HNC Working Group Newsletter 2 - Baylor College of · PDF fileElizabeth Chiao, MD; E. Susan...
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Spring 2016 April 18, 2016 HEAD & NECK CANCER DISEASE- ORIENTED WORKING GROUP NEWSLETTER Help us spread the word, please submit your awards, grants and funding, and publications to Nicole Trieu at [email protected]. Head and Neck Cancer Seed Grant Awardees Results of First Head and Neck Cancer Mini-Grant Competitions Congratulations to the winners of our first-ever head and neck cancer Mini-Grants competition: Dr. Masataka Suzuki (with co-PI, Dr. Stephen Gottschalk, both in the Center for Cell and Gene Therapy); and Dr. Kenneth W. Altman (with co-PI Dr. Farrah Kheradmand, in the Departments of Otolaryngology and Medicine, respectively). Principal Investigator: Masataka Suzuki, PhD of the Center for Gene and Cell Therapy Co-Investigator: Stephen Gottschalk, MD of Center for Cell and Gene Therapy Title: Combinatorial treatment of Ad gene therapy with CAR T-cell therapy for HNSCC immunotherapy Principal Investigator: Kenneth W. Altman, MD, PhD, FACS of the Department of Otolaryngology - Head and Neck Surgery Co-Investigator: Farrah Kheradmand, MD of the Department of Medicine - Section of Pulmonary, Critical Care and Sleep Medicine Title: Pre-malignant Degeneration and the Inflammatory Response to Smoke and Vape in a Murine Model Recent Head and Neck Cancer-Focused Faculty Recruitments k Yohannes T. Ghebre, PhD Dr. Yohannes Ghebre joined BCM in February 2016 as a faculty member of the Department of Radiation Oncology. Dr. Ghebre’s research is focused on drug reformulation and repurposing for the prevention and treatment of chemoradiation-induced complications including tissue inflammation and fibrosis. His group is also working on immunotherapeutic approaches for the treatment of head and neck as well as thoracic malignancies. Prior to joining BCM, Dr. Ghebre was a faculty member at Houston Methodist Research http://www.bcm.edu/hncancerprogram Dan L. Duncan Cancer Center 1
Transcript of HNC Working Group Newsletter 2 - Baylor College of · PDF fileElizabeth Chiao, MD; E. Susan...
Spring 2016 April 18, 2016
HEAD & NECK CANCER DISEASE-ORIENTED WORKING GROUP
NEWSLETTER Help us spread the word, please submit your awards, grants and funding, and publications to Nicole Trieu at [email protected].
Head and Neck Cancer Seed Grant Awardees Results of First Head and Neck Cancer Mini-Grant Competitions Congratulations to the winners of our first-ever head and neck cancer Mini-Grants competition: Dr. Masataka Suzuki (with co-PI, Dr. Stephen Gottschalk, both in the Center for Cell and Gene Therapy); and Dr. Kenneth W. Altman (with co-PI Dr. Farrah Kheradmand, in the Departments of Otolaryngology and Medicine, respectively).
Principal Investigator: Masataka Suzuki, PhD of the Center for Gene and Cell Therapy Co-Investigator: Stephen Gottschalk, MD of Center for Cell and Gene Therapy
Title: Combinatorial treatment of Ad gene therapy with CAR T-cell therapy for HNSCC immunotherapy
Principal Investigator: Kenneth W. Altman, MD, PhD, FACS of the Department of Otolaryngology - Head and Neck Surgery Co-Investigator: Farrah Kheradmand, MD of the Department of Medicine -
Section of Pulmonary, Critical Care and Sleep Medicine
Title: Pre-malignant Degeneration and the Inflammatory Response to Smoke and Vape in a Murine Model
Recent Head and Neck Cancer-Focused Faculty Recruitments
kYohannes T. Ghebre, PhD Dr. Yohannes Ghebre joined BCM in February 2016 as a faculty member of the Department of Radiation Oncology. Dr. Ghebre’s research is focused on drug reformulation and repurposing for the prevention and treatment of chemoradiation-induced complications including tissue inflammation and fibrosis. His group is also working on immunotherapeutic approaches for the treatment of head and neck as well as thoracic malignancies. Prior to joining BCM, Dr. Ghebre was a faculty member at Houston Methodist Research
http://www.bcm.edu/hncancerprogram Dan L. Duncan Cancer Center �1
Spring 2016 April 18, 2016
Institute (HMRI) and was trained at Stanford University, School of Medicine. Vlad C. Sandulache, MD, PhD
Dr. Vlad Sandulache will be joining us in July 2016 from University of Texas MD Anderson where he is currently a head and neck surgical oncology fellow. Dr. Sandulache is a clinician-scientist, whose clinical appointment will be at the Michael E. DeBakey VA Medical Center where he will focus on the surgical treatment of head and neck cancer patients. Dr. Sandulache’s research focus will be on cancer metabolism, and developing predictive biomarkers of cancer treatment response. His primary appointment is in the Department of Otolaryngology.
Hoda Badr, PhD
Dr. Hoda Badr is currently on faculty at the Icahn School of Medicine at Mount Sinai, and joining BCM faculty in July 2016. Dr. Badr is a behavioral scientist whose research focuses on family adjustment during the protracted course of cancer treatment, as well as interpersonal relationship factors that influence patient and caregiver quality of life. Dr. Badr will have a primary appointment in the Department of Medicine, Division of Health Services, and a secondary appointment in Otolaryngology.
Upcoming Events • Oral, Head and Neck Cancer Awareness Week - April 10 -16 (Be on the lookout for blogs on the
BCM Momentum Blog!)• Monthly Head and Neck Working Group Program Meeting: Wednesday, May 11, 2016 at 5pm
in Neurosensory Center NA511 Conference Room
Head and Neck Cancer Support Group at Ben Taub Hospital Led by BCM Speech Pathologists The Speech Pathology Department at Ben Taub Hospital began a Head and Neck Cancer Support Group in 2015 consisting of speech pathologists Rayna Bohmann, Maria Gomez-White, and Catherine Renee Garza. Their goal is to provide support, education and encouragement to patients who are currently in treatment for head and neck cancer or have completed treatment. This support group meets quarterly and has been well attended by current and past patients as well as family members. Patients enjoy having an outlet to express their concerns and struggles as well as learn from others who have gone through and/or are going though head and neck cancer treatment. Each support group begins with a patient sharing time followed by education on a particular topic. Topics of interest have included managing secretions and reflux, assistance with returning to work, use and benefits of heat posture exchange system, and common issues with tracheoesophageal speech.
http://www.bcm.edu/hncancerprogram Dan L. Duncan Cancer Center �2
Spring 2016 April 18, 2016
Approved IRB Protocols PI: Nadia Mohyuddin, MD Coordinator: Michael Yim, MDTitle: Optical Imaging for Detection of Oral Cavity LesionsInfo: The goal of this study is to test a novel cellphone-based system for identifying oral cancer and pre-cancerStatus: Approved, soon to open
Honors and Presentations Andrew Sikora, MD, PhD was elected to the Primary Untreated/Locoregionally Advanced (PULA) Disease Task Force of the NCI Head and Neck Steering Committee. The steering committee and its task forces work to build efficient, cost-effective, science-driven and transparent processes that identify and promote head and neck clinical research. This honor recognizes Dr. Sikora’s groundbreaking translational research in tumor immunology and cancer immunotherapy clinical trials.
Honors and Presentations cont.
Presidential Citation, Annual Meeting of the American Laryngological Association, Chicago, IL, May 2016 - Altman KW President-Elect, American Laryngological Association - Altman KWGuest Editor, Phoniatrics - BioMed Research International - Altman KW Altman KW, “Balancing the voice and cure in managing laryngeal leukoplakia,” (keynote address), The 2015 International Symposium of Voice Medicine, Beijing, China, October 24-25, 2015. Altman KW, “Improving Health Outcomes and Value with Care Pathways,” Visiting Professor, Grand Rounds, Department of Otorhinolaryngology - HNS, University of Pennsylvania, Philadelphia, PA, February 4, 2016.
Recently Awarded Research GrantsPI Project title Donor
PI: Michael McGrath, MD, PhDCo-I: Andrew Sikora, MD, PhD; Elizabeth Chiao, MD; E. Susan Amirian, PhD
Baylor College of Medicine ACSR HIV Epithelial Malignancies Biospecimen Cohort
National Institutes of Health
PI: Mathew Anderson, MD, PhD Head and Neck Cancer Co-I: Andrew Sikora, MD, PHD
Clinical Proteomics Tumor Analysis Consortium (CPTAC)
National Cancer Institute
PI: Kenneth W. Altman, MD, PhD, FACS
Pre-Malignant Degeneration and the Inflammatory Response to Smoke and Vape in Murine Model
BCM Head and Neck Cancer Program Seed Grants
PI: Cielito C. Reyes-Gibby, DR, PH BCM Site PI: Susan Eicher, MD
Molecular Epidemiology of Neuropathic Pain in Head and Neck Center
National Institute of Dental and Craniofaical Research (NIDCR)
PI: Stephen M. Gottschalk, MD; MAsataka Suzuki, PhD
Combinatorial treatment of Ad gene therapy with CAR T-cell therapy for HNSCC immunotherapy
BCM Head and Neck Cancer Program Seed Grants
http://www.bcm.edu/hncancerprogram Dan L. Duncan Cancer Center �3
Spring 2016 April 18, 2016
PublicationsDel Signore AG, Shah RN, Gupta N, Altman KW, Woo P. Complications and Failures of Office-Based Endoscopic Angiolytic Laser Surgery Treatment. J Voice. September 2015. doi:10.1016/j.jvoice.2015.08.022.
Gelbard A, Donovan DT, Ongkasuwan J, et al. Disease homogeneity and treatment heterogeneity in idiopathic subglottic stenosis. Laryngoscope. November 2015. doi:10.1002/lary.25708.
Veit JA, Heine D, Thierauf J, Sikora AG, et al. Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck. Head Neck. February 2016. doi:10.1002/hed.24403.
Parasher AK, Kidwai SM, Schorn VJ, Sikora AG, et al. High-resolution microendoscope imaging of inverted papilloma and normal sinonasal mucosa: evaluation of interobserver concordance. Int Forum Allergy Rhinol. 2015;5(12):1136-1140. doi:10.1002/alr.21603.
Richter AL, Ongkasuwan J, Ocampo EC. Long-term follow-up of vocal fold movement impairment and feeding after neonatal cardiac surgery. Int J Pediatr Otorhinolaryngol. 2016;83:211-214. doi:10.1016/j.ijporl.2016.02.014.
Rajagopal A, Homan EP, Joeng KS, Suzuki M, et al. Restoration of the serum level of SERPINF1 does not correct the bone phenotype in Serpinf1 null mice. Mol Genet Metab. 2016;117(3):378-382. doi:10.1016/j.ymgme.2015.11.015.
Timothy J. Vece, Abria Haynes, Jessica Runge, Ongkasuwan J, et al. The Microbiome of the Aerodigestive Tract as a Tool in the Diagnosis of Aspiration in Children. In: B54. PEDIATRIC DIAGNOSTIC TESTS AND INFECTIONS. American Thoracic Society International Conference Abstracts. American Thoracic Society; 2015:A6397-A6397. http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A6397. Accessed April 6, 2016.
Richards AL, Sugumaran M, Aviv JE, Woo P, Altman KW. The utility of office-based biopsy for laryngopharyngeal lesions: comparison with surgical evaluation. Laryngoscope. 2015;125(4):909-912. doi:10.1002/lary.25005.
Simmons C, Vinh D, Donovan DT, Ongkasuwan J. Tracheobronchopathia osteochondroplastica. Laryngoscope. December 2015. doi:10.1002/lary.25813.
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