H.Gaub / SS 2007 BPZ§4.3 1

All pore-forming ion channels are similar in structure

H.Gaub / SS 2007 BPZ§4.3 2

Struktur des K-Kanals

Rod MacKinnon

Chemie Nobelpreis 2003

H.Gaub / SS 2007 BPZ§4.3 3

Crystal is defined and stabilized by Antibodies

H.Gaub / SS 2007 BPZ§4.3 4

Chemistry of Ion Coordination and Hydration Revealed by a K+ Channel-Fab Complex at 2.0 Angstrom Resolution; MacKinnon, R., et al.; Nature, Vol. 414; January 1, 2001

Potassium Channel Receptor Site for the Inactivation Gate and Quaternary Amine Inhibitors; MacKinnon, R., et al.; Nature, Vol. 411; March 8, 2001

Energetic Optimization of Ion Conduction Rate by the K+ Selectivity Filter; MacKinnon, R., et al.; Nature, Vol. 414; November 1, 2001

H.Gaub / SS 2007 BPZ§4.3 5

Ionenselektivität des Natriumkanals

H.Gaub / SS 2007 BPZ§4.3 6

H.Gaub / SS 2007 BPZ§4.3 7

Alternative Stacking of K+ (Green) and Water (red)

High K+ Concentration (2M)

H.Gaub / SS 2007 BPZ§4.3 8

Gating by conformational changes of the tetramer