HIVToolbox: An Integrated Web Application for Investigating HIV
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HIVToolbox: An Integrated Web Application for Investigating HIV David P. Sargeant, Sandeep Deverasetty, Yang Luo, Angel Villahoz-Baleta, Stephanie Zobrist, Viraj R. Rathnaayake, Jacquelie C. Russo, Jay Vyas, Christy Strong, Mark A. Muesing, Martin R. Schiller July 25, 2012
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HIVToolbox: An Integrated Web Application for Investigating HIV . David P. Sargeant , Sandeep Deverasetty , Yang Luo , Angel Villahoz-Baleta , Stephanie Zobrist , Viraj R. Rathnaayake , Jacquelie C. Russo, Jay Vyas , Christy Strong, Mark A. Muesing , Martin R. Schiller July 25, 2012. - PowerPoint PPT Presentation
Transcript of HIVToolbox: An Integrated Web Application for Investigating HIV
HIVToolbox: An Integrated Web Application for Investigating HIV
David P. Sargeant, Sandeep Deverasetty, Yang Luo, Angel Villahoz-Baleta, Stephanie Zobrist, Viraj R. Rathnaayake, Jacquelie C. Russo, Jay
Vyas, Christy Strong, Mark A. Muesing, Martin R. Schiller
July 25, 2012
HIVToolbox for Sequence, Structure, and Function
Integrated display: HIV-1 proteins, ~300,000 sequences,~700 structures, ~1000 activities, ~1500 mutations
>16,000 searches
Linked to PDB
HIVToolbox2 for Drug Resistance
Darunavir Binding SiteDimerizationActive
site
Flap
Darunavir Resistance
Atazanavir Resistance
fosAmprenavir Resistance
Saquinavir Resistance
Ritonavir Resistance
Nelfinavir Resistance
Lopinavir Resistance
IndinavirResistance
Tipranaivir Resistance
>80% identity50,000 isolates
PrimaryPrimary SetBeneficialBeneficial SetSecondary
3JVY
Conserved
HIVGeoRes for Drug Resistance
Atazanavir Resistance
Darunavir Resistance
fosAmprenavir Resistance
Nelfinavir Resistance
Lopinavir Resistance
IndinavirResistance
Ritonavir Resistance
Saquinavir Resistance
Tipranaivir Resistance
IAVI Report, 2003
Geographic resistance profiles do not mimic subtype profiles
Hivtoolbox.bio-toolkit.comBio-toolkit.comSargeant et al. PLoS One
2011
