Honors Biology Chapter 7
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Honors Biology Chapter 7 Beyond Mendelian Genetics
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Honors Biology Chapter 7. Beyond Mendelian Genetics. Many Human Phenotypes Follow Mendelian Pattern. One gene / two alleles = 1 trait. Genetic Disorders Rare heritable illnesses . Most lethal disorders are recessive . Cystic Fibrosis. Huntington’s Disease – Dominant. - PowerPoint PPT Presentation
Transcript of Honors Biology Chapter 7
Honors Biology Chapter 7Beyond Mendelian Genetics
Many Human Phenotypes Follow Mendelian Pattern
One gene / two alleles = 1 trait
Genetic Disorders Rare heritable illnesses
• Most lethal disorders are recessive
Cystic Fibrosis
Huntington’s Disease – Dominant
Some Deleterious Genes Are Sex-Linked
• X-linked Recessive– Hemophilia (Bleeders Disease)
Hemophilia
Hemophilia
X-linked Dominant
• Retinitis Pigmentosa
Non-Mendelian GeneticsComplex Patterns of Inheritence
• Traits do not segregate according to Mendel’s Laws– X inactivation– Incomplete Dominance– Codominance– Polygenic Traits• Epistasis
– Multiple Alleles– Environmental Influences– Others
X-Inactivation
X-Inactivation
Epistasis
Incomplete Dominance
Codominance
Codominance
Multiple Alelles
Sex-linked Traits
Polygenic Traits
Polygenic Traits
Polygenic Traits
Polygenic Traits
Gene Linkage
KaryotypesPrepared from blood, bone marrow, amniotic fluid, placenta
Karyotypes
KaryotypesDetect Abnormal #
KaryotypesDetect Structural Defects
Pedigrees
