September – October 2017RESEARCH BULLETIN

HSDM RESEARCH AWARDSYingzi Yang, PhD, professor of Developmental Biology, received an R21 award from NIH/NIAAA for, “Mechanisms of Hippo Signaling in Alcoholic Liver Disease.” The goal of this explorative project is to determine whether alcohol attenuates liver regeneration and induces liver inflammation by dysregulating the Hippo signaling pathway in hepatocytes.

Brittany Seymour, DDS, MPH, assistant professor of Oral Health Policy and Epidemiology, received an award from the Abundance Foundation for, “The Global Health Learning Helix: Modeling 3D Global Health Education.” The goal of this project is to develop the Global Health Learning Helix, a longitudinal curriculum tool that is competency-based, and will incorporate didactic and experiential learning at Harvard.

Vicki Rosen, PhD, professor and chair of Developmental Biology, received a subcontract award from Massachusetts Institute of Technology for, “Cartilage-Bone-Synovium MPS: Musculoskeletal Disease Biology in Space” (PI: Grodzinsky; NIH/NCATS). Rosen will develop a protocol for histological assessment of osteochondral plugs and the subsequent analysis of bone changes in

osteochondral plugs undergoing cytokine treatment and injury.

Roland Baron, PhD, professor and chair of Oral Medicine, Infection and Immunity, received a subcontract award from Maine Medical Center for, “Cellular Mechanisms of PTH1R Activation With Osteoporosis Treatment” (PIs: Rosen and Black; NIH/NIAMS). Baron will be responsible for the analysis of the bone biopsies in a unique protocol aimed at assessing the micro-environmental interaction between bone

surface cellular activities and bone marrow adipocytes, including trabecular and cortical bone.

Hiroe Ohyama, DDS, MMSc, PhD, DMD, Receives HMS Academy Medical Education Fellowship & AACD Awards

Dr. Hiroe Ohyama, assistant professor and director of operative dentistry in the Department of Restorative Dentistry and Biomaterials Sciences, received The HMS Academy Medical Education Fellowship. This fellowship

will support Ohyama’s research entitled, “Integration of Digital 3D Technologies Into Dental Curriculum for Improvement of Students Self Assessment Abilities.” The HMS Academy Medical Education Fellowship provides educators with dedicated time to develop the expertise and skills needed to advance academic careers in medical education and medical education research.

Ohyama was also recognized for her research from The American Academy of Cosmetic Dentistry (AACD). She received first place in the 2016 Junior Faculty Materials Poster Category for, “Evaluation of Properties of Restorations using CAD/3D Printing Technology.” She received second place in the 2017 poster competition for, “Innovative Educational Tools: Digital 3D Technologies for Self-Assessment.” Lastly, Ohyama mentored Jie Sun, DMD’17 (photo left with Ohyama), who received the Senior Student AACD HEAPS Clinical Case Award.

2 Research Bulletin • September – October 2017 • Harvard School of Dental Medicine

POSTDOCS & SCHOLARSDian Teguh, PhD, joined the Ionescu Lab as a postdoctoral fellow in the Department of Developmental Biology. Teguh was born in Bali, Indonesia but spent half of her life in Perth, Western Australia. She completed her PhD in pathology working on the characterization of an ENU-induced mutant mouse with a phenotype of bone loss at the University of Western Australia, under the supervision of Drs.

Jiake Xu and Jennifer Tickner. In the Ionescu Lab, Teguh is working on isolating and characterizing a chondrocyte progenitor population with a relevance to osteoarthritis.

Jue Hou, PhD, joined the Intini Lab as a postdoctoral fellow in the Department of Oral Medicine, Infection and Immunity. Hou attended the University of California, Irving, where he earned his PhD in biomedical engineering working with Drs. Bruce Tromberg and Eric Potma on imaging breast cancer metabolism using multi-modal, non-linear optical microscopy. In the Intini Lab, Hou is working on

identifying and characterizing osteosarcoma cancer stem cell with a multi-fluorescent mouse model and intravital microscopy.

Qian Cong, PhD, joined the Yang Lab as a postdoctoral fellow in the Department of Developmental Biology.Cong comes from Shanghai Jiaotong University, where she worked in the Baojie Li Lab at the Bio-X Institution on the molecular mechanisms of bone-marrow mesenchymal cells and monocytes on bone development and metabolism. In the Yang Lab, Cong is working on exploring the role of ENPP1

on bone ossification and the mechanisms of progressing heterotopic ossification.

Xiaohui Wang, PhD, joined the Yang Lab as a postdoctoral fellow in the Department of Developmental Biology. Wang is from Zhoukou City, China and received his PhD degree in biomedical sciences from East Tennessee State University. In the Yang Lab, Wang is working on exploring the role of Hippo-YAP signaling pathway in alcohol- induced liver injury.

Zhengtao (Alex) Lyu, joined the Baron Lab as a visiting scholar in Oral Medicine, Infection and Immunity. Lyu is a PhD candidate at the Tongji Medical College of Huazhong University in China. In the Baron Lab, he will spend two years investigating the role of TGFβ signaling in osteocytes in bone homeostasis and osteoporosis.

Eneida Vencios, DDS, MS, PhD, photo left, with Dr. Sook Bin Woo), joined Woo, associate professor of oral and maxillofacial pathology in the Department of Oral Medicine, Infection and Immunity, as a visiting Fulbright Scholar from the Universidade Federal de Goiás, Brazil

where she is an Associate Professor of oral and maxillofacial pathology in the Department of Oral Medicine. Vencios spent the month of September visiting the Division of Oral and Maxillofacial Pathology, working with Woo and her advanced graduate oral pathology colleagues and students. She also worked with Dr. Jeffrey Krane, a head and neck pathologist at the Brigham and Women’s Hospital. Her interests are in the role of human papillomavirus in oral cancer in non-smoking patients and she will be collaborating with colleagues in many centers around the world for her research.

Nora Renthal, MD, PhD, joined the Rosen Lab as a postdoctoral fellow in the Department of Developmental Biology. Renthal received her MD and PhD degrees from the University of Texas Southwestern Medical Center. In the Rosen Lab, Renthal is working on exploring the role of GDF5 in joint development. She is also a pediatric endocrinology fellow at Boston Children’s Hospital.

Hossein Bassir DDS, DMSc17, Receives Robert Schoor Research Award

Dr. Hossein Bassir (photo left, with Dr. Giuseppe Intini), was selected as the recipient of the American Academy of Periodontology Foundation Robert S. Schoor Research Award. This award is given to the first author of a manuscript that is significant to the clinical practice of periodontology. The title of Bassir’s research, which was conducted under the mentorship of Dr. Intini in the Department of Oral Medicine, Infection and Immunity at HSDM, is “Paired-Related Homeobox 1 Expressing Cells Are Required for Periodontal Homeostasis and Periodontal Regeneration.”

Research Bulletin • September – October 2017 • Harvard School of Dental Medicine 3

HSDM PUBLICATIONS Developmental Biology

Choi Y, Chang J, Chung C, Tahk J, Kim K. Prediction of long-term success of orthopedic treatment in skeletal class III malocclusions. American Journal of Orthodontics and Dentofacial Orthopedics 2017;152(2):193-203.

Hu K, Olsen BR, Besschetnova T. Cell autonomous ANTXR1-mediated regulation of extracellular matrix components in primary fibroblasts. Matrix Biology 2017;62:105-114.

Johnston C, Skeete C, Fomenkov A, Roberts R, Rittling S.Restriction-modification mediated barriers to exogenous DNA uptake and incorporation employed by Prevotella intermedia. PLoS One.2017;12(9):e0185234.

Kim W, Khan S, Liu Y, Xu R, Park O, He Y, Cha B, Gao B, Yang Y. Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma. Gut 2017; Sep 2.

Tischfield M, Robson C, Gilette N, Chim S, Sofela F, DeLisle M, Gelber A, Barry B, MacKinnon S, Dagi L, Nathans J, Engle E. Cerebral vein malformations result from loss of Twist1 expression and BMP signaling from skull progenitor cells and dura. Developmental Cell 2017; Aug 22.

Wei X, Jiang L, Liu Y, Feng D, He P, Chen J, Yu D, Tan N. Serum uric acid as a simple risk factor in patients with rheumatic heart disease undergoing valve replacement surgery. Clinica Chimica Acta 2017; Jul 19.

Xu R, Hu J, Zhou X, Yang Y. Heterotopic ossification: Mechanistic insights and clinical challenges. Bone 2017; Aug 27.

Zhu Q, Li M, Yan C, Lu Q, Wei S, Gao R, Yu M, Zou Y, Sriram G, Tong H, Hunziker W, Seneviratne C, Gong Z, Olsen BR, Cao T. Directed differentiation of human embryonic stem cells to neural crest stem cells, functional peripheral neurons, and corneal keratocytes. Biotechnology Journal 2017; Aug 1.

Restorative Dentistry and Biomaterials SciencesBowley J, Kaye E, Garcia R. Theoretical axial wall angulation for rotational resistance form in an experimental-fixed partial denture. Journal of Advanced Prosthodontics 2017;9(4):278-86.

Kihara H, Sun J, Sakai M, Nagai S, Da Silva J. A survey of dental implant instruction in predoctoral dental curricula in North America. Journal of Dental Education 2017;81(9):1085-1090.

Kwon D, Lee S, Wikesjö U, Johansson P, Johansson C, Sul Y. Bone tissue response following local drug delivery of bisphosphonate through titanium oxide nanotube implants in a rabbit model. Journal of Clinical Periodontology 2017; Jul 13.

Oral Medicine, Infection and ImmunityBelstrøm D, Sembler-Møller M, Grande M, Kirkby N, Cotton S, Paster B, Holmstrup P. Microbial profile comparisons of saliva, pooled and site-specific subgingival samples in periodontitis patients. PLoS One 2017;12(8):e0182992.

Caetano-Lopes J, Lessard S, Hann S, Espinoza K, Kang K, Lim K, Horan D, Noonan H, Hu D, Baron R, Robling A, Warman M. Clcn7F318L/+ as a new mouse model of Albers-Schönberg disease. Bone 2017; Sep 20.

Colombo N, Kreling P, Ribas L, Pereira J, Kressirer C, Klein M, Tanner A, Duque C. Quantitative assessment of salivary oral bacteria according to the severity of dental caries in childhood. Archives of Oral Biology 2017;83:282-288.

Courbebaisse M, Lanske B. Biology of fibroblast growth factor 23: From physiology to pathology. Cold Spring Harbor Perspective in Medicine 2017; Aug 4.

Cuevas-Nunez M, Gomes C, Woo SB, Ramsey M, Chen X, Xu S, Xu T, Zhan Q, Murphy G, Lian C. Biological significance of 5-hydroxymethylcytosine in oral epithelial dysplasia and oral squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2017; Jun 16.

Figueroba S, Groppo M, Faibish D, Groppo F. The action of anti-inflammatory agents in healthy temporomandibular joint synovial tissues is sex-dependent. International Journal of Oral and Maxillofacial Surgery 2017; Sep 5.

Garrison B, Rybak A, Beerman I, Heesters B, Mercier F, Scadden D, Bryder D, Baron R, Rossi D. ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells. Blood 2017;130(5):619-624.

Hashemi S, Fernandez Martinez J, Saligan L, Sonis S. Exploring genetic attributions underlying radiotherapy-induced fatigue in prostate cancer patients. Journal of Pain Symptom Management 2017; Aug 7.

Johnston C, Skeete C, Fomenkov A, Roberts R, Rittling S. Restriction-modification mediated barriers to exogenous DNA uptake and incorporation employed by Prevotella intermedia. PLoS One 2017;12(9):e0185234.

Keller M, Kressirer C, Belstrøm D, Twetman S, Tanner A. Oral microbial profiles of individuals with different levels of sugar intake. Journal of Oral Microbiology 2017;9(1):1355207.

Kota S, Pernicone E, Leaf D, Stillman I, Waikar S, Kota S. BPI fold-containing family a member 2/parotid secretory protein is an early biomarker of AKI. American Society of Nephrology 2017; Aug 3.

Lalla R, Treister N, Sollecito T, Schmidt B, Patton L, Mohammadi K, Hodges J, Brennan M. Oral complications at six months after radiation therapy for head and neck cancer. Oral Diseases 2017; Jul 4.

Le P, Bishop K, Maridas D, Motyl K, Brooks D, Nagano K, Baron R, Bouxsein M, Rosen C. Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice. Bone 2017; Aug 15.

Lerman M, Almazrooa S, Lindeman N, Hall D, Villa A, Woo SB. HPV-16 in a distinct subset of oral epithelial dysplasia. Modern Pathology 2017; Aug 11.

Mika M, Maurer J, Korten I, Allemann A, Aebi S, Brugger S, Qi W, Frey U, Latzin P, Hilty M. Influence of the pneumococcal conjugate vaccines on the temporal variation of pneumococcal carriage and the nasal microbiota in healthy infants: A longitudinal analysis of a case-control study. Microbiome 2017;5(1):85.

Raizada M, Joe B, Bryan N, Chang E, Dewhirst F, Borisy G, Galis Z, Henderson W, Jose P, Ketchum C, Lampe J, Pepine C, Pluznick J, Raj D, Seals D, Gioscia-Ryan R, Tang W, Oh Y. Report of the National Heart, Lung, and Blood Institute working group on the role of microbiota in blood pressure regulation: Current status and future directions. Hypertension 2017; Jul 31.

Ribeiro A, Azcarate-Peril M, Cadenas M, Butz N, Paster B, Chen T, Bair E, Arnold R. The oral bacterial microbiome of occlusal surfaces in children and its association with diet and caries. PLoS One 2017;12(7):e0180621.

Sultan A, Zimering Y, Petruzziello G, Alyea E, Antin J, Soiffer R, Ho V, Sonis S, Woo SB, Marty F, Treister N. Oral health status and risk of bacteremia following allogeneic hematopoietic cell transplantation. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2017;124(3):253-260.

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4 Research Bulletin • September – October 2017 • Harvard School of Dental Medicine

Oral Health Policy and EpidemiologyCalvo J, Kwatra J, Yansane A, Tokede O, Gorter R, Kalenderian E. Burnout and work engagement among US dentists. Journal of Patient Safety 2017; Jun 30.

Razzaque M. Can adverse effects of excessive vitamin D supplementation occur without developing hypervitaminosis D? Journal of Steroid Biochemistry and Molecular Biology 2017; Jul 19.

Roberts H, Seymour B, Fish S, Robinson E, Zuckerman E. Digital health communication and global public influence: A study of the Ebola epidemic. Journal of Health Communications 2017;22(sup1):51-58.

Roig Jornet P, Kalenderian E. The effectiveness of an initial continuing education course in leadership for dentists. European Journal of Dental Education 2017; Jul 20.

Sengupta N, Nanavati S, Cericola M, Simon L. Oral health integration into a pediatric practice and coordination of referrals to a colocated dental home at a federally qualified health center. American Journal of Public Health 2017; Aug e1-e3.

Oral and Maxillofacial Surgery Abramowicz S, Kaban L, Wurtzel A, Roser S. Are oral and maxillofacial surgery residents being adequately trained to care for pediatric patients? Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2017; May 4.

Inverso G, Aizer A, Ziehr D, Hyatt A, Choueiri T, Hoffman K, Hu J, Beard C, D’Amico A, Martin N, Orio P, Trinh Q, Nguyen P. Incidence and determinants of 1-month mortality after cancer-directed surgery. Journal of Clinical Oncology 2014;32:282.

Kaban L, Cappetta A, George B, Lahey E, Bohnen J, Troulis M. Evaluation of oral and maxillofacial surgery residents’ operative skills: Feasibility and engagement study using SIMPL software for a mobile phone. Journal of Oral and Maxillofacial Surgery 2017; Jun 8.

Kooiman T, Calabrese C, Didier R, Estroff J, Padwa B, Koudstaal M, Resnick C. Prenatal measurement of micrognathia and oropharyngeal space in patients with robin sequence. Journal of Oral and Maxillofacial Surgery 2017; Jul 26.

Peacock Z. Controversies in oral and maxillofacial pathology. Oral and Maxillofacial Surgery Clinics of North America 2017; Sep 8.

Resnick C. Precise osteotomies for mandibular distraction in infants with Robin sequence using virtual surgical planning. International Journal of Oral and Maxillofacial Surgery 2017; Aug 16.

Resnick C. Virtual surgical planning for mandibular distraction in infants with Robin sequence. Plastic and Reconstructive Surgery 2017; 5(6):e1379.

Resnick C, Vakilian P, Kaban L, Peacock Z. Is Intra-articular steroid injection to the temporomandibular joint for juvenile idiopathic arthritis more effective and efficient when performed with image guidance? Journal of Oral Maxillofacial Surgery 2017;75(4):694-700.

Multi-DepartmentalGallucci G, Khoynezhad S, Yansane A, Taylor J, Buser D, Friedland B. Influence of the posterior mandible ridge morphology on virtual implant planning. International Journal of Oral and Maxillofacial Implants 2017;32(4):801-806.

He P, Iwanaga J, Truong M, Adeeb N, Tubbs R, Yamaki K. First report of tripled retromolar foramina. Cureus 2017;9(7):e1440.

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Ji Y, Donoff R, Peacock Z, Carlson E. Surgical landmarks to locating the main trunk of the facial nerve in parotid surgery: A systematic review. Journal of Oral and Maxillofacial Surgery 2017; Jun 30.

Patel N. Fee-for-value in the pharmaceutical industry: A policy framework applying data science to negotiate drug prices. Journal of Law and the Biosciences 2017;4(1):205-215.

Patel N, Ji Y, Dodson T, Donoff R. Health policy research may ensure the future of oral and maxillofacial surgery. Journal of Oral and Maxillofacial Surgery 2017; Aug 16.

Tain M, Schwartzstein R, Friedland B, Park S. Dental and medical students’ use and perceptions of learning resources in a human physiology course. Journal of Dental Education 2017;81(9):1091-1097.

Wenyuan Shi, PhD Appointed CEO/CSO of The Forsyth Institute

The Forsyth Institute has appointed Dr. Wenyuan Shi as chief executive officer and chief scientific officer. Shi is the co-author of over 200 scientific articles and is credited as co-inventor of 45 patents. Most notable among these inventions is an herbal lollipop that can treat tooth decay in children, which he designed and brought to market in 2008. In recent years, Shi

has worked to patent a series of inventions that aim to more effectively kill bacteria in the mouth, preventing dental problems like gum infections and tooth decay before they start. Prior to joining Forsyth, Shi was Chair of the Section of Oral Biology at the UCLA School of Dentistry and Doctoral Advisor for the Oral Biology PhD Program. “I am excited to be joining an organization whose mission so closely aligns with my passions,” said Dr. Shi. “The Forsyth Institute has long been a leader in bringing together great minds and fostering discussion and discovery. I truly believe that we can revolutionize the way oral health and overall health are perceived through foundational research discoveries, as well as through community outreach programs that educate the public about the importance of oral health. I look forward to furthering the Forsyth mission by elevating oral health into the national spotlight and by continuing to serve as a convenor around important discussions that will drive new discoveries.”