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    UNIVERSITATEA DE ŞTIINŢE AGRONOMICE ŞI MEDICINĂ VETERINARĂBUCUREŞTI

    FACULTATEA DE BIOTEHNOLOGII

    PROIECT

    DISCIPLINA: BIOTEHNOLOGII ALIMENTARE

    CADRU DIDACTIC:

    NASTASIA BELC

    STUDENTE:

    CHIVU IOANA-CRISTINA

    DRĂGAN ANDREEA-ALEXANDRA

    Grupa 6!

     

    BUCURE TI "!#$Ș

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    DENUMIREA PROIECTULUI:

    BACTERIOCINE%ANTIBIOTICE PRODUSE DE BACTERIILACTICE

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    CUPRINS

    • INTRODUCERE

    1. ANTIBIOTICE-ASPECTE GENERALE1.1BACTERIOCINELE: DEFINITIE SI ROLURI2. CLASIFICAREA BACTERIOCINELOR 

    2.1STABILITATEA BACTERIOCINELOR 2.2 PROPRIETATILE BIOFARMACEUTICE ALE BACTERIOCINELOR 

    3. BACTERIOCINELE-CA SUBSTANTE3.1 BACTERIOCINE SINTETIZATE DE BACTERII GRAM – 3.2 BACTERIOCINE SINTETIZATE DE BACTERII GRAM+

    4. IZOLAREA SI PURIFICAREA BACTERIOCINELOR 4.1 METODE DE PURIFICARE

    5. CONCLUZII

    6. REFERINTE BIBLIOGRAFICE

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    INTRODUCERE

    Ba!"#$%$&"'" a( )%*! "*%,"#$!" " !#" A. G#a!$a & a&(' 1/25 .E' (!a &%$ 0"!%" "%0%##" a a!"#$$'%# a#" a( (* 'a "*%,"#$#"a a &%$ a&!$$%!$" a# $ 'a "*%,"#$#"aș a!"#$%)a$'%#. P#$0a a!"#$%$& "*%,"#$! " A. G#a!$a a )%*! &(0$! %'$$& "%a#"" a%0%#! a!"#$a E. %'$. 

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    Ba!"#$$'" 'a!$" ,%! ,#%(" *(*!a&8" ( ")"! a&!$$%!$ a: ('a#$$&a a$%)$'$&aa#" ,%! #$ $&"a#"a %'$'%# a*!#%$&!"*!$&a'". U&"'" a!"#$$ 'a!$" *" ,%! aa,!a &%#a&$*0(' (0a& "%a#"" a( !"0,"#a!(#a %,!$0 " 3@C (0 a# )$ "'" $%'a!" $& 0$#%$%!a$&!"*!$&a' a *(a#$'%# La!%a$''(* a$%,$''(* 7$ La!%a$''(* $)$(*=.

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    #%ANTIBIOTICELE-ASPECTE GENERALE

    A&'()(*'(+,, #"a  ντί- contra, βίος- via ăἀ ț  = *(&! % #(, " 0"$a0"&!" a#"*" )%'%*"* 'a !#a!a0"&!(' %'$'%# $&)" $%a*" ,#%%a!" " a!"#$$. A&!$$%!$"'" *(&!ț)%'%*$!" a!%#$! a $(&$$ '%# a!"#$$" " a %0%#ț  a!"#$$'" *a( ,#%!%%a#"'".

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    •  a!"#$%*!a!$ " )#&a#" a &0(' $#$$ a!"#$$'%#ț

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    A&'()(*'(+,

    https://ro.wikipedia.org/wiki/Limba_greac%C4%83https://ro.wikipedia.org/wiki/Limba_greac%C4%83

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    #%#BACTERIOCINELE: DEFINITIE SI ROLURI

    Ba+',r(*+(&a "*!" % ,",!$ *a( % ,#%!"$& " $0"&*$(&" 0$. Ba!"#$%$&"'" *(&!

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    https://ro.wikipedia.org/wiki/Peptid%C4%83https://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Sensibilitate_la_cvorumhttps://ro.wikipedia.org/wiki/Antibiotichttps://ro.wikipedia.org/wiki/Antibiotichttps://ro.wikipedia.org/wiki/Peptid%C4%83https://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Sensibilitate_la_cvorumhttps://ro.wikipedia.org/wiki/Antibiotic

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    "%CLASIFICAREA BACTERIOCINELOR 

    Ba!"#$%$&"'" *(&! 'a*$)$a!" (, $)"#$!" #$!"#$$ :

    • (, !$,(' " a!"#$$ a#" '" ,#%(: a!"#$%$&" ,#%(*" " a!"#$$'" " %'%#a $"țG#a0 ,%$!$" $ a!"#$%$&" ,#%(*" " a!"#$$'" "ș  %'%#a $" G#a0ț  &"a!$"

    • (, 0"!%a & a#" %0%a# a!"#$$'": $*!#( 0"0#a&a "'('a# a!$%&"a ,#"(0 %&('"a *a( % "%9$#$%&('"a "!.

    • (, $&)%#0a $a "&"!$: *(&! %$)$a!" &ț   ,'a*0$" " $0"&*$(&$ 0$$ *a( 0a#$ *a(*(&! %$)$a!" #%0%%0a'

    • (, 0"!%a ,#$& a#" *(&! ,#%(*": *(&! ,#%(*" *a( &( "  #$%%0$ *()"# *a( &(0%$)$#$ ,%*!-!#a&*'a $%&a'"ț

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    N(2(&a

    https://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Plasmidhttps://ro.wikipedia.org/wiki/Plasmidhttps://ro.wikipedia.org/wiki/Ribozomhttps://ro.wikipedia.org/wiki/Ribozomhttps://ro.wikipedia.org/wiki/Acid_lactichttps://ro.wikipedia.org/wiki/Acid_lactichttps://ro.wikipedia.org/wiki/Acid_lactichttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Colora%C8%9Bie_Gramhttps://ro.wikipedia.org/wiki/Plasmidhttps://ro.wikipedia.org/wiki/Ribozomhttps://ro.wikipedia.org/wiki/Acid_lactic

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    • C'a*a II: $&'(" a!"#$%$&"'" " 0$$ $0"&*$(&$ #"$*!"&!" 'a !"0,"#a!(#$ #$$a!".

    A"a*!a 'a*a a )%*! $0,a#!$!a $& 3 *('a*":1. C'a*a II a: ,",!$" a!$" $0,%!#$a L$*!"#$a  #",#""&!a&!$ a#a!"#$*!$$

    *(&! ,"$%$& PA - 1 "&"0a .a. 1//@ = $ *a;a$& P.ș ș2. C'a*a II :)%#0a! $&!#-(& %0,'"9 " %(a ,",!$" $)"#$!" . A"*!"

     ,",!$" a( ,( $& *a( &$$ % a!$$!a!" $ *" ,a#" &( "9$*! *$0$'a#$! $ "ț ș ț*""& &!#" ,",!$"'" %0,'"0"&!a#" . I& a"*! #(, *(&! 'a!%%$& Gț$ ,'a&!a#$$&* " EF .ș

    3. C'a*a II : P",!$" 0$$ *!a$'" !"#0$ a#" *(&! !#a&*,%#!a!" " ,",!$"'$"# . I& a"*! *('a* *(&! *$!" &(0a$ a!"#$%$&* $"#$$& A $șa$%$& B.

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    4. C'a*a II : *(&! a!"#$%$&" '$&$a#" '%!%%$&a O=5. C'a*a II " *(&! a!"#$%$&" &"#$%%0a'" 0$#%$&a E4/2= %a!" $&

    *"#$&a $& #"$(&"a a#%9$ !"#0$&a'a.

    • C'a*a III: $&'(" a!"#$%$&" " $0"&*$(&$ 0a#$ H1 ;Da= a#" &( *(&! #"$*!"&!" 'a

    *$0#$'" " !"0,"#a!(#". & a"a*! 'a* *(&! "'"!$$&* %"#"# $ 'a"&a00"# ș

    1/?6= $ a(a0 .a. 1//2 = a$%)$'$$& A $ 'a!a$&* A $ B.C"'" 0a$ 0('!"ș ș ș ș$&!#" a!"#$%$&" ( #"(!a!" 0%'"('a# 0$ *(&! a!$%&$ 'a ,J @. $ a"*! '(#( ,a#"șa )$ % a#a!"#$*!$ (&$)$a!%a#" a!! a 'a&!$$%!$"'%# $ &%&'a&!$$%!$"'%# C$&!a* %'a ș21 = . La&!$$%!$"'" *(&! "'" 0a$ *!($a!" $ "9,'%#a!" $&(*!#$a'. N$*$&a (& 'a&!$$%!$ș ,#%(* " %$"$ " La!%%(* 'a!$* *(*, . 'a!$* "*!" (!$'$a! a (& a$!$ & ,#%(*"'"a'$0"&!a#" .T%a!" a#$a&!"'" " &$*$& *(&! a!$" 0,%!#$a a!"#$$'%# G#a0 - ,%$!$" (0 a# )$ L$*!"#$a *, M$#%%(* *, $ " a*"0"&"a ," a!"#$$ *,%#('a!" (0 a# )$șBa$''(* *, $ C'%*!#$$(0 *, G%&a'" - Ma#!$&" "! a' 23 = .ș  .

    A"*!" a!"#$%$&" *" $0,a#! $&:• C'a*a IIIa a#" *(&! "&$0" a!"#$%'$!$" " '$"aa "'('"'" *"&*$$'" "&!"#%'$$&a A=•

    C'a*a III *(&! ,#%!"$&" &"'$!$" a"$$&a ?=

    "%%STABILITATEA BACTERIOCINELOR 

    U&"'" *!($$ " a#a!"#$a#" a a!"#$%$&"'%# a#a! a"*!" 0%'"('" ,%! )$ a!$" &a&(0$!" $&!"#a'" " !"0,"#a!(# $ ,J . S"&*$$'$!a!"a 'a "&$0" ,#%!"%'$!$" "$"& $aș ța#a!"#$*!$a ,#%!"$)%#0a 'a a!"#$%$&" D" Ma#!$&* $ %'a 23= . I&a!$a#"a %0,'"!ș*a( #"("#" *"0&$)$a!$ a a!$$! $$ a&!$0$#%$"&" a a!"#$%$&"'%# ST2?MS $ ST26MSț ș ,#%(*" " La!%a$''(* ,'a&!a#(0 $%'a! " 0"'a* a )%*! %*"#a! (, !#a!a0"&!(' ( ,#%!"$&aa ,#%&aa ,",*$& $ !#$,*$& . A"*!" a!"#$%$&" a( #0a* *!a$'" (, $&(a#"ș ,"&!#( 2 'a a'%#$ " ,J &!#" 2. $ 12. . N( a )%*! $"&!$)$a!a &$$% *a"#" & a!$$!a!"așa&!$a!"#$a& (, / " 0$&(!" 'a 1C *a( 2 " 0$&(!" 'a 121 C T%#%% $ D$;* ș25 = .Ca#a!"#$*!$a !%'"#a& a !"#0$ a# ,(!"a )$ '"a!a&" *!#(!(#a 0%'"('a# aț a!"#$%$&"'%# " %$"$ %0,(*" $& ,",!$" 0$$ )# *!#(!(#a !"# $a#a T%#% 25= .ț

    "%" PROPRIETATILE BIOFARMACEUTICE ALE BACTERIOCINELOR 

    Ba!"#$%$&"'" $&'( 0%'"('" ( $0,%#!a&!a $%)a#0a"(!$a a!%#$!a a!$$!a!$$a&!$0$#%$"&" ," a#" % 0a&$)"*!a ( ,#"a"#" $0,%!#$a (&%# !(',$&$ ,a!%"&" " "9"0,'(:Candida albicans, Bacillus cereus *$K*a( Staphylococcus aureus=. S(&! *$&!"!$a!" $&!#a"'('a# 'a&$"' #$%%0a'= a# ,#$& 0"a&$*0" *,"$)$" *(&! "'$"#a!" $& 0"$(' "9!"#$%#.

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    F$(#a 1. T(',$&a " La!%a$''(* *,. La 0$#%*%,

    T(',$&$'" " a!"#$$ 'a!$" F$(#a 1= ,#%( ," 'a&a a!"#$%$&" % *"#$" " a'!$%0,(*$ *"(&a#$ a#" a( % a!$(&" *"0&$)$a!$a $0,%!#$a !(',$&$'%# ,a!%"&". P#$&$,a'a#(,a " %0,(*$ % #",#"$&!a a$$$ %#a&$$ " "9"0,'(: a$ 'a!$ a$ a"!$= a#" *a ,J-('.

    Ba!"#$%$&"'" *" $&a#"aa $& #(,a %0,(*$'%# ,#%!"$$ a# $& )$&a' a!$(&"a *" !#a(" ,#$& $&$a#"a (&%# #(," 'a#$ " !(',$&$ 0$#%$"&" G#a0 ,%$!$" *$ #a0 &"a!$". E)"!('%&*"#a&! 0a&$)"*!a! ,#$& #"*!"#"a ,"#$%a"$ " a'a$'$!a!" "*!" %*"#a! $& "&"#a' ,"&!#( (&%&*%#!$( " !(',$&$ 'a!$" *$ 0&a$ #a# ,"&!#( a!$(&"a (&"$ *$&(#" !(',$&$ ,"'"!$%&a!". S$&!"aa"*!%# %0,(*$ *" )a" ," a'" )"#0"&!a!$a.

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    aa(a *$ %0,"!$!$a )a!a " *$!(*(#$'" " )$9a#" a#" $&)'("&!"aa a,a$!a!"a " %'%&$a#" *$ "#"0a&"&!a 'a &$"' $&!"*!$&a'. C#"*!"#"a a,a$!a!$$ " *$&!"a a a"*!%# 0"!a%'$!$ *"(&a#$ *$#"*!"#"a " "'('" $a$'" 'a &$"' $&!"*!$&a' (,a $&"!a#"a a0$&$*!#a#$$ ,#%(*('($ "'('"'$%)$'$a!" " a!"#$$ 'a!$"- F$(#a 2= #",#"$&!a 0a#$#"a a,a$!a!$$ " #"a!$" a %#a&$*0('($ 'a ,#""&!a (&%# ,a!%"&$ *a( $&$a#"a a!$(&$$ $&!#-(& ,#%(* a'$0"&!a#. P%!"&!$a'(' a&!$0$#%$a&#",#"$&!a *(0a a!$(&$'%# $)"#$!$'%# %0,(*$ a&!$0$#%$"&$ ," a#" !(',$&a 0$#%$a&a $$ ,%a!"*$&!"!$a $&!#-(& 0"$( ")$&$! $& (&$!a!"a " !$0,. T%a!" a"*!"a %# ")$&$ a'%a#"a $%'%$a a

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    (&"$ !(',(&$ &a% $%'a!" *$ %# #",#""&!a a#a&!$a ")"!('($ %!$&(! $& %&$!$$'" (&"$ a0$&$*!#a#$$& $%.

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    %BACTERIOCINELE-CA SUBSTANTE

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    Ca#&%a!"#$(0 ,$*$%'a )%# !" %&!#%' %) L$*!"#$a 0%&%!%"&"* $&a((0,a;a" 0"a!. F%% M$#%$%'. Pa#aa . L."! a'. B#a$'$a& A#$"* %)B$%'% a& T"&%'% 542 S$! R. S(a% . C%*!a M. a& C$a0,$ L.23= E))"!* %) a a!"#$%$&-'$;" $&$$!%# *(*!a&" )#%0 Ca#&%a!"#$(0 ,$*$%'a aa$&*! (0a& a& *a'0%& $*%'a!"* %) L$*!"#$a 0%&%!%"&"*. I&!. .F%% M$#%$%'. S$! R. P. BX#Y(" P. A. C%*!a M. E. C$a0,$ L. R. a&B#$!% C. S. 26= Ba!"#$%$& '$;" *(*!a&" ,#%(!$%& Ca#&%a!"#$(0 ,$*$%'a $& a %&!$&(%(* **!"0 $! !#"" ('!(#" #%%!*. *!( %) a&!a%&$*0

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    http://www.microbialcellfactories.com/content/13/S1/S3https://ro.wikipedia.org/wiki/Bacteriocin%C4%83http://www.microbialcellfactories.com/content/13/S1/S3https://ro.wikipedia.org/wiki/Bacteriocin%C4%83