hypothalamo hypophyse

7/26/2019 hypothalamo hypophyse

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Scrte:La vasopressine

Locytocine

2 types de cellules diffrents


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Systme nerveux central

Neuromdiateurs

Stress

Hypothalamus

Anthypophyse

++++ --

Prolactine

BC461;C64CK10< *RS4C64CK10< (C09@C64CK10< (4CV6R "C4GC03-.3?39510O "C4GC03SRIF: somatotropin release inhibiting factor

+B*"H +@430C;C461;C64CK10 RC4GC03W *$"H *RS4CX10 561G>?9610O RC4GC03

ACTH TSH FSH

LH

GH

Somatostatine

(= SRIF)

GHRHGnRHTRHCRH Dopamine


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Systme nerveux central

Hypothalamus

Hypophyse antrieure

Glandes endocrines

Tissus cibles

B

A

A

A

H

H

Substrat

-

-

A Boucles longues

B Boucles courtes

C Boucles ultra courtes

C

--

H hormone


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EFFETS DE DIFFERENTS RYHTMES PULSATILES DE GnRH

SUR LA PRODUCTION DE LH ET FSH


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Hypophyse antrieure

Corticosurrnale

Thyrode Testicule Ovaire

Tissus cibles

ACTH TSH FSH

LH

FSH

LH

++ ++

Cortisol T4 Oestrogne

Testostrone

androgne T3 Progestrone

GH

Prolactine

+

-- -

-


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b

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LPH= lipotropin


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Stress

Dopamine

CRH Endorphine

Mlatonine

Lumire

GnRH(LHRH)

Hypothalamus

Scrtion complexe :

Rythmes pulsatilescircadien ( 7 10 pics/jour)

cyclique (mensuel)

dpendant de l

ge

sous-unit# commune

sous-unit spcifique

GONADOTROPHINES

FSH

LH

-

--

-


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Hypothalamus-pituitary -gon adal axis. FSH, follicle-stimulating hormone; GnRH, gonadotropin-releasi ng hormone; LH, luteinizing hormone.(Modified from Porterfield SP, White BA: Endocrine Physiology, 3rd ed. Philadelphia, Mosby, 2007.)

Scrtion complexe :

Rythmes pulsatiles

circadien (7 10 pics/jour)cyclique (mensuel)

dpendant de lge

FSH, LH

sous-unit#commune

sous-unit spcifique

endorphinsGONADOTROPHINES

Rcepteurs 7 domaines TM


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-30 0 60 120 180

Minutes

60

50

40

30

20

10

18

16

14

12

10

8

LHRH

LH

FSH

SERU

ML

H,mIU/ml

SERUMF

SH,mIU/ml

Plasma LH and FSH responses to GnRH 250 g IV in normal men.

The peak response of LH is greater and occurs earlier than that of FSH. LH (but not

FSH) responses in normal women are affected by the stage of the menstrual cycle,

with the greatest responses occurring at time of ovulation (modified from Snyder P.

et al.: J Clin Endocrinol Metab 41 : 938, 1975)


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100

125

50

75

125

50

75

100

- 6 0 6 12 18

Temps en heures

Perfusion IV

Testostrone

Perfusion IVOestradiol

LHPLASMA,%

DEVALEURDEB

ASE

(Diminution de la frquence et

de l

amplitude des pics de LH)


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Neuroendocrine reflex caused by suckling at the nipple and leading to secretion of oxytocin and prolactin. In turn, these hormones induce continued milkproduction (galactopoiesis) and milk let-down. Prolactin also induces lactational amenorrhea. (Modified from Porterfield SP, White BA: Endocrine Physiology, 3rd

ed. Philadelphia, Mosby, 2007.)


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Hypothalamus-pituitary -liver axis. ALS, acid labile subunit; GHBP, growth hormone-binding protein; GHRH, growth hormone-releasing hormone; IGFBP, insulin-like growth factor-binding protein; IGF-I, insulin-like growth factor I; SS, somatostatin. (From Porterfield SP, White BA: Endocrine Physiology, 3rd ed. Philadelphia, Mosby, 2007.)

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hypothalamo hypophyse

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