Heparin market global revenue, trends, growth, share, size and forecast to 2022

1

Global Heparin Market By Product

(Unfractionated Heparin, Low

Molecular Weight Heparin (LMWH),

Ultra Lower Molecular Weight

Heparin (ULMWH)), Route of

Administration (IV Injection,

Subcutaneous Injection),

Applications (Clinical Trials, Medical

Devices, Venous Thromboembolism)

and Geography (North America,

Europe, Asia Pacific, Middle East &

Africa, Latin America)-Market

Revenue and Forecast (2014-2022)

Scalar Market Research Inc.

September 2016

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Table of Contents

1 Introduction .................................................................................................................................. 13

2 Market Overview .......................................................................................................................... 14

2.1 Definitions ............................................................................................................................. 14

2.2 Research Methodology ......................................................................................................... 15

2.3 Market Segmentation ........................................................................................................... 18

2.4 Assumptions .......................................................................................................................... 19

3 Executive Summary ....................................................................................................................... 20

3 Market Dynamics .......................................................................................................................... 24

3.1 Drivers ................................................................................................................................... 25

3.2 Restraints .............................................................................................................................. 26

3.3 Opportunities ........................................................................................................................ 28

3.4 Trends ................................................................................................................................... 29

4 Industry Analysis ........................................................................................................................... 30

4.1 Supply Chain Analysis ............................................................................................................ 30

4.2 Suppliers Analysis .................................................................................................................. 31

4.3 Pricing Analysis ...................................................................................................................... 34

5 Heparin Market, by Product Segments ......................................................................................... 36

5.1 Market Overview .................................................................................................................. 36

5.2 Market Share Segmentation ................................................................................................. 38

5.3 Revenue Segmentation ......................................................................................................... 39

5.4 Volume Segmentation .......................................................................................................... 40

5.5 Products ................................................................................................................................ 42

5.5.1 Unfractionated Heparin (UFH) ...................................................................................... 42

5.5.2 Low Molecular Weight Heparin (LMWH) ...................................................................... 44

5.5.3 Ultra Low Molecular Weight Heparin (ULMWH) .......................................................... 46

6 Heparin Market, by Route of Administration (ROA) ..................................................................... 48

6.1 Market Overview .................................................................................................................. 48



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6.4 Route of Administration........................................................................................................ 51

6.4.1 Intravenous Injection .................................................................................................... 51

6.4.2 Subcutaneous Injection ................................................................................................. 53

7 Heparin Market, by Applications .................................................................................................. 55

7.1 Market Overview .................................................................................................................. 55




7.5 Applications ........................................................................................................................... 60

7.5.1 Clinical Trials.................................................................................................................. 60

7.5.2 Medical Devices ............................................................................................................ 61

7.5.3 Venous Thromboembolism ........................................................................................... 62

8 Heparin Market, By Regions ......................................................................................................... 63

8.1 Geographic Overview ............................................................................................................ 63




8.5 North America ....................................................................................................................... 70

8.5.1 By Regions ..................................................................................................................... 71

8.5.1.1 U.S. ............................................................................................................................ 71

8.5.1.2 Canada ...................................................................................................................... 71

8.5.2 By Product Segments .................................................................................................... 71

8.5.3 By Route of Administration ........................................................................................... 72

8.5.4 By Applications .............................................................................................................. 73

8.6 Europe ................................................................................................................................... 74

8.6.1 By Regions ..................................................................................................................... 75

8.6.1.1 Germany .................................................................................................................... 75

8.6.1.2 U.K ............................................................................................................................. 75

8.6.1.3 France ........................................................................................................................ 75

8.6.1.4 Italy ............................................................................................................................ 75

8.6.1.5 Rest of Europe ........................................................................................................... 75

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8.6.4 By Applications .............................................................................................................. 78

8.7 Asia-Pacific ............................................................................................................................ 79

8.7.1 By Regions ..................................................................................................................... 80

8.7.1.1 China ......................................................................................................................... 80

8.7.1.2 India........................................................................................................................... 80

8.7.1.3 Russia ........................................................................................................................ 80

8.7.1.4 Australia .................................................................................................................... 80

8.7.1.5 Indonesia ................................................................................................................... 81

8.7.1.6 Rest of Asia-Pacific .................................................................................................... 81



8.7.4 By Applications .............................................................................................................. 83

8.8 Middle East & Africa ............................................................................................................. 84

8.8.1 By Regions ..................................................................................................................... 85

8.8.1.1 Saudi Arabia .............................................................................................................. 85

8.8.1.2 Iran ............................................................................................................................ 85

8.8.1.3 Egypt ......................................................................................................................... 85

8.8.1.4 South Africa ............................................................................................................... 85

8.8.1.5 Nigeria ....................................................................................................................... 85

8.8.1.6 Kenya ......................................................................................................................... 86

8.8.1.7 Rest of Middle East & Africa ..................................................................................... 86



8.8.4 By Applications .............................................................................................................. 88

8.9 Latin America ........................................................................................................................ 89

8.9.1 By Regions ..................................................................................................................... 90

8.9.1.1 Brazil .......................................................................................................................... 90

8.9.1.2 Argentina ................................................................................................................... 90

8.9.1.3 Columbia ................................................................................................................... 90

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8.9.1.4 Rest of Latin America ................................................................................................ 90



8.9.4 By Applications .............................................................................................................. 93

9 Competitive Landscape ................................................................................................................. 94

9.1 Market Share Analysis ........................................................................................................... 94

10 Key Market Players ....................................................................................................................... 96

10.1 Sanofi S.A. ............................................................................................................................. 96

10.1.1 Overview ....................................................................................................................... 96

10.1.2 Key Strategies ................................................................................................................ 96

10.1.3 Recent Developments ................................................................................................... 96

10.2 Glaxo SmithKline plc ............................................................................................................. 98

10.2.1 Overview ....................................................................................................................... 98

10.2.2 Key Strategies ................................................................................................................ 98


10.3 Pfizer Inc. ............................................................................................................................... 99

10.3.1 Overview ....................................................................................................................... 99

10.3.2 Key Strategies ................................................................................................................ 99


10.4 Leo Pharma A/S ................................................................................................................... 100

10.4.1 Overview ..................................................................................................................... 100

10.4.2 Key Strategies .............................................................................................................. 100

10.4.3 Recent Developments ................................................................................................. 100

10.5 Aspen Holdings.................................................................................................................... 101

10.5.1 Overview ..................................................................................................................... 101

10.5.2 Key Strategies .............................................................................................................. 101


10.6 Fresenius Kabi AG ............................................................................................................... 102

10.6.1 Overview ..................................................................................................................... 102

10.6.2 Key Strategies .............................................................................................................. 102


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10.7 Baxter International Inc. ..................................................................................................... 103

10.7.1 Overview ..................................................................................................................... 103

10.7.2 Key Strategies .............................................................................................................. 103


11 Last Word: Scalar 360 Degree Market Perspective .................................................................... 105

12 Appendix ..................................................................................................................................... 107

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List of Tables

Table 1. Research Methodology ..................................................................................................... 15

Table 2. Assumptions ...................................................................................................................... 19

Table 3. Global Heparin Market Size (US$ million), (2016-2022) ................................................... 21

Table 4. Global Heparin API Production Capacity (trillion units), (2014-2022) .............................. 31

Table 5. Global Heparin API Production Capacity (trillion units), By Geography (2014-2022) ....... 31

Table 6. Pricing of Top Heparin Products with Average Market Price (2015) ................................ 34

Table 7. Global Heparin Market Size (US$ million), By Product Segments (2014-2022) ................ 39

Table 8. Global Heparin Volume (million units), By Product Segments (2014-2022) ..................... 41

Table 9. Global Unfractionated Heparin Market Size (US$ million), By Regions (2014-2022) ....... 43

Table 10. Global Low Molecular Weight Heparin Market Size (US$ million), By Regions (2014-2022)

........................................................................................................................................... 45

Table 11. Global Ultra Low Molecular Weight Market Size (US$ million), By Regions (2014-2022) ....

........................................................................................................................................... 47

Table 12. Global Heparin Market Size (US$ million), By Route of Administration (2014-2022) ...... 50

Table 13. Global Heparin Market for Intravenous Injection; Market Size (US$ million) (2014-2022)

........................................................................................................................................... 52

Table 14. Global Heparin Market for Subcutaneous Injection; Market Size (US$ million) (2014-

2022) ........................................................................................................................................... 54

Table 15. Global Heparin Market Size (US$ million), By Applications (2014-2022) ......................... 57

Table 16. Global Heparin Volume (million units), By Applications (2014-2022) .............................. 59

Table 17. Global Heparin Market for Clinical Trials; Market Size (US$ million) (2014-2022) ........... 60

Table 18. Global Heparin Market for Medical Devices; Market Size (US$ million) (2014-2022) ..... 61

Table 19. Global Heparin Market for Venous Thromboembolism; Market Size (US$ million) (2014-

2022) ........................................................................................................................................... 62

Table 20. Heparin Market Prospects, by Geography (2016-2022) ................................................... 64

Table 21. Global Heparin Market Size (US$ million), By Regions (2014-2022)................................. 66

Table 22. Global Heparin Market; Market Size (US$ million), By Major Countries (2014-2022) ..... 67

Table 23. Global Heparin Volume (million units), By Regions (2014-2022) ..................................... 69

Table 24. Heparin Market in North America; Market Size (US$ million) and Annual Growth Rate

(2014-2022). .......................................................................................................................................... 70

Table 25. Heparin Market in U.S; Market Size (US$ million), (2014-2022) ...................................... 71

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Table 26. Heparin Market in Canada; Market Size (US$ million), (2014-2022) ................................ 71

Table 27. Heparin Market in North America; Market Size (US$ million), By Product Segments

(2014-2022) ........................................................................................................................................... 72

Table 28. Heparin Market in North America; Market Size (US$ Million), By Route of Administration

(ROA) (2014-2022) ................................................................................................................................ 72

Table 29. Heparin Market in North America; Market Size (US$ million), By Applications (2014-

2022) ........................................................................................................................................... 73

Table 30. Heparin Market in Europe; Market Size (US$ million) and Annual Growth Rate (2014-

2022) ........................................................................................................................................... 74

Table 31. Heparin Market in Germany; Market Size (US$ million), (2014-2022) ............................. 75

Table 32. Heparin Market in U.K; Market Size (US$ million), (2014-2022) ...................................... 75

Table 33. Heparin Market in France; Market Size (US$ million), (2014-2022) ................................. 75

Table 34. Heparin Market in Italy; Market Size (US$ million), (2014-2022) ..................................... 75

Table 35. Heparin Market in Rest of Europe; Market Size (US$ million), (2014-2022) .................... 75

Table 36. Heparin Market in Europe; Market Size (US$ million), By Product Segments (2014-2022)

........................................................................................................................................... 76

Table 37. Heparin Market in Europe; Market Size (US$ million), By Route of Administration (ROA)

(2014-2022). .......................................................................................................................................... 77

Table 38. Heparin Market in Europe; Market Size (US$ million), By Applications (2014-2022) ...... 78

Table 39. Heparin Market in Asia-Pacific; Market Size (US$ million) and Annual Growth Rate (2014-

2022) ........................................................................................................................................... 79

Table 40. Heparin Market in China; Market Size (US$ million), (2014-2022) ................................... 80

Table 41. Heparin Market in India; Market Size (US$ million), (2014-2022) .................................... 80

Table 42. Heparin Market in Russia; Market Size (US$ million), (2014-2022).................................. 80

Table 43. Heparin Market in Australia; Market Size (US$ million), (2014-2022) ............................. 80

Table 44. Heparin Market in Indonesia; Market Size (US$ million), (2014-2022) ............................ 81

Table 45. Heparin Market in Rest of Asia-Pacific; Market Size (US$ million), (2014-2022) ............. 81

Table 46. Heparin Market in Asia-Pacific; Market Size (US$ million), By Product Segments (2014-

2022) ........................................................................................................................................... 82

Table 47. Heparin Market in Asia-Pacific; Market Size (US$ million), By Route of Administration

(ROA) (2014-2022) ................................................................................................................................ 82

Table 48. Heparin Market in Asia-Pacific; Market Size (US$ million), By Applications (2014-2022) ....

........................................................................................................................................... 83

Table 49. Heparin Market in Middle East & Africa; Market Size (US$ million) and Annual Growth

Rate (2014-2022) .................................................................................................................................. 84

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Table 50. Heparin Market in Saudi Arabia; Market Size (US$ million), (2014-2022) ....................... 85

Table 51. Heparin Market in Iran; Market Size (US$ million), (2014-2022) ..................................... 85

Table 52. Heparin Market in Egypt; Market Size (US$ million), (2014-2022) ................................... 85

Table 53. Heparin Market in South Africa; Market Size (US$ million), (2014-2022) ........................ 85

Table 54. Heparin Market in Nigeria; Market Size (US$ million), (2014-2022) ................................ 85

Table 55. Heparin Market in Kenya; Market Size (US$ million), (2014-2022) .................................. 86

Table 56. Heparin Market in Rest of Middle East & Africa; Market Size (US$ million), (2014-2022) ...

........................................................................................................................................... 86

Table 57. Heparin Market in Middle East & Africa; Market Size (US$ million), By Product Segments

(2014-2022). .......................................................................................................................................... 87

Table 58. Heparin Market in Middle East & Africa; Market Size (US$ million), By Route of

Administration (ROA) (2014-2022) ....................................................................................................... 87

Table 59. Heparin Market in Middle East & Africa; Market Size (US$ million), By Applications

(2014-2022) ........................................................................................................................................... 88

Table 60. Heparin Market in Latin America; Market Size (US$ million) and Annual Growth Rate

(2014-2022). .......................................................................................................................................... 89

Table 61. Heparin Market in Brazil; Market Size (US$ million), (2014-2022) ................................... 90

Table 62. Heparin Market in Argentina; Market Size (US$ million), (2014-2022) ............................ 90

Table 63. Heparin Market in Columbia; Market Size (US$ million), (2014-2022) ............................ 90

Table 64. Heparin Market in Rest of Latin America; Market Size (US$ million), (2014-2022) ......... 90

Table 65. Heparin Market in Latin America; Market Size (US$ million), By Product Segments (2014-

2022) ........................................................................................................................................... 91

Table 66. Heparin Market in North America; Market Size (US$ million), By Route of Administration

(ROA) (2014-2022) ................................................................................................................................ 92

Table 67. Heparin Market in Latin America; Market Size (US$ million), By Applications (2014-2022)

........................................................................................................................................... 93

Table 68. Revenue from Heparin (US$ million), By Major Players (2014 & 2015) ........................... 95

Table 69. Acronyms ........................................................................................................................ 107

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List of Figures

Figure 1. Research Methodology ..................................................................................................... 16

Figure 2. Global Heparin Market Share (%), By Regions (2015) ...................................................... 22

Figure 3. Global Heparin Market Share (%), By Product Segments (2015) ...................................... 22

Figure 4. Global Heparin Market Share (%), By Route of Administration (2015) ............................ 23

Figure 5. Global Heparin Market Share (%), By Applications (2015) ............................................... 23

Figure 6. Global Heparin API Production Market Share (%), By Major Suppliers (2015) ................. 32

Figure 7. Heparin API Production Capacity (trillion units), By Major Suppliers (2015) ................... 32

Figure 8. Heparin Pricing Analysis, By Product Segments ................................................................ 35

Figure 9. Market Attractiveness for different Heparin Product Segments ...................................... 36

Figure 10. Global Heparin Market By Product Segments: Market Size & Market

Penetration(2015).... ............................................................................................................................. 37

Figure 11. Global Heparin Market Share(%), By Product Segments (2015 & 2022) ...................... 38

Figure 12. Global Heparin Market Size (US$ million), By Product Segments (2014-2022) ............ 39

Figure 13. Global Heparin Market By Volume (million units), By Product Segments (2015) ........ 40

Figure 14. Global Heparin Volume (Million Units), By Product Segments (2015 & 2022) ............. 40

Figure 15. Global Unfractionated Heparin Market Size (US$ million), By Regions (2015 & 2022) 42

Figure 16. Global Low Molecular Weight Heparin Market Size (US$ million), By Regions (2015 &

2022) ....................................................................................................................................... 44

Figure 17. Global Ultra Low Molecular Heparin Market Size (US$ million), By Regions (2015 &

2022) ....................................................................................................................................... 46

Figure 18. Global Heparin Market Size (US$ million), By Route of Administration (2015) ............ 48

Figure 19. Global Heparin Market Share (%), By Route of Administration (2015 & 2022) ............ 49

Figure 20. Global Heparin Market Size (US$ million), By Route of Administration (2014-2022) .. 50

Figure 21. Global Heparin Market for Intravenous Injection; Market Size (US$ million) (2015 &

2022) ....................................................................................................................................... 51

Figure 22. Global Heparin Market for Subcutaneous Injection; Market Size (US$ million) (2015 &

2022) ....................................................................................................................................... 53

Figure 23. Global Heparin Market Size (US$ million), By Applications (2015) ............................... 55

Figure 24. Global Heparin Market Share (%), By Applications (2015 & 2022) ............................... 56

Figure 25. Global Heparin Market Size (US$ million), By Applications (2014-2022) ..................... 57

Figure 26. Global Heparin Market By Volume (million units) (2015) ............................................. 58

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Figure 27. Global Heparin Volume (million units), By Applications (2015 & 2022) ....................... 58

Figure 28. Global Heparin Market for Clinical Trials; Market Size (US$ million) (2015 & 2022) .. 60

Figure 29. Global Heparin Market for Medical Devices; Market Size (US$ million) (2015 & 2022) .

....................................................................................................................................... 61

Figure 30. Global Heparin Market for Venous Thromboembolism; Market Size (US$ million)

(2015 & 2022) ....................................................................................................................................... 62

Figure 31. Global Heparin Market Share (%), By Major Regions(2015 & 2022) ............................ 65

Figure 32. Top 5 Countries, By Market Share (%) (2015) ............................................................... 65

Figure 33. Top 5 Countries with Highest CAGR % (2016-2022) ..................................................... 66

Figure 34. Global Heparin Volume (million units), By Regions (2015) ........................................... 68

Figure 35. Heparin Market in North America; Snapshot (2015) .................................................... 70

Figure 36. Heparin Market in North America; Market Size (US$ million)(2014-2022) .................. 70

Figure 37. Heparin Market in North America; Market Size (US$ million), By Product Segments

(2014-2022) ....................................................................................................................................... 71

Figure 38. Heparin Market in North America; Market Size (US$ million), By Route of

Administration (2014-2022) .................................................................................................................. 72

Figure 39. Heparin Market in North America; Market Size (US$ million), By Applications (2014-

2022) ....................................................................................................................................... 73

Figure 40. Heparin Market in Europe; Snapshot (2015) ................................................................ 74

Figure 41. Heparin Market in Europe; Market Size (US$ million) (2014-2022) ............................. 74

Figure 42. Heparin Market in Europe; Market Size (US$ million), By Product Segments (2014-

2022) ....................................................................................................................................... 76

Figure 43. Heparin Market in Europe; Market Size (US$ million), By Route of Administration

(2014-2022) ....................................................................................................................................... 77

Figure 44. Heparin Market in Europe; Market Size (US$ million), By Applications (2014-2022) .. 78

Figure 45. Heparin Market in Asia-Pacific; Snapshot (2015) ......................................................... 79

Figure 46. Heparin Market in Asia-Pacific; Market Size (US$ million) (2014-2022) ...................... 79

Figure 47. Heparin Market in Asia-Pacific; Market Size (US$ million), By Product Segments (2014-

2022) ....................................................................................................................................... 81

Figure 48. Heparin Market in Asia-Pacific; Market Size (US$ million), By Route of Administration

(2014-2022) ....................................................................................................................................... 82

Figure 49. Heparin Market in Asia-Pacific; Market Size (US$ million), By Applications (2014-2022)

....................................................................................................................................... 83

Figure 50. Heparin Market in Middle East & Africa; Snapshot (2015) ........................................... 84

Figure 51. Heparin Market in Middle East & Africa; Market Size (US$ million) (2014-2022) ........ 84

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Figure 52. Heparin Market in Middle East & Africa; Market Size (US$ million), By Product

Segments(2014-2022) ........................................................................................................................... 86

Figure 53. Heparin Market in Middle East & Africa; Market Size (US$ million), By Route of

Administration (2014-2022) .................................................................................................................. 87

Figure 54. Heparin Market in Middle East & Africa; Market Size (US$ million), By Applications

(2014-2022) ....................................................................................................................................... 88

Figure 55. Heparin Market in Middle Latin America; Snapshot (2015) ......................................... 89

Figure 56. Heparin Market in Latin America; Market Size (US$ million) (2014-2022)................... 89

Figure 57. Heparin Market in Latin America; Market Size (US$ million), By Product Segments

(2014-2022) ......................................................................................................................................91

Figure 58. Heparin Market in Latin America; Market Size (US$ million), By Route of

Administration (2014-2022) .................................................................................................................. 92

Figure 59. Heparin Market in Latin America; Market Size (US$ million), By Applications (2014-

2022) ....................................................................................................................................... 93

Figure 60. Market Share (%) of Major Players (2015) .................................................................... 94

Figure 61. Dominant Players .......................................................................................................... 95

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2 Market Overview

2.1 Definitions

Global Heparin market is defined as the market size and market share estimation of

the various segments of the heparin market, capturing ongoing drivers, trends,

challenges of the market, industry analysis involving the supply chain, and studying

about the major participants and players in heparin market environment.

The 'Global Heparin Market – Market Size and Forecast (2014–2022)' report

includes market size and forecast estimates for the period 2014 to 2022. The scope

of this report is unfractionated heparin, low molecular weight heparin and ultra low

molecular weight heparin, and its applications in clinical trials, medical devices, and

venous thromboembolism. The report has 2014 as the base year, 2015 as current

year and years 2016 to 2022 as forecast years.

This report defines the heparin product type as-

Unfractionated Heparin (UFH) is a type of blood thinner widely used in thrombotic

disorders and in the treatment of deep vein thrombosis (DVT) and Pulmonary

Embolism (PE). The average molecular weight of unfractionated heparin is 15000

Daltons.

Low Molecular Weight Heparin (LMWH) is a type of anticoagulant which is derived

from depolymerization and fractionation of polymeric heparin and having an average

molecular weight ranging between 4500 to 8000 Daltons.

Ultra Low Molecular Weight Heparin (ULMWH) is a type of anticoagulant widely used

for cancer patients undergoing chemotherapy and having an average molecular

weight of 2500 Daltons.

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2.2 Research Methodology

The market study of heparin market incorporates two-way prolonged approaches,

secondary and primary research to collect the information commercially and study

the market. The data collection part was focused, and related to capturing whole

market from various perspective. Data collected from multiple sources was logically

linked and analyzed by our analysts.

Secondary Data

Secondary data gathering procedure, with subsequent references such as company

websites, journals, magazines, directories, databases such as Bloomberg, Hoovers,

Factiva, company annual reports, press releases, white papers, and government

publishing sources also have been taken into consideration. Data from these

sources have been used to obtain industry supply chain, company profiles and other

key areas such as market drivers, opportunities, trends from Heparin market

perspective

Table 1. Research Methodology

Report Parameter Secondary Source

Market Size, Share, Revenue Company Annual Reports, SEC Filings,

Financials, Press Releases, Directories,

Journals.

Industry Analysis, Supplier Analysis Company websites, market Journals, White

papers, magazines, other market studies.

Competitive Landscape Company Annual Reports, Financials, Press

Releases, Investors Relations, Directories,

Journals.

Primary Data

Primary data is the most important data in the research study. Primary data has

been considered and linked to the report in order to make study more crisp and

informative. Structured interviews with industry specialists, VPs, CEOs, directors,

technology consultants were taken in order to collect the key primary data. The

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primary data was focused on both the demand and supply side of the market. Market

engineering was carried out from the data, and excessive analysis has been done on

it. Primary data was also considered extensively in validating the secondary content.

Market engineering process involved both top-down and bottom-up approach to

estimate the market size and market forecast, and segment the market into more

sub-segments.

Market size estimation

Both, top-down and bottom-up approaches were used to estimate the size of the

global heparin market.

Figure 1. Research Methodology

Global

Market

Size

Market-specific Revenues of Key Market

Players

Revenues of Key Market Players

Global Market

Size

Segment-specific Market Size

Regional

Market

Size

Bottom-up

Top-down

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Economic Indicators

Scalar Market Research has conducted a comprehensive study of the global

economic conditions and economic indicators to evaluate their impact on the current

market conditions and forecast the market scenarios.

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2.3 Market Segmentation

Heparin Market

ProductRoute of

AdministrationApplications Regions

•UnfractionatedHeparin

• Low Molecular Weight Heparin

•Ultra Low Molecular Weight Heparin

• Intravenous Injection

•Subcutaneous Injection

• Clinical Trials

• Medical Devices

•Venous Thromboembolism

• North America

• Europe

• Asia-Pacific

• Middle East & Africa

•Latin America

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3 Executive Summary

Heparin refers to the anticoagulant which is stored in the mast cells and secreted at

the injury site and is intended towards prevention of blood clots. Heparin, primarily is

derived from pig intestine or bovine (cow) lungs, but after the crisis of bovine heparin

in 1980s, porcine heparin is widely adopted across the globe. Heparin is widely

applied in thrombotic and cardiovascular disorders, surgery and kidney dialysis, and

anticoagulant coatings.

Heparin market exhibits significant growth and value due to growing population of

VTE (venous thromboembolism), obesity, declining imports from China and growing

adoption of new oral anticoagulants. In addition to this, the possibility of regulatory

approval of synthetic heparin and the comeback of bovine heparin in the United

States will create new opportunities for manufacturers of heparin, crude heparin

suppliers to make strides in this market.

The major revenue opportunities are expected to come from application sectors such

as clinical trials, medical devices, retail, and venous thromboembolism disorders.

Whereas venous thromboembolism will account for 58.59% of the total revenue

generated by 2022, clinical trials and medical devices will demand a great potential

towards heparin market. Low molecular weight heparin (LMWH) will continue to

dominate in the heparin market while ultra low molecular weight heparin will see

increasing growth rate due to rising number of cancer patients. Areas for investment

in the heparin market will focus on improving research and development for synthetic

heparin, improving supply chain, and looking for new sources such as sheep heparin

than heparin from porcine.

China continues to be the largest supplier for crude heparin and is expected to

dominate during the forecast period. The demand for finished heparin products are

expected to shift to countries such as India, Australia, Russia, and major countries of

Middle East and Africa by 2022. The demand from European countries will remain

same mainly due to their acquaintance with cold climate.

The Global Heparin market was estimated to be US$ XX million in 2015. This market

is expected to grow at a CAGR of XX% in the forecast period and is expected to be

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Figure 2. Global Heparin Market Share (%), By Regions (2015)

52.09%

21.84%

14.67%

3.69%7.71%

NA

EUROPE

APAC

LA

MEA

Source: Scalar Market Research Analysis

Figure 3. Global Heparin Market Share (%), By Product Segments (2015)

92.50%

1.61%

5.89%

Low Molecular Weight Heparin(LMWH)

Ultra Low Molecular Weight Heparin(ULMWH)

Unfractionated Heparin(UFH)


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3 Market Dynamics

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3.1 Drivers

Drivers

Impact on the Market

2014-2016 2017-2019 2020-2022

Increase in ageing population

and life expectancy

●=High ◑=Medium ◔=Low

1. Increase in ageing population and life expectancy–

a. .

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4 Industry Analysis

4.1 Supply Chain Analysis

Slaughter Houses

Intestines

Casting Workshops

Crude Heparin

ConsolidatorsHeparin API

Finished Heparin

Pharma Buyers/End Users


China is the main market for crude heparin and heparin API.

There are more than 25000 slaughter houses with around 2 millions kills per

day.

More than 1000 casting workshops who buys around 10000 kg of intestinal

mucosa and produce on an average of 200 kg of crude heparin per month.

Mixing, dosing, precipitation, drying is done by consolidators who are majorly

heparin pharmaceutical companies.

Consolidators turn crude heparin to heparin API which is then purchased by

major vendors.

These vendors turn heparin API to finished dosage form and send them to the

market.

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4.2 Suppliers Analysis

One of the main ingredients for the finished heparin product is the Heparin API. With

the increasing demand of finished heparin products across the globe, the global

heparin API production increased from XX trillion units in 2014 to XX trillion units

approximating XX tons (measured by 140IU/mg). The global heparin API production

capacity is expected to reach to XX trillion units by 2022 growing at a CAGR of XX%.

Table 4. Global Heparin API Production Capacity (trillion units), (2014-2022)

Global Heparin

API Production

2014 2015 2016 2017 2018 2019 2020 2021 2022 CAGR%

(2016-

2022)

Trillion Units

Y-o-Y


Table 5. Global Heparin API Production Capacity (trillion units), By Geography

(2014-2022)

Region 2014 2015 2016 2017 2018 2019 2020 2021 2022 CAGR% (2016-2022)

NA

EUROPE

APAC

LA

MEA

TOTAL


Asia-Pacific was the largest region of the heparin API production in 2015. This region

is expected to grow at a CAGR of xx% from xx trillion units in 2015 to xx trillion units

in 2022.This is mainly due to China being the largest exporter and producer of crude

heparin and heparin API and accounts for almost xx% of the global demand for

heparin. Scalar Market Research estimates that the MEA region is expected to grow

at a higher rate for heparin API production due to the possibility of regulatory

approval of sheep derived heparin.

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4.3 Pricing Analysis

Table 6. Pricing of Top Heparin Products with Average Market Price (2015)

No. Product Major Companies/Vendors Product

Segment

Average Market

Price (US$)

1

2

4

6

7

8

9

10

11

12

13

14

15

16


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5 Heparin Market, by Product Segments

5.1 Market Overview

The Product segments of the Heparin market included in this report are

Unfractionated Heparin (UFH), Low Molecular Weight Heparin (LMWH), and Ultra

Low Molecular Weight Heparin (ULMWH). Low Molecular Weight Heparin (LMWH)

continues to be the largest product in 2015, while Ultra Low Molecular Weight

Heparin (ULMWH) is expected to grow at a faster rate during the forecast period.

Figure 9. Market Attractiveness for different Heparin Product Segments

Characteristics Unfractionated

Heparin(UFH)

Low Molecular

Weight Heparin

(LMWH)

Ultra Low Molecular

Weight Heparin

(ULMWH)

Market Size

Growth Rate

Cost Savings

Overall Attractiveness

●=Significantly Attractive ◑=Attractive ◔=Less Attractive

With the advent of more generics such as enoxaparin, nadroparin, tinzaparin, the

market for low molecular weight heparin continues to grow. Moreover, comparatively

lesser costs of treatment in deep vein thrombosis (DVT) compared to unfractionated

heparin, home monitoring is further expected to spur the demand for LMWHs. Ultra

low molecular weight heparin currently has a smaller market share, but with the rise

of cancer patients adopting chemotherapy, the ULMWH market is expected to see

significant growth by 2022, especially in the Europe and Asia-Pacific. The market for

unfractionated heparin is expected to decrease as most of the hospitals are

considering for replacing it with LMWHs as it proves more effective and cost efficient.

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Figure 10. Global Heparin Market By Product Segments: Market Size & Market

Penetration (2015)

Market Penetration

Ma

rke

t Siz

e

High

Hig

h

Low Molecular

Weight Heparin(LMWH)

Unfractionated Heparin(UFH)

Ultra LowMolecular Weight Heparin(ULMWH)

Source: Scalar Market Research Analysis SAMPLE

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6 Heparin Market, by Route of Administration (ROA)

6.1 Market Overview

Figure 18. Global Heparin Market Size (US$ million), By Route of Administration

(2015)

USD7230

Million


The Route of Administration segments of the Heparin market included in this report

are IV (Intravenous) injection and SC (Subcutaneous) injection.

The subcutaneous injection was the largest Route of Administration segment in

2015, and it’s also expected to be the fastest-growing formulation segment in the

forecast period. The rise in the self-injected heparin products, the upsurge in the

consumer preferences for the same and home monitoring are factors responsible for

the growth of this segment. Also, the growth is directly proportional to the growth of

LMWHs.

Subcutaneous Injection | US$ XX

Million

IV Injection | US$ XX Million

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6.2 Market Share Segmentation

Figure 19. Global Heparin Market Share (%), By Route of Administration (2015 & 2022)

31.64%

68.36%

IV Injection

Subcutaneous Injection

Market Share ,2015

31.08%

68.92%

IV Injection

Subcutaneous Injection

Market Share ,2022


Subcutaneous injection was the largest segment in the global heparin market for Route of

Administration accounting for XX% market share. This was mainly due to the rise of low

molecular weight heparins.

Scalar Market Research Analysis predicts that the market for subcutaneous injection in heparin

market for Route of Administration will continue to dominate during the forecast period, while

the market for intravenous injection in heparin market for Route of Administration will have

no effect and is expected to be stable.

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7 Heparin Market, by Applications

7.1 Market Overview

Figure 23. Global Heparin Market Size (US$ million), By Applications (2015)

USD7230

Million


The application segments of the heparin market included in this report are clinical

trials, medical devices, and venous thromboembolism.

Venous thromboembolism was the largest application segment in 2015, and it’s also

expected to be the growing application segment in the forecast period. The rise in

the ageing population, increasing diabetic patients, and rise of hospital acquired

infection patients globally are factors responsible for the growth of this application

segment.

Clinical Trials | US$ XX Million

Medical Devices |US$ XX Million

Venous Thromboembolism | US$ XX Million

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8 Heparin Market, By Regions

8.1 Geographic Overview

The regional segments of the heparin market included in this report are North

America (NA), Europe (EU), Asia-Pacific (APAC), Latin America (LA), and Middle

East & Africa (MEA). North America was the largest regional segment in 2015, while

Asia-Pacific is expected to be the fastest-growing regional segment in the forecast

period.

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Table 20. Heparin Market Prospects, by Geography (2016-2022)

Geography Growth Prospects Indicators

North America

Europe

Asia-Pacific

Latin America

Middle East &

Africa


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8.2 Market Share Segmentation

Figure 31. Global Heparin Market Share (%), By Major Regions (2015 & 2022)

52%

22%

14%

4%8%

45%

22%

19%

4%

10%

North America

Europe

Asia Pacif ic

Latin America

Middle East & Africa

Inside circle shows the market share for the year 2015 & outside circle shows market share

for the year 2022.

North America was the largest regional segment of the heparin market in 2015. The

market had a XX% share of the global market in 2015. However, North America is

expected to lose its market share to Asia Pacific and Middle East & Africa by 2022.

Figure 32. Top 5 Countries, By Market Share (%) (2015)

49.31%7.69%

4.43%

4.42%

3.74%

United States

Germany

China

United Kingdom

India


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9 Competitive Landscape

9.1 Market Share Analysis

Figure 60. Market Share (%) of Major Players (2015)

26.83%

4.84%

4.70%

5.04%

3.93%

4.96%

1.17%

Sanofi Aventis

Leo Pharma

Pfizer

Aspen

Baxter Healthcare

Fresnius Kabi AG

Amphastar Pharmaceuticals

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12 Appendix

Table 69. Acronyms

CAGR Compounded Annual Growth Rate

NA North America

EU Europe

APAC Asia-Pacific

MEA Middle East & Africa

LA Latin America

LMWH Low Molecular Weight Heparin

ULMWH Ultra Low Molecular Weight Heparin

UFH Unfractionated Heparin

ROA Route of Administration

IV Intravenous

SC Subcutaneous

HAI Hospital Acquired Infections

SAMPLE

Heparin market global revenue, trends, growth, share, size and forecast to 2022

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