How do drugs work?

Dr. Francisco Pérez García

Departament de Farmacologia

Donat el caràcter i la finalitat exclusivament docent i eminentment

il·lustrativa de les explicacions a classe d'aquesta presentació,

l’autor s’acull a l’article 32 de la Llei de Propietat Intel·lectual vigent

respecte de l'ús parcial d'obres alienes com ara imatges, gràfics o

altre material contingudes en les diferents diapositives

The term pharmacology comes from the Greek words:

•pharmakon - drug or medicine

•logos - the truth about or a rational discussion

Pharmacology

A synthesis of several biomedical sciences….

…but unique in its own right

Pharmacologists Study Science at Every Level

(2α,4α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-13-{[(2R,3S)- 3-(benzoylamino)-

2-hydroxy-3-phenylpropanoyl]oxy}- 1,7-dihydroxy-9-oxo-5,20-epoxytax-

11-en-2-yl benzoate = TAXOL

A LITTLE BIT OF CHEMISTRY AND A LITTLE BIT OF BOTANY

FROM AMINOACIDS TO PROTEIN DRUG RECEPTORS

RELATIONSHIP BETWEEN PROTEIN STRUCTURE AND FUNCTION

Function relies on interactions with other molecules

Binding of molecules to proteins is reversible

LOCK AND KEY THEORY

Ligand = molecule bound reversibly by a protein Binding site = site on protein where ligand binds

HIV protease + drug inhibitor

Kd = Kon/Koff = [D][R]/[DR]

Ka = 1/Kd = Koff/Kon =

[DR]/[D][R]

Induced fit model vs lock and key model

ACKNOWLEGMENTS The project «Contemporary Sciences and Research» (2012-2014) belongs to the Integrated Plan for Foreign Languages of Departament Of Education, Government of Catalonia

More info at www.formaciovirtual.com/cs and www.tecnologies.net

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