Herbalife Nutrition

Immune Health

What is the Immune

System?

• One of the ways our body uses its

immune system is as a defense

mechanism to fight disease,

bacteria, viruses and foreign matter

• Our bodies have a vast network of

cells and tissues on the lookout for

‘foreign invaders’

• As soon as these ‘invaders’ are

detected the immune system is

activated

There are 2 types of

Immune Responses:

Adaptive Immunity

Takes more time to develop, but

it is more precise and therefore

effective towards an attacking

pathogen (foreign invaders)

Innate Immunity

This is fast and reacts

quickly to eliminate

bacteria, viruses and any

foreign material

Physical• Skin

• Sneezing

• Coughing

Chemical• Mucus

• Stomach Acid

• Enzymes

Cellular• Phagocytes

• Turn On

• Turn Off

Adaptive System Innate System

Good

Nutrition +Healthy

Lifestyle=Immune

Health

=Immune

Health

Both malnutrition and overnutrition has been shown to impair immune functions

Alwarawrah, Y., Kiernan, K., & MacIver, N. J. (2018). Changes in Nutritional Status Impact Immune Cell Metabolism and Function. Frontiers in immunology, 9, 1055. https://doi.org/10.3389/fimmu.2018.01055

Wu, D., Lewis, E. D., Pae, M., & Meydani, S. N. (2019). Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance. Frontiers in immunology, 9, 3160.

https://doi.org/10.3389/fimmu.2018.03160

PROTEIN

• Protein is an essential

component of every cell in the

body including immune cells1

• Post-exercise protein has been

shown to have beneficial

effects for the immune system

in athletes2

• Aim to consume up to 30% of

your daily calories from

protein

1 Protein contributes to a growth in muscle mass and contributes to the maintenance of normal bones2 Gleeson M. Immunological aspects of sport nutrition. Immunol Cell Biol. 2016;94(2):117–123. doi:10.1038/icb.2015.109

HN Products Containing Protein

WheyPea, Quinoa &

Flax SeedSoy

FORMULA 1

A Shake Mix

containing 24 Vitamins

& Minerals including

Vitamins, A, C, D, B12,

Zinc, Folate &

Selenium

TRI BLEND

SELECT

Contains

sourced

naturally

sources of

Protein, Fibre &

Vitamin C

• Dietary fibres are the indigestible parts

of plant foods, such as vegetables,

fruits, grains and legumes

• An adequate amount of soluble and

insoluble fibre intake is an essential

part of taking care of our digestive

system1

• A healthy gut contributes to the

maintenance of a healthy immune

system2

FIBRE

1 Barley/oat/wheat grain fibre contributes to an increase in faecal bulk.

2 Mohajeri et al (2018) Eur. J. Nutr., 57(Suppl 1), 1–14.

Makki et al (2018) Cell host microbe, 23(6), 705–715.

Hachimura et al (2018) Biosci biotech bioch, 82(4), 584–599.

O’Grady et al (2019) Aliment Pharmacol Ther. 2019; 49: 506– 515.

Kim (2018). Immunology, 154: 220-229.

HN Products Containing Fibre

4 g Fibre/Serving

6 g Fibre/ Serving

5 g Fibre/Serving

• Healthy fats play a key role in our

bodies1

• They are needed for normal functioning

of the immune system as well as vision,

brain, and heart2

• Some healthy fats are also considered

essential, therefore we have to

consume them through foods

HEALTHY FATS

1. DHA contributes to the maintenance of normal brain function and normal vision (the beneficial effect is obtained with a daily intake of 250 mg

of DHA). EPA and DHA contribute to the normal function of the heart (the beneficial effect is obtained with a daily intake of 250 mg of EPA and

DHA).

2. Gutiérrez, S., Svahn, S. L., & Johansson, M. E. (2019). Effects of Omega-3 Fatty Acids on Immune Cells. International journal of molecular

sciences, 20(20), 5028. https://doi.org/10.3390/ijms20205028

Wu, D., Lewis, E. D., Pae, M., & Meydani, S. N. (2019). Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and

Clinical Relevance. Frontiers in immunology, 9, 3160. https://doi.org/10.3389/fimmu.2018.03160

Omega 3 Benefits

Normal

brain

function2

Normal blood

triglyceride

levels4

Normal

Vision3

Normal

blood

pressure5

1 EPA and DHA contribute to the normal function of the heart. The beneficial effect is obtained with a daily intake of 250 mg of EPA and DHA.

2 DHA contributes to maintenance of normal brain function. Beneficial effect is obtained with a daily intake of 250 mg of DHA.

3 DHA contributes to the maintenance of normal vision. The beneficial effect is obtained with a daily intake of 250 mg of DHA.

4 DHA and EPA contribute to the maintenance of normal blood triglyceride levels. The beneficial effect is obtained with a daily intake of 2 g of EPA and DHA. Supplemental daily intake of 5

g of EPA and DHA combined shouldn't be exceeded.

5 DHA and EPA contribute to the maintenance of normal blood pressure. the consumer that the beneficial effect is obtained with a daily intake of 3 g of EPA and DHA. Supplemental daily

intake of 5 g of EPA and DHA combined shouldn't be exceeded.

Normal

heart

function1

HN Products Containing Omega3

Vitamins &

Minerals

• Vitamins & Minerals are mainly

found in fresh fruits & vegetables

• Many of these essential nutrients

have a direct impact on our

immune system1

• 75% of the world’s population

does not consume enough fruits

and vegetables2

1Copper/Folate/Selenium/Vit A/Vit B12/Zinc/Vitamin C/Iron/Vit B6/Vit D contributes to the normal function of the immune system. EFSA Journal 2009;7(9):12112 WHO https://www.who.int/dietphysicalactivity/publications/f&v_promotion_initiative_report.pdf

Vitamins &

Minerals that

support your

Immune

System

Vitamin C

Vitamin D

Vitamin A Selenium

Zinc

Iron

1Copper/Folate/Selenium/Vit A/Vit B12/Zinc/Vitamin C/Iron/Vit B6/Vit D contributes to the normal function of the immune system. EFSA Journal 2009;7(9):1211.

CopperVitamins

B6 & B12

Folate

HN Products Containing Vitamins &

Minerals

Vitamin C

• Contributes to the normal

functioning of the immune

system

• Mainly found in fruits and

vegetables including citrus

fruits, broccoli, bell peppers

and strawberries

• NRV = 100 mg – equivalent to

2 small oranges

1Copper/Folate/Selenium/Vit A/Vit B12/Zinc/Vitamin C/Iron/Vit B6/Vit D contributes to the normal function of the immune system. EFSA Journal 2009;7(9):1211Nutrient reference values (NRVs) for Individuals 4 years and older

HN Products Containing

Vitamin C

18% NRV

Vitamin C

31% NRV

Vitamin C

80% NRV

Vitamin C100% NRV

Vitamin C

Nutrient reference values (NRVs) for Individuals 4 years and older

80% NRV

Vitamin C

Vitamin D

• Contributes to the normal

functioning of the immune system1

• Vitamin D can be produced by the

human body when exposed to

sunlight however, this is at times

insufficient 2-5

• Dietary sources of Vitamin D are

vital such as oily fish, eggs, etc.

• NRV = 15 mcg – equivalent to a

small portion of mackerel fillet

(63g)

1Copper/Folate/Selenium/Vit A/Vit B12/Zinc/Vitamin C/Iron/Vit B6/Vit D contributes to the normal function of the immune system. EFSA Journal 2009;7(9):1211.

2. Cashman, K. D. et al. Vitamin D deficiency in Europe: pandemic? The American journal of clinical nutrition 103, 1033-1044, doi:10.3945/ajcn.115.120873 (2016).3 EFSA. Dietary reference values for vitamin D. EFSA Journal 14, e04547-n/a, doi:10.2903/j.efsa.2016.4547 (2016).4 German Nutrition Society. New reference values for vitamin D. Annals of nutrition & metabolism 60, 241-246, doi:10.1159/000337547 (2012).5 SACN. Vitamin D and Health report. (Public Health England, 2016).

HN Products Containing

Vitamin D

13% NRV

Vitamin D

13% NRV

Vitamin D

13% NRV

Vitamin D67% NRV

Vitamin D

Zinc

• Contributes to the normal

functioning of the immune

system

• Mainly found in nuts, seeds,

meat, fish and shellfish, dairy

products seeds and pulses

• NRV = 11 mg – equivalent to

about 20 tablespoons of dried

sesame seeds1Copper/Folate/Selenium/Vit A/Vit B12/Zinc/Vitamin C/Iron/Vit B6/Vit D contributes to the normal function of the immune system. EFSA Journal 2009;7(9):1211.

Selenium

• Contributes to the normal

functioning of the immune

system

• Found in brazil nuts, fish, meat,

vegetables, wholegrain cereals

• NRV = 55 mcg – equivalent to

about 1-2 brazil nuts

1Copper/Folate/Selenium/Vit A/Vit B12/Zinc/Vitamin C/Iron/Vit B6/Vit D contributes to the normal function of the immune system. EFSA Journal 2009;7(9):1211.

HN Products Containing

Zinc & Selenium

38% NRV Selenium

35% NRV Zinc

38% NRV Selenium

35% NRV Zinc

38% NRV Selenium

35% NRV Zinc

100% NRV Selenium

91% NRV Zinc

Formulated with a unique complex

of ingredients such as:

• EpiCor®, a yeast based fermentate

• High in vitamins C & D

• High in minerals Zinc & Selenium

• With delicious Elderberry Juice

Provides 80% NRV of vitamins C

and 67% NRV of vitamin D which

contribute to the normal function of

the immune system

EpiCor® is a registered trademark of Embria Health Sciences, L.L.C.

PHYTONUTRIENTS• Are plant-based only nutrients

• Can help reduce oxidative stress & boost

immune system1-2

• This is why is important to have your 5 a day!

1 Olive oil polyphenols contribute to the protection of blood lipids from oxidative stress. The beneficial effect is obtained with a daily intake of 20 g of olive oil.It is applicable only for olive oil which

contains at least 5 mg of hydroxytyrosol and its derivatives (e.g. oleuropein complex and tyrosol) per 20 g of olive oil

2 Wu, D., Lewis, E. D., Pae, M., & Meydani, S. N. (2019). Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance. Frontiers in immunology, 9, 3160.

https://doi.org/10.3389/fimmu.2018.03160

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2018). Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic

inflammatory disorders. International immunopharmacology, 61, 231–240. https://doi.org/10.1016/j.intimp.2018.06.00

Rose Guard contains a range of

carefully selected botanical

ingredients including rosemary

and turmeric, that help top-up

your daily intake of antioxidant

substances 1-4

Provides 89% NRV of vitamins A

and 80% NRV of vitamin C which

contribute to the normal function

of the immune system

1 de Oliveira et al (2019). J Biomed Sci 26(1), 5.

2 Kocaadam & Şanlier (2017). Crit Rev Food Sci Nutr, 57(13), 2889–2895.

3 Nieto, G., Ros, G., & Castillo, J. (2018). Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review. Medicines (Basel, Switzerland), 5(3), 98.

https://doi.org/10.3390/medicines5030098

4de Oliveira, J. R., Camargo, S., & de Oliveira, L. D. (2019). Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent. Journal of biomedical science, 26(1), 5.

https://doi.org/10.1186/s12929-019-0499-8

EXERCISE

• Regular moderate-intensity

exercise helps to maintain a proper

immune function1

• Aim to exercise for at least 150

minutes a week at a moderate

intensity2

1 Simpson, R.J., et al., Exercise and the regulation of immune functions, in Progress in molecular biology and translational science. 2015, Elsevier. p. 355-380.

2 WHO Physical activity, Key Facts. Updates 23 February 2018. Online. Available at https://www.who.int/news-room/fact-sheets/detail/physical-activity [accessed on 14 Jun 2019]

REST & SLEEP

• Sleep represents a key part of our

lives 1It influences our emotional

wellbeing, cognitive functions, daily

performance, as well as our physical

health

• There is emerging evidence that chronic

partial sleep loss might be more

detrimental to immune functions than

short-term total sleep loss2

• Sleep deprivation can lead to increased

risks of a compromised immune system3

1. Golem DL, et al. Adv Nutr 2014;5:742–759.

2. 1Penelope A. Bryant, John Trinder, Nigel Curtis. Sick and tired: Does sleep have a vital role in the immune system? Nature Reviews Immunology 2004; Volume 4: 457–467.

3. Charlene E Gamaldo, Annum K Shaikh, Justin C McArthur: The Sleep-Immunity Relationship. Neurologic Clinics 2012; Volume 30, Issue 4:1313-1343.

Herbalife Nutrition

Immune Health