Histo-blood group antigens as allo- and/or autoantigens Nydegger, U.E. and Flegel, W.A. University...
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Transcript of Histo-blood group antigens as allo- and/or autoantigens Nydegger, U.E. and Flegel, W.A. University...
![Page 1: Histo-blood group antigens as allo- and/or autoantigens Nydegger, U.E. and Flegel, W.A. University of Bern, Switzerland and University of Ulm, Germany.](https://reader038.fdocuments.net/reader038/viewer/2022110319/56649c535503460f948fcca4/html5/thumbnails/1.jpg)
Histo-blood group antigens as allo- and/or autoantigens
Nydegger, U.E. and Flegel, W.A.
University of Bern, Switzerland and University of Ulm, Germany
[email protected] - www.immune-complex.ch
4th International Congress Autoimmunity Budapest 2004
![Page 2: Histo-blood group antigens as allo- and/or autoantigens Nydegger, U.E. and Flegel, W.A. University of Bern, Switzerland and University of Ulm, Germany.](https://reader038.fdocuments.net/reader038/viewer/2022110319/56649c535503460f948fcca4/html5/thumbnails/2.jpg)
Blood group antigens assigned to systems
0
10
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ABO P LU LE JK YT SC CO CH/RG XK CR IN
No of antigens
Intrinsic antigens defined byred cell membrane proteins
Intrinsic antigens defined byglycosyltransferase genes
Acquired antigens (notintrinsic to red cell)
Slide courtesy of D. Anstee 1997
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World Wide Web sites for Blood Group Antigens
• http://www.bioc.aecom.yu.edu/bgmut/index.htm
• http://www.uni-ulm.de/~wflegel/RH/
• http://jove.prohosting.com/~scarfex/blood/groups.html
Nydegger UE, Flegel WA 2004
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Blood group antigens as autoantigens
• I/i
• P
• Kell
• Lewis
• MN
• Cold agglutinins
• Cold agglutinins
• Donath-Landsteiner antibodies
• Warm-reactive autoantibodies
• Helicobacter pylori– molecular mimicry
• Treponema pallidum– molecular mimicry
Nydegger UE, Flegel WA 2004
![Page 5: Histo-blood group antigens as allo- and/or autoantigens Nydegger, U.E. and Flegel, W.A. University of Bern, Switzerland and University of Ulm, Germany.](https://reader038.fdocuments.net/reader038/viewer/2022110319/56649c535503460f948fcca4/html5/thumbnails/5.jpg)
Blood groups on the RBC
Gerbich
Knops
Kell
Lutheran
LW
Duffy
MNS
ABOIi
RhIndian
Cromer
Yt
Diego
Slide courtesy of E. Sjoberg-Wester
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Chemical basisof the ABO and Lewis blood group system
ß-D-Gal(1-3)ß-D-GlcNAc
O
O
O
N
H
O
O
R
ß
Gal
ß(1-3)
Type 1 Precursur Substance
-L-Fuc(1-2) ß-D-Gal(1-3)ß-D-GlcNAc
H type 1
O
O
O
N
H
O
O
A type 1
-D-GalNAc(1-3) [-L-Fuc(1-2)] ß-D-Gal(1-3)ß-D-GlcNAc
B type 1
-D-Gal(1-3) [-L-Fuc(1-2)] ß-D-Gal(1-3)ß-D-GlcNAc
O
O
O
H
O
O
Leb
-L-Fuc(1-2) ß-D-Gal(1-3)[-L-Fuc(1-4)]ß-D-GlcNAcß-D-Gal(1-3)[-L-Fuc(1-4)]ß-D-GlcNAc
Lea
Nyd
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ger U
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lege
l WA
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Disappearance of B and appearance of H Antigen
Ko
estn
er et al. Lan
cet 3
63(2004)1523
B type O type O typeMonoclonal antibodies Lectin
M
on
ths
po
st t
ran
spla
nt
Co
ntr
ols
36
3
0
1
4
2
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ABOI heart allograft: follow up for 44 months post transplant
B Antigen
H Antigen
Post transplant: 12 24 36 44 months
Nyd
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Conclusion
• Numerous blood group system antigens– occur not only on red blood cells
– but are also expressed on cells of various other tissues
• Hence, autoantibodies – known to impinge on red cells
– are also reactive for various other tissues
• Blood group antigens– might be more frequently involved as tissue autoantigens
– and should be more often considered in this context
Nydegger UE, Flegel WA 2004