I S A ISA - CLARA · Fragment-based drug design Identification, quantification, quality control....
Transcript of I S A ISA - CLARA · Fragment-based drug design Identification, quantification, quality control....
METHODS andTOOLSforbiomedicalDIAGNOSTIC
BIOMARKERclinicalevaluationandquantification
CHARACTERISATIONof
BIOLOGICS,LIPIDSandDRUGS
METHODS forsmall-molecule
DRUGDISCOVERY
SciencesforHealthatISA
ProteomicsMetabolomics
Micro/NanoBiotechnologies,Biosensors
MRIcontrastagents
StructuralBiologybyNMR
Fragment-baseddrugdesign
Identification,quantification,qualitycontrol
Fragment-Based DrugDesign
Chimiothèque defragmentsMassemolaire<250g/mol
CriblageRMN Modélisation,RMNX-ray
Synthèse
Conceptiondenouvellesmolécules
MéthodesRMN
Fragments
Versducriblagediscriminant
VersdesinhibiteursallostériquesdeRCPG
Versdenouveauxantibiotiques
IsabelleKRIMMThématiquesderecherche
Versdenouveauxanticancéreux
IsabelleKRIMM
ü Identification,validationdeligands
ü Étudesstructuralesü FBDD,criblageü InteractionHSA-molécule
NécessiteuneCIBLEthérapeutiqueidentifiéeetpurifiée
Expertises