I Zapolsky, E Kyzar , S Gaikwad , A Roth, J Green,
description
Transcript of I Zapolsky, E Kyzar , S Gaikwad , A Roth, J Green,
I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff
(New Orleans, USA)
ZEBRAFISH NEUROPHENOME PROJECT
The ZNP was started by the ZNRC, and is dedicated toward producing a ZND
Let’s start by defining these acronyms
The ZNRCZebrafish Neuroscience Research Consortium
Allan Kalueff - USA Georgianna Gould - USA Oliver Braubach - Canada Anderson Manoel Herculano - Brazil David Echevarria - USA Joe Schroeder - USA Jason Warnick - USA Dominic Wright - SwedenCarla Denise Bonan - BrazilMônica Ryff Moreira Roca Vianna - BrazilZofia Zukowska - USA
The main goal of ZNRC is to promote zebrafish neuroscience research.
Created in February 2010, ZNRC offers excellent networking opportunities and peer support for active zebrafish labs.
ZNDZebrafish Neurophenome Database
Goals:PioneeringAccessibleEasy to useUseful
Emerging Model Organism
The Zebrafish is an emerging model animal for vertebrate development and neurological function
Offers a good compliment to other animal models
Advantages Easy to take care of Inexpensive Easy to test Quantifiable behavioral endpoints
Inspiration
MiceMouse Genome
Informatics (G+P)Mouse Phenome
Database (P) Rats
Rat Genome Database (G)
National BioResource Project (P)
ZebrafishZFIN (Genome)NCBI (Genome)
The point?A Phenome
database for the Zebrafish does not yet exist, but inevitably will sometime soon
PubMed search“zebrafish”
1900-1985 - 61 papers1985-1990 - 114 papers1990-1995 - 487 papers1995-2000 - 1981
papers2000-2005 - 4946
papers2005-2010 - 7538
papers
Between 2005 and 2010 the total number of zebrafish-related papers ever written doubled.
ZNDZebrafish Neurophenome Database
Goals:Pioneering (so far)AccessibleEasy to useUseful
www.kaluefflab.com/znpindex-or-
www.tulane.edu/~znpindex/search
ZNDZebrafish Neurophenome Database
Goals:Pioneering (so far)Accessible (the internet)Easy to useUseful
What we see, Not easy
What you’ll see
What you’ll see
What you’ll see
Everything you need to know… Hopefully
If not..
Submit your data! More on this later
How it’s organized
Experiment 1
Interval 1.1
Treatment 1.1.1
Interval 1.2
Interval 1.3
Treatment 1.1.2
Parent/Child Format
Caffeine L/D Box
15 min
100 mg/kg I.P.
250 mg/kg I.P.
Chronic
Acute withdraw
al
Experiment
Interval
Treatment
that’s what you’re seeing here
Experiment
IntervalTreatment
TestResults
ZNDZebrafish Neurophenome Database
Goals:Pioneering (so far)Accessible (the internet)Easy to use (we hope so) Useful
Only With Your Help
Submit your data! (2 methods)1.Direct info submission with the
submission template (next slide)2.Send us a paper (please use step
#1)
Submission Template
If you send us a paper…
We fill out the template
ZNDZebrafish Neurophenome Database
Goals:Pioneering (so far)Accessible (the internet)Easy to use (we hope so) Useful (with your help)
Special Thanks
Budd Hirons - who has been essential to the actualization of this idea.
ILC (Innovative Learning Center) & Tulane University Technology Services
Also, Tulane has been kind enough to supply us with the server space that is required to host such a database.
In Conclusion
The Zebrafish is an emerging animal model for vertebrate development and neurological function
We hope to work closely with other zebrafish-based databases to help provide a better, more comprehensive user experience
Check in regularly at: http://www.tulane.edu/~znpindex/search Or just search ZNP or Zebrafish Phenome
You can help by submitting your data.