Hemostatik 2012
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Transcript of Hemostatik 2012
BLOOD COAGULATION AND ANTICOAGULANT,
THROMBOLYTIC, AND ANTIPLATELET DRUGS
Alfi YasminaDea Arie Kurniawan
Antikoagulan, Antitrombotik, Trombolitik,Hemostatik
Beberapa Istilah• Hemostasis
• Koagulasi• Trombosis
• Antikoagulan• Antitrombotik
• Trombolitik• Hemostatik
• Indirect Trombin Inhibitor– Heparin– Warfarin– Rivaroxaban
• Direct Trombin Inhibitor– Bivalirudin, Hirudin, Lepirudin,
Argatroban– Dabigatran, Ximelagatran
Antikoagulan
• LMWH– Bemiparin, dalteparin, enoxaparin,
reviparin, fondaparinux• Monitoring pemeriksaan darah• Indikasi: trombosis vena, emboli
paru, PJR, penyakit jantung iskemik
Antikoagulan
AspirinDipiridamolTiklopidin
KlopidogrelEpoprostenol (PGI2)
Abciximab
Antitrombotik
Fosfolipid membran
Asam arakidonat
Rangsang
Gangguan pada membran sel
Hidroperoksid
Leukotrien
Endoperoksid (PGG2/PGH)
PGE2, PGF2, PGD2, PGI2 Tromboksan A2
FosfolipaseSiklooksigenaseLipooksigenase Aspirin
• Indikasi: cegah trombosis pada TIA/stroke, infark miokard, bedah kardiovaskuler, Raynaud’s phenomen
Antitrombotik
• Streptokinase• Urokinase
• Plasminogen activator(u-PA, t-PA)
Trombolitik
• Indikasi: infark, emboli paru, trombosis vena/arteri
• Mahal
Trombolitik
• Transfusi• Faktor VIII• Kompleks faktor II, V, IX, X• Fibrinogen• Vitamin K• Asam aminokaproat• Asam traneksamat• Karbazokrom
Hemostatik
Further Reading• Katzung BG, Masters SB, Trevor AJ. Basic and
Clinical Pharmacology 11th Edition. McGraw-Hill, 2009.
• Goodman & Gilman’s Manual of Pharmacology and Therapeutics. McGraw-Hill, 2008