http://etp.ciaa.be

Be healthy for longer

Be free from Health Problems Give

Children a Good Start

Consumer life goals re food

Huge global issues in nutrition

4bn people affected by malnutrition deserve the chance to develop physically & mentally

to get more out of life.

50% of world’s population have blood cholesterol that’s too high.

30% of world’s population have blood pressure that’s too high.

Pop

ula

tion

num

bers

Healthy Unhealthy

Target population for pharma industries

Target population for food industries & public healthcare

Green MR and van der Ouderaa F, Nature Pharmacogenomics - 2003

A vision for improving population health

ETP Food for Life Vision

An effective integration of strategically-focussed, trans-national, concerted

research in the nutritional-, food- and consumer sciences and food chain management will deliver innovative, novel and improved food products for, and to, national, regional and global markets in line with consumer needs and expectations.

These products, together with recommended changes in dietary regimes and lifestyles, will have a positive impact on public health and overall quality of life (‘adding life to years’).

Such targeted activities will support a successful and competitive pan-European agro-food industry having global business leadership securely based on economic growth, technology transfer, sustainable food production and consumer confidence.

European Technology Platform Food for Life

-

FoodQuality &

Manu-facturing

Food &Health

Food Safety

SustainableFood Production

Food &Consumer

Communication,Training &

Technology Transfer

Food Chain Management

Stakeholders’ proposal for a Strategic Research Agenda

April, 2006

The key innovation challenges

The development of this ETP has been driven by the activities of its eight Working Groups

To optimize the synergy of its internal interactions, the Stakeholders’ Strategic Research Agenda, SSRA, has been drafted according to the seven Key Challenges for Innovation facing the European agri-food sector

These Challenges map closely with the goals and deliverables of the individual Working Groups

Well-being/appearance

Age

Add life to years

Healthy ageing: Goal

Food & Health

Delivering a healthy diet

Working group: Prof Wim Saris, DMS & Univ Maastricht, NL (chair) Dr Jacqueline Castenmiller, WCFS, NL (fascilitator)

Prof Nils-Georg Asp, LU, SE Prof Robert-Jan Brummer, WCFS, NL Dr Irene Corthesy, CRN, Nestlé, CH Prof Hannelore Daniel, Techn Univ, München, D Dr Gerd Hazer, Kraft, D Dr Ian Johnson, IFR, Norwich, UK Prof Bertold Koletzko, Univ München, D Prof Ian Macdonald, Univ Nottingham,UK Dr Gert Meijer, Unilever, NL Dr Moïse Riboh, Danone, F

METABOLIC FUNCTIONS

IMMUNE- & INTESTINALFUNCTIONS

BRAIN FUNCTIONSINFANT

ELDERLY

life-stage

Food & Health: priority research areas

How did we work?

TOWARDS A STRATEGIC RESEARCH AGENDA FOR FOOD, NUTRITION & HEALTH

• 1. Please define research questions for each cell in the table.

• 2. For each of the research questions, describe:– - (Knowledge) deliverables;– - When to reach these deliverables: 2010, 2015

or 2020;– - Bottlenecks to solve the research questions;– - The breakthrough potential on a scale from 1 to

5 (low to high potential)? This is about the potential of the research to contributing to breakthrough chances or opening up new horizons for application-inspired research.

How did we work? 2

Table. Scientific targets

Life cycle Metabolic function

Immune function Brain function

Cell plasticity Cell plasticity Cell plasticity

In-utero, new-borns, infants and young children

-To optimise development 1

-Early disease prevention – minimising risk for later life 2

-Physical activity 3

-Programming and imprinting 4

-Optimal weaning foods to maximise resistance and to minimise food allergy 5

-Immune tolerance 6

-Nutrition and cognitive function 7

-Brain conditioning (e.g., taste perception) 8

How did we work 3

No.

Research question Knowledge deliverables

Bottlenecks When Break-through potenial

1 Which nutritional factors during pregnancy determine optimal foetal development?

Basis for development of optimal foods/diets

Dietary survey methodology, ethical constraints limiting intervention studies

2015 3

2 How important is caloric excess and macronutrient imbalance for early risk factor development?

Refined recommendations on infant nutrition

Limited possibilities to perform intervention studies

2015 3

Food & Health

Delivering a healthy diet Understanding brain function in relation to diet Understanding dietary effects on immune and

intestinal function Understanding the link between diet and metabolic

function (obesity and associated metabolic disorders)

Understanding consumer behaviour in relation to health and nutrition

Goal 1: Understanding brain function in relation to diet

Diet and cognitive functions Brain conditioning Mood and optimal performance Prevention of cognitive decline Food intake regulation and hunger/satiety Nutrition and interorgan signalling - esp gut-central

nervous system interaction

Goal 2 Understanding dietary effects on immune and intestinal function

Modify systemic inflammatory activity by diet Dietary factors that improve barrier functions Biomarkers for intestinal health Diet before and during pregnancy and lactation -

immunefunction and allergy Improved allergome database for foods

Goal 3 Understanding the link between diet and metabolic function (obesity and associated metabolic disorders

Early biomarkers of metabolic syndrome Individual variations in metabolic energy efficiency Food components that regulate food intake and

increase termogenesis Intervention strategies Counteract age-associated muscle wasting Low-grade inflammation - obesity/insulin

resistance/metabolic syndrome Epigenetic events - chronic disease Maternal and infant recommendations for opt health Meal composition and size - energy uptake, satiety

Goal 4 Understanding consumer behaviour in relation to health and nutrition

Key determinants of food habits Biological determinants in food choice Methodology to understand and quantify determinants Perception and determinants of ”healthy lifestyle” Better tools for effective communication Consumer knowledge - consumer understanding of

health schemes, health claims, simplified labelling - and personalised nutrition based on nutrigenomics

Horizontal Activities

The role of Horizontal Activities is to optimise the impact of the ETP through:

Ensuring internal complementarity: Minimising gaps or duplication across the SRA

Establishing effective links with nationally- and FP6- funded projects, and other ETPsMaximising the effectiveness of European food chain science

Establishing the Mirror Group:Effecting a dialogue with national funding bodies, policy makers and opinion formers, COST, EUREKA, ESF etc

Promoting the ETP: Gaining the support of all European stakeholders

Organising national and regional consultations:Ensuring that the SRA addresses the needs and opportunities of all of Europe

Developing Scenario Studies Raising awareness of long-term challenges and opportunities for the food chain.

http://etp.ciaa.be