How Toxins Change Metabolism and May Lead to Obesity

How Toxins Change How Toxins Change Metabolism and Metabolism and

May Lead to May Lead to Obesity Obesity

Mark Schauss, MBA, DB

Director, Lab Test Division, Crayhon Research, Reno, Nevada, USA

Mark Schauss, M.B.A., Mark Schauss, M.B.A., D.B.D.B.

• I have been researching the field of I have been researching the field of laboratory testing since 1985.laboratory testing since 1985.

• Developed a computerized laboratory Developed a computerized laboratory test analysis system with 2 U.S. test analysis system with 2 U.S. patents.patents.

• Discovered mathematical algorithms Discovered mathematical algorithms allowing for the discovery of Krebs's allowing for the discovery of Krebs's Cycle disruptions and solutions due to Cycle disruptions and solutions due to environmental toxicity.environmental toxicity.

A Personal Reason For My A Personal Reason For My ResearchResearch

• Environmental Environmental health took a health took a personal note with personal note with the poisoning of the poisoning of my daughter my daughter Anastasya and her Anastasya and her subsequent subsequent development of a development of a severe form of severe form of epilepsy.epilepsy.

……a little backgrounda little background• Our home was sprayed with pesticides Our home was sprayed with pesticides

two weeks before her first seizures.two weeks before her first seizures.• We lived downhill from a leaking We lived downhill from a leaking

gasoline storage tank.gasoline storage tank.• Because of my research trying to Because of my research trying to

uncover the causes of Tasya’s epilepsy uncover the causes of Tasya’s epilepsy as well as trying to develop a as well as trying to develop a nutritional program to help her control nutritional program to help her control her condition, I made a few profound her condition, I made a few profound discoveries.discoveries.

……a little backgrounda little background• I uncovered a series of testing I uncovered a series of testing

methods to determine the areas of methods to determine the areas of the Citric Acid Cycle (Krebs's or TCA the Citric Acid Cycle (Krebs's or TCA Cycle) that are disturbed due to Cycle) that are disturbed due to environmental toxins.environmental toxins.

• The implications crossed over to The implications crossed over to many major diseases and illnesses many major diseases and illnesses that are increasing in prevalence in that are increasing in prevalence in today’s world, especially obesity.today’s world, especially obesity.

Implications of ToxicityImplications of Toxicity• My topic today relates to the way My topic today relates to the way

environmental toxins ranging from environmental toxins ranging from heavy metals to petrochemicals to heavy metals to petrochemicals to mycotoxins can slow down the mycotoxins can slow down the ability of our cells to create energy ability of our cells to create energy from food, especially from from food, especially from carbohydrates.carbohydrates.

Implications of ToxicityImplications of Toxicity• Aside from hormonal, neurological, Aside from hormonal, neurological,

and endocrine disruption, and endocrine disruption, environmental toxins can slow down environmental toxins can slow down the resting metabolic rate which the resting metabolic rate which may be one of the most important may be one of the most important reasons for the increase of obesity reasons for the increase of obesity worldwide.worldwide.

Toxicity – Implications in Toxicity – Implications in Weight ManagementWeight Management

• Laboratory animals undergoing toxicity Laboratory animals undergoing toxicity testing showed decreased body temperature.testing showed decreased body temperature.

• Researchers believe that the movement Researchers believe that the movement towards hypothermia may be a protective towards hypothermia may be a protective device used by the body to slow down the device used by the body to slow down the effects of the toxins.effects of the toxins.

• A theoretical model I have proposed over 5 A theoretical model I have proposed over 5 years ago is that the greater number of years ago is that the greater number of people being seen today with low basal people being seen today with low basal temperature is our response to an increase temperature is our response to an increase in toxic load.in toxic load.


• Lower resting metabolism and low Lower resting metabolism and low basal temperature due to toxicity = basal temperature due to toxicity = slower toxic effects = decreased ATP slower toxic effects = decreased ATP production = more weight gain or production = more weight gain or slower weight loss.slower weight loss.

• This theory may explain why so many This theory may explain why so many more people are becoming obese and more people are becoming obese and overweight despite interventions such overweight despite interventions such as exercise and dietary restrictions.as exercise and dietary restrictions.


• I’d like to add one issue here and that solvents I’d like to add one issue here and that solvents have a strong negative effect on the insulin have a strong negative effect on the insulin regulatory system of the hypothalamus.regulatory system of the hypothalamus.

• As we know the hypothalamus regulates body As we know the hypothalamus regulates body temperature, blood pressure, heartbeat, temperature, blood pressure, heartbeat, metabolism of fats and carbohydrates, and metabolism of fats and carbohydrates, and sugar levels in the blood.sugar levels in the blood.

• This effect is not only on obesity but may have This effect is not only on obesity but may have powerful implications on the development of powerful implications on the development of Type II diabetes as well.Type II diabetes as well.


• In the July 2004 In the July 2004 International Journal International Journal of Obesityof Obesity, Dr. Angelo Tremblay of , Dr. Angelo Tremblay of Laval University in Quebec, Canada Laval University in Quebec, Canada said the following:said the following:

““Pollution seems to be a new factor Pollution seems to be a new factor affecting the control of thermogenesis affecting the control of thermogenesis in some obese individuals experiencing in some obese individuals experiencing

body-weight loss.”body-weight loss.”


• If a person were to ingest 2,500 If a person were to ingest 2,500 calories daily and they were moderately calories daily and they were moderately physically active, their resting physically active, their resting metabolism would be responsible for metabolism would be responsible for burning approximately 1,875 calories. burning approximately 1,875 calories. If toxicity caused a moderate 7% If toxicity caused a moderate 7% reduction in the ability to convert the reduction in the ability to convert the calories to energy, we would be left calories to energy, we would be left with 131 unburned calories daily.with 131 unburned calories daily.


• We then assume that 7,714 calories is We then assume that 7,714 calories is equivalent to 1 kilogram of weight.equivalent to 1 kilogram of weight.

• In over year, at 131 calories a day, In over year, at 131 calories a day, the person would have 47,815 the person would have 47,815 calories unburned. (131 x 365)calories unburned. (131 x 365)

• This would equate to 6.19 kilograms This would equate to 6.19 kilograms of additional weight gain per year or of additional weight gain per year or 30.95 kilograms in a 5 year period.30.95 kilograms in a 5 year period.


• In the United States, the most toxic In the United States, the most toxic city is Houston, Texas. It is also the city is Houston, Texas. It is also the most obese city in the country.most obese city in the country.

• Since many of the toxins involved in Since many of the toxins involved in the disruption of the Citric Acid Cycle the disruption of the Citric Acid Cycle are stored in the adipose tissue, the are stored in the adipose tissue, the increased levels of dietary fat intake increased levels of dietary fat intake among the obese, compound the among the obese, compound the problem.problem.


• Using urinary organic acid testing, which I Using urinary organic acid testing, which I will discuss in my other talk, I discovered that will discuss in my other talk, I discovered that it is at the entry point to the Citric Acid Cycle it is at the entry point to the Citric Acid Cycle where the first metabolic blockade occurs due where the first metabolic blockade occurs due to toxicity.to toxicity.

• Calculations done by my company, Crayhon Calculations done by my company, Crayhon Research, on CAC metabolites Pyruvate, Research, on CAC metabolites Pyruvate, Lactate and Citrate pinpointed the Lactate and Citrate pinpointed the abnormality and allows us to determine the abnormality and allows us to determine the possible type of toxin (heavy metal or possible type of toxin (heavy metal or petrochemical/solvent).petrochemical/solvent).

Citric Acid Cycle Entry Citric Acid Cycle Entry BlockadeBlockade

Lactate

Toxicity – Citric Acid Cycle - Toxicity – Citric Acid Cycle - TreatmentTreatment

• Three different protocols are universal:Three different protocols are universal:– The use of the amino acid Glycine (1-3 grams daily) is The use of the amino acid Glycine (1-3 grams daily) is

critical.critical.– The buildup of stores and production of the tri-peptide The buildup of stores and production of the tri-peptide

Glutathione.Glutathione.– The use of a Citric Acid Cycle stimulant and gentle The use of a Citric Acid Cycle stimulant and gentle

detoxifying agents such as detoxifying agents such as lymphomyosotlymphomyosot, , berberisberberis homaccordhomaccord, and , and nuxnux vomicavomica homaccordhomaccord from Heel.from Heel.

• Crayhon Research and Heel GmBH are in the Crayhon Research and Heel GmBH are in the early stages of a research project looking at the early stages of a research project looking at the efficacy of Heel’s Detoxification products.efficacy of Heel’s Detoxification products.

Transgenerational Transgenerational EpigeneticsEpigenetics

• I also believe there is a deeper threat and that I also believe there is a deeper threat and that is our passing on the legacy of environmental is our passing on the legacy of environmental toxicity to future generations because of the toxicity to future generations because of the newly discovered effect of transgenerational newly discovered effect of transgenerational epigenetics.epigenetics.

• In a study published in the journal In a study published in the journal ScienceScience, , researchers led by Anway, found that fetal researchers led by Anway, found that fetal exposure to certain endocrine disrupting toxins exposure to certain endocrine disrupting toxins not only affected the individuals exposed in the not only affected the individuals exposed in the womb but in subsequent generations.womb but in subsequent generations.– Anway MD, Cupp AS, Uzumcu M, and Skinner MD, Anway MD, Cupp AS, Uzumcu M, and Skinner MD,

Epigenetic Transgenerational Acitions of Endocrine Epigenetic Transgenerational Acitions of Endocrine Disruptors and Male Fertility. Science, 308:1466-Disruptors and Male Fertility. Science, 308:1466-1469, June 2005.1469, June 2005.

Transgenerational Transgenerational EpigeneticsEpigenetics

• The fourth generation of rats tested had the The fourth generation of rats tested had the same damage as the exposed rat did in same damage as the exposed rat did in generation one.generation one.

• The inheritance of the damage was not to the The inheritance of the damage was not to the DNA but by altering patterns of DNA DNA but by altering patterns of DNA methylation.methylation.

• The transgenerational epigenetic effect makes The transgenerational epigenetic effect makes detoxification of individuals, especially those of detoxification of individuals, especially those of child bearing age more important than ever.child bearing age more important than ever.

• Obesity will no longer be a disorder of impaired Obesity will no longer be a disorder of impaired energy production but an inherited disorder energy production but an inherited disorder which will be far more difficult to overcome.which will be far more difficult to overcome.

Transgenerational Effects Transgenerational Effects Being Seen TodayBeing Seen Today

Therapeutic Treatment Therapeutic Treatment ModalitiesModalities

• In reviewing potential treatment In reviewing potential treatment modalities it has become increasingly modalities it has become increasingly apparent that broad, population apparent that broad, population based protocols are bound to fail for based protocols are bound to fail for the great majority of individuals.the great majority of individuals.

• The relatively new field of The relatively new field of MetabonomicsMetabonomics holds the key to holds the key to treating each person in a treating each person in a biochemically individualized manner.biochemically individualized manner.

Metabonomics: Biochemical Metabonomics: Biochemical Individuality in the Treatment of Individuality in the Treatment of

ToxicityToxicity• A paper in the April 20A paper in the April 20th, 2006 issue of , 2006 issue of Nature

confirmed my long standing belief in biochemical confirmed my long standing belief in biochemical individuality as noted biochemist Dr. Jeremy K. individuality as noted biochemist Dr. Jeremy K. Nicholson of Imperial College London believed Nicholson of Imperial College London believed that a multitude of factors aside from genetics that a multitude of factors aside from genetics have a huge influence of how our bodies process have a huge influence of how our bodies process medications. medications.

• While his study was on the processing of drugs, While his study was on the processing of drugs, the ramifications of his paper shows that in the the ramifications of his paper shows that in the laboratory, genetically identical mice had a wide laboratory, genetically identical mice had a wide range of reactions to acetaminophen (Tylenol) range of reactions to acetaminophen (Tylenol) and these reactions were highly correlated to and these reactions were highly correlated to urinary marker patterns. urinary marker patterns.

http://www.nature.com/


ToxicityToxicity• The patterns include a number of The patterns include a number of

markers looked at by urinary organic markers looked at by urinary organic acid tests that Crayhon Research has acid tests that Crayhon Research has been interpreting for years.been interpreting for years.

• In the LabAssist Reports, we developed In the LabAssist Reports, we developed a method of looking at both blood and a method of looking at both blood and urinary markers and how they relate to urinary markers and how they relate to toxin interactions. toxin interactions.


ToxicityToxicity• Our other breakthroughs came in the Our other breakthroughs came in the

personalizing of nutritional interventions personalizing of nutritional interventions based on cross-correlated markers of based on cross-correlated markers of blood and urine metabolites. blood and urine metabolites.

• By measuring the results from these tests By measuring the results from these tests we are able to help medical professionals we are able to help medical professionals construct biochemically individualized construct biochemically individualized nutritional protocols which will maximize nutritional protocols which will maximize the dollar spent by the patient towards the dollar spent by the patient towards achieving optimal health.achieving optimal health.


ToxicityToxicity• Using this theory is critical in developing Using this theory is critical in developing

proper and proper and safesafe detoxification protocols detoxification protocols for toxic patients.for toxic patients.

• We must also be of the opinion that We must also be of the opinion that presently all humans are carrying a presently all humans are carrying a significant amount of toxins in their blood.significant amount of toxins in their blood.

• It then becomes paramount that we It then becomes paramount that we determine excretion capacity of these determine excretion capacity of these toxins. toxins.

Urinary Environmental Solvent Urinary Environmental Solvent Testing in Conjunction with Testing in Conjunction with

Organic AcidsOrganic Acids• US Biotek in Seattle, Washington, U.S.A. has US Biotek in Seattle, Washington, U.S.A. has

developed a urinary Environmental Pollutant developed a urinary Environmental Pollutant Biomarker test.Biomarker test.

• It looks for the solvent metabolites of Benzene, It looks for the solvent metabolites of Benzene, Styrene, Xylene, Toluene, Parabens, Styrene, Xylene, Toluene, Parabens, Trimethylbenzene, and Phthalates.Trimethylbenzene, and Phthalates.

• Combining it with their urinary organic acid Combining it with their urinary organic acid test allows the practitioner to pinpoint the test allows the practitioner to pinpoint the predominant toxin and the appropriate predominant toxin and the appropriate treatment protocol using the theory of treatment protocol using the theory of metabonomics over genetics.metabonomics over genetics.

The Time Has ComeThe Time Has Come• While researching my upcoming book, While researching my upcoming book,

“Achieving Victory Over A Toxic World” “Achieving Victory Over A Toxic World” one thing has become apparent; we one thing has become apparent; we must act now to avert a catastrophic must act now to avert a catastrophic disaster awaiting humankind.disaster awaiting humankind.

• While I focused on obesity, the legacy While I focused on obesity, the legacy we leave behind to the coming we leave behind to the coming generations will include numerous generations will include numerous diseases, especially those neurological diseases, especially those neurological in nature.in nature.

The Time Has ComeThe Time Has Come• It is critical that each person lessens their It is critical that each person lessens their

environmental footprint on our world, environmental footprint on our world, especially those of us in the United States.especially those of us in the United States.

• It is all of our responsibilities to educate It is all of our responsibilities to educate our patients, friends and relatives as well.our patients, friends and relatives as well.

• We must make detoxification a We must make detoxification a cornerstone of our practices in order to cornerstone of our practices in order to allow the patient the best opportunity to allow the patient the best opportunity to achieve optimal health.achieve optimal health.

Mark A. Schauss, M.B.A., Mark A. Schauss, M.B.A., D.B.D.B.

Crayhon ResearchCrayhon Research5355 Capital Court #101 5355 Capital Court #101

Reno, Nevada, 89502Reno, Nevada, 89502U.S.A.U.S.A.

[email protected]@crayhon.comwww.MarkSchauss.comwww.MarkSchauss.com

How Toxins Change Metabolism and May Lead to Obesity

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