MANAGEMENT REGIMES FOR HERPES SIMPLEX INF

SYMPTOMATIC MANAGEMENT• Maintain Hygeine, Keep area dry and clean

• Treatment indicated in case of Persistence, Burning / Pain / Fever, Superadded infection,

• TOPICALS DOCOSANOL 10% CREAM LA 5 TIMES DAILY X 07-10 DAYS PENCICLOVIR 1% CREAM LA q 2 hrs X 07-10 DAYS ACYCLOVIR 5% CREAM LA 5 TIMES DAILY X 07-10 DAYS (Muco-adhesive Buccal Tablet (Sitavig 50mg) Single dose to Canine Fossa)

SYSTEMIC ANTIVIRALSREDUCTION :

Healing time of lesions 16 12 days 07 05 days

Post-herpetic pain 07 05 days04 02 days

Constitutional symp 06 03 days04 03 days

No effect on Latency

ORO-FACIAL HERPES

PRIMARY INFECTION

T ACYCLOVIR 400 mg TDS X 07-10 daysT VALACYCLOVIR 1 g BD X 07-10 daysT FAMCICLOVIR 250 mg TDS X 07-10 days

ACYCLOVIR 15 mg/kg/dose 5 times a day x 07-10 days (Pediatric)

Also for Herpes Gladiatorum / Whitlow / Scrumpox

ORO-FACIAL HERPES

• RECURRENT : EPISODIC

T ACYCLOVIR 400 mg 5 times a day X 04-05 dT VALACYCLOVIR 2 g BD X 01 dT FAMCICLOVIR 500 mg TDS X 01 d

ORO-FACIAL HERPES

• RECURRENT : SUPPRESSION

T ACYCLOVIR 400 mg BD x 12 months

GENITAL HERPES (CDC-2010)

• PRIMARY INFECTION

T ACYCLOVIR 400 mg TDS X 07-10 daysT VALACYCLOVIR 1 g BD X 07-10 daysT FAMCICLOVIR 250 mg TDS X 07-10 days

Extended > 10 days if inadequate healing

ACYCLOVIR 15 mg/kg/dose 5 times a day x 07-10 days (Pediatric)

GENITAL HERPES

• RECURRENT : EPISODIC

T ACYCLOVIR 400 mg TDS X 05 dT VALACYCLOVIR 1g OD X 05 dT FAMCICLOVIR 125 mg BD X 05 d

GENITAL HERPES

• RECURRENT : SUPPRESSION

T ACYCLOVIR 400 mg BD X 12 monthsT VALACYCLOVIR 500 mg BD X 12 monthsT FAMCICLOVIR 250 mg TDS X 12 months

GENITAL HERPES

• RECURRENT : SUPPRESSION in PREGNANCY

T ACYCLOVIR 400 mg TDS 36th Week of Gestation till Delivery

OCULAR HERPES

• PRIMARY INFECTION

T ACYCLOVIR 400 mg 5 times a dayT VALACYCLOVIR 1 gm BD

Topical 1 % ED TRIFLURIDINE, 0.1 % ED IDOXURIDINE or 0.5 % Ointment, 3 % Ointment VIDARABINE q 2 hrs Day + q 4 hrs Night

OCULAR HERPES

• RECURRENCE : SUPPRESSION

T ACYCLOVIR 400 mg TDS X 12 months

NEONATAL HERPES

• Inj ACYCLOVIR 20 mg/kg/dose TDSx 02 – 03 weeks

(Max 80 mg/kg/day)

ECZEMA HERPETICUM

T ACYCLOVIR 400 mg TDS X 14-21 daysT VALACYCLOVIR 1 g BD X 14-21 daysT FAMCICLOVIR 250 mg TDS X 14-21 days

Inj ACYCLOVIR 10-15 mg/kg/dose TDS X 02 -03 weeks

HERPES SIMPLEX ENCEPHALITIS

• Inj ACYCLOVIR IV10-15 mg/kg/dose TDS X 14-21 days

Also for Disseminated Herpes Simplex Inf

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