Heavy Metals Detection in Cannabis by ICP-MS

103/15/2019

Dr. Iouri Kalinitchenko Head of ICPMS R&D, Analytik Jena, GermanyHarj Sandhu Value Scientific, Analytik Jena, AustraliaDr. Siqi Sun Application Specialist, Analytik Jena US Dr. Oliver Büttel Director Business Development Analytik Jena US

Percentage of cannabis users - including Australia/NZ

203/15/2019

https://www.google.com.au/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=2ahUKEwj9s_TEtJfhAhVDAXIKHa1KB3EQjRx6BAgBEAU&url=https://www.msn.com/en-gb/news/other/cannabis-use-worldwide/ss-BBOm0Xl?parent-title%3Dcannabis-twice-as-strong-as-a-decade-ago%26parent-ns%3Dar%26parent-content-id%3DBBRAJkq%26fullscreen%3Dtrue&psig=AOvVaw3CIikJK3G7K70wFYJ1L3Jr&ust=1553401184481136

Legal situation

303/15/2019

Legal as authorized by a physician Legal for any use (no prescription required)

Australia - legal• Victoria: Legal for use by children with severe,

treatment-resistant epilepsy, from early 2017 • Queensland: Legal by prescription from specialists

for use by patients with a range of conditions including MS, epilepsy, cancer, and HIV/AIDS, from March 2017:

• NSW: Legal for use by adults with end-of-life illnesses, from July 2016: Poisons and Therapeutic Goods Amendment Regulation 2016.

• ACT: People who fall under category 6 illnesses within certain criteria as of 2017

• Tasmania: Controlled Access Scheme began in 2017 to allow patients to access unregistered medicinal cannabis.

• WA: Legal by prescription from doctors under certain conditions, from November 2016

• NT: The Australian Government Department of Health regulates therapeutic medicines containing cannabinoids through the Therapeutic Goods

Cannabis market: Global Legal Annual Grow Rate - GAGR 36%

03/15/2019 4

03/15/2019 5

Market dynamics driven by prescriptions, medical and health issues

U.S. Medical Marijuana Market, By Application, 2013 – 2024

Combined: legal / illegal

Medical: legal

Distribution by application

https://www.google.com.au/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=2ahUKEwiYvOnj7ZfhAhXZZCsKHYTqBYQQjRx6BAgBEAU&url=https://mjbizdaily.com/australian-medical-marijuana-revenues-could-hit-au36-million-in-2019/&psig=AOvVaw1LMLUstjoiy1hlpl2J4oDF&ust=1553416557875491https://www.google.com.au/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&ved=2ahUKEwims-KK9pfhAhWJe30KHfZ9AjoQjRx6BAgBEAU&url=https://www.gminsights.com/industry-analysis/medical-marijuana-market&psig=AOvVaw3WDRCRSC8zdbHF-wIP782F&ust=1553418754520486

Elements of major Interest are poisonous :

Arsenic, Cadmium, Mercury, Lead Source:

Water and Soil during growth Natural -> Erosion of Minerals, volcanic activity

Man-Mad -> fertilizers and herbicides/pesticides

Impurities of raw materials during processing

Medical cannabis is for health – means monitoring for Heavy Metals in raw Cannabis or Cannabis Products by

6Wolfram Weisheit03/14/2019

Action levels for “big 4”

Element ppm

Inorganic Arsenic 3

Cadmium 0,5

Lead 5

Methyl Mercury 0,5

With increased state regulations, cannabis suppliers are required to conduct trace metals testing to ensure safe and high-quality products.

A simple and accurate analysis method for screening the “Big Four” heavy metals (As, Pb, Cd and Hg) is highly demanded.

“Big four” elements - approach is similar and different to Q3DUSP drugs regulation where ICPMS instrument is used

703/15/2019

Regulation by California Bureau of Marijuana Control

Heavy Metal

Action Level for Medical Edible Cannabis Products, Suppositories,

Sublingual Products, and Other Manufactured Products (μg/g)

Action Level for All Inhaled

Medical Cannabis Goods

(μg/g)

Action Level for Topical and

Transdermal Medical Cannabis

Goods (μg/g)

Cadmium 0.5 0.2 5Lead 0.5 0.5 10

Arsenic 1.5 0.2 3Mercury 3 0.1 1

USP232, Daily permitted exposure to elemental impurities

Sample Preparation Challenges Suitable for all types of cannabis product (plant

material, edibles and concentrates)

Prevent the loss of analyte

Avoid contamination

Solution

Closed vessel microwave digestion enables easy and efficient sample preparation

Challenges and Solutions

803/15/2019

Challenges and Solutions - ICPMS

903/15/2019

Analysis Challenges

Low detection limits

Easy remove matrix and plasma induced spectroscopic interferences

Short analysis time

Solutions

ICP-MS offers low detection limits, multi-element capabilities, and low sample consumption

Integrated Collision Reaction Cell design effectively eliminates spectroscopic interferences PQMS ICP-MS

Designed in Melbourneby ex-VARIAN R&D team Produced in Germany

Auto-sampler Designed/produced in Brisbane

TOPwave with PM60 vessels were used for all cannabis digestion.

Procedure

1. Weigh 0.5 g plant material (or 0.2 g oil) into a PM60 vessel

2. Add 5 mL HNO3, 1 mL HCl and 1 mL H2O23. Wait 5 minutes before close the vessel

4. Run the TOPwave with the following temperature program

5. Add deionized water and gold stabilizer to the sample to final volume of 50 mL

Sample preparation

03/15/2019 10

Temperature programCannabis flower and oil

Step Temperature (°C) Pressure (bar) Ramp Time (min) Hold Time (min) Power (%)

1 150 40 5 5 752 200 40 5 15 903 50 0 1 20 0

TOPwave with PM60 vessels were used for all cannabis digestion.

Procedure

1. Weigh 0.5 g plant material (or 0.2 g oil) into a PM60 vessel

2. Add 5 mL HNO3, 1 mL HCl and 1 mL H2O23. Wait 5 minutes before close the vessel

4. Run the TOPwave with the following temperature program

5. Add deionized water and gold stabilizer to the sample to final volume of 50 mL

Sample preparation

03/15/2019 11

Temperature programCannabis flower before (left) and after (right) digestion

Step Temperature (°C) Pressure (bar) Ramp Time (min) Hold Time (min) Power (%)

1 150 40 5 5 752 200 40 5 15 903 50 0 1 20 0

Sample Preparation:

SpeedMILL Plus assisted milling and enzymatic digestion with Proteinase K Weigh 100 mg of samples

Add spherical milling beads and mill sample to powder

Add 1mL of Lysis buffer and Proteinase K for enzymatic digestion

Shake for 30 min at 55 °C

TOPwave assisted digestion of Cannabis in HNO3 and HCl Weigh 150 mg – 500 mg of samples

Add 4 mL HNO3 and 1 mL HCl (for stabilizing Hg)

1 step Microwave digestion (20 min ramp up to 240 °C and hold for 15 min)

Collect liquids and fill up to 10 mL

Dilution of liquid samples with 1 % HNO3 and 0,5 % HCl to decrease Matrixeffects

Heavy Metals in Cannabis or Cannabis Products

12Wolfram Weisheit03/14/2019

ICP-MS Analysis

03/15/2019 13

All analyses were performed on a Analytik Jena PlasmaQuant Elite ICP-MS.

Operating condition

Parameter Setting

RF Power 1400 WPlasma gas flow 9 L/min

Nebulizer gas flow 1.04 L/minAuxiliary gas flow 1.2 L/min

iCRC gas flow 80 mL/min He, 75 mL/min H2Stablization delay 30 s

Sample Uptake delay 40 sRinse time 40 s

Dewell time 30 msScans/replicate 15 (peak hopping, 1pt/peak)No. of replicate 5

Pump rate 15 rpm with black/black PVC pump tubing

ICP-MS Analysis

03/15/2019 14

Analysis results of cannabis flower

Element Gas mode R2 LOD (µg/L) Average of three digestions (µg/g) Spike recovery (%)

Co59 He 0.9998 0.0232 0.6548 85.10Ni60 He 0.9994 0.0457 0.1283 116.40Cu65 He 0.9996 0.3459 10.6981 101.88Zn66 He 1.0000 4.9018 66.2541 91.83As75 H2 0.9999 0.0694 0.0952 124.90

Cd111 none 0.9999 0.0124 0.0117 103.15Hg202 none 1.0000 0.0027

Excellent detection limits LoD - ppq, ppt

Wide elemental coverage - from Li - U over 70 elements measurable

High throughput, < 40sec per sample! all elements determined (almost

simultaneously)Wide dynamic range

• linear over 11+ orders• Dynamic range ppq – %

Sensitive and precise fully quantitative measurements external calibration standard additions

Powerful semi-quantitative analysis no standards needed

Isotopic analysis isotope ratios isotope dilution

Routine technique many users run systems overnight 1000+ samples a day

General question: Why ICP-MS ?

Why ICPMS from Analytik Jena?

• designed in Australia (Melbourne), ex-VARIAN team • Produced in Germany (Jena) and Australia

the most advanced ICP-MS

VARIAN -> AnalytikJena ICPMS expertise

30years!

Year 1988 1993 2003 2005 2008 2010 2013 2014 2015

Ultramass 800 810 820 m90 Elite PlasmaQuant MS

AnalytikJena (Germany/Australia)Bruker (Melbourne)VARIAN (Melbourne)

Varian ICPMS technology Ion Mirror, iCRC with Analytik Jena plasma

2019

Most innovative, patented ICPMS

2015

Designed to be fast, precise, economical and robust

18

Virtual Ground Plasma - ½ argon iCRC Interface,simplicity

Ion Optics – x10 better sensitivity

Analytik Jena design protected by 8 inventions:1. ½ Ar plasma, robust 2. Robust interface 3. x10 times better sensitivity Ion Optics4. Never clean Ion Optics 5. Never clean mass-analyser6. Low noise quadrupole 7. iCRC - integrated Collision Reaction Cell 8. All digital detector, ADD11.

Plasma generation

½ Ar plasma technology Fassel torch No shield Robust plasma

Economical - ½ Argon Only 9L/min of argon consumption. Saves annually about 13000 EUR

100% Ethanol Direct sea water - 3.5% TDS

Robust and matrix tolerant: any sample, any matrix

100% IPA24% NaCl

21

Interface(robustness test)

Direct sea water - 3.5% TDS

Neat Sea Water – direct, 3 days, non-stop

No clogging, no salt blockage

Photo of the cones after 3.5 % NaCl run for 3 days non-stop

Ion Optics

Never clean Ion Optics x10 times better sensitivity

• Extremely robust Ion Mirror • x10 better sensitivity

Absolute robustnessOnly ions reflected into the mass-analyser

Video is available on https://www.analytik-jena.de

Maximum signal x10 sensitivity No contamination No drift No maintenance Stable signal

• Neutrals passing through the field inside of the ring

• The field cannot be contaminated

Stableat any sample, any matrix!

24

• Collecting data x10 times faster• Approximately x6 - 7 times more samples per hour. Yes, x 6-7times • Measurement precision RSD

Analytik Jena - best technical specification ICPMS

Sensitivity and LoD

Element GuaranteedSpecification 1ppb [kcps]

Typical2.11.16

installation, (Germany), 1 ppb [kcps]

Li7 250 317Be9 50 84

Mg24 600 815Co59 1000 1532Y89 1200 1960

In115 1500 2470

Tl205 950 1950Bi209 1000 2021Th232 1000 2663U238 1000 2108

CeO+/Ce+

• Extra High Sensitivity ICP-MS of the ELITE model

• Part-per-quadrillion (pg/L) detection limits for REEElement Detection Limits(pg/L)

La 21Ce 13Pr 8Nd 20Sm 39Eu 13Gd 27Tb 6Dy 20Ho 4Er 15Tm 6Yb 24Lu 5

LoD - ppq rangeLoD

Rare Earth Elements

Best technical specification for Sensitivity; LoD - practice

About the Limits of Detection

Be9 Bi209 Cd112

Tl 203Ag107

Bi209

Cs133

Element no gas H2Li7 0,5 2,5

Be9 0,4 0,7

B11 6,9 17

Na23 25 13

Mg24 1,1 2,0

Al27 0,9 2,4

Ca44 303 23

Sc45 3,5 n. m.

Ti49 0,6 n. m.

V51 2,3 0,8

Cr52 6,1 0,5

Mn55 0,7 0,8

Fe56 n. m. 1,6

Fe57 571 76

Co59 0,1 0,4

Ni60 22 10

Cu63 0,4 0,7

Zn66 1,6 2,1

Ga69 0,1 0,4

As75 5,4 1,9Se78 15 13

Rb85 0,1 0,9

Sr88 0,04 0,05

Y89 0,01 n. m.

Zr90 0,05 n. m.

Nb93 0,02 n. m.

Mo95 0,1 n. m.

Mo98 0,1 n. m.

Ru101 0,06 n. m.

Rh103 0,008 n. m.

Pd105 0,05 n. m.

Ag107 0,03 0,1

Cd112 0,06 0,1In115 0,01 0,03

Sn120 0,1 n. m.

Sb121 0,04 n. m.

Te125 0,4 1,4

Cs133 0,05 0,09

Ba138 0,07 0,07

La139 0,02 n. m.

Ce140 0,01 n. m.

Pr141 0,006 n. m.

Nd146 0,03 n. m.

Sm147 0,03 n. m.

Eu153 0,01 n. m.

Gd157 0,03 n. m.

Tb159 0,004 n. m.

Dy163 0,02 n. m.

Ho165 0,003 n. m.

Er166 0,009 n. m.

Tm169 0,004 n. m.

Yb172 0,02 n. m.

Lu175 0,003 n. m.

Hf178 0,02 n. m.

Ta181 0,005 n. m.

W182 0,02 n. m.

Re185 0,01 n. m.

Ir193 0,01 n. m.

Pt195 0,04 n. m.

Au197 0,03 n. m.

Hg202 0,4 n. m.Tl205 0,03 0,03

Pb… 0,04 0,03Bi209 0,01 0,01

Th232 0,02 0,05

U238 0,01 n. m.

Pb208LoD - 72 [ng/L] ppq

Limits of Detection LoD, [ng/L], ppt

Moving to ppq limits of detection

Sheet1

Elementno gasH2

Li70,52,5

Be90,40,7

B116,917

Na232513

Mg241,12,0

Al270,92,4

Ca4430323

Sc453,5n. m.

Ti490,6n. m.

V512,30,8

Cr526,10,5

Mn550,70,8

Fe56n. m.1,6

Fe5757176

Co590,10,4

Ni602210

Cu630,40,7

Zn661,62,1

Ga690,10,4

As755,41,9

Se781513

Rb850,10,9

Sr880,040,05

Y890,01n. m.

Zr900,05n. m.

Nb930,02n. m.

Mo950,1n. m.

Mo980,1n. m.

Ru1010,06n. m.

Rh1030,008n. m.

Pd1050,05n. m.

Ag1070,030,1

Cd1120,060,1

In1150,010,03

Sn1200,1n. m.

Sb1210,04n. m.

Te1250,41,4

Cs1330,050,09

Ba1380,070,07

La1390,02n. m.

Ce1400,01n. m.

Pr1410,006n. m.

Nd1460,03n. m.

Sm1470,03n. m.

Eu1530,01n. m.

Gd1570,03n. m.

Tb1590,004n. m.

Dy1630,02n. m.

Ho1650,003n. m.

Er1660,009n. m.

Tm1690,004n. m.

Yb1720,02n. m.

Lu1750,003n. m.

Hf1780,02n. m.

Ta1810,005n. m.

W1820,02n. m.

Re1850,01n. m.

Ir1930,01n. m.

Pt1950,04n. m.

Au1970,03n. m.

Hg2020,4n. m.

Tl2050,030,03

Pb…0,040,03

Bi2090,010,01

Th2320,020,05

U2380,01 n. m.

 Hab ich von 0,02 auf 0,01 reduziert. Hatte bei den Highthroughputmessungen 40c/s BG und 1,4Mcps sensitivity

ð  Würde in 0,13 resultieren => 0,01 sollte kein Problem sein.

Sheet2

Sheet3

Sheet1

Elementno gasH2

Li70,52,5

Be90,40,7

B116,917

Na232513

Mg241,12,0

Al270,92,4

Ca4430323

Sc453,5n. m.

Ti490,6n. m.

V512,30,8

Cr526,10,5

Mn550,70,8

Fe56n. m.1,6

Fe5757176

Co590,10,4

Ni602210

Cu630,40,7

Zn661,62,1

Ga690,10,4

As755,41,9

Se781513

Rb850,10,9

Sr880,040,05

Y890,01n. m.

Zr900,05n. m.

Nb930,02n. m.

Mo950,1n. m.

Mo980,1n. m.

Ru1010,06n. m.

Rh1030,008n. m.

Pd1050,05n. m.

Ag1070,030,1

Cd1120,060,1

In1150,010,03

Sn1200,1n. m.

Sb1210,04n. m.

Te1250,41,4

Cs1330,050,09

Ba1380,070,07

La1390,02n. m.

Ce1400,01n. m.

Pr1410,006n. m.

Nd1460,03n. m.

Sm1470,03n. m.

Eu1530,01n. m.

Gd1570,03n. m.

Tb1590,004n. m.

Dy1630,02n. m.

Ho1650,003n. m.

Er1660,009n. m.

Tm1690,004n. m.

Yb1720,02n. m.

Lu1750,003n. m.

Hf1780,02n. m.

Ta1810,005n. m.

W1820,02n. m.

Re1850,01n. m.

Ir1930,01n. m.

Pt1950,04n. m.

Au1970,03n. m.

Hg2020,4n. m.

Tl2050,030,03

Pb…0,040,03

Bi2090,010,01

Th2320,020,05

U2380,01 n. m.

 Hab ich von 0,02 auf 0,01 reduziert. Hatte bei den Highthroughputmessungen 40c/s BG und 1,4Mcps sensitivity

ð  Würde in 0,13 resultieren => 0,01 sollte kein Problem sein.

Sheet2

Sheet3

Sheet1

Elementno gasH2

Li70,52,5

Be90,40,7

B116,917

Na232513

Mg241,12,0

Al270,92,4

Ca4430323

Sc453,5n. m.

Ti490,6n. m.

V512,30,8

Cr526,10,5

Mn550,70,8

Fe56n. m.1,6

Fe5757176

Co590,10,4

Ni602210

Cu630,40,7

Zn661,62,1

Ga690,10,4

As755,41,9

Se781513

Rb850,10,9

Sr880,040,05

Y890,01n. m.

Zr900,05n. m.

Nb930,02n. m.

Mo950,1n. m.

Mo980,1n. m.

Ru1010,06n. m.

Rh1030,008n. m.

Pd1050,05n. m.

Ag1070,030,1

Cd1120,060,1

In1150,010,03

Sn1200,1n. m.

Sb1210,04n. m.

Te1250,41,4

Cs1330,050,09

Ba1380,070,07

La1390,02n. m.

Ce1400,01n. m.

Pr1410,006n. m.

Nd1460,03n. m.

Sm1470,03n. m.

Eu1530,01n. m.

Gd1570,03n. m.

Tb1590,004n. m.

Dy1630,02n. m.

Ho1650,003n. m.

Er1660,009n. m.

Tm1690,004n. m.

Yb1720,02n. m.

Lu1750,003n. m.

Hf1780,02n. m.

Ta1810,005n. m.

W1820,02n. m.

Re1850,01n. m.

Ir1930,01n. m.

Pt1950,04n. m.

Au1970,03n. m.

Hg2020,4n. m.

Tl2050,030,03

Pb…0,040,03

Bi2090,010,01

Th2320,020,05

U2380,01 n. m.

 Hab ich von 0,02 auf 0,01 reduziert. Hatte bei den Highthroughputmessungen 40c/s BG und 1,4Mcps sensitivity

ð  Würde in 0,13 resultieren => 0,01 sollte kein Problem sein.

Sheet2

Sheet3

Highest sensitivity means the highest speed of analysis – 82 samples per hour

Sensitivity vs Speed of analysis

50 elements case

Example of 50 elements to measure:

• Peak hopping method (single point per peak)• 20ms – dwell time per element • x50 scans Total time - 1s per replicate

Replicates - x10 Integration time per element: 1s x10replicates = 10 sec

Total measurement time for 50 elements50 x 10s = 500s

Sample washout and stabilization time 20sTotal time per sample: 520s

RESULT 7 samples per hour

Example of 50 elements to measure:

• Peak hopping method (single point per peak)• 2ms – dwell time per element • x50 scans Total time - 0.1s per replicate

Replicates - x10 Integration time per element: 1s x10replicates = 1 sec

Total measurement time for 50 elements50 x 1s = 50s

Sample washout and stabilization time 20sTotal time per sample: 70s

RESULT 51 samples per hour

x7 times more samples !

Standard non sensitive ICP-MS x10 times more sensitive ICP-MS

precision RSD - 2%

82 samples per hourExample is drinking water, USEPA 200.8, 21 elements, 2.2% RSD

82 drinking water samples per hour with 21 elements (RSD

Sensitivity benefit: 82 samples per hour,

Calculations:• PQMS argon consumption < 9l/min • One 50L bottle - 2 days, 20h• 2 days productivity 1600 samples • One Bottle cost - 100EUR. • Cost of argon - 6.2c per sample

• RSD 2.2% - 82 samples/hour• RSD 1.5% - 60 samples/hour

Argon consumption Cost per sample

6.2c

Drinking water USEPA 200.8, 21 elements, 2.2% RSD

USEPA 200.8 requires

Quadrupole mass-analyzer

Patent 1: Contamination protection and low noise

Patent 2: Zero maintenance mass-analyser pre-filter

• Maintenance free

Advanced ADD 11

All Digital Detector

The detector converts ions into electrical pulses. Adjustment of voltage applied to control dynode provides attenuation of final output signal.

Control Section

Signal Output

Quadrupole Gain Control

Ion to e-Conversion

Amplification

e-e-e-

+ e-

36

Innovative All Digital Detector ADD 11

• Discrete Dynode Electron Multiplier: - Operates in pulse counting mode at all times

• Extended Dynamic Range: - Provides 11 decades of linear dynamic range 0.1 – 10 10 c/s

• No Pulse to Analog Cross Calibration Required: - 2 stage digital attenuation

Analytik Jena ADD11 – Australian design/production• The ADD11 detector has been designed by ETP (Sydney) in

collaboration with Varian (now Analytik Jena) R&D (Melbourne)• Produced in Australia by ETP in Sydney

References:

Compact instrument to work in laboratory

MS

ICP• ‘Open Book’ concept - fastest access to the

interface maintenance • Square footprint - smallest on market

Why is the vertical orientation?

MS

ICP

All Digital Detection 11 orders linear range

39

German quality - pumps

Leybold SV40 or Dry pump

HiPace300

G forceprotection

Magnetic bearing

Stator Rotor60000rpm

Axis

Lowerbearing

Turbine blades pitch optimised for best compression ratio

Electronicsmodule

Foreline outlet Optimised Drag stage for 15Torr continues pressure

Magnetic bearing system - robust1. Robust magnetic bearing system - 10G force2. Smooth running – no start up/shutting

resonances3. Extremely - quiet 4. Mean time to failure > 200,000 hours, 22+ years

CONCLUSION: HiPace300 is a high quality pump made in Germany, it is best fit for ICPMS

Two Magnetic bearings turbo pumps from Germany

Innovation summary

Highest x10 times sensitivity among ICPMS - 1.5 109 c/s per ppm: Faster to measure sample by x2 times ½ argon consumption

PQMS Elite at Clinical laboratory, Royal North Shore Hospital (RNSH)Australia, Sydney, March 2019

Analytik Jena ICPMS – in Australia

Analytik Jena – product portfolio

03/15/2019 42

Analytik Jena (Germany) is a division of Endress + Hauser corporation (Switzerland)

03/15/2019 43

Analytik Jena clients

03/15/2019 44

Who is E+H?

Thanks for attention. Questions please.Dr. Iouri Kalinitchenko, Head of ICPMS R&D, Analytik Jena, Germany/Australia

Iouri.Kalinitchenko@analytik-jena.com

Heavy Metals Detection in Cannabis by ICP-MS ��Percentage of cannabis users - including Australia/NZ�Legal situationCannabis market: Global Legal Annual Grow Rate - GAGR 36%�Market dynamics driven by prescriptions, medical and health issues Medical cannabis is for health – means monitoring for Heavy Metals in raw Cannabis or Cannabis Products by �“Big four” elements - approach is similar and different to Q3D�USP drugs regulation where ICPMS instrument is used Challenges and SolutionsChallenges and Solutions - ICPMSSample preparationSample preparationHeavy Metals in Cannabis or Cannabis ProductsICP-MS AnalysisICP-MS AnalysisGeneral question: Why ICP-MS ?Slide Number 16VARIAN -> AnalytikJena ICPMS expertise ��30years!Slide Number 18Slide Number 19Economical - ½ Argon Slide Number 21Slide Number 22Absolute robustness �Only ions reflected into the mass-analyserSlide Number 24Slide Number 25Slide Number 26Slide Number 27About the Limits of DetectionSlide Number 29Slide Number 30Sensitivity vs Speed of analysis�50 elements case Slide Number 32Slide Number 33Slide Number 34Slide Number 35Slide Number 36Analytik Jena ADD11 – Australian design/productionSlide Number 38Slide Number 39Slide Number 40Slide Number 41Analytik Jena – product portfolioAnalytik Jena (Germany) is a division of �Endress + Hauser corporation (Switzerland)Slide Number 44Thanks for attention. Questions please.�Dr. Iouri Kalinitchenko, Head of ICPMS R&D, Analytik Jena, Germany/Australia�Iouri.Kalinitchenko@analytik-jena.com