Histology Independent Indications - European Medicines Agency · • Allow answering multiple...
Transcript of Histology Independent Indications - European Medicines Agency · • Allow answering multiple...
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Histology Independent Indications The HTA view
Anja Schiel, PhD, Senior Assessor Norwegian Medicines Agency
15/12/17
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Heterogeneity is not just a RCT problem • To obtain a consolidated opinion from HTA’s is pretty much
close to impossible due to the large heterogeneity of methodologies in use
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Heterogeneity is not just a RCT problem • To obtain a consolidated opinion from HTA’s is pretty much
close to impossible due to the large heterogeneity of methodologies in use
• Consequently new trial designs pose different problems for different HTA’s
• With the help of Michelle Mujoomdar from EUnetHTA / ZIN we performed a ‘quick and dirty’ mini-survey among members of EUnetHTA and international HTA’s.
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Survey • Questions were aimed at exploring the
• Awareness around new trial designs • experience with them • acceptability in the health-economic context • specific problems arising from such trials
• 5 EU, Canada and Australia
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Summary • All HTA’s answered that they are familiar with terms like
‘basket’ or ‘umbrella’ but that the definitions what actually comprises such designs are blurry.
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Summary • All HTA’s answered that they are familiar with terms like
‘basket’ or ‘umbrella’ but that the definitions what actually comprises such designs are blurry.
• Some agencies had experience assessing such trials, some mainly in early phase development, but not all
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Summary • All HTA’s answered that they are familiar with terms like
‘basket’ or ‘umbrella’ but that the definitions what actually comprises such designs are blurry.
• Some agencies had experience assessing such trials, some mainly in early phase development, but not all
• No agency disapproved of such trials but similar methodological concerns were raised as discussed earlier
• Statistical power • Uncontrolled aspects of some trial designs • Independence !
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What are the advantages • Faster and more efficient drug development
(Pts/Reg/Ind/HTA?/Pay?)
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What are the advantages • Faster and more efficient drug development
(Pts/Reg/Ind/HTA?/Pay?) • In some rare diseases the only feasible option
(Pts/Reg/Ind/HTA?/Pay?)
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What are the advantages • Faster and more efficient drug development
(Pts/Reg/Ind/HTA?/Pay?) • In some rare diseases the only feasible option
(Pts/Reg/Ind/HTA?/Pay?) • Allow answering multiple research questions in parallel
(Pts/Reg/Ind/HTA/Pay?)
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What are the advantages • Faster and more efficient drug development
(Pts/Reg/Ind/HTA?/Pay?) • In some rare diseases the only feasible option
(Pts/Reg/Ind/HTA?/Pay?) • Allow answering multiple research questions in parallel
(Pts/Reg/Ind/HTA/Pay?) While some advantages are identified for other
stakeholders, the majority of HTA’s couldn’t see advantages for the health-economic assessment.
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Methodological challenges • Multiplicity issue, statistical strength, chance findings due to
small baskets
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Methodological challenges • Multiplicity issue, statistical strength, chance findings due to
small baskets • Lack of robust comparative data
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Methodological challenges • Multiplicity issue, statistical strength, chance findings due to
small baskets • Lack of robust comparative data • Translation of results into a relevant patient-level outcomes
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Methodological challenges • Multiplicity issue, statistical strength, chance findings due to
small baskets • Lack of robust comparative data • Translation of results into a relevant patient-level outcomes • Lack of (statistical) methodology that ensures robust
assessment of the (relative) effectiveness
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Methodological challenges • Multiplicity issue, statistical strength, chance findings due to
small baskets • Lack of robust comparative data • Translation of results into a relevant patient-level outcomes • Lack of (statistical) methodology that ensures robust
assessment of the (relative) effectiveness There is not enough experience at the moment to relieve
the reluctance to endorse these approaches
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Relative effectiveness • Making reimbursement decisions based on a biomarker
approach is not principally considered impossible by the HTA’s included in the survey!
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Relative effectiveness • Making reimbursement decisions based on a biomarker
approach is not principally considered impossible by the HTA’s included in the survey!
• The question is rather how the population is defined whether a standard of care can be established
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Relative effectiveness • Making reimbursement decisions based on a biomarker
approach is not principally considered impossible by the HTA’s included in the survey!
• The question is rather how the population is defined whether a standard of care can be established
• Baskets would by most HTA’s be considered separately (see the earlier presentation)
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Relative effectiveness • Making reimbursement decisions based on a biomarker
approach is not principally considered impossible by the HTA’s included in the survey!
• The question is rather how the population is defined whether a standard of care can be established
• Baskets would by most HTA’s be considered separately (see the earlier presentation)
• The acceptability of endpoints (hard versus surrogate, clinically relevant versus patient relevant) is not considered dependent on the ‘type’ of study.
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Conclusion • We need get our terminology aligned • The elements that make up a study are the key, not the
wrapper • The design elements need to be agreed on at an early stage
by all stakeholders • Flexibility in designs is a pro, too much flexibility not • Results need to be interpretable! • Nothing is impossible, some things are just difficult
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Thanks go to • Michelle from ZIN for setting up the survey and tapping into
her international network • All HTA’s that did try to answer our (not always clear)
questions • The organizers of the workshop for inviting also the HTA’s to
provide their opinion
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