Huntington’s Disease II: Genetics and cell pathology

Neurobiology of Disease

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

1983 - Gusella, Wexler and colleagues identify locus1993 - Huntintin cloned, CAG, poly Q repeats identified

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

Myers 2004 NeuroRx. 1:255-62.

Paulson Fischbeck Annu. Rev. Neurosci. 1996 19:79-107

Mutant mice:

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

Rubinsztein 2002

Harjes, Wanker Trends Biochem. Sci. 28:425

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

Landles,Bates 2004EMBO Reports 5:958

Landles,Bates 2004EMBO Reports 5:958

Neurotrophins and Receptors

NGF BDNF NT4/5 NT3

NGFBDNF

NT3NT4/5

TrkA TrkB TrkCp75NTR

(Adapted from Neet & Campenot, 2001)

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

Bacquet et al. 2004 J Neurosci. 24:4250-8

Arrasate et al. 2004 Nature 431:805

Fig. 2

Gauthier et al. 2004 Fig. 1

Gauthier et al. 2004 Fig. 1

Schroer 2004