HYSTERIA ? W.Fliess & S.Freud PPG SPOT biposuisse institute berne 1 P terygo- P alatine G anglion...

HYSTERIA? W.Fliess & S.Freud

PPGSPOT

biposuisse institute berne1

HOW the P terygo- P alatine G anglion matters in… BIPOLARITYtooG. Treviranus, Berne

12th International Review ofBIPOLAR DISORDER

Nice, 22.May 2012

• 0,1 mm

Beckers 1991

Major part

1: 1st output CGRP, PACAP, SP

Mast Cell (CGRP-R+) Lennerz 2008

MC degranulation Theoharides 2005

2: NO DURA CGRP-receptors NO AXON-REFLEX for TG

«Brainstem disorder»

1

Sp5C V1

SSN

1st

2nd

3rdPACAP

ICA miniG

? Retrograde INFL

TNF-a

ACh via M2

inflames BBB

PPG

MCTG

May 2009

GM metaAn

SSN-“TG-CERVICAL-

complex”

Fasmer

1893

1894

NO ACh

VIP PACAP

OUTPUT

STIMULATE PPG &

HEAL Cluster Headache

CR 61%, PR 16%, NR 23%

within minutes!

OPEN BBB

BLOCK PPG &

STOP HEADPAIN, C2-C3, asthma, (LBP etc.) NOT

allodynia in MIG

Hysteria & HeadacheFACIAL V1,2 PPG eye, PPG ? BBB

TGG

Non –B~stem

ARTERIES

TENS CH MIG :

?

rose odor brainstemIN MIG attack

MC by CGRP PACAP

No CGRP !

S1 INS

Noseda 2010

biposuisse institute berne 22

The Naso-genital Link to ... Mast cells

Brain MAST cells

CLOSE TO N~s & Art. 3% MIGRATEVARIATE species, area, eco

ACTIVE SP, NGF ,E2DEGRAN’ PACAP, CGRP, etc.

GFs (NGF…), serine proteasee, iNOS, cytokines (TNFa), heparin, histamine, tryptase, 5-H.T, etc.

FEMALE & MCs1: ablation of PPGs in rats causes pseudopregnancy

2: estrus (E2 max) MC cycle anogenital erogenic areas of VPL thalami ? from dura

3: Ovulation=danger signal IR. Polycystic or post-MP ovaries MCs

4: doves: MC in med. habenula courtship and parenthood.

5: PNS-nerve ligation MC thalamus

MALE & MCs

1:animal:intraspecies fights MCs med. habenula attracted by NGF2: BLOCKED MCs ANX-like bhv rat Mast cells

PNS / CNS Mast Cells

MC in psychiatry: PAIN DISORDER AUTISM? Theoharides 2011 2012

BPAD ? Borderline PD ?

MC in Defense:

++ brain function avoidance cleaning bhv

++Allergic preventive

++Anti Microbial Peptides

+ «suicidal» extra-cellular fibrin traps against germs ? WMHIBUILD VESSELS (VEGF)

Yin & yang of MC in MS

biposuisse institute berne3

Headache ? MCA

Posterior CA !

Search for ? repetitive BBB opening factors w/

periarterial neurotrophic or toxic effect

3Mast

Cells?

Only L Globus pallidus larger Kempton 2008

Shape! BP ? ACA-MCA-PCA

Putamen

Arterial pathology of BPAD

PPG PACAP

+

-

Hwang (Seoul) no Li+

2006 Li+

BPAD = MC-«GOUT retroceeding to the brain»Bugs: bacteria fungi, (virus)LesionAllergenChemicals Heat, cold

Top-down

DRGA-d

2nd orderascension

Dorsal

Horn

S1 S2

wikipedia, lymphnotes.com & WebMD Scientific American® PICTORIAL SOURCES

A-b

Insula

Thalamus3rd order

LymphaticAPC to

PNS 1st orderGlu =< AMPA

MC

LymphNODES:NGFTimidity, LT-defense,

status NT p75

SNS virusSloan 2007

D6 Chemokine-scavenging Rec.

Small Slow C-Fiber“noceffectors”

PAIN+ = TLR4 x HSp90 (?) Hutchinson 2009

LEFT axilla

via the lymphatics ?

i.perit. MC activator rat at spinal medulla to C2 for head pain

at L6-L2 for visceral pain

Co-occurrence OR (Arnold 2006)

P(BP|FM+)/P(BP|FM-)=x135

P(UP|FM+)/P(UP|FM-)=x2.7

Most BP,UP FM

4


injured PNS TNFa in brain• Spared-Nerve-Injury r&m TNA a in in plasma -

in CSF in HIPPOCAMPUS WORKING-MEMORY

TNFa released by MCs, glia and neurons

M2 ACh facilitate cognition

M2 antagonist methoctramine activates MCs

M2 k.o. mice : like TNFa WORKING-MEMORY - maybe M2-cholinergic output of PPG dampens inflammatory mast cell activity.

W. Ren {Guangzhou}. Neuropsychopharmacology 2011; 36:979-2

• TNFa byMCs?

• dampened by

PPG?

«fibrofog»

5


VIP PACAP

Master of N/Immune cell crosstalk

VIP GABA VAthalamus MC release of NGF and repair & recovery in Parkinson-rats Korkmaz 2010, 2012

PACAP-38 >>VIP PLC Dural MC degranulation Baun 2012

N~protective EAE (MS); auto-reactive Th1/Th17

VIP Microglia colitis mice

Memory & learning

Blushing heat (Kellogg 2010)

VIP Serum in Cluster headache

12th International Review of

Nice, 23.May 2012BIPOLAR DISORDER

6


PPG :: just vasodilation OR shame, dissociation, pain,?

7

SHAME w/ BLUSH (PPG) : pervasive, also cognitive BRAKE of excess, esp. AGGRESSION with SUBMISSIVE dysplay in „neurotic“ CONSPECIFIC

STRUGGLE ISTDP NEUROSIS chron. defeated/-ing inflamed immune system choleric hierarchy, triggered by «CLENCH, dont BITE»?

age

Silvan Tomkins

Habib Davanloo

R guilt shame L

gyrus rectus

Nestor 2012 (Boston)

Tangney (Fairfax)

CPS-like symptomsDefine Blumer’s SUBICTAL DYSPHORIA in psychiatry …

SIDS 2nd same hit?

AW-InfectPPGBBBdysmorphic brainstem /caseinoMO entry +

Auton. brainstem

31%

42%

Adol’s50’s

MDD mother ORx4.9

5,6% 8,1%Dietrich Blumer

PPG

Yarnitzki 2003


MCs need PKC & GSK3β TMXMC exocytosis starts with Ca2+-store opener I145P3 ::

Ca2+ replenished by SOCE e.g. TRPC3 by LI

PKC b slacks the reins (MARCKS-ED) on I145P3 further needed (Gadi 11) – at least IF by IgE-on-FcεRI

• IP3 IMPase-(„on site II“)-inhibitor LI

• MARCKS LI, VPA (Watson 98)

• PKC in Mania, sleep(-), AMPH; GWAS-BP: enz(PKC) – in Depression: pmort, model PKC

PKC-iso LI, VPA, x iso: a, e CNS ! TMX , , , , a bI h dz bI bII (a, d) LI, VLPA, SGA NO conc. change but function (Pandev 02, 08) ? g only CNS ! SRI x iso: g, d

• GSK3β in MC essential 4: cytokine prod, chemoattraction, and survival :: GSK3β-inhibitors: LI etc.

„the ability of the PFC to regulate emotion, thought and action is markedly impaired by overactivity of PKC “ Zarate Manji 2009

8

Questions …


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HYSTERIA ? W.Fliess & S.Freud PPG SPOT biposuisse institute berne 1 P terygo- P alatine G anglion...

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