HIFU mediated drug delivery: Vascular shutdown facilitates drug depot effect
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Transcript of HIFU mediated drug delivery: Vascular shutdown facilitates drug depot effect
HIFU mediated drug delivery: Vascular shutdown facilitates drug depot effect
Gasselhuber A.1, Appanaboyina S. 1, Dreher M.R.2, Wood B.J.2, Haemmerich D.1
1Dept. Pediatrics, Medical Univ. of South Carolina2Center for Interventional Oncology, National Cancer Institute
Disclosures
none
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Low-Temperature Sensitive Liposomes (LTSL)
Drug release (Doxorubicin) at hyperthermic temperatures
Doxorubicin Release from LTSL(from Gasselhuber et al., Int J Hyperthermia 2010)
HIFU-mediated targeted drug delivery
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From Staruch et al., Int J Hyperthermia 2011
Computer Simulation of HIFU+LTSL drug delivery• Heat transfer model• Drug Delivery Model
Two heating scenarios: 7 min hyperthermia (42 ºC) 7 min hyperthermia + brief ablation pulse
(to shut down blood flow)
Study Goal
Computer Model:HIFU + LTSL
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TissueTemperature
Perfusion
Heat-Transfer Model
LTSL ReleaseLTSL Release
Pharmacokinetic Model
IntravascularSpace
Tissue
Mathematical Drug Delivery Model
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Drug delivery from LTSL in tumor(see also Gasselhuber et al., Int J Hyperthermia 2010)
Hyperthermia vs. HT+Ablation
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Temperature
Perfusion
Hyperthermia HT+Ablation
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Hyperthermia HT+Ablation
Drug Concentrations: HT + Ablation
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HIFU HIFU+Ablation
Elimination of blood flow by brief high-temperature heating pulse considerably increases tissue drug uptake Depot Effect Other blood flow reducing methods
(embolization) would have similar effect
Summary
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Questions?
ABLATION. MUSC.EDUCharleston, SC
Funding: NIH R01CA118990, R21 CA135519