hypertrophic microglia are associated with more tangles and less neurons in primary

progressive aphasia with Alzheimer pathology

Daniel Ohm, Alfred Rademaker, Eileen Bigio, M.-Marsel Mesulam, Emily Rogalski,

Changiz Geula (Chicago/US)

P248 Biopsy in Dementia: A case report

Catharina Prix, Johannes Levin (Munich/DE), Nibal Ackl (Munich, Münsterlingen/CH),

Elisabeth Wlasich, Rupert Egensperger, Christoph Schwartz, Friedrich-Wilhelm

Kreth, Armin Giese, Adrian Danek (Munich/DE)

P249 C9ORF72 in 3D: A Novel Dimension in FTD-MND iPSN Cultures

Veronica Porterfield, Qing Zhong, Phylindia Gant, Erin Foff (Charlottesville/US)

P250 ER chaperones in the pathogenesis of amyotrophic lateral sclerosis (ALS)

ANAND GOSWAMI, Alfred Yamoah, Alice Dreser (Aachen/DE), Dirk Troost

(Amesterdam/NL), Joachim Weis (Aachen/DE)

P251 Cerebellar c9RAN proteins associate with clinical and neuropathological

characteristics of C9ORF72 repeat expansion carriers

Tania Gendron, Marka van Blitterswijk, Kevin Bieniek, Lillian Daughrity

(Jacksonville/US), Jie Jiang (La Jolla/US), Beth Rush, Otto Pedraza, John Lucas,

Melissa Murray, Pamela Desaro, Amelia Robertson, Karen Overstreet, Colleen

Thomas, Julia Crook, Monica Castanedes-Casey, Linda Rousseau (Jacksonville/US),

Keith Josephs, Joseph Parisi, David Knopman, Ronald Petersen, Bradley Boeve

(Rochester/US), Neill Graff-Radford, Rosa Rademakers (Jacksonville/US), Clotilde


31

Lagier-Tourenne (Charlestown/US), Dieter Edbauer (Munich/DE), Don Cleveland (La

Jolla/US), Dennis Dickson, Leonard Petrucelli, Kevin Boylan (Jacksonville/US)

P252 Pick ‘n’ mix: neuropathological detection of peri-tumour tauopathy.

Roisin Lonergan (Dublin/US), Vijay Ashankar, Fiona Carty, Michael Alexander, Peter

Kelly, Killian O'Rourke, Michael Farrell, Tim Lynch (Dublin/IE)

12:00–14:00 Postersession II - Progressive aphasias

Room Ballroom

P253 Eyes Reveal Semantic Deficit Early in Primary Progressive Aphasia

Argye Hillis, David Race (Baltimore/US)

P254 Semantic dementia and the left and right temporal lobes

Julie Snowden, Jennifer Harris, Jennifer Thompson, Christopher Kobylecki, Matthew

Jones, Anna Richardson, David Neary (Manchester/GB)

P255 UK speech and language therapy services for Primary Progressive Aphasia (PPA):

Referral patterns and barriers to access.

Anna Volkmer, Jason Warren, Aimee Spector, Suzanne Beeke (London/GB)

P256 Dynamic perceptual ‘stress tests’ in primary progressive aphasia

Chris Hardy, Rebecca Bond, Kankamol Jaisin, Charles Marshall, Camilla Clark, Lucy

Russell, Jonathan Rohrer, Sebastian Crutch, Jason Warren (London/GB)

P257 Distinctive clinical presentations in Asian patients with left and right anterior temporal

atrophy

Amitabha Ghosh (Kolkata/IN), Ryuji Fukuhara (Kumamoto/JP), Adeline Ng Su Lyn

(Singapore/SG), Jacqueline Dominguez (Manila/PH), Paulus Anam Ong

(Bandung/ID), Aparna Dutt, Kishalaya Karan (Kolkata/IN), Manabu Ikeda

(Kumamoto/JP)

P258 Functional neuroanatomy of speech signal decoding in primary progressive aphasias

Chris Hardy, Charles Marshall, Camilla Clark, Lucy Russell, Emilie Brotherhood,

David Thomas, Sebastian Crutch, Jonathan Rohrer, Jennifer Agustus, Jason Warren

(London/GB)

P259 Progressive aphasias as disorders of auditory information processing: behavioural

signatures and structural neuroanatomy

Chris Hardy, Charles Marshall, Camilla Clark, Lucy Russell, Emilie Brotherhood,

David Thomas, Sebastian Crutch, Jonathan Rohrer, Jennifer Agustus, Jason Warren

(London/GB)

P260 Cross-sectional and longitudinal features of non-fluent/agrammatic primary

progressive aphasia with underlying corticobasal degeneration or progressive

supranuclear palsy pathology.

Miguel Angel Santos-Santos, Maria Luisa Mandelli (San Francisco/US), Richard J.

Binney (Philadelphia, San Francisco/US), Edoardo Spinelli (Milan, San Francisco/IT),

Jennifer Ogar (San Francisco/US), Maya L. Henry (Austin, San Francisco/US), Isabel

Hubbard (San Francisco/US), Stephen M. Wilson (Tuscon, San Francisco/US), John

Q. Trojanowski (Philadelphia/US), Lea T. Grinberg, Howie Rosen, Adam L. Boxer,

Bruce L. Miller, William W. Seeley, Maria Luisa Gorno-Tempini (San Francisco/US)


32

P261 Grammatical dissociation in a Primary Progressive Aphasia patient: a prospective

assessment

Geraldine Borovinsky, Jesica Ferrari, Noelia Pontello, Juan Pablo Barreyro, Teresa

Torralva, Facundo Manes, Macarena Martinez-Cuitiño (Buenos Aires/AR)

P262 Concreteness effect in a Semantic variant of Primary Progressive Aphasia patient:

semantic processing and neuroanatomic areas

Geraldine Borovinsky, Jesica Ferrari, Noelia Pontello (Buenos Aires/AR), Teresa

Torralva (BUenos Aires/AR), Facundo Manes, Macarena Martinez-Cuitiño (Buenos

Aires/AR)

P263 Distinct neural correlates underlying the relative preservation of episodic memory in

semantic-variant PPA

Muireann Irish, Steffie Bunk, Sicong Tu (Sydney/AU), Michael Hornberger (Sydney,

Norwich/GB), John Hodges, Olivier Piguet (Sydney/AU)

P264 Focal Temporal Pole Atrophy and Network Degeneration in Semantic Variant Primary

Progressive Aphasia

Jessica Collins (Charlestown/US), Victor Montal (Barcelona/ES), Maria Luisa Gorno-

Tempini (San Francisco/US), Brad Dickerson (Charlestown/US)

P265 Limited abstract word processing in behavioral variant frontotemporal degeneration

Katheryn Cousins, Sharon Ash, Murray Grossman (Philadelphia/US)

P266 Patterns of hippocampal atrophy and memory loss among language subtypes of

Frontotemporal dementia and Alzheimer’s disease

Jagan Pillai, Aaron Bonner-Jackson, Michael Parsons, James Leverenz

(Cleveland/US)

P267 Transcranial direct current stimulation as a potential therapy for symptoms of Primary

Progressive Aphasia

Nicole White, Felix Gervits, Sharon Ash, H. Branch Coslett, Roy Hamilton, Murray

Grossman (Philadelphia/US)

P268 Neural Network Underlying Abnormal Syntax Processing in Primary Progressive

Aphasia: Evidence from Resting State Functional Magnetic Resonance Imaging

Borna Bonakdarpour, Allan Wang, Emily Rogalski, Robert Hurley, Marsel Mesulam

(Chicago/US)

P269 Recognizing Primary Progressive Aphasia between Frontotemporal Dementia

variants: Denomination mistakes like a tool for differential diagnosis

Nathalia Rodriguez, María Del Pilar Mayorga Sierra, Diana Lucía Matallana Eslava

(Bogotá/CO)

P270 Principal components analysis of neuropsychological features in nonfluent and

logopenic variant PPA

Jennifer Harris, Jennifer Adams, Matthew Jones, Anna Richardson, David Neary,

Julie Snowden, Jennifer Thompson (Manchester/GB)

P271 Characterising Primary progressive Aphasia – a neuropsychological study

Jennifer Harris, Jennifer Adams, Matthew Jones, Anna Richardson, David Neary,

Julie Snowden, Jennifer Thompson (Manchester/GB)

P272 MRI in nonfluent and logopenic variant PPA: ASl, DTI and VBM

Jennifer Harris, Jennifer Adams, Jennifer Thompson, Laura Parkes, Stephen Carter,

Anna Richardson, David Neary, Julie Snowden, Matthew Jones (Manchester/GB)


33

P273 Different biomarkers of neurodegeneration in the CSF distinguishing progressive

non-fluent aphasia from other frontotemporal dementias

Peter Koertvelyessy (Magdeburg/DE), Johannes Prudlo (Rostock/DE), Hans-Jochen

Heinze, Daniel Bittner (Magdeburg/DE)

P274 Quantification of motor speech in primary progressive aphasia and frontotemporal

dementia

Matthew Poole (Parkville, Melbourne/AU), Amy Brodtmann, David Darby

(Melbourne/AU), Adam Vogel (Parkville, Melbourne, Tubingen/AU)

P275 Apraxia profiles - A novel cognitive marker for differentiating clinical variants of FTLD

and AD

Andreas Johnen, Sophia Reul, Thomas Duning, Hubertus Lohmann (Münster/DE)

P276 PPA interventions with impact: Making everyone happy

Regina Jokel (Toronto/CA)

P277 Artificial Grammar Learning in Vascular and Progressive Non-Fluent Aphasia

Identifies Domain General Impairments.

Thomas E Cope (Cambridge/GB), Benjamin Wilson (Newcastle/GB), Holly Robson

(Reading/GB), Lauren Dean, Manon Grube (Newcastle/GB), Karalyn Patterson

(Cambridge/GB), Timothy D Griffiths (Newcastle/GB), James B Rowe

(Cambridge/GB), Chris Petkov (Newcastle/GB)

P278 PET-FLORBETAPIR FINDINGS IN PRIMARY PROGRESSIVE APHASIA.

Alberto Villarejo, Sara Llamas-Velasco, Adolfo Gomez-Grande, Verónica Puertas-

Martín, Pilar Sarandeses-Fernández, Marta Gonzalez-Sánchez, Sebastian Ruiz-

Solis, Patrick Pilkington, David A. Pérez-Martínez, Alejandro Herrero-San Martín

(Madrid/ES)

P279 Developing an international graded naming task.

Ornella Billette (Magdeburg/DE), Zsolt Cséfalvay (Magdeburg/SK), Elisabeth Tute,

Peter Nestor (Magdeburg/DE)

P280 Classifying primary progressive aphasias individually with support vector machine

approaches in MRI data

Sandrine Bisenius, Karsten Mueller (Leipzig/DE), Janine Diehl-Schmid (Munich/DE),

Klaus Fassbender (Homburg/DE), Frank Jessen (Bonn/DE), Jan Kassubek (Ulm/DE),

Johannes Kornhuber (Erlangen/DE), Anja Schneider (Goettingen/DE), Katharina

Stuke (Leipzig/DE), Adrian Danek (Munich/DE), Markus Otto (Ulm/DE), Matthias L.

Schroeter (Leipzig/DE), FTLD Study Group Germany (Ulm/DE)

P281 Electrostimulation effects in the logopenic and non-fluent variants of primary

progressive aphasia

Kyrana Tsapkini, Tushar Chakravarty, Bronte Ficek, Kim Webster, John Desmond,

Chiadi Onyike, Constantine Frangakis, Argye Hillis (Baltimore/US)

P282 Verb regularization errors as an analogue for surface dyslexia in semantic dementia

in languages with high grapheme-phoneme transparency

Ornella Billette, Daniel Preiß, Peter Nestor (Magdeburg/DE)

P283 Aspects of natural conversation in primary progressive aphasia.

Cathleen Taylor-Rubin (Waverley, Sydney, Sydney/AU), Karen Croot, Emma Power

(Sydney/AU), Sharon A. Savage (Exeter/GB), John R. Hodges, Leanne Togher

(Sydney/AU)


34

P284 Semantic dementia with combined TDP-43 and FUS pathology

Maria Landqvist Waldö, Christina Elfgren, Lars Gustafson, Ulla Passant (Lund/SE),

Alexander Frizell Santillo (Malmö/SE), Elisabet Englund (Lund/SE)

P285 Common and divergent neural correlates of anomia in amnestic and logopenic

presentations of Alzheimer’s disease

Cristian Leyton, John Hodges, Olivier Piguet, Kirrie Ballard (Sydney/AU)

P286 Dissecting neurocognitive mechanisms underpinning sentence-processing deficits in

PPA

Cristian Leyton, John Hodges, Olivier Piguet, Kirrie Ballard (Sydney/AU)

P287 Convergent language network involvement in non-semantic PPA variants

Cristian Leyton, Ramon Landin-Romero, Fiona Kumfor, James Burrell, John Hodges,

Olivier Piguet (Sydney/AU)

P288 Domain Specific learning Disabilities within Atypical neurodenerative diseases

primary progressive aphasia and Posterior Cortical atrophy

Zachary Miller (San Francisco/US), Lynne Rosenberg (New York/US), Miguel

Santos, Melanie Stephens, Maria Luisa Mandelli, Gil Rabinovici, Bruce Miller, Maria

Luisa Gorno-Tempini (San Francisco/US)

P289 Lexical representation and parsing of morphologically complex words in non-fluent

variant PPA and non-fluent post-stroke aphasia

Eleni Peristeri (Thessaloniki/GR), Ianthi-Maria Tsimpli (Cambridge/GB), Gonia

Jarema (Montréal/CA), Kyrana Tsapkini (Baltimore/US)

P290 Executive functions in non-fluent variant PPA: A comparison to non-fluent post-stroke

aphasia

Eleni Peristeri (Thessaloniki/GR), Ianthi-Maria Tsimpli (Cambridge/GB), Kyrana

Tsapkini (Baltimore/US)

P291 The effect of verbal working memory capacity in sentence comprehension: A

comparison between non-fluent post-stroke aphasia and non-fluent variant PPA

Eleni Peristeri (Thessaloniki/GR), Ianthi-Maria Tsimpli (Cambridge/GB), Kyrana

Tsapkini (Baltimore/US)

P292 Non-right handed primary progressive aphasia and apraxia of speech

Hugo Botha, Jennifer Whitwell, Joseph Duffy, Edythe Strand, Mary Machulda, Val

Lowe, Keith Josephs (Rochester/US)

P293 Neurochemical markers in the differential diagnosis of primary progressive aphasias:

Data from the German FTLD consortium

Patrick Oeckl, Sarah Anderl-Straub (Ulm/DE), Janine Diehl-Schmid (Munich/DE),

Christine A.F. von Arnim (Ulm/DE), Klaus Fassbender (Homburg/DE), Emily

Feneberg (Ulm/DE), Klaus Fliessbach (Bonn/DE), Hans Förstl (Munich/DE), Holger

Jahn (Hamburg/DE), Bernhard Landwehrmeyer (Ulm/DE), Martin Lauer

(Würzburg/DE), Johannes Levin (Munich/DE), Albert C. Ludolph (Ulm/DE), Johannes

Prudlo (Rostock/DE), Anja Schneider (Göttingen/DE), Matthias Schroeter

(Leipzig/DE), Elisa Semler, Petra Steinacker, Ingo Uttner (Ulm/DE), Jens Wiltfang

(Göttingen/DE), Adrian Danek (Munich/DE), Markus Otto (Ulm/DE)

P294 Speech fluency as a tool to differentiate between FTLD variants.

Angela Martínez (Bogotá, Lyon/CO), Diana Matallana (Bogotá/CO), Frédérique

Gayraud (Lyon/FR)


35

P295 Predicting rate of clinical decline using neuroimaging in progressive agrammatic

aphasia and apraxia of speech

Jennifer Whitwell, Stephen Weigand, Joseph Duffy, Heather Clark, Edythe Strand,

Mary Machulda, Anthony Spychalla, Matthew Senjem, Clifford Jack, Keith Josephs

(Rochester/US)

P296 Cross-cultural Adaptation of the Boston Diagnostic Aphasia Examination - Short

Form in Filipino

Howell Henrian Bayona (Taguig City, Manila, Philippines/PH), Ivan Paul Bondoc

(Honolulu, Hawaii/US), Ellyn Loise Namoro, Fatima Faye Aclan, Alrenzo Ludwig

Domingo (Manila, Philippines/PH), Jacqueline Dominguez (Taguig City/PH)

P297 Long-Term functional and behavior features of Primary Progressive Aphasia

Syndrome.

Ismael L Calandri, María Alejandra Amengual, Daiana Actis, Ricardo F Allegri

(Buenos Aires/AR)

P298 Is the impairment on Luria three-step examination in FTD patients associated with

language impairments?

Linda Repetto, Peter Connick, Shuna Colville, Suvankar Pal, Thomas H. Bak

(Edinburgh/GB)

P299 Different patterns of motor impairment in the behavioural and aphasic form of

Frontotemporal Dementia

Giulia Melchiorre, Peter Connick, Shuna Colville, Suvankar Pal, Thomas H Bak

(Edinburgh/GB)

P300 Predictors of conversion to dementia in Primary Progressive Aphasia

Laura Veronelli (Milan, Italy, Boston, MA/IT), Sara J. Makaretz, Megan Quimby

(Boston, MA/US), Massimo Corbo (Milan, Italy/IT), Bradford C. Dickerson (Boston,

MA/US)

P301 Distinctive profile of verbal fluency tasks and overall cognitive functioning in a

Mexican sample in patients with frontotemporal dementia and Alzheimer's disease

José Alberto Téllez Martínez, Juan Francisco Flores Vázquez, Gilberto Isaac Acosta

Castillo, Airam Campos Jiménez, Loreli Álvarez Díaz, Adrian Martínez Ruíz, Ana

Luisa Sosa Ortíz (México/MX)

P302 Assessment of frontal function and behavioral symptoms across subtypes of primary

progressive aphasia, semantic dementia and progressive apraxia of speech

Erin Golden (Rochester/GB), Hugo Botha, Joseph Duffy, Edythe Strand, Heather

Clark, Mary Machulda, Jennifer Whitwell, Keith Josephs (Rochester/US)

P303 Cognitive and neuroanatomical features of amyloid positivity in primary progressive

aphasia (PPA)

Miguel Angel Santos-Santos, Gil D. Rabinovici, Nagehan Ayakta, Leonardo

Iaccarino, Gautam Tammewar, Maya L. Henry, Andreas Lazaris, Zachary Miller,

Maria Luisa Mandelli, Edoardo Spinelli, H. Isabel Hubbard, Howie Rosen, William

Jagust, Bruce L. Miller, Lea T. Grinberg, William W. Seeley, Maria Luisa Gorno-

Tempini (san francisco/US)

P304 Differentiating Frontotemporal Dementia Phenotypes in a Cinical Setting Using the

Computerized Self-Test (CST)

Monica Crane, Robert Anthony, Kevin Sellers, Kelly Knolton, John H. Dougherty

(Knoxville/US)


36

14:00–15:30 Session 6: CBS, PSP and MND

Room Lecture Hall

Chairs Günter Höglinger (Munich/DE), Albert Ludolph (Ulm/DE)

14:00 PSP & CBD: overlaps and distinctions within the FTLD spectrum

Günter Höglinger (Munich/DE)

14:25 ALS - Pathology, genotype and phenoptype

Albert Ludolph (Ulm/DE)

14:50 Plasma neurofilament light chain predicts disease progression in progressive

supranuclear palsy

O11 Julio Rojas, Anna Karydas, Jee Bang, Richard Tsai (San Francisco, CA/US), Kaj

Blennow, Victor Liman (Gothenburg/SE), Joel Kramer, Howard Rosen, Bruce Miller

(San Francisco, CA/US), Henrik Zetterberg (Gothenburg, London/SE), Adam Boxer

(San Francisco, CA/US)

15:05 Converging Multimodal Evidence of Myelin Associated Proteins As Biomarkers in

Four-Repeat Tauopathy

O12 Corey McMillan, David Irwin, Matthew Byrne, Felicia Cooper, Kim Firn, Charles

Jester, Eunran Suh, Vivianna Van Deerlin, John Trojanowski, Murray Grossman

(Philadelphia/US)

15:20 Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-

analysis

DB19 Zhangyu Zou, Chunhui Che, Changyun Liu, Huapin Huang (Fuzhou/CN)

15:22 [18F]AV-1451 PET imaging differentiates the tauopathies of Progressive

Supranuclear Palsy (PSP) and Alzheimer’s disease (AD)

DB20 Patricia Vazquez Rodriguez, Luca Passamonti (Cambridge/GB)

15:24 On The Clinical Overlap Between Progressive Supranuclear Palsy and Corticobasal

Syndrome: evidence from the PiPPIN epidemiology study

DB21 James Rowe, Ian Gilchrist (Cambridge/GB)

15:26 Clinical comparison of FTLD and ALS-FTD patients – is there a difference?

DB22 Angela Rosenbohm, Raphael S Peter, Elisa Semler, Gabriele Nagel, Dietrich

Rothenbacher, Markus Otto, Albert C Ludolph, ALS-FTLD Register Swabia Study

Group (Ulm/DE)

16:00–17:30 Session 7: Biomarkers for FTLD

Room Lecture Hall

Chairs Markus Otto (Ulm/DE), Alessandro Padovani (Brescia/IT)

16:00 New physiological biomarkers of FTLD

Jason Warren (London/GB)

16:25 Blood and CSF biomarkers in the presymptomatic stage of hereditary FTD

John van Swieten (Rotterdam/NL)


37

16:50 Data-driven Regions of Interest for Longitudinal Change in Three Variants of

Frontotemporal Lobar Degeneration

O13 Howard Rosen, Richard Binney, Aleksandr Pankov, Gabriel Marx, Faye McKenna,

Xuanzie He, Adam Staffaroni, John Kornak, Suneth Attygalle, Adam Boxer, Norbert

Schuff, Maria-Luisa Gorno-Tempini, Michael Weiner, Joel Kramer, Bruce Miller (San

Francisco/US)

17:05 Multimodal imaging analysis of C9orf72-associated FTD in the Genetic

Frontotemporal dementia Initiative (GENFI) study

O14 Martina Bocchetta, Nicolas Toussaint, Michael Hutel, Marc Modat, M. Jorge Cardoso,

Elizabeth Gordon, Katrina M Dick, David M Cash (London/GB), John van Swieten

(Rotterdam/NL), Barbara Borroni (Brescia/IT), Daniela Galimberti (Milan/IT), Mario

Masellis (Toronto/CA), Caroline Graff (Huddinge, Stockholm/SE), Fabrizio Tagliavini

(Milan/IT), Giovanni B Frisoni (Brescia/IT), Robert Laforce Jr (Québec City/CA),

Elizabeth Finger (London Ontario/CA), Alexandre de Mendonça (Lisbon/PT), Sandro

Sorbi (Florence/IT), Jason D Warren, Sebastien Ourselin, Jonathan D. Rohrer, on

behalf of the Genetic FTD Initiative (GENFI) (London/GB)

17:20 Increased CSF levels of biomarkers for neurodegeneration in FTLD-GRN mutation

carriers.

DB23 Joery Goossens, Sara Van Mossevelde, Tobi Van den Bossche, Anne Sieben, Jean-

Jacques Martin, Johan Goeman, Peter Paul De Deyn, Christine Van Broeckhoven,

Julie van der Zee, Sebastiaan Engelborghs (Antwerp/BE)

17:22 Presymptomatic structural connectivity loss in familial frontotemporal dementia – a

four year follow-up study of Dutch FTD pedigrees

DB24 Lize Jiskoot, Jessica Panman, Elise Dopper, Janne Papma (Rotterdam/NL), Mark

Bouts, Christiane Möller (Leiden/NL), Tom den Heijer, Rick van Minkelen

(Rotterdam/NL), Serge Rombouts (Leiden/NL), John van Swieten (Rotterdam/NL)

17:24 Exosomal microRNAs in the cerebrospinal fluid as biomarkers in familial FTD

DB25 Raphael Schneider, TaeHyung Kim, Paul McKeever (Toronto/CA), Caroline Graff

(Stockholm/SE), John van Swieten (Rotterdam/NL), Robert Laforce Jr (Quebec

City/CA), Daniela Galimberti (Milan/IT), Mario Masellis (Toronto/CA), Jonathan

Rohrer (London/GB), Zhaolei Zhang, Janice Robertson, Maria Carmela Tartaglia

(Toronto/CA)

17:26 Brain glucose metabolic abnormalities differ between predementia carriers of GRN

and C9ORF72 mutations

DB26 Claudia Jacova (Hillsboro/US), Ging-Yuek Robin Hsiung, Elham Shahinfard, Katie

Dinelle, Pheth Sengdy, Siobhan McCormick, Vesna Sossi, A. Jon Stoessl, Howard

Feldman, Ian R Mackenzie (Vancouver/CA)

19:00–00:00 Social Evening

Room Hofbräukeller


38

08:30–09:30 Session 8: Hot topics - Late breaking news

Room Lecture Hall

Chairs Glenda Halliday (Sydney/AU), Masato Hasegawa (Tokyo/JP)

08:30 Selected Talk (To be selected after Late breaking news abstract submission

deadline)

08:45 Selected Talk (To be selected after Late breaking news abstract submission

deadline)

09:00 A mouse model for FTD-like syndrome due to TREM2 mutations

O15 Gernot Kleinberger, Benedikt Wefers, Marc Suárez-Calvet, Fargol Mazaheri

(Munich/DE), Atanas Todorov (Basel/CH), Matthias Brendel (Munich/DE), Eva

Mracsko (Basel/CH), Wolfgang Wurst (Munich/DE), Thomas Mueggler (Basel/CH),

Axel Rominger (Munich/DE), Irene Knuesel (Basel/DE), Christian Haass (Munich/DE)

09:15 TDP-43 loss of function inhibits endosomal trafficking and alters signaling in neurons

DB27 Benjamin Schwenk, Hannelore Hartmann, Alperen Serdaroglu, Martin Schludi

(Munich/DE), Daniel Hornburg, Felix Meißner (Martinsried/DE), Michael Peitz

(Bonn/DE), Thomas Klopstock (Munich/DE), Albert Ludolph (Ulm/DE), Thomas

Arzberger, Peer-Hendrik Kuhn, Dieter Edbauer (Munich/DE)

09:17 Neuronal Progranulin Overexpression Reverses Social Deficits in Progranulin-

insufficient Mice

DB28 Andrew Arrant, Anthony Filiano, Daniel Unger, Allen Young, Erik Roberson

(Birmingham, AL/US)

09:19 Trehalose enhances progranulin expression in progranulin-deficient patient cells and

mouse brain

DB29 Christopher Holler, Georgia Taylor, Zachary McEachin, Qiudong Deng, William

Watkins, Kathryn Hudson, Charles Easley, William Hu, Chadwick Hales, Wilfried

Rossoll, Gary Bassell, Thomas Kukar (Atlanta/US)

09:21 Chloroquine rescues Cerebrospinal fluid progranulin deficiency in FTD

DB30 Daniel Bittner, Peter Körtvelyessy, Hans-Jochen Heinze, Mandy Busse, Stefan

Busse (Magdeburg/DE)

10:00–11:30 Session 9: Mechanisms of cell death

Room Lecture Hall

Chairs Dieter Edbauer (Munich/DE), Adrian Isaacs (London/GB)

10:00 Insights on motor neuron degeneration in a mouse model of TDP-43 proteinopathy

Virigina Lee (Philadelphia, PA/US)

10:25 Insights from iPSC and Drosophila Models of C9ORF72‐ Related ALS/FTD

O16 Fen-Biao Gao (Worcester/US)

10:40 Loss of TDP-43 Contributes to Non-coding RNA Mediated Toxicity

O17 Elaine Liu, Jenny Russ, Edward Lee (Philadelphia/US)


39

10:55 Fus regulates the transcriptome of the developing mouse brain through several

mechanisms

DB31 Chiara Valori (Tuebingen/DE), Cemil Kerimoglu (Göttingen/DE), Chieh-Yu Cheng,

Vignesh Sakthivelu (Tuebingen/DE), Ronald Naumann (Dresden/DE), Andre Fischer

(Göttingen/DE), Manuela Neumann (Tuebingen/DE)

10:57 Progranulin is neurotrophic in vivo, stimulating functional recovery after nerve crush

injury

DB32 Sander Beel, Louis De Muynck, Ludo Van Den Bosch, Wim Robberecht, Philip Van

Damme (Leuven, Belgium/BE)

10:59 C9orf72 differential expression in brain and monocytes suggests a possible role for

C9orf72 in monocyte function

DB33 Emily Lynes, Patrizia Rizzu, Ashutosh Dhingra, Melissa Castillo-Lizardo, Margherita

Franscescatto, Cornelis Blauwendraat, Sasja Heetveld, Elwira Pyz, Javier Simon-

Sanchez, Matthis Synofzik, Peter Heutink (Tuebingen/DE)

11:01 RNA destabilization in frontotemporal lobar dementia and amyotrophic lateral

sclerosis

DB34 Hilary Archbold, Elizabeth Tank, Michelle Paulsen, Mats Ljungmann, Sami Barmada

(Ann Arbor/US)

11:05 Panel discussion: What is the toxic species for C9FTD/ALS?

Dieter Edbauer (Munich/DE), Adrian Isaacs (London/GB)

11:30–13:30 Postersession III - CBS, PSP, MND

Room Ballroom

P305 PLS-FTLD, expanding the spectrum of dementia in motor neuron disease

Michael van Es, Balint de Vries, Laura Rustemijer (Utrecht/NL), Anneke van der Kooi

(Amsterdam/NL), Joost Raaphorst (Amsterdam, Nijmegen/NL), Carin Schroder,

Tanja Nijboer, Joeren Hendrikse, Jan Veldink, Leonard van den Berg (Utrecht/NL)

P306 A voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) whole-

brain analysis of gray matter and white matter changes in amyotrophic lateral

sclerosis (ALS) without dementia

Foteini Christidi, Efstratios Karavasilis, Sophia Xirou, Michael Rentzos, George

Velonakis, Vasiliki Zouvelou, Ioannis Zalonis, Panagiotis Ferentinos, Loukia Poulou,

Panagiotis Toulas, Thomas Zambelis, Nikolaos Karandreas, Nikolaos Kelekis,

Ioannis Evdokimidis (Athens, Greece/GR)

P307 Impaired corticopontocerebellar tracts underlie pseudobulbar affect in motor neuron

disorders

Mary Kay Floeter, Rohan Katipally, Meridith Kim, Olivia Schanz, Matthew Stephen,

Laura Danielian, Tianxia Wu (Bethesda, MD/US), Edward Huey (New York, NY/US),

Avner Meoded (Bethesda, MD/US)

P308 Visuoperception test predicts pathologic diagnosis of Alzheimer disease in

corticobasal syndrome

Clara Boyd (New York, NY/US), Michael Tierney, Eric Wassermann (Bethesda,

MD/US), Salvatore Spina, Adrian Oblak, Bernardino Ghetti (Indianapolis, IN/US),

Jordan Grafman (Chicago, IL/US), Edward Huey (New York, NY/US)


40

P309 Investigating progressive supranuclear palsy using VBM and SVM classification

Karsten Mueller (Leipzig/DE), Robert Jech, Cecilia Bonnet, Jaroslav Tintěra

(Prague/CZ), Harald E Möller (Leipzig/DE), Klaus Fassbender (Homburg/DE), Jan

Kassubek, Markus Otto (Ulm/DE), Evžen Růžička (Prague/CZ), Matthias L Schroeter

(Leipzig/DE)

P310 Genome-wide association study of plasma tau levels identifies risk variants for PSP

and CBD

Jin-Tai Yu, Jason Chen (San Francisco/US), Hui-Fu Wang (San Francisco/CN),

Henrik Zetterberg, Kaj Blennow (San Francisco/SE), Jennifer Yokoyama, Michael

Weiner, Joel Kramer, Howard Rosen, Bruce Miller, Giovanni Coppola, Adam Boxer

(San Francisco/US)

P311 The sequence of progression of symptom domains in the PSP-Rating Scale (PSP-

RS)

Claire Brittain (Windlesham/GB), Michael Irizarry (Windlesham/US), Jeremie Lebrec

(Windlesham/PT), Adam Boxer (San Francisco/US)

P312 Disentangling the neural correlates of corticobasal syndrome & corticobasal

degeneration with systematic & quantitative ALE meta-analyses

Franziska Albrecht, Sandrine Bisenius, Rodrigo Morales Schaack, Matthias

Schroeter (Leipzig/DE)

P313 Rapid progression of brain atrophy in progressive supranuclear palsy and

corticobasal degeneration

Shubir Dutt (San Francisco/US), Richard Binney (San Francisco, Philadelphia/US),

Hilary Heuer, Phi Luong, Suneth Attygalle, Priyanka Bhatt, Gabe Marx, Jonathan

Elofson (San Francisco/US), Maria Carmela Tartaglia (Toronto/CA), Irene Litvan (San

Diego/US), Scott McGinnis, Bradford Dickerson (Charlestown/US), John Kornak (San

Francisco/US), Dana Waltzman (San Francisco, Stanford/US), Lisa Voltarelli, Norbert

Schuff, Gil Rabinovici, Joel Kramer (San Francisco/US), Clifford Jack

(Rochester/US), Bruce Miller, Adam Boxer (San Francisco/US)

P314 Cerebrospinal Fluid Phosphorylated Tau Associated with Survival in 4-Repeat

Tauopathies

Kim Firn, Leslie M. Shaw, David J. Irwin, Murray Grossman, Corey T. McMillan

(Philadelphia/US)

P315 The relationship of iron accumulation to motor and cognitive performance

in amyotrophic lateral sclerosis

Nicola Spotorno, Julio Acosta-Cabronero, Judith Machts, Susanne Abdulla

(Magdeburg/DE), Katja Kollewe, Susanne Preti (Hannover/DE), Stefan Vielhaber,

Peter J. Nestor (Magdeburg/DE)

P316 Revised Clinical Diagnostic Criteria for Progressive Supranuclear Palsy (PSP)

Günter Höglinger, Gesine Respondek (Munich/DE), Maria Stamelou (Neurology/GR),

Carolin Kurz (Munich/DE), Keith Josephs (Rochester/US), Anthony Lang

(Toronto/CA), Brit Mollenhauer (Kassel/DE), Ulrich Müller (Giessen/DE), Christer

Nilsson (Lund/SE), Jennifer Whitwell (Rochester/US), Thomas Arzberger

(Munich/DE), Ellen Gelpi (Barcelona/BE), Armin Giese (Munich/DE), David Irwin

(Philadelphia/US), Wassilios Meissner (Bordeaux/FR), Alexander Pantelyat

(Baltimore/US), John van Swieten (Rotterdam/NL), Claire Troakes (London/GB),

Angelo Antonini (Venice/IT), Kailash Bhatia (London/GB), Yvette Bordelon (Los

Angeles/US), Jean Christophe Corvol (Paris/FR), Carlo Colosimo (Roma/IT), Richard

Dodel (Marburg/DE), Murray Grossman (Philadelphia/US), Jan Kassubek (Ulm/DE),

Florian Krismer (Innsbruck/AT), Johannes Levin (Munich/DE), Huw Morris


41

(London/GB), Peter Nestor (Magdeburg/DE), Wolfgang Oertel (Marburg/DE), Gil

Rabinovici (San Francisco/US), James Rowe (Cambridge/GB), Thilo van Eimeren

(Cologne/DE), Gregor Wenning (Innsbruck/AT), Jin-Tai Yu (San Francisco/US),

Lawrence I. Golbe (New Brunswick/US), Irene Litvan (San Diego/US), Adam Boxer

(San Francisco/US)

P317 Whole-brain pattern of iron-aware tissue magnetostatics in amyotrophic lateral

sclerosis

Julio Acosta-Cabronero, Judith Machts (Magdeburg/DE), Katja Kollewe

(Hannover/DE), Susanne Abdulla (Magdeburg/DE), Susanne Petri (Hannover/DE),

Stefan Vielhaber, Peter Nestor (Magdeburg/DE)

P318 PROGRESSIVE SUPRANUCLEAR PALSY IN THE SPECTRUM OF

FRONTOTEMPORAL DEMENTIA: A NEUROPSYCHOLOGICAL AND

NEUROIMAGING STUDY

Leonardo Cruz de Souza, Elisa de Paula França Resende, Francisco Eduardo Costa

Cardoso, Henrique Cerqueira Guimarães, Leandro Boson (Belo Horizonte/BR),

Michael Hornberger, Maxime Bertoux (Norwich/GB), Paulo Caramelli, Antônio Lúcio

Teixeira (Belo Horizonte/BR)

P319 H46R SOD1 mutation is consistently associated with a relatively benign form of

Amyotrophic Lateral Sclerosis with very slow progression

Zhangyu Zou (Fuzhou/CN), Mingsheng Liu, Xiaoguang Li, Liying Cui (Beijing/CN)

P320 Mutations in FUS are the most frequent genetic cause in juvenile sporadic ALS

patients of Chinese origin

Zhangyu Zou (Fuzhou/CN), Xiaoguang Li, Mingsheng Liu, Liying Cui (Beijing/CN)

P321 Predicting Disease Progression in Progressive Supranuclear Palsy in Multicenter

Clinical Trials

Jee Bang, Iryna Lobach (San Francisco/US), Anthony Lang (Toronto/CA), Murray

Grossman (Philadelphia/US), David Knopman (Rochester/US), Bruce Miller (San

Francisco/US), Lon Schneider (Los Angeles/US), Rachelle Doody (Houston/US),

Andrew Lees (London/GB), Michael Gold (Research Triangle/US), Bruce Morimoto

(Lincoln/US), Adam Boxer (San Francisco/US)

P322 Unusual sporadic 4R-tauopathy with bulbar onset MND-like syndrome preceding

bvFTD

Johannes Prudlo, Stefan Teipel, Andreas Buettner (Rostock/DE), Manuela Neumann

(Tuebingen/DE)

P323 TDP-43 in the hypoglossal nucleus identifies amyotrophic lateral sclerosis in

behavioral variant frontotemporal dementia

Rachel Tan (Randwick, Sydney/AU), Matthew Kiernan, Jillian Kril (Sydney/AU),

Masato Hasegawa, Masami Masada-Suzukake (Japan/JP), Carol Dobson-Stone,

John Kwok (Randwick, Sydney/AU), Michael Hornberger (Norwich/GB), John

Hodges, Glenda Halliday (Randwick, Sydney/AU)

P324 Loosing words and hand! A rare case of Semantic Dementia overlapping with

Corticobasal Syndrome.

Noémie MOREAU (Aix en Provence/FR), Marie LEGRAND (Pertuis/FR), Charlotte

ROSEAU (Aix en Provence/FR), Guillaume PUIGSERVER (Pertuis/FR), Laurent

RENIE, Bernadette BONNEFOI (Aix en Provence/FR)


42

P325 Natural history and progression to dementia in progressive supranuclear palsy

Andrea Pilotto (Brescia, Italy, Tuebingen, Germany/IT), Stefano Gazzina, Alberto

Benussi, Marta Manes, Valentina Dell'Era, Maura Cosseddu, Rosanna Turrone,

Barbara Borroni, Alessandro Padovani (Brescia, Italy/IT)

P326 DESCRIPTION OF PROGRESSIVE SUPRANUCLEAR PALSY SUBTYPES FROM

THE NAVARRA BRAIN BANK

Javier Sánchez Ruiz de Gordoa, María Victoria Zelaya Huerta, Teresa Tuñon

Álvarez, Federico García Bragado, María Teresa Mendioroz Iriarte, Valle Coca

Pueyo, Elena Erro Aguirre (Pamplona/ES)

P327 Joint analysis of GWAS with epigenetic data revealed candidate markers in

FTD/MND, and convergence in pathways

Erdogan Taskesen, Aniket Mishra, Danielle Posthuma, Yolande Pijnenburg

(Amsterdam/NL)

P328 Multiple Pathologies and Heterogeneity in Corticobasal Syndrome and Corticobasal

Degeneration: complications in a complex disease

Rodrigo A. Santibanez (Vancouver, Santiago/CA), Ian R. Mackenzie, Michael

Marnane, Shervin Mortazavi, Connor Keller, Jennifer Li, Angela Kim, Ging-Yuek R.

Hsiung (Vancouver/CA)

P329 Disease-Specific Relationship Between Cerebrospinal Fluid & Longitudinal

Neuroimaging

Charles Jester, Kim Firn, Kylie Ternes, Leslie M Shaw, David Irwin, Dan Weintraub,

Murray Grossman, Corey McMillan (Philadelphia/US)

P330 Creutzfeldt Jakob Disease (CJD) and Supranuclear Palsy (PSP) in one patient - two

sides of the same medal?

Felix Mueller-Sarnowski, Wiebke Valentin, Janine Diehl-Schmid (Munich/DE)

P331 The Edinburgh Cognitive and Behavioural ALS Screen (ECAS); the effect of age,

education, and IQ.

Monica Mariana De Icaza Valenzuela, Thomas Bak, Suvankar Pal, Sharon

Abrahams (Edinburgh/GB)

P332 Serum neurofilament light chain (NfL) in Progressive Supranuclear Palsy (PSP)

Laura Donker Kaat, Lieke Meeter, Agnita Boon, Wan Zeng Chiu, John van Swieten

(Rotterdam/NL)

P333 Neuropathologic and Neurobiologic Characterization of Early Onset Amyotrophic

Lateral Sclerosis Associated with a Novel TDP43 S375G Variant

Kathy Newell (Kansas City/US), Bernardino Ghetti, Jill Murrell (Indianapolis/US),

Maurizio Romano, Elisa Salis, Christiana Stuani, Emanuele Buratti (Trieste/IT)

P334 Social Cognition in Amyotrophic Lateral Sclerosis in an Argentinean-cohort.

Preliminary Data.

Federico Exequiel Nahas (Ciudad Autonoma de Buenos Aires, Buenos Aires/AR),

Bruno De Ambrosi, Ismael Calandri, Fernanda Tapajoz, Patricia Zanuso, Martin

Nogues (Ciudad Autonoma de Buenos Aires/AR), Ricardo Allegri (Ciudad Autonoma

de Buenos Aires, Buenos Aires/AR)


43

P335 Measuring Clinical and Cognitive Decline in CBD and PSP for Multicenter Clinical

Trials – the 4-Repeat Tauopathy Neuroimaging Initiative (4RTNI)

Dan Luong, Lisa Voltarelli, Hilary Heuer, John Kornak (San Francisco/US), Kimiko

Domoto-Reilly, Bradford Dickerson (Boston/US), Irene Litvan (San Diego/US), Maria

Carmela Tartaglia (Toronto/CA), Bruce Miller, Adam Boxer (San Francisco/US)

11:30–13:30 Postersession III - Blood and Imaging biomarkers

Room Ballroom

P336 IDENTIFYING CORTICAL ATROPHY IN THE MAIN VARIANTS OF FRONTO-

TEMPORAL DEMENTIA, IN 48 COLOMBIAN PATIENTS: A VBM ANALYSIS

Pablo Reyes, Maria Ortega, Santiago Gutierrez, Hernando Santamaría-García,

Felipe Uriza, Diana Matallana (Bogotá/CO)

P337 The diffuse not focal frontal atrophy subtype shows worse prognosis in behavioral


Jin San Lee (Seoul/KR), Na-Yeon Jung, Eun-Joo Kim (Busan/KR), Juyoun Lee

(Daejeon/KR), Young Kyoung Jang, Yeo Jin Kim, Hee Jin Kim, Sang Won Seo, Jae-

Hong Lee (Seoul/KR), Byeong C. Kim (Gwangju/KR), Kyung-Won Park (Busan/KR),

Soo Jin Yoon (Daejeon/KR), Jee H. Jeong (Seoul/KR), Sang Yun Kim

(Seongnam/KR), Key-Chung Park (Seoul/KR), David S. Knopman (Rochester/US),

Duk L. Na (Seoul/KR)

P338 Tau imaging in patients with ALS/PDC in the Kii Peninsula

YASUMASA KOKUBO (Tsu/JP), Hitoshi Shinotoh, Hitoshi Shimada, Fumitoshi Niwa

(Chiba/JP), Ryogen Sasaki, Satoru Morimoto (Tsu/JP), Hironobu Endo, Soichiro

Kitamura, Shigeki Hirano (Chiba/JP), Ikuko Aiba (Nagoya/JP), Masanori Miyamura

(Ise/JP), Naruhiko Sahara (Chiba/JP), Shigeki Kuzuhara (Suzuka/JP), Makoto

Higuchi, Tetsuya Suhara (Chiba/JP)

P339 Analysis of regional MRI volumes and thicknesses on frontotemporal dementia

patients with C9ORF72 expansion

Ramona Haanpää, Yawu Liu, Anette Hall, Päivi Hartikainen (Kuopio/FI), Virpi

Moilanen (Oulu/FI), Hilkka Soininen, Anne Remes (Kuopio/FI)

P340 Brain network organization in frontotemporal dementia across countries, recordings

and methods

Lucas Sedeño (BUENOS AIRES/AR), Olivier Piguet (Sydney/AU), Adolfo García, Sol

Fitipaldi, Sofía Abrevaya, Indira García-Cordero, Sandra Baez, Laura Alethia de la

Fuente (BUENOS AIRES/AR), Fiona Kumfor (Sydney/AU), Teresa Torralva

(BUENOS AIRES/AR), John Hodges (Sydney/AU), Agustin Ibanez (BUENOS

AIRES/AR)

P341 Frontotemporal dementia and language networks: cortical thinning is driven by

dyslexia susceptibility genes

Marta Antonia Manes, Donata Paternicò (Brescia/IT), Enrico Premi (Brescia/JM),

Maura Cosseddu, Stefano Gazzina, Antonella Alberici (Brescia/IT), Silvana Archetti,

Elisa Bonomi (Brescia,Italy/IT), Maria Sofia Cotelli, Marinella Turla, Maria Cotelli

(Brescia, Italy/IT), Anna Micheli (Bergamo, Italy/IT), Roberto Gasparotti (Brescia,

Italy/IT), Barbara Borroni, Alessandro Padovani (Brescia/IT)


44

P342 A novel approach to investigate a rare Frontotemporal Disorder: proteomic studies

about Nasu-Hakola Disease.

Anna Maria Agresta, Antonella De Palma, Dario Di Silvestre (Segrate (Milan)/IT),

Anna Maria Bardoni, Roberta Salvini, Paolo Iadarola (Pavia/IT), Pier Luigi Mauri

(Segrate (Milan)/IT)

P343 Evolution of Cerebral PET Glucose Metabolism from presymptomatic to symtomatic

Frontotemporal Dementia Linked to Chromosome 3 (FTD-3) – a voxel based SPM

Analysis

Peter Johannsen, Ian Law, Christian Hansen, Peter Roos, Jette Stokholm

(Copenhagen/DK), Adrian M. Isaacs (London/GB), Jerry Brown (Cambridge/GB),

Jorgen E. Nielsen (Copenhagen/DK)

P344 Tau [18F]AV-1451 PET Uptake in Patients with Suspected 4-Repeat Tauopathy

Corey McMillan (Philadelphia/US), Daniel Schonhaut (San Francisco/US), David

Russell (New Haven, CT/US), Adam Boxer (San Francisco/US), Irene Litvan (San

Diego/US), Erik Roberson (Birmingham, AL/US), Ilya Nasrallah, Andrew Siderowf,

Michael Devous, Murray Grossman (Philadelphia/US), Gil Rabinovici (San

Francisco/US)

P345 In genetic frontotemporal dementia, functional network efficiency is maintained until

the onset of symptoms: evidence for functional resilience to structural change

Timothy Rittman, Robin Borchert, Simon Jones (Cambridge/GB), John Van Swieten

(Rotterdam/NL), Barbara Borroni (Brescia/IT), Daniela Galimberta (Milan/IT), Mario

Marsellis (Toronto/CA), Caroline Graff (Stockholm/SE), Fabrizio Tagliavini (Milan/IT),

Giovanni Frisoni (Geneva/CH), Robert La Force (Quebec/CA), Elizabeth Finger

(London/CA), Alexandre Mendonça (Lisbon/PT), Sandro Sorbi (Florence/IT),

Jonathan Rohrer (London/GB), James Rowe (Cambridge/GB), on behalf of the

Genetic FTD Initiative (GENFI) (London/GB)

P346 Disease-specific patterns of cortical and subcortical degeneration in a longitudinal

study of Alzheimer's disease and behavioural-variant frontotemporal dementia

Ramon Landin-Romero, Fiona Kumfor, Cristian Leyton, Muireann Irish, John Hodges,

Olivier Piguet (Sydney/AU)

P347 White matter changes in frontotemporal dementia and the C9ORF72 gene

expansions

Ramon Landin-Romero (Sydney/AU), Bonnie Yin Ka Lam (Hong Kong/HK), Fiona

Kumfor, Emma Devenney, Lauren Bartley, Glenda Halliday, John Hodges, Olivier

Piguet (Sydney/AU)

P348 The synaptic protein neurogranin as a clinical CSF biomarker in the diagnosis of FTD

Alexander Santillo, Shorena Janelidze, Joakim Hertze (Malmö/SE), Henrik Zetterberg

(Mölndal/SE), Maria Landqvist Waldö (Lund/SE), Kaj Blennow (Mölndal/SE), Oskar

Hansson (Malmö/SE)

P349 Different binding behavior of the Tau-PET tracer [F-18]-AV-1451 in AD and Tau-

positive FTLD

Jochen Hammes (Cologne/DE), Gérard N Bischof (Cologne, Jülich/DE), Klaus

Fliessbach (Bonn/DE), Kathrin Giehl, Frank Jessen, Bernd Neumaier, Juraj Kukolja,

Özgür Onur, Alexander Drzezga (Cologne/DE), Thilo van Eimeren (Cologne,

Jülich/DE)

P350 Transcriptome analysis in FTD patients: genes, pathways and networks

Wouter De Coster, Sara Van Mossevelde, Sebastiaan Engelborghs (Antwerp/BE),

Mathieu Vandenbulcke (Edegem/BE), Ligia Mateiu, Maria Mattheijssens, Karin


45

Peeters (Antwerp/BE), Rik Vandenberghe (Leuven/BE), Patrick Cras (Antwerp,

Edegem/BE), Peter Paul De Deyn (Antwerp, Groningen/BE), Marc Cruts, Christine

Van Broeckhoven (Antwerp/BE)

P351 Neural network organization in frontotemporal degeneration by means of graph

theory on resting-state EEG recordings: a study on behalf of the Italian FTD Network

Laura Bonanni, Raffaella Franciotti (Chieti/IT), Alberto Benussi (Brescia/IT), Marco

Bozzali (Rome/IT), Annachiara Cagnin (Padua/IT), Amalia Bruni (Lamezia Terme/IT),

Silani Vincenzo (Milan/IT), Giancarlo Logroscino (Bari/IT), Roberta Ghidoni

(Brescia/IT), Benedetta Nacmias (Florence/IT), Fabrizio Tagliavini (Milano/IT),

Alessandro Padovani (Brescia/IT), Marco Onofrj (Chieti/IT), Daniela Galimberti

(Milan/IT), Barbara Borroni (Brescia/IT)

P352 Characteristics and Progress on the Initial 256 Participants in the Advancing

Research and Treatment in Frontotemporal Lobar Degeneration (ARTFL) North

American Rare Disease Clinical Research Consortium

Adam Boxer, Howard Rosen (San Francisco/US), Brad Boeve (Rochester/US), Hilary

Heuer, Samara Laxineta (San Francisco/US), Murray Grossman (Philadelphia/US),

Giovanni Coppola (Los Angeles/US), Bradford Dickerson (Cambridge, MA/US),

Yvette Bordelon (Los Angeles/US), Robin Conwit (Bethesda/US), Christina Dheel

(Rochester/US), Kelley Faber (Indianapolis, IN/US), Howard Feldman

(Vancouver/CA), John Ferguson (Bethesda/US), Julie Fields (Rochester/US), Jamie

Fong (San Francisco/US), Tatania Foroud (Indianapolis, IN/US), Wendy Galpern

(Washington, DC/US), Nupur Ghoshal (St. Louis/US), Neill Graff-Radford

(Jacksonville, FL/US), Robin Hsiung (Vancouver/CA), Edward Huey (New York/US),

David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Daniel Kaufer (Chapel

Hill/US), Anna Karydas (San Francisco/US), Alex Klein (New York/US), David

Knopman (Rochester/US), John Kornak, Joel Kramer (San Francisco/US), Walter

Kukull (Seattle/US), Irene Litvan (San Diego/US), Ian Mackenzie (Vancouver/CA),

Mario Mendez (Los Angeles, Baltimore, MD/US), Bruce Miller (San Francisco/US),

Matthew Miller (Rochester/US), Chiadi Onyike, Alexander Pantelyat (Baltimore,

MD/US), Rosa Rademakers (Jacksonville, FL/US), Erik Roberson (Jacksonville, FL,

Birmingham/US), Margaret Sutherland (Bethesda/US), Maria Carmela Tartaglia

(Toronto/CA), Nadine Tatton (Radnor, PA/US), Arthur Toga (Los Angeles/US),

Ashley Vetor (Indianapolis, IN/US), Sandra Weintraub (Chicago/US), Zbigniew

Wszolek (Jacksonville, FL/US)

P353 Grey Matter Disease Distributions in a Colombian Cohort of Patients with


Pablo Reyes (Bogota/CO), Hernando Santamaría-Garcia (Bogota, Bogotá/CO),

Felipe Uriza, Angela Martinez (Bogota/CO), Angela Iragorri, Diana Matallana, Jose

Santacruz, Carlos Cano (Bogota, Bogotá/CO), Katya Rascovsky, Corey MacMillan,

Murray Grossman (Philadelphia, PA/US)

P354 EEG dominant frequency peak differentiates between Alzheimer’s disease and

frontotemporal lobar degeneration.

Joery Goossens (Antwerp/BE), Jorne Laton, Jeroen Van Schependom, Jeroen

Gielen (Brussels/BE), Hanne Struyfs, Sara Van Mossevelde, Tobi Van den Bossche,

Johan Goeman, Peter Paul De Deyn, Anne Sieben, Jean-Jacques Martin, Christine

Van Broeckhoven, Julie van der Zee (Antwerp/BE), Guy Nagels (Brussels/BE),

Sebastiaan Engelborghs (Antwerp/BE)

P355 The sAPPβ/YKL-40 ratio in cerebrospinal fluid as a novel diagnostic marker in

frontotemporal lobar degeneration-related syndromes: a multicentre study

Daniel Alcolea, Eduard Vilaplana, Marc Suárez-Calvet, Rafael Blesa, Jordi Clarimon

(Barcelona, Madrid/ES), Albert Lladó, Raquel Sánchez-Valle, José L. Molinuevo


46

(Barcelona/ES), Guillermo García-Ribas (Madrid/ES), Yaroslau Compta, María José

Martí (Madrid, Barcelona/ES), Gerard Piñol-Ripoll (Lleida/ES), Guillermo Amer-

Ferrer, Aina Noguera, Ana García-Martín (Palma de Mallorca/ES), Juan Fortea,

Alberto Lleó (Barcelona, Madrid/ES)

P356 CSF exploratory biomarker study for (differential) diagnosis of frontotemporal lobar

degeneration.

Joery Goossens, Julie van der Zee (Antwerp/BE), Sara Van Mossevelde (Antwerp,

Edegem/BE), Eugeen Vanmechelen (Ghent/BE), Tobi Van den Bossche (Antwerp,

Edegem/BE), Bart De Vil, Anne Sieben, Jean-Jacques Martin (Antwerp/BE), Patrick

Cras (Edegem, Antwerp/BE), Johan Goeman, Peter Paul De Deyn, Christine Van

Broeckhoven, Sebastiaan Engelborghs (Antwerp/BE)

P357 Dynamic connectivity state oscillations in presymptomatic GRN disease: from

Connectome to Chronnectome.

Enrico Premi (Brescia/JM), Matteo Diano (Turin/IT), Stefano Gazzina (Brescia/IT),

Franco Cauda (Turin/IT), Silvana Archetti, Roberto Gasparotti, Alessandro Padovani,

Barbara Borroni (Brescia/IT)

P358 Structural deficits and altered network connectivity in presymptomatic C9ORF72

Suzee Lee, Ana C. Sias, Maria Luisa Mandelli, Jesse A. Brown, Alainna B. Brown

(San Francisco/US), Anna M. Khazenzon (Stanford/US), Anna A. Vidovszky,

Theodore P. Zanto, Anna M. Karydas (San Francisco/US), Mochtar Pribadi, Giovanni

Coppola, Dan H. Geschwind (Los Angeles/US), Rosa Rademakers (Jacksonville/US),

Maria Luisa Gorno-Tempini, Howard J. Rosen, Bruce L. Miller, William W. Seeley

(San Francisco/US)

P359 Longitudinal decline of cerebral glucose metabolism in Frontotemporal Lobar

Degeneration Continuum

Alexandre Bejanin, Nagehan Ayakta, Daniel R Schonhaut, Gabe Marx, Gautam

Tammewar, Yann Cobigo, Faye McKenna, Leonardo Iaccarino, Marilu Gorno-

Tempini, Bruce L. Miller, William J. Jagust, Howard J. Rosen, Gil D. Rabinovici (San

Francisco/US)

P360 Serum neurofilament light chain protein is a measure of disease intensity in


Ione Woollacott, Jonathan Rohrer, Katrina Dick, Emilie Brotherhood, Elizabeth

Gordon, Alexander Fellows, Jamie Toombs, Ronald Druyeh, M. Jorge Cardoso,

Sebastien Ourselin, Jennifer Nicholas (London/GB), Niklas Norgren (Umea/SE),

Simon Mead (London/GB), Ulf Andreasson, Kaj Blennow (Gothenburg/SE), Jonathan

Schott, Nick Fox, Jason Warren (London/GB), Henrik Zetterberg (London,

Gothenburg/SE)

P361 Default, salience, and executive control network functional connectivity changes in

behavioural variant FTD and Alzheimer’s disease

Juan Wang, Adeline Ng, Joseph Lim, Boon Linn Choo, Christabel See, Levinia Lim,

Ting Ting Yong, Russell Chander, Heidi Foo, Angeline Zhang, Joanna Su, Ashwati

Vipin, Simon Ting, Shahul Hameed, Nagaendran Kandiah, Helen Zhou

(Singapore/SG)

P362 Principal Component Analysis of [18F]-AV-1451 Tau PET in Alzheimer Disease and


Karl Friedrichsen, Shruti Mishra, Nupur Ghoshal, Brian Gordon, Nelly Joseph-

Mathurin, Yi Su, Jon Christensen, Patricia Aldea, Jon McConathy, Beau Ances, Nigel

Cairns, John Morris, Tammie Benzinger (Saint Louis/US)


47

P363 Grey matter network differences between behavioural variant Frontotemporal

Dementia and Alzheimer’s disease

Everard Vijverberg (Amsterdam, The Hague/NL), Betty Tijms, Joana Dopp, Yun

Jeong Hong, Philip Scheltens, Frederik Barkhof, Yolande Pijnenburg

(Amsterdam/NL)

P364 The REGISTRY FOR EARLY-ONSET DEMENTIA AND CAREGIVERS IN HONG

KONG (REACH) study – clinical characteristics of FTD patients in Hong

Kong

Bonnie Yin Ka Lam, Lisa Wing Chi Au, Adrian Wong, Valerie Wong, Lorraine Law, Liz

Yuen, Vincent Chung Tong Mok (Hong Kong/HK)

P365 Distinct subcortical atrophy patterns across four different neurodegenerative

syndromes

Julia Neitzel, Mallissa Watts, Janine Diehl-Schmid, Marion Ortner, Timo Grimmer,

Igor Yakushev (Munich/DE), Peter Bublak, Christoph Preul (Jena/DE), Kathrin Finke,

Christian Sorg (Munich/DE)

P366 Testing the network degeneration hypothesis for intrinsic brain networks and four

distinct neurodegenerative syndromes

Julia Neitzel (Munich/DE), Mallissa Watts, Janine Diehl-Schmid, Marion Ortner, Timo

Grimmer, Igor Yakushev (Munich/DE), Peter Bublak, Christoph Preul (Jena/DE),

Kathrin Finke, Christian Sorg (Munich/DE)

P367 Neurofilament light chain: a biomarker for disease onset and survival in genetic


Lieke Meeter, Elise Dopper, Lize Jiskoot (Rotterdam/NL), Raquel Sanchez-Valle

(Barcelona/ES), Caroline Graff (Stockholm/SE), Luisa Benussi, Roberta Ghidoni

(Brescia/IT), Yolande Pijnenburg (Amsterdam/NL), Barbara Borroni (Brescia/IT),

Daniela Galimberti (Milano/IT), Robert Jr Laforce (Québec/CA), Mario Masellis

(Toronto/CA), Rik Vandenberghe (Leuven/BE), Isabelle Le Ber (Paris/FR), Markus

Otto (Ulm/DE), Rick van Minkelen, Janne Papma (Rotterdam/NL), Serge Rombouts

(Leiden/NL), Mircea Balasa (Barcelona/ES), Linn Öijerstedt, Vesna Jelic

(Stockholm/SE), David Cash, Sophie Harding, M Jorge Cardoso, Sebastien Ourselin,

Katrina Dick, Martin Rossor (London/GB), Giuliano Binetti, Alessandro Padovani

(Brescia/IT), Elio Scarpini, Chiara Fenoglio (Milano/IT), Carmela Tartaglia

(Toronto/CA), Foudil Lamari (Paris/FR), Christian Barro, Jens Kuhle (Basel/CH),

Jonathan Rohrer (London/GB), Charlotte Teunissen (Amsterdam/NL), John van

Swieten (Rotterdam, Amsterdam/NL)

P368 Novel CSF biomarkers discriminating FTLD-TDP from non-demented controls.

Marta del Campo, Naura Elias, Marleen Koel-Simmelink, Lynn Boonkamp

(Amsterdam/NL), Daniela Galimberti (Milan/IT), William Hu (Atlanta/US), Charlotte

Teunissen (Amsterdam/NL)

P369 Analysis of Frontotemporal Lobar Degeneration Patients Using Automated Magnetic

Resonance Imaging Analyzing Tool: The MRI Characteristics of C9ORF72 Expansion

Carriers

Antti Cajanus, Anette Hall, Yawu Liu (Kuopio/FI), Timo Urhemaa, Juha Koikkalainen

(Tampere/FI), Daniel Rueckert (London/GB), Steen Hasselbalch (Copenhagen/DK),

Patrizia Mecocci (Perugia/IT), Wiesje van der Flier (Amsterdam/NL), Hilkka Soininen

(Kuopio/FI), Jyrki Lötjönen (Tampere/FI), Anne Remes (Kuopio/FI)


48

P370 Accelerated Structural Gray Matter and White Matter Changes in Preclinical

Progranulin Mutation Carriers

Christopher Olm, Corey McMillan, David Irwin, Vivianna Van Deerlin, James Gee,

Murray Grossman (Philadelphia/US)

P371 Local thalamic atrophy in behavioural variant FTD

Alexander Santillo (Malmö/SE), David Jakabek (Wollongong/AU), Mark Walterfang

(Melbourne/AU), Karin Nilsson, Danielle van Westen (Lund/SE), Jeffrey Looi

(Canberra/AU), Brian Power (Fremantle/AU)

P372 STRUCTURAL BRAIN IMAGING DIFFERENTIATES BEHAVIORAL VARIANT OF

FRONTOTEMPORAL DEMENTIA FROM LATE LIFE DEPRESSION

Duygu Tosun, Howard Rosen, Jessica Zakrzewski, Bruce Miller, Joel Kramer,

Michael Weiner, Owen Wolkowitz, Craig Nelson, Scott Mackin (San Francisco/US)

P373 DIAGNOSTIC UTILITY OF ARTERIAL SPIN LABELED MAGNETIC RESONANCE

IMAGING AND FLOURODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY

IN THE BEHAVIORAL VARIANT OF FRONTOTEMPORAL DEMENTIA AND

ALZHEIMER’S DISEASE

Duygu Tosun, Norbert Schuff, Gil Rabinovici, Nagehan Ayakta, Bruce Miller (San

Francisco/US), William Jagust (Berkeley/US), Joel Kramer, Michael Weiner, Howard

Rosen (San Francisco/US)

P374 Replication of pathology-confirmed atrophy patterns via cortical thickness analysis in

dementia

Jee Hoon Roh, Jihye Hwang, Chan Mi Kim, Sohee Park, Jae-Hong Lee (Seoul/KR)

P375 Neuroanatomic and Neuropsychological Evidence of Cognitive Reserve in the ALS-

FTD spectrum

Katerina Placek, Kylie Ternes, Lauren Massimo, John Woo, Lauren Elman, David

Irwin, Murray Grossman, Corey T. McMillan (Philadelphia/US)

P376 Alteration of the brain morphometry and metabolism following donepezil treatment in

Alzheimer's disease: VBM with DARTEL and 1H-MR spectroscopy

Gwang-Woo Jeong, Choong-Man Mooon (Gwang-Ju/KR)

P377 Progranulin plasma levels predict the presence of GRN mutations but not the

development of symptoms

Daniela Galimberti, Chiara Fenoglio, Sara Cioffi, Giorgio Fumagalli, Andrea Arighi

(Milan/IT), Barbara Borroni, Alessandro Padovani (Brescia/IT), Fabrizio Tagliavini

(Milan/IT), Mario Masellis, Carmela Tartaglia (Toronto/CA), John Van Swieten, Lieke

Meeter (Rotterdam/NL), Caroline Graff (Stockholm/SE), Alexandre Mendonca

(Lisbon/PT), Jonathan Rohrer (London/GB), Elio Scarpini (Milan/IT), on behalf of the

Genetic Initiative (GENFI) (London/GB)

P378 Regional differences in FDG-PET uptake in asymptomatic FTD patients with GRN

and C9ORF72 mutations

Karteek Popuri, Mahadev Bhalla, Adrienne Buller, Sohrab Towfighi (Burnaby/CA),

Pheth Sengdy (Vancouver/CA), Claudia Jacova (Oregon/US), Rosa Rademakers

(Jacksonville/US), Howard Feldman (Vancouver/CA), Lei Wang (Chicago/US), Ging-

Yuek Hsiung, Ian R Mackenzie (Vancouver/CA), Mirza Faisal Beg (Burnaby/CA)

P379 Network measures of glucose metabolism are altered in asymptomatic FTD subjects


Pheth Sengdy (Vancouver/CA), Claudia Jacova (Oregon/US), Rosa Rademakers


49

(Jacksonville/US), Howard Feldman (Vancouver/CA), Lei Wang (Chicago/US), Ging-

Yuek Hsiung, Ian R Mackenzie (Vancouver/CA), Mirza Faisal Beg (Burnaby/CA)

P380 Network-level analysis of cortical gray matter atrophy in asymptomatic FTD subjects


Pheth Sengdy (Vancouver/CA), Rosa Rademakers (Jacksonville/US), Howard

Feldman, Ging-Yuek Hsiung (Vancouver/CA), Lei Wang (Chicago/US), Ian R

Mackenzie (Vancouver/CA), Mirza Faisal Beg (Burnaby/CA)

P381 Distinct patterns of brain atrophy in genetic frontotemporal dementia: visual rating

scales in the GENFI cohort

Giorgio Giulio Fumagalli, Paola Basilico (Milan/IT), Sophie Harding (London/GB),

Andrea Arighi (Milan/IT), Martina Bocchetta (London/GB), Matteo Mercurio (Milan/IT),

Katrina Dick (London/GB), John van Swieten (Rotterdam/NL), Barbara Borroni

(Brescia/IT), Caroline Graff (Stockholm/SE), Mario Masellis (Toronto/CA), Fabrizio

Tagliavini (Milan/IT), James Rowe (Cambridge/GB), Robert Laforce (Quebec/CA),

Elizabeth Finger (London Ontario/CA), Giovanni Frisoni (Brescia/IT), Alexandre

Mendoca (Lisbon/PT), Sandro Sorbi (Florence/IT), Elio Scarpini (Milan/IT), Jonathan

Rohrer (London/GB), Daniela Galimberti (Milan/IT)

P382 Comparison of diagnostic significance of voxel-based diffusion tensor imaging and

FDG-PET in bvFTD

Gero Lueg, Julia Julia Lange-Grumfeld, Alexis Vrachimis, Hubertus Lohmann,

Andreas Johnen, Thomas Duning (Münster/DE)

P383 Novel Connectome Approach Identifies Imaging-Genetic Associations in Sporadic


Radhika Madhavan (Bangalore/IN), Asha Singanamalli (Niskayuna/US), Rakesh

Mullick, Vivek Vaidya (Bangalore/IN), Chinnappa Kodira (Niskayuna/US), Vivianna

Van Deerlin, Murray Grossman, David Irwin, Corey McMillan (Philadelphia/US)

P384 Altered expression of non-coding RNAs in neural-derived serum exosomes in

patients with FTD

Chiara Fenoglio, Maria Serpente, Sara Cioffi, Marina Arcaro, Emanuela Oldoni,

Giorgio Fumagalli, Andrea Arighi, Paola Basilico, Alessandra Cattaneo, Laura

Porretti, Daniela Galimberti, Elio Scarpini (Milan/IT)

P385 Autosomal Dominant and sporadic Frontotemporal Lobar Degeneration: from non-

coding RNAs to the identification of preclinical biomarkers and therapeutic targets

Maria Serpente, Chiara Fenoglio, Sara Cioffi, Marina Arcaro, Emanuela Oldoni,

Andrea Arighi, Giorgio Fumagalli, Elio Scarpini, Daniela Galimberti (Milan/IT)

P386 In vivo molecular imaging of beta-amyloid and tau aggregates in monozygotic twins

with discordant clinical phenotypes

Ryan Townley, David Jones, Bradley Boeve, David Knopman, Ronald Peterson, Val

Lowe, Clifford Jack (Rochester/US)

P387 CSF neurofilament-light chain and p-Tau180/t-Tau for discrimination of

frontotemporal lobar degeneration pathology subtypes

Julio Rojas, Carole Scherling, Anna Karydas, Joel Kramer, Howard Rosen, Gil

Rabinovici, Zachary Miller, Bruce Miller, Adam Boxer (San Francisco, CA/US)

P388 18F-AV-1451 in frontotemporal dementia spectrum disorders

Richard Tsai, Alexandre Bejanin (San Francisco/US), Daniel Schonhaut (San

Francisco, Berkeley/US), Rik Ossenkoppele (Amsterdam/NL), James O'Neil, Mustafa

Janabi, Suzanne Baker (Berkeley/US), Andreas Lazaris (San Francisco/US),


50

Nagehan Ayakta, Gautam Tammewar (San Francisco, Berkeley/US), Marilu Gorno-

Tempini, Bruce Miller, Adam Boxer (San Francisco/US), William Jagust

(Berkeley/US), Gil Rabinovici (San Francisco, Berkeley/US)

P389 Differential Longitudinal Decline of White Matter Integrity in Frontotemporal Lobar

Degeneration and Alzheimer’s Disease

Gabriel Marx, Fanny Elahi, Howie Rosen (Oakland/US)

P390 Patient-tailored disease epicenters in behavioral variant frontal temporal dementia

and semantic variant primary progressive aphasia

Jesse Brown, Jersey Deng, Isabel Sible, Ana Sias, Suzee Lee, Marilu Gorno-

Tempini, Howard Rosen, Bruce Miller, William Seeley (San Francisco/US)

P391 Atlas-based volumetric MRI analysis of c9orf72 mutation carriers

Sonja Schönecker, Christiane Neuhofer, Janine Diehl-Schmid, Markus Otto,

Catharina Prix (Munich/DE), German FTLD-Consortium (Germany/DE), Bavarian

Brain Banking Alliance (Bavaria/DE), Thomas Arzberger, Dieter Edbauer, Berend

Feddersen, Thomas Klopstock, Johannes Levin (Munich/DE)

P392 Blood markers of neuroinflammation in frontоtemporal dementia

Nataliya Mikhaylova, Lubov Androsova, Svetlana Zozulya, Yana Fedorova, Igor

Kolykhalov, Tatiyana Kliushnik (Moscow/RU)

P393 Results from the Frontotemporal Lobar Degeneration Neuroimaging Initiative

(FTLDNI)

Howard Rosen (San Francisco/US), David Knopman (Rochester/US), Bradford

Dickerson (Boston/US), Brad Boeve (Rochester/US), Marissa Urbano, Alyssa

Caplan, Samara Laxineta, Bruce Miller (San Francisco/US)

P394 Decreased prefrontal cortex and posterior cingulate activation during matrix

reasoning in asymptomatic carriers of GRN mutations

Courtney Alexander (Hillsboro/US), Dasa Zeithamova (Eugene/US), Ging-Yuek R.

Hsiung, Ian Mackenzie (Vancouver/CA), Claudia Jacova (Hillsboro/US)

P395 Comparison of [18F]T807 PET regional retention patterns in FTLD-tau and FTLD-

TDP

Charles Burke, Namita Multani, Karen Misquitta, Pablo Rusjan, Alan Wilson, Sylvain

Houle, David Tang-Wai, Maria Carmela Tartaglia (Toronto/CA)

P396 Patterns of longitudinal neuroanatomical change in genetic FTD: results from the

Genetic FTD Initiative (GENFI)

Jonathan Rohrer, Martina Bocchetta, Elizabeth Gordon, David Cash, Katrina Dick,

David Thomas, Jennifer Nicholas, M Jorge Cardoso, Sebastien Ourselin

(London/GB), John van Swieten (Rotterdam/NL), Barbara Borroni (Brescia/IT),

Daniela Galimberti (Milano/IT), Mario Masellis (Toronto/CA), Caroline Graff

(Stockholm/SE), Fabrizio Tagliavini (Milano/IT), Giovanni Frisoni (Brescia/IT), Robert

Laforce Jr (Quebec/CA), Elizabeth Finger (London Ontario/CA), Alexandre Mendonca

(Lisboa/PT), Sandro Sorbi (Firenze/IT), Martin Rossor (London/GB)

P397 A case of Wilson’s disease presenting with depression as the initial symptom.

Hyuk Chang, Hyunyoung Park, JinSung Cheong (Iksan/KR)

P398 A Patient with Frontotemporal Dementia Presenting with Unilateral Apraxia.

Hyunyoung Park, Hyuk Chang, JinSung Cheong (Iksan/KR)


51

P399 DTI changes in individuals with Primary Progressive Aphasia

Daniel Preiß, Ornella Billette, Julio Acosta-Cabronero, Peter Nestor (Magdeburg/DE)

P400 Clinical, genetic and pathological stratification in frontotemporal dementia:

implications for clinical trial design.

Elizabeth Gordon, Martina Bocchetta, M. Jorge Cardoso, Sebastien Ourselin, Jason

D. Warren, Jonathan D. Rohrer (London/GB)

P401 Computational modelling of combined M/EEG in FTD: layer specific insights into

altered neurobiology during the auditory mismatch negativity.

Alexander Shaw, Laura Hughes, James Rowe (Cambridge/GB)

P402 Frailty correlates with insula hypometabolism and frontal cortex atrophy in bvFTD

Innocenzo Rainero, Martina Amanzio, Federico D'Agata, Antonello Galati, Sara

Palermo, Elisa Rubino, Milena Zucca, Lorenzo Pinessi, Giancarlo Castellano

(Turin/IT)

P403 Phenomenology and anatomy of abnormal behaviours in frontotemporal dementia as

measured by the Cambridge Behavioural Inventory

Elizabeth Gordon, Jason D. Warren, Jonathan D. Rohrer (London/GB)

P404 Alteration in plasma lipids in frontotemporal dementia

Woojin Kim, Eve Jary, Russell Pickford, Lauren Bartley, Olivier Piguet, John Hodges,

Glenda Halliday (Sydney/AU)

P405 [18F]AV1451 PET in frontotemporal dementia from a MAPT mutation

William Bevan-Jones, Thomas Cope, Luca Passamonti, Timothy Fryer, Young Hong,

Simon Jones, Jonathan Coles, Patricia Vazquez Rodriguez, Ajenthan

Surendranathan, Robert Arnold, Franklin Aigbirhio, John O'Brien, James Rowe

(Cambridge/GB)

P406 The Inverse Cingulate Island Sign in Hippocampal Sclerosis Dementia

Will Mantyh, David Knopman, Jonathan Graff-Radford (Rochester/US), Melissa

Murray, Dennis Dickson (Jacksonville/US), David Jones (Rochester/US)

P407 Serum neuron-specific enolase is increased in mild neurocognitive disorder / mild

cognitive impairment and related to white matter hyperintensities

Maryna Polyakova, Katrin Arelin, Leonie Lampe, Francisca Then, Tobias Luck,

Jürgen Kratzsch, Karl-Titus Hoffmann, Steffi Rieder-Heller, Arno Villringer, Peter

Schoenknecht, Matthias L. Schroeter (Leipzig/DE)

P408 Can Neuroimaging Measures of Hippocampal Structure Predict Alzheimer's vs. FTLD

Neuropathologies?

Lei Wang, Veronika Hanko, Kathryn Alpert, Julie Schneider, Konstantinos Arfanakis,

David Bennett (Chicago/US)

P409 [18F]AV1451 PET imaging in Semantic Dementia

William Bevan-Jones, Thomas Cope, Luca Passamonti, Patricia Vazquez Rodriguez,

Ajenthan Surendranathan, Robert Arnold, Simon Jones, Timothy Fryer, Young Hong,

Jonathan Coles, Franklin Aigbirhio, John O'Brien, James Rowe (Cambridge/GB)

P410 Presymptomatic changes in gray matter volume, white matter integrity and

neuropsychological assessment in C9orf72 mutation carriers

Jessica L. Panman (Rotterdam, Leiden/NL), Lize C. Jiskoot, Elise G.P. Dopper

(Rotterdam, Leiden, Amsterdam/NL), Serge A.R.B. Rombouts (Leiden/NL), Tom den

Heijer, Sanne Franzen (Rotterdam/NL), Yolande A.L. Pijnenburg (Amsterdam/NL),


52

Rick van Minkelen, Janne M. Papma (Rotterdam/NL), John C. van Swieten

(Rotterdam, Amsterdam/NL)

P411 Tau PET, Amyloid PET, and Structural Imaging in Primary Progressive Aphasia

Adam Martersteck, M.-Marsel Mesulam, Emily Rogalski (Chicago/US)

P412 PET Tau Imaging with AV-1451 in N279K and S305N Microtubule Associated Protein

Tau (MAPT) Mutation Carriers Relative to Alzheimer’s Disease Dementia and

Controls

Brad Boeve, David Jones, Val Lowe, Heather Wiste, Matthew Senjem, Kejal Kantarci,

David Knopman, Christina Dheel (Rochester/US), Zbigniew Wszolek, Rosa

Rademakers (Jacksonville/US), Ronald Petersen, Clifford Jack, Jr. (Rochester/US)

P413 Neurofilament light chain protein concentration in CSF and atrophy are correlated in

bvFTD patients – Data from the multicentric FTLD consortium’s study

Sebastian Meyer, Karsten Mueller, Sandrine Bisenius (Leipzig/DE), Janine Diehl-

Schmid (Munich/DE), Hans Foerstl (Leipzig, Munich/DE), Klaus Fassbender

(Homburg/DE), Jan Kassubek, Bernhard Landwehrmeyer, Albert Christian Ludolph

(Ulm/DE), Johannes Kornhuber (Erlangen/DE), Johannes Prudlo (Rostock/DE), Anja

Schneider (Goettingen/DE), Katharina Stuke, Matthias Schroeter (Leipzig/DE)

P414 Evolution from the Asymptomatic to Symptomatic State in Familial FTD: Longitudinal

Neuropsychological and MRI Findings in Three MAPT Mutation Carriers

Christina Dheel, Scott Przybelski, Matthew Senjem, Kejal Kantarci, David Jones,

Julie Fields, Mary Machulda, Clifford Jack, Jr. (Rochester/US), Rosa Rademakers

(Jacksonville/US), David Knopman (Rochester/US), Zbigniew Wszolek

(Jacksonville/US), Ronald Petersen, Bradley Boeve (Rochester/US)

P415 Neurofilament light chain, progranulin, and S-100B in longitudinal serum samples of

patients with amyotrophic lateral sclerosis

Petra Steinacker, André Huss, Benjamin Mayer, Patrick Oeckl, Dorothée Lulé,

Jochen Weishaupt (Ulm/DE), Jens Kuhle (Basel/CH), Thomas Meyer (Berlin/DE),

Susanne Petri (Hannover/DE), Albert C. Ludolph, Markus Otto (Ulm/DE)

P416 Presymptomatic cerebral perfusion biomarker changes in genetic frontotemporal

dementia: results from the GENetic Frontotemporal dementia Initiative (GENFI)

Henk Mutsaerts, Saira Saeed Mirza (Toronto/CA), Jonathan Rohrer, David Thomas,

David Cash, Enrico De Vita, Katrina Dick, Sebastien Ourselin (London/GB), John van

Swieten (Rotterdam/NL), Daniela Galimberti (Milan/IT), James B. Rowe

(Cambridge/GB), Caroline Graff (Stockholm/SE), Fabrizio Tagliavini (Milan/IT),

Robert Laforce Jr (Quebec/CA), Elizabeth Finger (London/CA), Alexandre Mendonça

(Lisbon/PT), Jo Knight (Lancaster/GB), Bradley MacIntosh, Mario Masellis

(Toronto/CA)

P417 Decreased Global Field Synchronization (GFS) is an EEG classifier of frontotemporal

dementia

Vesna Jelic (Stockhom/SE), Per Östberg (Stockholm/SE), Lars-Olof Wahlund

(Stockhom/SE), Thomas Koenig (Bern/CH)

P418 Longitudinal Arterial Spin Labeling in the Behavioral Variant of Frontotemporal Lobar

Degeneration

Faye McKenna, Yann Cobigo, Gabe Marx, Suneth Attygale, Howard Rosen, Bruce

Miller (San Francisco, CA/US)


53

P419 longstanding Bipolar Affective Disorder and Behavioral Variant Frontotemporal

Dementia. Findings in Clinical and Neuroanatomical Phenotypic Patterns.

Francy Cruz Sanabria, Rodrigo Pardo Turriago, Diana Matallana Eslava, Pablo

Reyes Gavilán (Bogotá/CO)

P420 Cerebral glucose metabolism in C9orf72 mutation carriers

Timo Grimmer, Janine Diehl-Schmid, Igor Yakushev (Munich/DE), German FTLD-

Consortium (Ulm/DE)

P421 Increased neurofilament light chain correlates with decreased white matter integrity in

presymptomatic and symptomatic granulin carriers

Jessica L. Panman (Rotterdam, Leiden/NL), Lieke H.H. Meeter (Rotterdam/NL), Elise

G.P. Dopper, Lize C. Jiskoot (Rotterdam, Leiden, Amsterdam/NL), Mark J.M.J. Bouts,

Christiane Möller (Leiden/NL), Rick van Minkelen (Rotterdam/NL), Raquel Sanchez-

Valle, Mircea Balasa (Barcelona/ES), Caroline Graff, Linn Öijerstedt, Vesna Jelic

(Huddinge, Stockholm/SE), Luisa Benussi, Roberta Ghidoni, Giuliano Binetti, Borroni

Barbara, Alessandro Padovani (Brescia/IT), Daniela Galimberti, Elio Scarpini, Chiara

Fenoglio (Milan/IT), Robert Jr Laforce (Québec/CA), Rik Vandenberghe (Leuven/BE),

Isabelle Le Ber, Foudil Lamari (Paris/FR), Markus Otto (Ulm/DE), Jonathan D.

Rohrer, David M. Cash (London/GB), Serge A.R.B. Rombouts (Leiden/NL), Charlotte

E. Teunissen (Amsterdam/NL), Janne M. Papma (Rotterdam/NL), John C. van

Swieten (Rotterdam, Amsterdam/NL)

P422 Tau-PET imaging with THK-5351 in patients with clinically diagnosed progressive

supranuclear palsy

Sonja Schönecker, Matthias Brendel, Joachim Havla, Günter Höglinger, Kai Bötzel,

Adrian Danek, Axel Rominger, Johannes Levin (Munich/DE)

P423 Multivariate diagnostic approaches in Frontotemporal lobar degeneration - Data from

the german FTLDc

Sarah Straub (Ulm/DE), Matthias L. Schroeter (Leipzig/DE), Janine Diehl-Schmid,

Adrian Danek (Munich/DE), Christine v. Arnim (Ulm/DE), Lars Bertram (Berlin/DE),

Beate Einsiedler (Ulm/DE), Klaus Fassbender (Homburg/Saar/DE), Emily Feneberg

(Ulm/DE), Klaus Fliessbach (Bonn/DE), Hans Förstl (Munich/DE), Hans-Jürgen

Huppertz (Zurich/CH), Holger Jahn (Hamburg/DE), Frank Jessen (Cologne/DE),

Elisabeth Kasper (Rostock/DE), Jan Kassubek, Hans A. Kestler (Ulm/DE), Johannes

Kornhuber (Erlangen/DE), Christian Kubisch (Hamburg/DE), Bernhard

Landwehrmeyer (Ulm/DE), Martin Lauer (Würzburg/DE), Ludwig Lausser (Ulm/DE),

Christina M. Lill (Berlin/DE), Albert Ludolph (Ulm/DE), Manuel Maler (Erlangen/DE),

Rainer Muche, Elmar Pinkhardt (Ulm/DE), Johannes Prudlo (Rostock/DE), Lina Riedl

(Munich, Rostock/DE), Anja Schneider (Göttingen/DE), Robert Schomburg

(Homburg/Saar/DE), Stefan Teipel (Rostock/DE), Ingo Uttner (Ulm/DE), Alexander E.

Volk (Hamburg/DE), Markus Otto (Ulm/DE)

P424 Functional connectivity differences between behavioral-variant frontotemporal

dementia and early-onset Alzheimer's disease

Gabriel Castrillon (Medellin, Munich/CO), Lina Velilla, Margarita Giraldo, Alejandra

Zapata, Catalina bustamante, Francisco Lopera (Medellin/CO), Yakeel Quiroz

(Medellin, Boston/US)

P425 A mass spectrometry based search for biomarkers in FTD-PGRN

Diana Nijholt, Lieke Meeter, Lennard Dekker, Jeroen van Rooij, Theo M. Luider, John

van Swieten (Rotterdam/NL)


54

11:30–13:30 Postersession III - Mechanisms of cell death

Room Ballroom

P426 Cellular changes and toxicity in mouse neuronal cell cultures produced by the

cerebrospinal fluid from motor neuron disease patients.

Alida Spalloni, Michele Nutini (Roma/IT), Antonella Alberici, Barbara Borroni,

Alessandro Padovani (Brescia/IT), Patrizia Longone (Roma/IT)

P427 Simulation of Pathogenic Protein Spread in an Artificial Neural Network

Konstantinos Georgiadis, Selina Wray, S_x0013_ebastien Ourselin, Jason D.

Warren, Marc Modat (London/GB)

P428 Regulation of synaptic growth by Rab8, IK2/TBK1 and AKT, modifiers of


Sean Sweeney, Ryan West (York/GB)

P429 The C9ORF72 repeat expansion induces apoptosis by the DNA damage response

(DDR)

Julie Atkin (Sydney/AU)

P430 Prion-like properties of fragmented α-synuclein fibrils

Airi Tarutani, Genjiro Suzuki, Aki Shimozawa, Takashi Nonaka, Shin-ichi Hisanaga,

Masato Hasegawa (Tokyo/JP)

P431 Loss-of progranulin leads to early cell type-specific changes in lysosomes of

Progranulin knockout mice

Julia Götzl, Alessio-Vittorio Colombo, Fargol Mazaheri (Munich/DE), Scott Smith

(Boston/US), Katrin Fellerer (Munich/DE), Oleg Butovsky (Boston/US), Sabina

Tahirovic, Anja Capell, Christian Haass (Munich/DE)

P432 Role of Trem2 in Neurodegeneration: A systems biology approach

Fargol Mazaheri, Gernot Kleinberger, Anna Daria, Georg Werner, Sabina Tahirovic,

Dietrich Trümbach, Sebastian Bultmann (Munich/DE), Oleg Butovsky (Munich/US),

Christian Haass (Munich/DE)

P433 Disease model for GRN-linked FTLD using patient- and engineered stem cells.

Joke Terryn, Philip Van Damme, Catherine Verfaillie (Leuven/BE)

P434 Characterization of the expression and effects of C9ORF72 in cell-based models and

human brain

Stina Leskelä, Ville Juutilainen, Mari Takalo, Mikael Marttinen, Hilkka Soininen, Mikko

Hiltunen, Anne Remes, Annakaisa Haapasalo (Kuopio/FI)

P435 Expression and function of frontotemporal dementia gene C9ORF72 in neuronal cells

Stina Leskelä, Mari Takalo, Hilkka Soininen, Anne Remes, Mikko Hiltunen,

Annakaisa Haapasalo (Kuopio/FI)

P436 Modeling frontotemporal lobar degeneration using patient-specific iPSCs and iPSC-

derived cortical neurons

Julia Japtok, Arun Pal, Benedikt Kretner, Vitaly Zimyanin, Xenia Lojewski, Marcel

Naumann, Jared Sterneckert (Dresden/DE), Tobias M. Boeckers (Ulm/DE),

Alexander Storch (Rostock/DE), Andreas Hermann (Dresden/DE)

P437 Using induced pluripotent stem cells to model C9orf72-linked Frontotemporal

Dementia


55

Elisavet Preza (London/GB), Ming Zhang, Ekaterina Rogaeva (Toronto/CA), Adrian

Isaacs, Martin Rossor, John Hardy, Selina Wray (London/GB)

P438 The “stressed” autophagy: Environmental stress triggers Tau aggregation pathology

through an m-TOR-dependent blockage of autophagic clearance

Ioannis Sotiropoulos, Joana Silva, Maria Bélem Marques (Braga,

Braga/Guimarães/PT), Akihiko Takashima (Obu/JP), Paula Ludovico, Nuno Sousa

(Braga, Braga/Guimarães/PT)

P439 Impaired TDP-43 Repression of Nonconserved Cryptic Exons in Alzheimer’s Disease

Liam Chen (Baltimore/US)

P440 Modelling dipeptide pathology in C9orf72-linked frontotemporal dementia

Sarah Ryan, Janis Bennion Callister, Joan Sim, Sara Rollinson, Stuart Pickering-

Brown (Manchester/GB)

P441 Developmental regulation of tau splicing and phosphorylation is conserved in iPSC-

neurons and disrupted by the 10+16 intronic mutation in MAPT

Teresa Sposito, Elisavet Preza, Argyro Alatza, Colin Mahoney (London/GB), Trevor

Bushell, Michele Zagnoni (Glasgow/GB), Tilo Kunath (Edinburgh/GB), Nick Fox,

Martin Rossor, John Hardy, Selina Wray (London/GB)

P442 CAGE expression profiling of the human iPS-derived neurons carrying mutations in

the C9orf72.

Ashutosh Dhingra, Elwira Pyz, Javier Simon-Sanchez, Melissa Castillo-Lizardo,

Yvonne Theurer, Ludger Schöls (Tuebingen/DE), Dagmar Timmann-Braun

(Essen/DE), Johannes Prudlo (Rostock/DE), Matthis Synofzik, Patrizia Rizzu, Peter

Heutink (Tuebingen/DE)

P443 TDP-43 aggregation reflects its loss of function at the proteome level

Sonja Prpar Mihevc (Ljubljana/SI), Emanuele Buratti, Marco Baralle, Francisco

Ernesto Baralle (Trieste/IT), Boris Rogelj (Ljubljana/SI)

P444 C9orf72 loss of function in mice produces FTD like behavioral deficits

Maria Belen Lopez Herdoiza, Baptiste Wilmet, Stéphanie Godart, Delphine Roussel,

Caroline Le Duigou, Magali Frah, Jonas Beal, Delphine Bouteiller, Sebastien

Dussaud, Gaelle Bruneteau, Isabelle La Ber, Sophie Nicole, Alexis Brice, Morwena

Latouche (Paris/FR)

P445 Intranuclear (GGGGCC)n RNA foci induce formation of paraspeckle-like structures

Simona Darovic, Maja Štalekar (Ljubljana/SI), Youn-Bok Lee (London/GB), Jure

Pohleven (London/SI), Miha Modic (Munich/DE), Marko Fonovič, Boris Turk

(Ljubljana/SI), Micha Drukker (Munich/DE), Christopher Shaw (Munich/GB), Boris

Rogelj (Ljubljana/SI)

P446 Early markers of tau pathology in young Tau.P301L mice: synaptic plasticity,

cognition and neuronal synchrony

Amira Latif-Hernandez, An Schreurs, Tariq Ahmed (Leuven/BE), Disha Shah

(Antwerp/BE), Fred Van Leuven (Leuven/BE), Annemie Van der Linden

(Antwerp/BE), Rudi D'Hooge, Detlef Balschun (Leuven/BE)

P447 A Biphasic Social Dominance Phenotype in Progranulin-insufficient Mice is

Associated With Abnormal Cell Signaling and Neuronal Morphology in the Amygdala

and Prefrontal Cortex

Andrew Arrant, Anthony Filiano, Brian Warmus, Alicia Hall, Erik Roberson

(Birmingham, AL/US)


56

P448 Production, detection, and characterization of proganulin (PGRN) and granulins

(GRNs).

Christopher Holler, Georgia Taylor, Tom Kukar (Atlanta/US)

11:30–13:30 Postersession III - Disease modulation

Room Ballroom

P449 Drug screening for progranulin-deficient FTD

James Julian Doyle, Claudia Maios, Andrew Bateman, Hugh Bennett, J. Alex Parker

(Montreal/CA)

P450 Clinical evidence for disease anticipation in C9orf72 families

Sara Van Mossevelde (Antwerp, Edegem/BE), Sebastiaan Engelborghs, Ilse

Gijselinck (Antwerp/BE), Jan De Bleecker (Ghent/BE), Julie van der Zee

(Antwerp/BE), Anne Sieben (Antwerp, Ghent/BE), Kristel Sleegers (Antwerp/BE), Rik

Vandenberghe (Leuven/BE), Tim Van Langenhove, Jonathan Baets (Antwerp,

Edegem/BE), Olivier Deryck (Edegem, Bruges/BE), Patrick Santens (Ghent/BE),

Adrian Ivanoiu (Brussels/BE), Christiana Willems (Hasselt/BE), Veerle Bäumer, Van

den Broeck Marleen, Karin Peeters, Maria Mattheijssens (Antwerp/BE), De Jonghe

Peter, Patrick Cras, Jean-Jacques Martin (Antwerp, Edegem/BE), Marc Cruts, Peter

P. De Deyn, Christine Van Broeckhoven (Antwerp/BE)

P451 Intracerebroventricular infusion of streptozotocin alters brain neurochemistry:

Embelin attenuates streptozotocin-induced neurochemical alterations and cognitive

impairment in rats

Rahul Deshmukh, Rimpi Arora (Moga/IN)

P452 The role of FTD/ALS assciated protein, TDP-43, in neurite and synapse health and

function

Rachel Atkinson, Jacqueline Leung, Carmen Fernandez-Martos (Hobart/AU), Julie

Atkin (Sydney/AU), James Vickers, Anna King (Hobart/AU)

P453 The Belgian GRN founder family anno 2016: a textbook example of phenotype

heterogeneity

Eline Wauters, Sara Van Mossevelde, Kristel Sleegers, Ilse Gijselinck, Stéphanie

Philtjens, Anne Sieben (Antwerp/BE), Tim Van Langenhove (Antwerp, Edegem/BE),

Sebastiaan Engelborghs (Antwerp/BE), Mathieu Vandenbulcke (Leuven/BE), Maria

Mattheijssens, Karin Peeters, Ivy Cuijt, Jean-Jacques Martin (Antwerp/BE), Patrick

Cras (Antwerp, Edegem/BE), Patrick Santens (Ghent/BE), Rik Vandenberghe

(Leuven/BE), Peter P. De Deyn (Antwerp, Groningen, The Netherlands/BE), Julie van

der Zee, Marc Cruts, Christine Van Broeckhoven (Antwerp/BE)

P454 Loss-of progranulin leads to a cell-autonomous lysosomal phenotype

Georg Werner, Katrin Fellerer, Christina M. Lang, Christian Haass, Anja Capell

(Munich/DE)

P455 Nature and nurture in modulating brain damage in pre-symptomatic monogenic FTD:

results from the GENFI study.

Enrico Premi (Brescia/JM), Jonathan Rohrer (London, UK/GB), Mario Grassi (Pavia,

Italy/IT), John van Swieten (Rotterdam, Netherlands/NL), Daniela Galimberti (Milan,

Italy/IT), Caroline Graff (Huddinge, Sweden/SE), Mario Masellis (Toronto,

Canada/CA), Fabrizio Tagliavini (Milan, Italy/IT), James Rowe (Cambridge, UK/GB),

Robert Laforce (Laval, QC, Canada/CA), Elizabeth Finger (London, ON,


57

Canada/CA), Giovanni Frisoni (Brescia, Italy/IT), Alexandre de Mendoça (Lisbon,

Portugal/PT), Sandro Sorbi (Florence, Italy/IT), Stefano Gazzina, Maura Cosseddu

(Brescia/IT), Silvana Archetti, Roberto Gasparotti (Brescia, Italy/IT), Marta Manes,

Alessandro Padovani, Barbara Borroni (Brescia/IT)

P456 New onset Autoimmune disease presenting in symptomatic Fronotemporal dementia

patients

Zachary Miller, Natanya Russek, Robin Ketelle, Anna Karydas, Lea Grinberg, Maria

Luisa Gorno-Tempini, Bill Seeley, Bruce Miller (San Francisco/US)

P457 Lifecourse factors and cognitive reserve in FTD: education, bilingualism, and place of

dwelling play a role

Suvarna Alladi (Bengaluru/IN), Thomas H Bak (Edinburgh/GB), Shailaja Mekala,

Divyaraj Gollahalli, Bapiraju Surampudi, Vasanta Duggirala, Jaydip Ray Chaudhuri,

Subhash Kaul (Hyderabad/IN)

P458 TDP-43 and FUS are exported from the nucleus independent of Exportin-1/CRM1

Helena Ederle, Dorothee Dormann (Planegg-Martinsried/DE)

P459 Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau

pathology in wild-type and MAPT transgenic mice

Robert Rottscholl, Marlen Lunow, Britta Jainsch (Marburg/DE), Gesine Respondek,

Matthias Höllerhage, Thomas W. Rösler, Hong Xu (Marburg, Munich/DE), Emilie

Bony, Jessica Le Ven (Châtenay-Malabry/FR), Vincent Guérineau (Gif-sur-

Yvette/FR), Isabelle Schmitz-Afonso (Gif-sur-Yvette, Mont-Saint-Aignan Cedex/FR),

Pierre Champy (Châtenay-Malabry/FR), Wolfgang H. Oertel (Marburg/DE), Elizabeth

S. Yamada (Marburg, Belém/BR), Günter U. Höglinger (Marburg, Munich/DE)

11:30–13:30 Treatment (pharmacological/ non-pharmacological)

Room Ballroom

P460 TREM2-deficiency reduces the efficacy of immunotherapeutic amyloid clearance

Xianyuan Xiang, Georg Werner (Munich/DE), Bernd Bohrmann (Basel/CH), Fargol

Mazaheri, Anja Capell, Regina Feederle (Munich/DE), Irene Knuesel (Basel/DE),

Gernot Kleinberger, Christian Haass (Munich/DE)

P461 Low-dose Lithium treatment for agitation in Frontotemporal dementia: A case series

D.P. Devanand, Gregory Pelton, Kristina D'Antonio, Jesse Strickler, William Kreisl,

James Noble, Karen Marder, Anne Skomorowsky, Edward Huey (New York, NY/US)

P462 Communication Bridge: An internet-based person centered intervention for improving

access to care and quality of life for individuals with dementia

Emily Rogalski, Marie Saxon, Marya Corden, M.-Marsel Mesulam, Kathryn Borio,

Becky Khayum (Chicago/US)

P463 Improving speech production in progressive non-fluent aphasia: a study protocol

Carlo Wilke, Marc Himmelbach, Matthis Synofzik (Tuebingen/DE)

P464 INTERACTIVE SYSTEM DESIGN TO MAINTAIN FUNCTIONALITY IN FTLD

PATIENTS.

Angela Martínez (Bogotá, Lyon/CO), Daniela Patino-Hernandez, Elkin García-

Cifuentes, Silvia Suarez, Andrea Patiño, Carlos A. Cano-Gutiérrez, Omar Ramírez

Perez, Diego A. Chavarro-Carvajal (Bogotá/CO)


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P465 Neuroprotective effects of Cerebrolysin in triple repeat (3R) tau transgenic model of

Pick’s disease and fronto-temporal tauopathies

Edward Rockenstein, Kirenjeet Ubhi, Michael Mante, Jazmin Florio, Anthony Adame

(La Jolla/US), Stefan Winter, Dieter Meier (Unterach/AT), Eliezer Masliah (La

Jolla/US), Hemma Brandstaetter (Unterach/AT)

P466 Disease Modifing Treatment for a bvFTD case.

Mikel Tainta, Myriam Barandiarán, Alazne Gabilondo, Fermin Moreno, Begoña

Indakoetxea, Adolfo López de Munain (San Sebastian/ES)

P468 Non-invasive salience network modulation in behavioral variant frontotemporal

dementia: preliminary results from a case series

Lorenzo Pini (Brescia/IT), Ilaria Boscolo Galazzo (Verona, London/IT), Chiara

Cobelli, Clarissa Ferrari, Maria Cotelli (Brescia/IT), Giovanni Battista Frisoni (Brescia,

Geneva/IT), Rosa Manenti (Brescia/IT), Francesca Benedetta Pizzini (Verona/IT),

Michela Pievani (Brescia/IT)

P469 Identification of best-practice-strategies in caring for people with behavioral variant

frontotemporal dementia (bvFTD): Exploration of clinical expertise - Study protocol

Claudia Dinand (Witten/DE), Martin Berwig (Witten, Leipzig/DE), Margareta Halek

(Witten/DE)

P470 Efficacy of a group visual art therapy with frontotemporal dementia patients: a pilot

study

Silvia Fostinelli, Guido Uggeri, Michela Facchinetti, Luisa Benussi, Roberta Ghidoni,

Giuseppina Di Giovanni, Giuseppe Rossi, Elena Bertocchi, Rosaria Pioli, Giuliano

Binetti (Brescia/IT)

P471 Application of MarteMeo® Counselling to people with behavior variant frontotemporal

dementia and their caregivers (AMEO-FTD) – Study protocol for a feasibility study

Martin Berwig (Witten, Leipzig/DE), Claudia Dinand, Margareta Halek (Witten/DE)

P472 Effect of repetitive transcranial magnetic stimulation on cognitive, behavioral and

emotional functioning in behavioral variant of frontotemporal dementia

Katarzyna Kowalska, Jakub Antczak, Marta Banach, Aleksandra Klimkowicz -

Mrowiec (Kraków/PL)

P473 Advanced frontotemporal dementia - an indication for palliative care?

Lina Riedl, Janine Diehl-Schmid (Munich/DE)

P474 Improvement of speed processing and neuropsychiatric symptoms in Fronto-

Temporal Dementia after transcranial Direct Current Stimulation

Simona Gardini (Parma/IT), Roberta Ferrucci, Fabiana Ruggiero, Maurizio Vergari,

Francesca Mameli (Milan/IT), Marco Spallazzi, Federica Barocco, Anna Miucci

(Parma/IT), Andrea Arighi (Milan/IT), Paolo Caffarra (Parma, Parma, italy/IT), Elio

Scarpini, Alberto Priori (Milan/IT)

P475 Targeting tau protein in therapy of human tauopathies: Can we use the same vaccine

for treatment of various tau neurodegenerative diseases?

Norbert Zilka, Branislav Kovacech, Eva Kontsekova, Michal Novak (Bratislava/SK)

P476 Frontotemporal dementia (FTD): A review and a general approach to non-

pharmacological treatment – the Hong Kong experience

Connie Tin Yee YAN, Joshua TSOH, Daphne ST LAW (Hong Kong/HK)


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P477 Study design of a phase 2 randomized controlled trial of intranasal oxytocin for

symptomatic treatment in FTD

Elizabeth Finger (London/CA), Harold Feldman (San Diego, Vancouver/US), Jeffrey

Cummings (Las Vegas/US), Adam Boxer (San Francisco/US)

P478 Clinical drug trials in behavioral variant frontotemporal dementia: problems and

challenges

Janine Diehl-Schmid (Munich/DE)

13:30–14:50 Session 10: Disease modulation

Room Lecture Hall

Chairs Christian Haass (Munich/DE), Don Cleveland (San Diego, CA/US)

13:30 Gene silencing therapy for human neurodegenerative disease

Don Cleveland (San Diego, CA/US)

13:55 Therapeutic reduction of ataxin 2 improves motor performance and extends lifespan

in a mouse model of TDP-43 proteinopathy

Aaron Gitler (Stanford, CA/US)

14:20 hnRNP proteins as general enhancers or suppressors of TDP-43 gain- and loss-of-

function pathological properties

O18 Emanuele Buratti, Chiara Appocher, Sara Cappelli, Cristiana Stuani, Maurizio

Romano, Fatemeh Mohagheghi, Fabian Feiguin (Trieste/IT)

14:35 Reducing levels of Tmem106b as a therapeutic strategy in an FTLD-TDP mouse

model

O19 Alexandra Nicholson, Ralph Perkerson, Jeannie Chew, Aishe Kurti, Tammee

Parsons, Emilie Perkerson, Karen Jansen-West, Monica Castanedes-Casey, Linda

Rousseau, Jeannette Stankowski, Dennis Dickson, John Fryer, Leonard Petrucelli,

Rosa Rademakers (Jacksonville/US)

15:10–16:40 Session 11: Treatment

Room Lecture Hall

Chairs Adam Boxer (San Francisco, CA/US), Jonathan Rohrer (London/GB)

15:20 A phase 3 trial of the tau and TDP-43 aggregation inhibitor, leuco-methylthioninium-

bis(hydromethanesulfonate) (LMTM), for behavioural variant frontotemporal dementia

(bvFTD)

O20 Howard Feldman (La Jolla/US), Serge Gauthier (Quebec/CA), Lon Schneider (Los

Angeles/US), Gordon Wilcock (Oxford/GB), Giovanni Frisoni (Geneva/CH), Peter

Bentham (Birmingham/GB), Jiri Hardlund (Aberdeen/GB), Karin Kook (Bethesda/US),

Damon Wischik, Bjoern Schelter, John Storey, Charles Harrington, Claude Wischik

(Aberdeen/GB)

15:35 An 8-week, Open-label, Dose-Finding Study of Nimodipine for the Treatment of

Progranulin Insufficiency from GRN Gene Mutations

O21 Sharon Sha (Palo Alto/US), Zachary Miller, Sang-Won Min, Yungui Zhou, Laura Mitic,

Anna Karydas, Mary Koestler, Richard Tsai, Chiara Corbetta-Rastelli, Sophie Lin,

Emma Hare, Jesse Brown, Ryan Fitch, Ryan Powers, Lauren Herl Martens (San

Francisco/US), Mehrdad Shamloo (Palo Alto/US), Anne Fagan (St. Louis/US), Robert

Farese, Jr., William Seeley, Rodney Pearlman, Bruce Miller, Li Gan, Adam Boxer

(San Francisco/US)


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15:50 Clinical trial of COMT-inhibition in 28 patients with FTD

O22 Edward Huey (New York, NY/US), Venkata Mattay (Baltimore, MD/US), Christopher

Habeck, Masood Manoocheheri (New York, NY/US), Nicole Armstrong (Baltimore,

MD/US), D.P. Devanand (New York, NY/US), Daniel Weinberger (Baltimore, MD/US),

Jordan Grafman (Chicago, IL/US)

16:05 Panel discussion: Update and future directions on clinical trials in FTD and

associated disorders

Adam Boxer (San Francisco, CA/US), Jonathan Rohrer (London/GB)

16:40–17:00 Closing Remarks

Room Lecture Hall

Chairs Janine Diehl-Schmid (Munich/DE), Manuela Neumann (Tuebingen/DE)

ICFTD 2016 Program August 31, 2016 Scientific Program€¦ · 15:42 Embodied Cognition of Dynamic...

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