292997

Parkin DM et al. Int J Cancer 1999;80:827-841, Pisani P et al. Int J Cancer 1999;83:18-29, Ferlay J et al. Int J Cancer 2015;136:E359-E386.

2012

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de Martel C, Forman D, Plummer M. Gastric cancer: epidemiology and risk factors. Gastroenterol Clin North Am. 2013 Jun;42(2):219-40. doi: 10.1016/j.gtc.2013.01.003. Epub 2013 Mar 29. Review. PubMed PMID: 23639638

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The World Cancer Research Fund (WCRF): Continuous Update Project (CUP), Diet, Nutrition, physical activity and stomach cancer, 2016.

2016 DECREASES RISK

INCREASES RISK

STRONG EVIDENCE

Convincing

Probable

()()

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CD

STRONGEVIDENCE

2000 (GLOBOCAN, 2008)

Peleteiro B et al. Dig Dis Sci. 2014 Aug;59(8):1698-709.

60

Peleteiro B et al. Dig Dis Sci. 2014 Aug;59(8):1698-709.

?

5

Ueda J et al. Helicobacter. 2014 Apr;19(2):105-10.

1997-201320

2008-2010

Tamura T et al. Nagoya J Med Sci. 2012 Feb;74(1-2):63-70.

J-MICC

60-69 50-59

Graph11940s1950s1960s1970s40-4935-39PrevalenceBirth-yearPrevalence (%)50.339.425.819.6Sheet1Prevalence1940s50.31950s39.41960s25.81970s19.6

Hirayama Y et al. J Gastroenterol Hepatol 2014; 29 (suppl 4): 16-19

T-companys Annual Health Check-up, Tokyo

Graph1HokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoHokaidoAichiAichiAichiAichiAichiAichiAichiAichi40-4930-3960-6950-59Age at enrollmentbirth yearTotalBirth-yearPrevalence (%)190079191083192083192754Sheet1birth yearTotalHokaido190079Hokaido191083Hokaido192083Aichi192754Hokaido193073Tokyo193081Total194046Hokaido194059Tohoku194045Kanto194051Chubu194050Kinki194044Chugoku194044Kyushu194046Hokaido194079Tokyo194071Daiko194450Aichi194942Total195037Hokaido195044Tohoku195034Kanto195036Chubu195040Kinki195040Chugoku195045Kyushu195049Hokaido195041Tokyo195054Daiko195439Total196023Hokaido196028Tohoku196025Kanto196021Chubu196016Kinki196026Chugoku196026Kyushu196028Hokaido196026Tokyo196043Aichi196124Daiko196426Total197018Hokaido197017Tohoku197016Kanto197027Chubu197020Kinki197020Chugoku197013Kyushu197018Hokaido197019Tokyo197028Daiko197220Hokaido19806Aichi198814Nagano19903Nagano19918Nagano19925Osaka20002Akita20006Osaka20015Osaka20022Osaka20023Osaka20031Osaka20032Osaka20041Osaka20042Osaka20053Osaka20054Osaka20061Osaka20061Osaka20070Osaka20070Osaka20082Osaka20080Osaka20093Osaka20090Osaka20100Osaka20100Osaka20110

Sasayama, Hyogo Prefecture, 2011 (n=835)

Okuda M, et al. Helicobacter. 2015 Apr;20(2):133-8.

Graph1200020012002200320042005200620072008200920102011TotalPrevalence (%)Birth-year%1.64.91.511.43.30.902.32.9001.8Sheet1Prevalence (%)20001.620014.920021.52003120041.420053.320060.92007020082.320092.92010020110Total1.8Graph1200020012002200320042005200620072008200920102011TotalPrevalence (%)Birth-yearPrevalence of H. pyloriby birth-year (%)1.64.91.511.43.30.902.32.9001.8Sheet1Prevalence (%)20001.620014.920021.52003120041.420053.320060.92007020082.320092.92010020110Total1.8

-HERPACC III (2005-2013), Aichi Cancer Center, Nagoya, Japan-

Figure 2. Trends in the prevalence of Helicobacter pylori infection (a) and proportion of high-risk individuals for gastric cancer (b) by three-birth-year moving-average method in Joinpointregression analysis. *Statistical significance was set at P < 0.05. BPC, birth-year percent change.

Watanabe M et al. Cancer Sci. 2015 Dec;106(12):1738-43.BPC: Birth year percent change

Asaka M Gastroenterol 1992; 102:760-766. Akamatsu T et al. J Gastroenterol 2011; 46: 1353-1360Ueda J et al. Helicobacter. 2014;19(2):105-10. Tamura T et al. Nagoya J Med Sci. 2012;74(1-2):63-70. Hirayama Y et al. J Gastroenterol Hepatol 2014; 29 (suppl 4): 16-19Okuda M, et al. Helicobacter. 2015;20(2):133-8 Watanabe M et al. Cancer Sci. 2015;106(12):1738-43.

Inoue M. Changing epidemiology of Helicobacter pylori in Japan. Gastric Cancer. 2017 Mar;20(Suppl 1):3-7.

Graph11900191019201927193019301940194019401940194019401940194019401940194419491950195019501950195019501950195019501950195419601960196019601960196019601960196019601961196419701970197019701970197019701970197019701972198019881990199119922000200020012002200220032003200420042005200520062006200720072008200820092009201020102011TotalBirth YEar%Prevalence (%)798383547381.246.158.644.950.55044.443.846.17971.450.34237.443.634.435.940.140.14548.74154.339.422.928.125.121.216.125.925.828.32643.12425.81817.21626.519.720.312.5181928.419.66143.47.64.91.65.74.91.53.311.81.42.23.33.70.90.8002.302.90000Sheet1birth yearTotalHokaido190079Hokaido191083Hokaido192083Aichi192754Hokaido193073Tokyo193081Total194046Hokaido194059Tohoku194045Kanto194051Chubu194050Kinki194044Chugoku194044Kyushu194046Hokaido194079Tokyo194071Daiko194450Aichi194942Total195037Hokaido195044Tohoku195034Kanto195036Chubu195040Kinki195040Chugoku195045Kyushu195049Hokaido195041Tokyo195054Daiko195439Total196023Hokaido196028Tohoku196025Kanto196021Chubu196016Kinki196026Chugoku196026Kyushu196028Hokaido196026Tokyo196043Aichi196124Daiko196426Total197018Hokaido197017Tohoku197016Kanto197027Chubu197020Kinki197020Chugoku197013Kyushu197018Hokaido197019Tokyo197028Daiko197220Hokaido19806Aichi198814Nagano19903Nagano19918Nagano19925Osaka20002Akita20006Osaka20015Osaka20022Osaka20023Osaka20031Osaka20032Osaka20041Osaka20042Osaka20053Osaka20054Osaka20061Osaka20061Osaka20070Osaka20070Osaka20082Osaka20080Osaka20093Osaka20090Osaka20100Osaka20100Osaka20110

2012 6 7 82000 (GLOBOCAN, 2008)2008-2010Sasayama, Hyogo Prefecture, 2011 (n=835) -HERPACC III (2005-2013), Aichi Cancer Center, Nagoya, Japan- 27