HEPATITIS. Introduction Hepatitis: Inflammation of Liver viral alcoholic immuneDrugs Toxins biliary...

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Transcript of HEPATITIS. Introduction Hepatitis: Inflammation of Liver viral alcoholic immuneDrugs Toxins biliary...

IMAGE CHALLENGE C.T. CHEST

HEPATITISDR : RAMY A. SAMY M.D. / lecturer of internal medicine Dr_ramisami@fmed.bu.edu.egIntroductionHepatitis: Inflammation of LiverviralalcoholicimmuneDrugsToxinsbiliary obstruction - gall stonesTypes :AcuteChronicFulminant Viral Hepatitis :Hepatitis A, B, C, D, E, & other systemicspecificCMV, EBV& otherPattern of Viral HepatitisCarrier state

asymptomatic phaseAcute hepatitisChronic HepatitisFulminant hepatitisCirrhosisHCC1- Chronic Persistent Hepatitis (CPH)2- Chronic Active Hepatitis (CAH) ACUTE HEPATITISDef: Acute inflammation of the liver. Etiology: 1- Viral: A, B, C, D, E, F, G. 2- Non viral: (inf.) - Toxoplasma. - Leptospira hegica. 3- Drugs: - Halothan. - Paracetamol. - Mono Amino oxidase Inhibitor (MAOI). 4- Poisons: - Aflatoxins - Amanitaphaloids. 5- Misscellaneous: - pregnancy. - Wilsons disease. - Circulatory insufficiency. - Alcohol.

Pathology:

Hepatocytes swollen and become granular with variable.

distribution: * Centrizonal. * Focal (spotty). OR * Massive. Dead hepatocytes become shrunken. Lobules: portal tract infiltration with lymphocytes.

N.B.: in Pregnancy Alcoholism Fatty changes S.Hepatitis C

Causes:Hepatitis AHAVInfective hepatitisHepatitis BHBVserum hepatitisHepatitisDHDVHepatitis CHCVPost transfusion hepatitisHepatitis EHEVEpidemic/ Entralvirus27 nm RNA42 nm DNAHepa virus35 nm IncompleteRNA+HBsAg30 60 nmRNA flavi firus32 nm RNAtransmissionFeco-oral Paraentral and post transfusionSexual low risk 1-5 %Intrauterine low risk