Higher-order structure of chromosomes
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Transcript of Higher-order structure of chromosomes
![Page 1: Higher-order structure of chromosomes](https://reader035.fdocuments.net/reader035/viewer/2022062407/56812fa4550346895d95243d/html5/thumbnails/1.jpg)
Mateusz SkowronPaweł Ślusarczyk
Supervisor: Joanna Deperas-Standyło
Higher-order structure of chromosomes
![Page 2: Higher-order structure of chromosomes](https://reader035.fdocuments.net/reader035/viewer/2022062407/56812fa4550346895d95243d/html5/thumbnails/2.jpg)
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
![Page 3: Higher-order structure of chromosomes](https://reader035.fdocuments.net/reader035/viewer/2022062407/56812fa4550346895d95243d/html5/thumbnails/3.jpg)
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0/G1 have formof long and screwed strings
![Page 4: Higher-order structure of chromosomes](https://reader035.fdocuments.net/reader035/viewer/2022062407/56812fa4550346895d95243d/html5/thumbnails/4.jpg)
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0 / G1 have formof long and screwed strings
Firstly believed to form a chaotic spaghetti-like structure
![Page 5: Higher-order structure of chromosomes](https://reader035.fdocuments.net/reader035/viewer/2022062407/56812fa4550346895d95243d/html5/thumbnails/5.jpg)
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0 / G1 have formof long and screwed strings
Firstly believed to form a chaotic spaghetti-like structure
1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories
![Page 6: Higher-order structure of chromosomes](https://reader035.fdocuments.net/reader035/viewer/2022062407/56812fa4550346895d95243d/html5/thumbnails/6.jpg)
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0 / G1 have formof long and screwed strings
Firstly believed to form a chaotic spaghetti-like structure
1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories
![Page 7: Higher-order structure of chromosomes](https://reader035.fdocuments.net/reader035/viewer/2022062407/56812fa4550346895d95243d/html5/thumbnails/7.jpg)
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0 / G1 have formof long and screwed strings
Firstly believed to form a chaotic spaghetti-like structure
1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories
![Page 8: Higher-order structure of chromosomes](https://reader035.fdocuments.net/reader035/viewer/2022062407/56812fa4550346895d95243d/html5/thumbnails/8.jpg)
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0 / G1 have formof long and screwed strings
Firstly believed to form a chaotic spaghetti-like structure
1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories
![Page 9: Higher-order structure of chromosomes](https://reader035.fdocuments.net/reader035/viewer/2022062407/56812fa4550346895d95243d/html5/thumbnails/9.jpg)
Nucleus – sphere
Chromosomal domain – sphere
Domains can overlap each other
Nucleus model
Chromosomal domains in the
nucleus
![Page 10: Higher-order structure of chromosomes](https://reader035.fdocuments.net/reader035/viewer/2022062407/56812fa4550346895d95243d/html5/thumbnails/10.jpg)
Model chromosome – a chain of connectedspheres
CHROMOSOME MODEL
Chromosomal territories in the nucleus
Spheres in each chromosome cannot overlap each other
A real chromosome
![Page 11: Higher-order structure of chromosomes](https://reader035.fdocuments.net/reader035/viewer/2022062407/56812fa4550346895d95243d/html5/thumbnails/11.jpg)
Cпасибо for your attention!