Hypersensitivity Reactions (Nusa Purnawan Putra)
-
Upload
nusa-purnawan-putra -
Category
Documents
-
view
238 -
download
0
Transcript of Hypersensitivity Reactions (Nusa Purnawan Putra)
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
1/20
Hypersensitivity Reactions
NUSA PURNAWAN PUTRA 08610500312008 Medical Student of Christian University of Indonesia
PRESENTED BY
I m m u n o l o g i c a l l y M e d i a t e d D i s e a s e s
CHAPTER 21 INTEGUMENTARY SYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
2/20
CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
Hypersensitivity reactions refers to a state of
altered reactivity in which the body reacts with an
exaggerated immune response to what is perceived
as a foreign substance
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
3/20
CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
Type Prototype Disorder Immune Mechanisms Pathologic Lesions
Immediate(type I)hypersensitivity
Anaphylaxis;
allergies;
bronchial asthma
(atopic forms)
Production of IgE antibody
immediate release of vasoactive
amines and other mediators from
mast cells; recruitment of
inflammatory cells (late-phase
reaction)
Vascular
dilation, edema,
smooth muscle
contraction,
mucus
production,
inflammation
Antibody-mediated (type II)
hypersensitivity
Autoimmune hemolytic
anemia; Goodpasture
syndrome
Production of IgG, IgM binds to antigen on target
cell or tissue phagocytosis or lysis of target cell by
activated complement or Fc receptors; recruitment of
leukocytes
Cell lysis; inflammation
Immune complex-mediated
(type III) hypersensitivity
Systemic lupus
erythematosus; some
forms of
glomerulonephritis;serum sickness; Arthus
reaction
Deposition of antigen-antibody complexes
complement activation recruitment of leukocytes
by complement products and Fc receptors release
of enzymes and other toxic molecules
Necrotizing vasculitis
(fibrinoid necrosis);
inflammation
Cell-mediated (type IV)
hypersensitivity
Contact dermatitis;
multiple sclerosis; type I,
diabetes; transplant
rejection; tuberculosis
Activated T lymphocytes i) release of cytokines
and macrophage activation; ii) T cell-mediated
cytotoxicity
Perivascular cellular
infiltrates; edema; cell
destruction; granuloma
formation
Mechanisms of Immunologically Mediated Diseases
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
4/20
CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
5/20
CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
6/20
CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
7/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
8/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
9/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
Type Prototype Disorder Immune Mechanisms Pathologic Lesions
Immediate (type I)
hypersensitivity
Anaphylaxis; allergies;
bronchial asthma (atopicforms)
Production of IgE antibody immediate release of
vasoactive amines and other mediators from mastcells; recruitment of inflammatory cells (late-phase
reaction)
Vascular dilation, edema,
smooth musclecontraction, mucus
production,
inflammation
Antibody-
mediated
(type II)hypersensitivity
Autoimmune
hemolytic
anemia;
Goodpasture
syndrome
Production of IgG, IgM binds to
antigen on target cell or tissue
phagocytosis or lysis of target cell
by activated complement or Fc
receptors; recruitment of
leukocytes
Cell lysis;
inflammation
Immune complex-mediated
(type III) hypersensitivity
Systemic lupus
erythematosus; some
forms of
glomerulonephritis;
serum sickness; Arthus
reaction
Deposition of antigen-antibody complexes
complement activation recruitment of leukocytes
by complement products and Fc receptors release
of enzymes and other toxic molecules
Necrotizing vasculitis
(fibrinoid necrosis);
inflammation
Cell-mediated (type IV)
hypersensitivity
Contact dermatitis;
multiple sclerosis; type I,
diabetes; transplant
rejection; tuberculosis
Activated T lymphocytes i) release of cytokines
and macrophage activation; ii) T cell-mediated
cytotoxicity
Perivascular cellular
infiltrates; edema; cell
destruction; granuloma
formation
Mechanisms of Immunologically Mediated Diseases
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
10/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
11/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
SYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
12/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
Type Prototype Disorder Immune Mechanisms Pathologic Lesions
Immediate (type I)
hypersensitivity
Anaphylaxis; allergies;
bronchial asthma (atopicforms)
Production of IgE antibody immediate release of
vasoactive amines and other mediators from mastcells; recruitment of inflammatory cells (late-phase
reaction)
Vascular dilation, edema,
smooth musclecontraction, mucus
production,
inflammation
Antibody-mediated (type II)
hypersensitivity
Autoimmune hemolytic
anemia; Goodpasture
syndrome
Production of IgG, IgM binds to antigen on target
cell or tissue phagocytosis or lysis of target cell by
activated complement or Fc receptors; recruitment of
leukocytes
Cell lysis; inflammation
Immune
complex-
mediated
(type III)hypersensitivity
Systemic lupuserythematosus;
some forms of
glomerulonephrit
is; serum
sickness; Arthus
reaction
Deposition of antigen-antibodycomplexes complement
activation recruitment of
leukocytes by complement
products and Fc receptors
release of enzymes and other toxic
molecules
Necrotizingvasculitis
(fibrinoid
necrosis);
inflammation
Cell-mediated (type IV)
hypersensitivity
Contact dermatitis;
multiple sclerosis; type I,
diabetes; transplant
rejection; tuberculosis
Activated T lymphocytes i) release of cytokines
and macrophage activation; ii) T cell-mediated
cytotoxicity
Perivascular cellular
infiltrates; edema; cell
destruction; granuloma
formation
Mechanisms of Immunologically Mediated Diseases
SYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
13/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
CHAPTER 21INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
14/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
CHAPTER 21INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
15/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
CHAPTER 21INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
16/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
Type Prototype Disorder Immune Mechanisms Pathologic Lesions
Immediate (type I)
hypersensitivity
Anaphylaxis; allergies;
bronchial asthma (atopicforms)
Production of IgE antibody immediate release of
vasoactive amines and other mediators from mastcells; recruitment of inflammatory cells (late-phase
reaction)
Vascular dilation, edema,
smooth musclecontraction, mucus
production,
inflammation
Antibody-mediated (type II)
hypersensitivity
Autoimmune hemolytic
anemia; Goodpasture
syndrome
Production of IgG, IgM binds to antigen on target
cell or tissue phagocytosis or lysis of target cell by
activated complement or Fc receptors; recruitment of
leukocytes
Cell lysis; inflammation
Immune complex-mediated(type III) hypersensitivity
Systemic lupuserythematosus; some
forms of
glomerulonephritis;
serum sickness; Arthus
reaction
Deposition of antigen-antibody complexescomplement activation recruitment of leukocytes
by complement products and Fc receptors release
of enzymes and other toxic molecules
Necrotizing vasculitis(fibrinoid necrosis);
inflammation
Cell-
mediated
(type IV)hypersensitivity
Contact
dermatitis;multiple
sclerosis; type I,
diabetes;
transplant
rejection;
tuberculosis
Activated T lymphocytes i)
release of cytokines andmacrophage activation; ii) T cell-
mediated cytotoxicity
Perivascular
cellularinfiltrates;
edema; cell
destruction;
granuloma
formation
Mechanisms of Immunologically Mediated Diseases
CHAPTER 21INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
17/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
CHAPTER 21INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
18/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
CHAPTER 21INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
19/20CREATED BY NUSA PURNAWAN PUTRA 0861050031 2008 Medical Student of Christian University of Indonesia
CHAPTER 21 INTEGUMENTARYSYSTEM
-
7/29/2019 Hypersensitivity Reactions (Nusa Purnawan Putra)
20/20
Thank YouNUSA PURNAWAN PUTRA 0861050031
2008 Medical Student of Christian University of Indonesia
PRESENTED BY
R E F E R E N C E S
Fitzpatrick Dermatology Atlas.
Harrison's Internal Medicine .
Robbins and Cotran Pathologic Basis of Disease.