Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI...

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www.harriswilliams.com Member FINRA/SIPC Healthcare & Life Sciences Industry Update September 2012

Transcript of Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI...

Page 1: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

www.harriswilliams.com

Member FINRA/SIPC

Healthcare & Life Sciences Industry Update

September 2012

Page 2: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

What We’ve Been

Reading

September 2012

1

• In an article published in The New Yorker titled “Big Med,” Dr. Atul Gawande compares

the need for standardization while reducing costs in medicine to the accomplishments of

casual dining restaurant chains like the Cheesecake Factory. He contrasts the generally

reliable levels of food quality delivered at these restaurants for well-defined prices to the

U.S. hospital system’s tendency to deliver highly variable quality while charging a wide

range of (often high) prices for the same services. The article is tongue-in-cheek, but the

discussion around the need to gain scale, standardize processes, and measure quality are

very real and relevant to the current challenges facing U.S. hospitals.

• In early September, the Institute of Medicine (IOM) released its report, “Best Care at

Lower Cost.” The report suggests that the U.S. healthcare system is performing far short of

its potential and continues unsustainable cost increases. For example, the report estimates

that $750 billion of U.S. healthcare expenditures are wasted and that one-third of the 40

million Americans hospitalized each year are harmed in the process. The solution, as

proposed by the report, is for the healthcare system to adopt practices already in use by

other industries. For example, the non-transferability of medical records between

practitioners can be remedied by mimicking online banking. The report goes on to discuss

practices that can be borrowed from other industries such as manufacturing or airlines.

• The Wall Street Journal published an article highlighting the tendency for physician groups

to raise their rates for the same services following acquisition by a larger hospital system.

As private physician practices are integrated into larger hospitals, they are able to bill their

services based on the reimbursement schedule the hospital has in place with insurers which

tends to be more generous than the arrangements they operated under previously. Insurers

and employers have cited the increased volume of practice acquisitions by hospitals as a

major driver in rising provider healthcare costs.

Page 3: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

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Key Trading

Statistics

(detail begins

on page 6)

Equity Trading

Overview

September 2012

Public Company

Sector

Performance

(12-month %

change in stock

price)

Change in Stock Price

3 mos. 12 mos. Revenue EBITDA Revenue EBITDA

Clinical Laboratories 3 $8,147 6.3% 20.8% 1.7x 8.1x 1.7x 7.8x

Contract Pharma Manufacturing 5 870 53.9% 72.1% 1.5x 16.0x 1.5x 10.6x

Contract Research Organizations 5 1,596 7.6% 7.6% 1.2x 9.6x 1.1x 8.7x

Disease Management 2 3,014 31.1% (20.7%) 1.5x 7.5x 1.4x 8.0x

Emergency Services 1 2,027 27.9% 75.1% 2.6x 8.7x 2.4x 8.3x

Health Care Staffing 4 1,102 12.3% 52.6% 0.9x 11.9x 0.8x 11.2x

HMO - Medical 11 13,072 (2.6%) 14.3% 0.4x 6.1x 0.4x 6.8x

Information Services 12 2,241 5.6% 11.3% 2.6x 11.7x 2.8x 9.8x

Specialty Managed Care 2 1,648 2.1% (1.9%) 0.7x 5.5x 0.7x NA

Specialty Pharmacy Management 4 18,475 22.9% 21.2% 0.6x 8.8x 0.8x 10.0x

Dental Products 4 19,028 8.5% 12.7% 2.6x 11.1x 2.5x 10.4x

Durable Medical Equipment 4 2,265 4.5% (1.0%) 1.2x 6.2x 1.2x 7.3x

Life Sciences Tools 3 13,608 3.9% 0.8% 2.1x 8.4x 2.2x 8.1x

Medical Devices and Products 14 35,653 7.7% 6.7% 2.4x 9.1x 2.4x 8.7x

Medical / Surgical / Dental Supplies 7 8,686 2.2% (2.7%) 0.2x 7.6x 0.2x 7.1x

Acute-Care Hospitals 6 12,762 10.0% 4.2% 0.9x 6.3x 0.9x 6.2x

Assisted Living 7 1,648 31.6% 34.9% 2.0x 13.4x 1.6x 8.9x

Diagnostic Imaging 3 2,454 16.7% (6.7%) 1.4x 5.7x 1.6x 7.5x

Dialysis Services 2 22,426 14.1% 18.8% 2.1x 10.0x 2.0x 9.5x

Home Care / Hospice 6 601 20.5% 4.4% 0.5x 5.2x 0.5x 5.4x

Long-Term Care 4 969 25.4% 28.0% 0.6x 5.7x 0.6x 4.9x

Physician Practice Management 4 1,320 19.9% 8.1% 1.5x 8.4x 1.4x 7.9x

Psychiatric Hospitals / Management 3 2,248 3.1% (0.5%) 0.3x 6.1x 0.3x 6.3x

Surgicenters / Rehabilitation 4 2,149 9.8% 30.4% 1.6x 7.3x 1.5x 7.3x

Payer, Provider, & Pharmacy Support Services 49 $5,219 16.7% 25.2% 1.4x 9.4x 1.4x 9.0x

Products & Devices 32 $15,848 5.4% 3.3% 1.7x 8.5x 1.7x 8.3x

Provider-Based Services 39 $5,175 16.8% 13.5% 1.2x 7.6x 1.2x 7.1x

HW&Co. HCLS Composite Index 120 $7,417 14.4% 16.3% 1.4x 8.5x 1.4x 8.1x

S&P 500 7.3% 15.4%

Payer

, P

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& P

harm

acy

Su

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ort

Ser

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es

Pro

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Pro

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es

Median TEV/

Forward MulitplesSectorNumber of

Companies

Average

Enterprise

Value ($ mm)

Median TEV/

LTM Multiples

Emergency Services

Contract Pharma Manufacturing

Health Care Staffing

Assisted Living

Surgicenters / Rehabilitation

Long-Term Care

Specialty Pharmacy Management

Clinical Laboratories

Dialysis Services

HW&Co. HCLS Composite Index

S&P 500

HMO - Medical

Dental Products

Information Services

Physician Practice Management

Contract Research Organizations

Medical Devices and Products

Home Care / Hospice

Acute-Care Hospitals

Life Sciences Tools

Psychiatric Hospitals / Management

Durable Medical Equipment

Specialty Managed Care

Medical / Surgical / Dental Supplies

Diagnostic Imaging

Disease Management

(40.0%) (30.0%) (20.0%) (10.0%) (0.0%) 10.0% 20.0% 30.0% 40.0% 50.0% 60.0% 70.0% 80.0% 90.0%

Page 4: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

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Healthcare &

Life Sciences

Industry Stock

Performance

Top 25 Equity

Offerings

(by proceeds)

Equity Markets

Overview

September 2012

37.1%

39.4%

30.2%

40

60

80

100

120

140

160

Aug-09 Nov-09 Feb-10 May-10 Aug-10 Nov-10 Feb-11 May-11 Aug-11 Nov-11 Feb-12 May-12 Aug-12

S&P 500 Dow Jones U.S Health Care Index HW&Co. HCLS Index

Closing Date Filing Date Issuer Ticker Transaction Type

Gross Proceeds

($mm)

08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0

08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5

08/07/12 08/07/12 Isis Pharmaceuticals Inc ISIS Convertible 201.3

08/02/12 07/31/12 Idenix Pharmaceuticals Inc IDIX Follow-On 176.0

08/09/12 06/08/12 Exelixis Inc EXEL Follow-On 146.6

08/02/12 03/28/12 Globus Medical Inc GMED IPO 115.0

08/09/12 04/15/11 Infinity Pharmaceuticals Inc INFI Follow-On 88.4

08/14/12 08/14/12 Horizon Pharma Inc HZNP Follow-On 75.0

08/24/12 08/24/12 AP Pharma Inc APPA Follow-On 74.5

08/16/12 04/04/12 Fluidigm Corp FLDM Follow-On 60.0

08/01/12 02/12/10 MAP Pharmaceuticals Inc MAPP Follow-On 59.8

08/28/12 08/28/12 OvaScience Inc NA IPO 42.0

08/30/12 03/03/11 Achillion Pharmaceuticals Inc ACHN Follow-On 41.8

08/13/12 08/13/12 MRI Interventions Inc MRIC Follow-On 30.6

08/31/12 08/31/12 Cerus Corp CERS Follow-On 30.0

08/31/12 08/31/12 Oragenics Inc ORNI Follow-On 21.4

08/09/12 07/17/12 Sunshine Heart Inc SHC Follow-On 20.8

08/31/12 08/31/12 Cytomedix Inc CMXI Follow-On 20.4

08/02/12 05/01/12 Solta Medical Inc SLTM Follow-On 17.4

08/01/12 06/20/12 Zalicus Inc ZLCS Follow-On 14.6

08/24/12 08/24/12 NeoStem Inc NBS Follow-On 13.8

08/24/12 08/24/12 OncoSec Medical Inc ONCSD Follow-On 10.0

08/23/12 06/26/12 Alexza Pharmaceuticals Inc ALXA Follow-On 8.1

08/24/12 08/24/12 NeoStem Inc NBS Follow-On 7.7

08/31/12 08/31/12 AcelRx Pharmaceuticals Inc ACRX Follow-On 7.5

Page 5: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

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Announced

Healthcare &

Life Sciences

M&A

Announced Healthcare & Life Sciences Transactions Median Healthcare & Life Sciences Transaction Multiples

PEG Investments and Exits PEG Investments by Segment (Last 3 Years)

Healthcare &

Life Sciences

M&A Trends

Announced

Private Equity

M&A Activity

Middle Market Healthcare Transaction Highlights Quarterly M&A Activity

LTM Deal Statistics

Note: Transactions based on publicly available information

223

278 279

255

225242

256267

245 236219

229

146

11

17 18

19

17

13

1816

1318

11

20

10

0

50

100

150

200

250

300

350

3Q09 4Q09 1Q10 2Q10 3Q10 4Q10 1Q11 2Q11 3Q11 4Q11 1Q12 2Q12 3Q12

Nu

mb

er o

f T

ra

nsa

cti

on

s__

PEG Acquirer Strategic Acquirer

$389.4

$194.1 $174.6

$110.6

$141.4

$86.1

0

200

400

600

800

1000

1200

1400

$0

$50

$100

$150

$200

$250

$300

$350

$400

$450

$500

2007 2008 2009 2010 2011 2012 YTD

Nu

mb

er o

f Tra

nsa

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ns_

_

Ag

greg

ate

Tra

nsa

cti

on

Va

lue (

$ i

n b

illi

on

s)

Aggregate Deal Value # of deals

15.5x 15.2x

7.7x

12.8x 11.1x

11.1x

0.0x

0.5x

1.0x

1.5x

2.0x

2.5x

3.0x

3.5x

4.0x

0x

3x

6x

9x

12x

15x

18x

21x

2007 2008 2009 2010 2011 2012 YTD

EV

/ LT

M R

ev

en

ue M

ultip

le_

_EV

/ L

TM

EB

ITD

A M

ult

iple

__

TEV / LTM EBITDA TEV / LTM Sales

31

40

58

69

94

113

79

42

71

65

41

2327

40

60 62

95

49 50

80

120

87

0

20

40

60

80

100

120

140

2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 YTD

Tra

nsa

cti

on

Vo

lum

e'

Number of Investments Number of Exits

HC&LS Industry Number of

Segment Companies

Biotechnology 3

Healthcare Technology 20

Healthcare Distributors 9

Healthcare Equipment 21

Healthcare Facilities 37

Healthcare Services 60

Healthcare Supplies 9

Life Sciences Tools & Services 12

Managed Healthcare 6

Pharmaceuticals 21

Aggregate Number Median Transaction Multiples

Value ($bn) of Deals TEV/Rev TEV/EBITDA

$124.2 963 2.09x 11.0x

Announced Target Buyer

8/31/2012 ConnectYourCare, LLC ABS Capital Partners

8/31/2012 180 Medical, Inc. ConvaTec Inc.

8/29/2012 Accugenix, Inc. Charles River Laboratories International

8/21/2012 Sunrise Senior Living Inc. Health Care REIT, Inc.

8/20/2012 IntegraCare Holdings, Inc. Kindred Healthcare Inc.

8/19/2012 Coventry Health Care Inc. Aetna Inc.

8/17/2012 Avid Health, Inc. Church & Dwight Co. Inc.

8/7/2012 InterDent, Inc. H.I.G. Capital, LLC

8/5/2012 Brighton Bay The Carlyle Group LP

8/2/2012 Octagon Research Solutions, Inc. Accenture plc

M&A Overview

September 2012

Page 6: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

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Key Credit

Statistics

Top Recent

Healthcare &

Life Sciences

Debt Offerings

(by deal amount)

Average Secondary Spread

Average Spread on Healthcare Loans

Credit Statistics

Quarterly Healthcare Loan Volume

Debt Markets

Overview

September 2012

L + 0

L + 200

L + 400

L + 600

L + 800

L + 1000

Av

era

ge

Sp

rea

d O

ver

LIB

OR

__

0.0x

2.0x

4.0x

6.0x

Debt/EBITDA Senior Debt/EBITDA EBITDA/Cash Interest EBITDA - Capex/Cash Interest

EB

ITD

A M

ult

iple

__

2006 2007 2008 2009 2010 2011 2012 YTD

L + 0

L + 100

L + 200

L + 300

L + 400

L + 500

2006 2007 2008 2009 2010 2011 2012 YTD

Aver

age

Sp

read

Over

LIB

OR

__

Revolving Credit / Term Loan A Weighted-Average Institutional

$0

$3

$6

$9

$12

$15

$18

$21

$24

2Q06 4Q06 2Q07 4Q07 2Q08 4Q08 2Q09 4Q09 2Q10 4Q10 2Q11 4Q11 2Q12

Lo

an

Vo

lum

e b

y Q

ua

rte

r (

$ i

n b

illi

on

s)_

__

Pro Rata Institutional

Date Effective Borrower Name Description Tranche Amount ($mn) Type Rating Spread

08/21/12 DaVita Inc Kidney dialysis centers $1,350 Term Loan A B / B2 L+ 250

08/21/12 DaVita Inc Kidney dialysis centers 1,650 Term Loan B B / B2 L+ 300

08/22/12 Stryker Corp Surgical appliances and supplies 1,000 Revolver/Line >= 1 Yr. A+ / A3 L+ 88

08/13/12 Capsugel, Capsugel Financeco SCA Pharmaceutical preparations 875 Term Loan B BB- / B1 N/A

08/20/12 Immucor Inc Diagnostic substances 615 Term Loan B B- / Caa1 L+ 450

08/10/12 HealthSouth Corp Offices & clinics of medical doctors 600 Revolver/Line >= 1 Yr. BB- / B1 L+ 175

08/17/12 Warner Chilcott Corp Pharmaceutical preparations 300 Term Loan B NR / WR L+ 325

08/17/12 Warner Chilcott Corp Pharmaceutical preparations 300 Term Loan B NR / WR L+ 300

08/01/12 Haemonetics Corp Surgical and medical instruments 50 Revolver/Line >= 1 Yr. NR / NR L+ 138

08/01/12 Haemonetics Corp Surgical and medical instruments 475 Term Loan A NR / NR L+ 138

08/17/12 One Call Medical Offices & clinics of medical doctors 35 Revolver/Line >= 1 Yr. B+ / Ba3 L+ 575

08/17/12 One Call Medical Offices & clinics of medical doctors 415 Term Loan B B+ / Ba3 L+ 575

08/23/12 Trinity Health Corp Offices & clinics of medical doctors 200 Revolver/Line >= 1 Yr. NR / Aa2 L+ 56

08/29/12 Correct Care Solutions LLC Offices & clinics of medical doctors 25 Revolver/Line >= 1 Yr. NR / NR L+ 450

08/29/12 Correct Care Solutions LLC Offices & clinics of medical doctors 145 Term Loan A NR / NR L+ 650

08/10/12 Quidel Corp Surgical and medical instruments 140 Revolver/Line >= 1 Yr. NR / NR L+ 150

08/10/12 Fayette Regional Health System General medical & surgical hospitals 46 Standby Letter of Credit NR / NR N/A

Page 7: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

Healthcare & Life Sciences Trading Statistics

September 2012

As of August 31, 2012 6

Payer, Provider, & Pharmacy Support Services Stock Price

% Change 52 Week8/31/2012 3 mos. 12 mos. High Low Revenue EBITDA EBIT Revenue EBITDA EBIT Revenue EBITDA Revenue EBITDA

Clinical LaboratoriesBio-Reference Laboratories Inc. $26.12 35.8% 29.1% $30.15 $11.41 $723 $24 $20 $727 $637 $88 $72 Jul-12 Oct-11 $662 $93 $76 1.1x 8.2x 1.1x 7.8xLaboratory Corp. of America Holdings 87.95 5.6% 5.3% 95.30 74.57 8,434 2,110 124 10,440 5,617 1,279 1,085 Jun-12 Dec-11 5,687 1,330 1,100 1.9x 8.1x 1.8x 7.8xQuest Diagnostics Inc. 60.47 6.3% 20.8% 63.98 45.13 9,600 3,823 174 13,275 7,629 1,647 1,358 Jun-12 Dec-11 7,636 1,640 1,350 1.7x 7.9x 1.7x 8.1xNumber of Companies 3 Median: 6.3% 20.8% Total $18,757 $8,147 $13,883 $13,985 1.7x 8.1x 1.7x 7.8x

Mean: 15.9% 18.4% $8,147 1.6x 8.1x 1.6x 7.9x

Contract Pharma ManufacturingAkorn, Inc. $13.84 1.4% 72.1% $16.87 $7.10 $1,316 $103 $24 $1,394 $194 $64 $56 Jun-12 Dec-11 $261 $95 $84 7.2x 21.8x 5.3x 14.6xCambrex Corporation. 12.18 69.4% 145.1% 12.96 4.40 361 81 22 420 274 57 35 Jun-12 Dec-11 275 59 37 1.5x 7.5x 1.5x 7.1xIntegrated Biopharma Inc. 0.20 248.2% 143.8% 0.33 0.02 4 13 1 16 23 1 1 Mar-12 Jun-11 NA NA NA 0.7x 16.0x NA NA Patheon Inc. 2.78 53.9% 69.8% 3.02 1.10 359 317 35 655 721 52 9 Jul-12 Oct-11 727 53 20 0.9x 27.8x 0.9x 12.4xWest Pharmaceutical Services, Inc. 47.35 (0.9%) 18.0% 51.82 35.50 1,612 386 107 1,865 1,230 214 139 Jun-12 Dec-11 1,243 212 132 1.5x 8.5x 1.5x 8.8xNumber of Companies 5 Median: 53.9% 72.1% Total $3,652 $870 $2,442 $2,506 1.5x 16.0x 1.5x 10.6x

Mean: 74.4% 89.8% $870 2.4x 16.3x 2.3x 10.7x

Contract Research OrganizationsAlbany Molecular Research Inc. $3.33 28.6% (4.6%) $3.65 $2.08 $103 $8 $13 $97 $201 $10 ($8) Jun-12 Dec-11 $209 $26 $8 0.5x 9.6x 0.5x 3.8xCharles River Laboratories International, Inc. 36.32 8.8% 9.7% 37.56 25.52 1,770 686 76 2,375 1,139 265 183 Jun-12 Dec-11 1,142 267 197 2.1x 8.9x 2.1x 8.9xCovance Inc. 47.79 3.0% (3.6%) 53.02 42.02 2,633 330 398 2,565 2,149 303 195 Jun-12 Dec-11 2,168 303 189 1.2x 8.4x 1.2x 8.5xICON Public Limited Company 22.92 6.8% 7.6% 25.03 15.03 1,370 0 95 1,202 1,013 78 36 Jun-12 Dec-11 1,094 115 72 1.2x 15.3x 1.1x 10.5xPAREXEL International Corporation 28.79 7.6% 41.3% 29.42 17.56 1,733 220 214 1,740 1,397 161 95 Jun-12 Jun-12 1,647 200 134 1.2x 10.8x 1.1x 8.7xNumber of Companies 5 Median: 7.6% 7.6% Total $7,608 $1,596 $5,898 $6,260 1.2x 9.6x 1.1x 8.7x

Mean: 10.9% 10.1% $1,596 1.2x 10.6x 1.2x 8.1x

Disease ManagementAlere Inc. $18.78 2.2% (24.8%) $27.22 $17.13 $1,516 $3,559 $304 $5,380 $2,609 $607 $187 Jun-12 Dec-11 $2,774 $596 $488 2.1x 8.6x 1.9x 9.0xHealthways Inc. 10.48 60.0% (16.6%) 12.31 5.59 351 299 1 649 692 101 51 Jun-12 Dec-11 687 93 41 0.9x 6.4x 0.9x 7.0xNumber of Companies 2 Median: 31.1% (20.7%) Total $1,867 $3,014 $3,300 $3,461 1.5x 7.5x 1.4x 8.0x

Mean: 31.1% (20.7%) $3,014 1.5x 7.5x 1.4x 8.0x

Emergency ServicesAir Methods Corp. $116.54 27.9% 75.1% $119.33 $56.17 $1,502 $553 $28 $2,027 $792 $232 $151 Jun-12 Dec-11 $839 $245 $160 2.6x 8.7x 2.4x 8.3xNumber of Companies 1 Median: 27.9% 75.1% Total $1,502 $2,027 $792 $839 2.6x 8.7x 2.4x 8.3x

Mean: 27.9% 75.1% $2,027 2.6x 8.7x 2.4x 8.3x

Health Care StaffingAMN Healthcare Services Inc. $8.40 40.0% 52.5% $8.41 $3.60 $343 $194 $15 $546 $913 $61 $46 Jun-12 Dec-11 $935 $65 $51 0.6x 9.0x 0.6x 8.4xCross Country Healthcare, Inc. 4.05 (10.8%) (17.8%) 6.73 3.76 125 36 6 154 509 15 5 Jun-12 Dec-11 511 14 3 0.3x 10.3x 0.3x 11.3xOn Assignment Inc. 16.51 (0.9%) 117.2% 19.37 6.27 858 467 18 1,307 774 76 66 Jun-12 Dec-11 1,217 118 102 1.7x 17.1x 1.1x 11.0xTeam Health Holdings, Inc. 28.55 25.5% 52.8% 28.85 15.08 1,899 518 14 2,404 1,891 178 142 Jun-12 Dec-11 2,035 206 148 1.3x 13.5x 1.2x 11.7xNumber of Companies 4 Median: 12.3% 52.6% Total $3,225 $1,102 $4,087 $4,698 0.9x 11.9x 0.8x 11.2x

Mean: 13.5% 51.1% $1,102 1.0x 12.5x 0.8x 10.6x

TEV/ LTM MultiplesEquity Mkt. Value

Total Debt Cash and Equiv.

Total Ent.

Value (TEV)

Lastest Twelve Months (LTM)

TEV/ Fwd MultiplesForward EstimateCompany Name LTM

PeriodLastest

FYE Date

Page 8: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

Healthcare & Life Sciences Trading Statistics

September 2012

As of August 31, 2012 7

Payer, Provider, & Pharmacy Support Services Stock Price

% Change 52 Week8/31/2012 3 mos. 12 mos. High Low Revenue EBITDA EBIT Revenue EBITDA EBIT Revenue EBITDA Revenue EBITDA

HMO - Medical

Commercial:Aetna Inc. $38.41 (6.1%) (4.0%) $51.14 $33.43 $12,839 $4,706 $922 $16,624 $34,799 $3,677 $3,218 Jun-12 Dec-11 $35,571 $3,297 $2,782 0.5x 4.5x 0.5x 5.0xCigna Corp. 45.77 4.2% (2.1%) 49.89 38.79 13,198 5,222 3,045 15,375 25,325 2,483 2,221 Jun-12 Dec-11 28,835 2,946 2,457 0.6x 6.2x 0.5x 5.2xCoventry Health Care Inc. 41.63 36.9% 26.6% 42.29 25.78 5,572 1,585 1,516 5,641 13,341 923 797 Jun-12 Dec-11 14,174 811 677 0.4x 6.1x 0.4x 7.0xHealth Net, Inc. 23.25 (9.3%) (5.8%) 41.22 16.65 1,895 489 633 1,750 11,557 235 205 Jun-12 Dec-11 11,256 152 155 0.2x 7.4x 0.2x 11.5xHumana Inc. 70.08 (8.3%) (9.7%) 96.46 59.92 11,333 1,878 3,869 9,342 38,275 2,384 2,072 Jun-12 Dec-11 39,583 2,238 1,991 0.2x 3.9x 0.2x 4.2xUnitedhealth Group, Inc. 54.30 (2.6%) 14.3% 60.75 41.32 56,076 12,617 11,578 57,115 105,743 9,516 8,687 Jun-12 Dec-11 109,904 9,779 8,715 0.5x 6.0x 0.5x 5.8xWellPoint Inc. 59.87 (11.2%) (5.4%) 74.73 52.52 19,469 11,916 1,953 29,432 61,538 5,072 4,380 Jun-12 Dec-11 61,066 4,327 3,906 0.5x 5.8x 0.5x 6.8xNumber of Companies 7 Median: (6.1%) (4.0%) Total $120,382 $19,326 $290,578 $300,389 0.5x 6.0x 0.5x 5.8x

Mean: 0.5% 2.0% $19,326 0.4x 5.7x 0.4x 6.5x

Government:AMERIGROUP Corporation $90.92 45.7% 83.8% $91.15 $37.57 $4,475 $478 $624 $4,328 $7,246 $286 $267 Jun-12 Dec-11 $8,806 $390 $334 0.6x 15.1x 0.5x 11.1xCentene Corp. 40.61 12.4% 27.3% 50.98 24.26 2,094 409 422 2,077 6,648 180 127 Jun-12 Dec-11 8,314 195 121 0.3x 11.5x 0.2x 10.6xMolina Healthcare, Inc. 24.24 (5.0%) 26.1% 36.83 13.93 1,128 270 727 672 5,393 104 57 Jun-12 Dec-11 5,983 51 (16) 0.1x 6.5x 0.1x 13.2xWellCare Health Plans, Inc. 56.69 0.4% 23.7% 74.41 33.29 2,443 143 1,150 1,435 6,747 440 424 Jun-12 Dec-11 7,241 407 382 0.2x 3.3x 0.2x 3.5xNumber of Companies 4 Median: 6.4% 26.7% Total $10,140 $2,128 $26,035 $30,344 0.3x 9.0x 0.2x 10.9x

Mean: 13.4% 40.2% $2,128 0.3x 9.1x 0.3x 9.6x

Information Services

Data/Analytics:Accelrys Inc. $7.69 (1.4%) 18.3% $8.48 $5.68 $427 $0 $81 $283 $154 $15 ($8) Jun-12 Dec-11 $164 $33 $23 1.8x 18.5x 1.7x 8.5xNational Research Corp. 49.76 15.8% 47.3% 53.00 28.00 339 14 11 341 81 26 21 Jun-12 Dec-11 87 28 23 4.2x 13.2x 3.9x 12.4xNumber of Companies 2 Median: 7.2% 32.8% Total $766 $312 $235 $251 3.0x 15.9x 2.8x 10.4x

Mean: 7.2% 32.8% $312 3.0x 15.9x 2.8x 10.4x

eHealth:WebMD Health Corp. 14.94 (35.1%) (57.7%) 40.24 13.52 733 800 964 569 505 65 49 Jun-12 Dec-11 $462 $65 ($11) 1.1x 8.7x NA NA Number of Companies 1 Median: (35.1%) (57.7%) Total $733 $569 $505 $462 1.1x 8.7x NA NA

Mean: (35.1%) (57.7%) $569 1.1x 8.7x NA NA

Hospital/Physician:Allscripts Healthcare Solutions, Inc. $10.50 (3.0%) (41.5%) $21.66 $8.84 $1,799 $491 $120 $2,169 $1,487 $237 $147 Jun-12 Dec-11 $1,499 $343 $236 1.5x 9.1x 1.4x 6.3xathenahealth, Inc. 88.37 21.6% 52.4% 97.37 40.79 3,181 0 92 3,026 376 49 30 Jun-12 Dec-11 430 87 64 8.0x 61.4x 7.0x 34.9xCerner Corporation 73.14 (6.2%) 10.9% 88.32 55.69 12,520 176 303 11,716 2,416 658 522 Jun-12 Dec-11 2,614 822 584 4.9x 17.8x 4.5x 14.3xComputer Programs & Systems Inc. 50.55 (7.1%) (28.6%) 74.62 41.80 559 0 5 537 174 42 39 Jun-12 Dec-11 191 50 46 3.1x 12.8x 2.8x 10.8xHMS Holdings Corp. 34.46 28.6% 31.4% 37.19 22.45 2,975 341 105 3,211 419 131 91 Jun-12 Dec-11 506 174 108 7.7x 24.5x 6.3x 18.5xMedAssets, Inc. 17.07 50.8% 49.3% 17.38 8.52 998 948 5 1,941 613 182 79 Jun-12 Dec-11 628 198 82 3.2x 10.7x 3.1x 9.8xMerge Healthcare Incorporated 3.16 34.5% (46.6%) 7.23 2.20 291 250 33 506 248 49 30 Jun-12 Dec-11 253 53 25 2.0x 10.4x 2.0x 9.6xQuality Systems Inc. 17.67 (38.2%) (61.6%) 50.70 15.04 1,049 0 130 914 448 122 111 Jun-12 Mar-12 492 131 113 2.0x 7.5x 1.9x 7.0xSunCoke Energy Inc. 15.82 12.7% 11.7% 17.53 9.20 1,109 725 190 1,679 1,758 184 115 Jun-12 Dec-11 1,927 263 179 1.0x 9.1x 0.9x 6.4xNumber of Companies 9 Median: 12.7% 10.9% Total $24,481 $2,855 $7,940 $8,538 3.1x 10.7x 2.8x 9.8x

Mean: 10.4% (2.5%) $2,855 3.7x 18.2x 3.3x 13.1x

Company Name Equity Mkt. Value

Total Debt Cash and Equiv.

Total Ent.

Value (TEV)

Lastest Twelve Months (LTM) LTM

PeriodLastest

FYE DateForward Estimate TEV/ LTM Multiples TEV/ Fwd Multiples

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Healthcare & Life Sciences Trading Statistics

September 2012

As of August 31, 2012 8

Payer, Provider, & Pharmacy Support Services Stock Price

% Change 52 Week8/31/2012 3 mos. 12 mos. High Low Revenue EBITDA EBIT Revenue EBITDA EBIT Revenue EBITDA Revenue EBITDA

Specialty Managed CareAssurant Inc. 35.25 5.6% 0.2% 44.54 32.31 2,858 1,067 1,107 2,818 8,375 1,075 945 Jun-12 Dec-11 8,419 NA 947 0.3x 2.6x 0.3x NA CorVel Corporation 43.80 (1.4%) (4.0%) 54.64 39.46 493 0 15 478 415 57 41 Jun-12 Mar-12 430 NA NA 1.2x 8.4x 1.1x NA Number of Companies 2 Median: 2.1% (1.9%) Total $3,351 $1,648 $8,790 $8,849 0.7x 5.5x 0.7x NA

Mean: 2.1% (1.9%) $1,648 0.7x 5.5x 0.7x NA

Specialty Pharmacy ManagementBioScrip Inc. $8.50 25.7% 34.3% $8.53 $5.05 $481 $257 $138 $600 $1,867 $59 $45 Jun-12 Dec-11 $636 $42 $23 0.3x 10.1x 0.9x 14.3xExpress Scripts Holding Company 62.62 20.0% 33.4% 62.80 34.47 50,769 18,242 1,420 67,591 63,498 3,493 2,722 Jun-12 Dec-11 94,915 5,391 5,040 1.1x 19.3x 0.7x 12.5xOmnicare Inc. 32.38 2.7% 9.0% 36.48 20.36 3,612 2,051 564 5,099 6,231 686 550 Jun-12 Dec-11 6,209 678 560 0.8x 7.4x 0.8x 7.5xPharMerica Corporation 12.60 26.9% (14.5%) 16.45 9.03 372 250 12 610 1,972 104 73 Jun-12 Dec-11 1,838 100 70 0.3x 5.9x 0.3x 6.1xNumber of Companies 4 Median: 22.9% 21.2% Total $55,234 $18,475 $73,567 $103,598 0.6x 8.8x 0.8x 10.0x

Mean: 18.8% 15.6% $18,475 0.6x 10.7x 0.7x 10.1x

TEV/ LTM Multiples TEV/ Fwd MultiplesTotal Ent.

Value ( )

Lastest Twelve Months (LTM) LTM

PeriodLastest

FYE DateForward Estimate

Company Name Equity Mkt. Value

Total Debt Cash and Equiv.

Page 10: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

Healthcare & Life Sciences Trading Statistics

September 2012

As of August 31, 2012 9

Products & Devices Stock Price

% Change 52 Week8/31/2012 3 mos. 12 mos. High Low Revenue EBITDA EBIT Revenue EBITDA EBIT Revenue EBITDA Revenue EBITDA

Dental Products3M Co. $92.60 9.7% 11.6% $94.30 $68.63 $64,016 $6,307 $3,308 $65,887 $29,640 $7,569 $6,307 Jun-12 Dec-11 $30,151 $7,877 $6,596 2.2x 8.7x 2.2x 8.4xDENTSPLY International Inc. 36.27 (2.0%) 3.0% 41.38 28.35 5,143 1,913 53 7,037 2,837 467 351 Jun-12 Dec-11 2,931 595 470 2.5x 15.1x 2.4x 11.8xSirona Dental Systems Inc. 53.14 24.2% 13.9% 55.42 39.15 2,927 79 105 2,905 951 236 162 Jun-12 Sep-11 956 259 230 3.1x 12.3x 3.0x 11.2xYoung Innovations Inc. 37.27 7.4% 36.0% 38.25 25.06 294 0 9 285 108 29 25 Jun-12 Dec-11 109 30 26 2.6x 9.8x 2.6x 9.5xNumber of Companies 4 Median: 8.5% 12.7% Total $72,380 $19,028 $33,536 $34,147 2.6x 11.1x 2.5x 10.4x

Mean: 9.8% 16.1% $19,028 2.6x 11.5x 2.6x 10.2x

Durable Medical EquipmentHill-Rom Holdings, Inc. $27.73 (5.7%) (8.5%) $36.13 $24.69 $1,724 $95 $220 $1,599 $1,633 $300 $213 Jun-12 Sep-11 $1,620 $317 $203 1.0x 5.3x 1.0x 5.0xInvacare Corporation 13.74 (7.7%) (45.3%) 25.63 13.21 437 260 25 671 1,795 123 83 Jun-12 Dec-11 1,703 NA 48 0.4x 5.4x 0.4x NA ResMed Inc. 37.57 21.3% 21.3% 37.85 23.37 5,336 251 810 4,778 1,369 381 295 Jun-12 Jun-12 1,499 425 338 3.5x 12.5x 3.2x 11.2xSteris Corp. 34.24 14.7% 6.4% 34.61 27.08 1,989 210 187 2,014 1,425 287 224 Jun-12 Mar-12 1,433 277 210 1.4x 7.0x 1.4x 7.3xNumber of Companies 4 Median: 4.5% (1.0%) Total $9,487 $2,265 $6,222 $6,255 1.2x 6.2x 1.2x 7.3x

Mean: 5.6% (6.5%) $2,265 1.6x 7.6x 1.5x 7.8x

Life Sciences ToolsAgilent Technologies Inc. $37.16 (8.6%) 0.8% $46.28 $28.67 $12,913 $2,214 $1,923 $13,207 $6,819 $1,439 $1,169 Jul-12 Oct-11 $6,857 $1,569 $1,362 1.9x 9.3x 1.9x 8.4xBecton, Dickinson and Company 75.98 3.9% (6.6%) 80.56 69.59 15,162 4,171 1,659 17,142 7,974 2,211 1,688 Jun-12 Sep-11 7,700 2,126 1,574 2.1x 7.7x 2.2x 8.1xLife Technologies Corporation 47.71 16.6% 13.6% 50.84 36.07 8,363 2,400 260 10,476 3,827 1,251 842 Jun-12 Dec-11 3,786 1,348 1,107 2.7x 8.4x 2.8x 7.8xNumber of Companies 3 Median: 3.9% 0.8% Total $36,439 $13,608 $18,620 $18,342 2.1x 8.4x 2.2x 8.1x

Mean: 4.0% 2.6% $13,608 2.3x 8.5x 2.3x 8.1x

Medical Devices and Products

Abbott Laboratories $65.54 6.1% 24.8% $67.45 $48.96 $102,854 $18,087 $7,053 $110,025 $39,458 $11,578 $8,595 Jun-12 Dec-11 $39,702 $12,512 $9,759 2.8x 9.5x 2.8x 8.8xArthroCare Corporation 29.58 13.0% (8.6%) 32.63 23.54 820 0 181 718 360 20 (3) Jun-12 Dec-11 363 93 68 2.0x 35.5x 2.0x 7.7xBaxter International Inc. 58.68 15.9% 4.8% 60.54 47.55 32,112 5,334 2,353 35,154 14,033 3,809 3,111 Jun-12 Dec-11 14,181 3,961 3,258 2.5x 9.2x 2.5x 8.9xBoston Scientific Corporation 5.40 (5.9%) (20.4%) 6.67 4.79 7,663 4,257 371 11,549 7,416 1,626 947 Jun-12 Dec-11 7,292 1,642 986 1.6x 7.1x 1.6x 7.0xCR Bard Inc. 98.11 0.9% 3.0% 108.31 80.80 8,224 1,214 714 8,724 2,944 945 828 Jun-12 Dec-11 2,989 950 820 3.0x 9.2x 2.9x 9.2xDanaher Corp. 53.57 3.1% 16.9% 56.45 39.34 37,250 4,903 1,118 41,101 18,032 4,016 3,195 Jun-12 Dec-11 18,281 3,947 3,163 2.3x 10.1x 2.2x 10.4xHanger, Inc. 28.61 32.6% 52.3% 29.01 14.57 972 504 42 1,435 953 168 135 Jun-12 Dec-11 984 166 130 1.5x 8.6x 1.5x 8.6xHologic Inc. 19.63 17.1% 18.0% 22.16 13.90 5,196 1,542 905 5,833 1,881 647 338 Jun-12 Sep-11 1,946 674 604 3.1x 9.0x 3.0x 8.7xHospira Inc. 33.58 7.4% (27.3%) 46.29 26.92 5,544 1,790 720 6,614 3,990 468 226 Jun-12 Dec-11 4,041 636 454 1.7x 13.1x 1.6x 10.4xJohnson & Johnson 67.43 8.0% 2.5% 69.75 60.83 185,907 17,565 14,042 171,509 64,874 19,627 16,376 Jul-12 Jan-12 67,292 20,736 17,504 2.6x 8.7x 2.5x 8.3xMedtronic, Inc. 40.66 10.4% 15.9% 41.79 31.06 41,678 10,871 861 49,964 16,246 5,446 4,627 Jul-12 Apr-12 16,435 6,055 5,285 3.1x 9.0x 3.0x 8.3xStryker Corporation 53.26 3.5% 9.0% 57.15 44.55 20,262 1,766 1,393 18,568 8,513 2,501 2,011 Jun-12 Dec-11 8,626 2,558 2,108 2.2x 7.4x 2.2x 7.3xThermo Fisher Scientific, Inc. 57.35 13.6% 4.4% 58.37 43.06 20,964 6,532 732 26,760 12,354 2,541 1,579 Jun-12 Dec-11 12,234 2,680 2,337 2.2x 10.5x 2.2x 10.0xZimmer Holdings, Inc. 61.78 1.9% 8.6% 66.41 47.00 10,793 1,730 651 11,193 4,465 1,497 1,121 Jun-12 Dec-11 4,480 1,683 1,322 2.5x 7.5x 2.5x 6.7xNumber of Companies 14 Median: 7.7% 6.7% Total $480,241 $35,653 $195,519 $198,844 2.4x 9.1x 2.4x 8.7x

Mean: 9.1% 7.4% $35,653 2.4x 11.0x 2.3x 8.6x

Medical / Surgical / Dental SuppliesAmerisourceBergen Corporation $38.52 4.1% (2.7%) $42.32 $34.74 $9,693 $1,876 $1,656 $9,913 $80,609 $1,401 $1,256 Jun-12 Sep-11 $80,341 $1,423 $1,282 0.1x 7.1x 0.1x 7.0xCardinal Health, Inc. 39.55 (4.4%) (6.9%) 46.23 38.56 13,490 2,894 2,274 13,989 107,552 2,191 1,866 Jun-12 Jun-12 100,091 2,288 1,984 0.1x 6.4x 0.1x 6.1xHenry Schein, Inc. 76.81 3.4% 16.5% 80.38 58.56 6,800 535 88 7,608 8,752 730 610 Jun-12 Dec-11 8,958 743 624 0.9x 10.2x 0.8x 10.2xMcKesson Corporation 87.11 (0.2%) 9.0% 97.23 66.61 20,559 3,580 2,013 22,126 123,552 2,919 2,363 Jun-12 Mar-12 124,933 3,117 2,618 0.2x 7.6x 0.2x 7.1xOwens & Minor Inc. 27.99 (1.7%) (4.9%) 32.00 25.87 1,777 212 225 1,766 8,776 251 217 Jun-12 Dec-11 8,897 253 219 0.2x 7.0x 0.2x 7.0xPatterson Companies, Inc. 33.97 2.2% 16.3% 36.42 26.68 3,696 850 581 3,965 3,577 403 359 Jul-12 Apr-12 3,689 421 377 1.1x 9.8x 1.1x 9.4xPSS World Medical Inc. 21.59 6.7% (8.4%) 25.99 18.51 1,086 457 107 1,439 2,131 171 135 Jun-12 Mar-12 1,717 147 116 0.7x 8.4x 0.8x 9.8xNumber of Companies 7 Median: 2.2% (2.7%) Total $57,100 $8,686 $334,950 $328,626 0.2x 7.6x 0.2x 7.1x

Mean: 1.4% 2.7% $8,686 0.5x 8.1x 0.5x 8.1x

Forward EstimateCompany Name

Equity Mkt. Value Total Debt

TEV/ LTM Multiples TEV/ Fwd MultiplesCash and Equiv.

Total Ent.

Value

Lastest Twelve Months (LTM) LTM

PeriodLastest

FYE Date

Page 11: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

Healthcare & Life Sciences Trading Statistics

September 2012

As of August 31, 2012 10

Provider-Based Services Stock Price

% Change 52 Week8/31/2012 3 mos. 12 mos. High Low Revenue EBITDA EBIT Revenue EBITDA EBIT Revenue EBITDA Revenue EBITDA

Acute-Care HospitalsCommunity Health Systems, Inc. $27.04 22.9% 32.8% $28.79 $14.61 $2,411 $9,547 $115 $12,276 $14,368 $1,880 $1,204 Jun-12 Dec-11 $12,962 $1,937 $1,207 0.9x 6.4x 0.9x 6.3xHealth Management Associates Inc. 7.66 19.5% (6.8%) 9.26 4.81 1,964 3,708 36 5,547 6,355 896 584 Jun-12 Dec-11 6,705 972 638 0.9x 6.2x 0.8x 5.7xHCA Holdings, Inc. 28.55 9.8% 42.5% 31.39 17.20 12,581 27,481 518 40,718 34,779 6,378 4,792 Jun-12 Dec-11 36,099 6,460 4,753 1.2x 6.3x 1.1x 6.3xLifepoint Hospitals Inc. 40.42 9.8% 10.1% 42.19 32.61 1,976 1,612 172 3,464 3,761 556 358 Jun-12 Dec-11 3,911 564 377 0.9x 6.2x 0.9x 6.1xTenet Healthcare Corp. 5.19 10.2% (1.7%) 6.05 3.46 2,163 4,748 82 6,943 9,801 1,100 681 Jun-12 Dec-11 9,846 1,236 811 0.7x 6.3x 0.7x 5.6xUniversal Health Services Inc. 39.95 3.1% (4.0%) 45.31 31.35 3,871 3,506 33 7,623 7,616 1,203 904 Jun-12 Dec-11 7,654 1,210 923 1.0x 6.3x 1.0x 6.3xNumber of Companies 6 Median: 10.0% 4.2% Total $24,965 $12,762 $76,680 $77,177 0.9x 6.3x 0.9x 6.2x

Mean: 12.5% 12.2% $12,762 0.9x 6.3x 0.9x 6.1x

Assisted LivingAssisted Living Concepts Inc. $7.79 (43.7%) (42.0%) $20.33 $6.93 $181 $183 $3 $358 $233 $64 $42 Jun-12 Dec-11 $230 $50 ($22) 1.5x 5.6x 1.6x 7.1xBrookdale Senior Living Inc. 21.73 31.8% 34.9% 22.45 10.98 2,661 2,587 39 5,209 2,385 368 115 Jun-12 Dec-11 2,761 454 131 2.2x 14.1x 1.9x 11.5xCapital Senior Living Corp. 12.03 21.8% 67.5% 12.50 5.44 329 336 37 628 284 44 17 Jun-12 Dec-11 306 51 15 2.2x 14.6x 2.1x 12.4xEmeritus Corp. 20.02 31.6% 14.5% 21.00 13.36 902 2,228 75 3,055 1,294 216 79 Jun-12 Dec-11 1,316 227 94 2.4x 14.3x 2.3x 13.5xFive Star Quality Care Inc. 4.73 52.6% 45.5% 5.02 2.15 227 102 24 296 1,288 41 16 Jun-12 Dec-11 1,392 49 21 0.2x 7.1x 0.2x 6.0xSkilled Healthcare Group, Inc. 5.72 3.8% 5.3% 8.41 3.30 220 463 6 678 869 113 87 Jun-12 Dec-11 879 110 82 0.8x 5.9x 0.8x 6.2xSunrise Senior Living Inc. 14.38 138.9% 93.8% 14.44 3.68 819 541 55 1,311 651 70 26 Jun-12 Dec-11 1,289 147 NA 2.0x 13.4x 1.0x 8.9xNumber of Companies 7 Median: 31.6% 34.9% Total $5,340 $1,648 $7,004 $8,173 2.0x 13.4x 1.6x 8.9x

Mean: 33.8% 31.4% $1,648 1.6x 10.7x 1.4x 9.4x

Diagnostic ImagingAlliance Healthcare Services, Inc. $1.36 30.8% (14.5%) $2.19 $0.72 $70 $637 $62 $696 $489 $148 $41 Jun-12 Dec-11 NA NA NA 1.4x 4.6x NA NA RadNet, Inc. 2.80 16.7% (6.7%) 3.64 1.87 107 556 0 664 663 111 52 Jun-12 Dec-11 664 119 56 1.0x 5.7x 1.0x 5.6xVarian Medical Systems Inc. 58.79 0.2% 3.2% 71.95 48.72 6,509 175 633 6,003 2,770 645 589 Jun-12 Sep-11 2,806 645 588 2.2x 9.3x 2.1x 9.3xNumber of Companies 3 Median: 16.7% (6.7%) Total $6,686 $2,454 $3,921 $3,470 1.4x 5.7x 1.6x 7.5x

Mean: 15.9% (6.0%) $2,454 1.5x 6.5x 1.6x 7.5x

Dialysis ServicesDaVita Inc. $97.27 19.7% 32.2% $100.52 $59.14 $9,202 $4,521 $273 $14,093 $7,574 $1,602 $1,307 Jun-12 Dec-11 $7,876 $1,643 $1,338 1.9x 8.7x 1.8x 8.6xFresenius Medical Care AG & Co. KGAA 71.86 8.5% 5.4% 75.86 58.16 21,925 8,784 677 30,759 13,379 2,734 2,154 Jun-12 Dec-11 13,976 2,974 2,368 2.3x 11.2x 2.2x 10.3xNumber of Companies 2 Median: 14.1% 18.8% Total $31,126 $22,426 $20,952 $21,853 2.1x 10.0x 2.0x 9.5x

Mean: 14.1% 18.8% $22,426 2.1x 10.0x 2.0x 9.5x

Home Care / HospiceAddus HomeCare Corporation $4.87 22.1% (2.8%) $5.35 $3.00 $53 $26 $1 $77 $276 $13 $10 Jun-12 Dec-11 $280 $14 $11 0.3x 5.8x 0.3x 5.5xAlmost Family Inc. 22.08 (0.7%) 11.7% 26.87 12.50 208 1 38 172 352 35 32 Jun-12 Dec-11 351 35 30 0.5x 4.9x 0.5x 5.0xAmedisys Inc. 14.08 28.4% (17.0%) 18.20 9.12 431 128 37 524 1,492 109 69 Jun-12 Dec-11 1,508 100 59 0.4x 4.7x 0.3x 5.3xGentiva Health Services Inc. 10.98 95.7% 44.3% 11.95 2.81 336 938 155 1,120 1,762 179 149 Jun-12 Dec-11 1,728 181 151 0.6x 4.5x 0.6x 6.2xLHC Group, Inc. 17.40 3.9% (12.9%) 20.26 12.34 318 8 0 340 628 61 54 Jun-12 Dec-11 639 63 56 0.5x 5.5x 0.5x 5.4xChemed Corp. 66.03 18.9% 13.7% 67.20 47.66 1,261 171 60 1,372 1,399 186 162 Jun-12 Dec-11 1,439 205 167 1.0x 7.4x 1.0x 6.7xNumber of Companies 6 Median: 20.5% 4.4% Total $327 $601 $1,013 $1,039 0.5x 5.2x 0.5x 5.4x

Mean: 28.0% 6.2% $601 0.5x 5.5x 0.5x 5.7x

Long-Term CareThe Ensign Group, Inc. $29.44 15.9% 26.2% $29.93 $19.70 $632 $204 $33 $810 $795 $116 $89 Jun-12 Dec-11 $835 $130 $102 1.0x 7.0x 1.0x 6.2xKindred Healthcare Inc. 11.16 34.9% (13.8%) 13.62 7.60 591 1,650 38 2,166 6,153 403 209 Jun-12 Dec-11 6,237 439 242 0.4x 5.4x 0.3x 4.9xNational Healthcare Corp. 44.69 4.4% 29.8% 49.06 29.97 624 10 69 638 749 96 66 Jun-12 Dec-11 744 NA NA 0.9x 6.0x 0.9x NA Sun Healthcare Group, Inc. 8.45 74.2% 98.4% 8.50 2.06 216 92 44 264 1,909 68 36 Jun-12 Dec-11 1,857 75 40 0.1x 3.9x 0.1x 3.5xNumber of Companies 4 Median: 25.4% 28.0% Total $2,063 $969 $9,606 $9,673 0.6x 5.7x 0.6x 4.9x

Mean: 32.4% 35.2% $969 0.6x 5.6x 0.6x 4.9x

TEV/ Fwd MultiplesCompany Name

Equity Mkt. Value Total Debt

Cash and Equiv.

Total Ent.

Value

Lastest Twelve Months (LTM) LTM

PeriodLastest

FYE DateForward Estimate TEV/ LTM Multiples

Page 12: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

Healthcare & Life Sciences Trading Statistics

September 2012

As of August 31, 2012

Stock Price% Change 52 Week

8/31/2012 3 mos. 12 mos. High Low Revenue EBITDA EBIT Revenue EBITDA EBIT Revenue EBITDA Revenue EBITDA

Physician Practice Management

Multispecialty / Primary Care:IPC The Hospitalist Company, Inc. $44.19 26.3% 10.2% $48.29 $29.70 $735 $0 $9 $727 $491 $53 $49 Jun-12 Dec-11 $523 $58 $55 1.5x 13.8x 1.4x 12.4xNumber of Companies 1 Median: 26.3% 10.2% Total $735 $727 $491 $523 1.5x 13.8x 1.4x 12.4x

Mean: 26.3% 10.2% $727 1.5x 13.8x 1.4x 12.4x

Specialty:Integramed America Inc. $14.02 26.2% 64.4% $14.04 $6.70 $168 $9 $57 $120 $287 $18 $9 Jun-12 Dec-11 $301 $21 $11 0.4x 6.8x 0.4x 5.6xMEDNAX, Inc. 69.28 13.6% 6.1% 75.86 59.24 3,322 0 12 3,307 1,685 394 366 Jun-12 Dec-11 1,811 417 386 2.0x 8.4x 1.8x 7.9xNumber of Companies 2 Median: 19.9% 35.2% Total $3,490 $1,714 $1,972 $2,112 1.2x 7.6x 1.1x 6.8x

Mean: 19.9% 35.2% $1,714 1.2x 7.6x 1.1x 6.8x

Dental:Birner Dental Management Services Inc. $16.36 3.6% (2.3%) $19.49 $14.75 $32 $5 $1 $37 $62 $4 $1 Jun-12 Dec-11 NA NA NA 0.6x 8.7x NA NA Number of Companies 1 Median: 3.6% (2.3%) Total $32 $37 $62 $0 0.6x 8.7x NA NA

Mean: 3.6% (2.3%) $37 0.6x 8.7x NA NA

Psychiatric Hospitals / ManagementMagellan Health Services Inc. $49.61 17.6% (0.5%) $56.58 $40.24 $1,357 $0 $168 $1,118 $2,987 $192 $161 Jun-12 Dec-11 $3,282 $239 $174 0.4x 5.8x 0.3x 4.7xProvidence Service Corp. 11.41 (14.2%) 7.2% 15.94 8.35 149 145 50 252 1,019 39 25 Jun-12 Dec-11 1,094 37 23 0.2x 6.4x 0.2x 6.8xUniversal Health Services Inc. 39.95 3.1% (4.0%) 45.31 31.35 3,871 3,506 33 7,623 7,616 1,203 904 Jun-12 Dec-11 7,654 1,210 923 1.0x 6.3x 1.0x 6.3xNumber of Companies 3 Median: 3.1% (0.5%) Total $5,378 $2,248 $11,622 $12,030 0.3x 6.1x 0.3x 6.3x

Mean: 2.2% 0.9% $2,248 0.4x 4.6x 0.5x 5.9x

Surgicenters / Rehabilitation

Surgery Centers:AmSurg Corp. $29.41 7.7% 30.0% $32.17 $19.86 $929 $420 $38 $1,618 $883 $299 $270 Jun-12 Dec-11 $926 $312 $285 1.8x 5.4x 1.7x 5.2xNumber of Companies 1 Median: 7.7% 30.0% Total $929 $1,618 $883 $926 1.8x 5.4x 1.7x 5.2x

Mean: 7.7% 30.0% $1,618 1.8x 5.4x 1.7x 5.2x

Rehabilitation / Long Term Acute Care:HEALTHSOUTH Corp. $22.90 19.6% 7.1% $24.62 $13.65 $2,191 $1,219 $41 $3,809 $2,088 $484 $405 Jun-12 Dec-11 $2,135 $498 $416 1.8x 7.7x 1.8x 7.6xSelect Medical Holdings Corporation 10.35 12.0% 42.8% 14.89 5.81 1,448 1,374 22 2,834 2,907 395 327 Jun-12 Dec-11 2,960 403 335 1.0x 7.0x 1.0x 7.0xUS Physical Therapy Inc. 25.97 6.9% 30.8% 27.39 16.58 306 21 9 336 247 42 37 Jun-12 Dec-11 253 39 40 1.4x 7.9x 1.3x 8.6xNumber of Companies 3 Median: 12.0% 30.8% Total $3,945 $2,326 $5,241 $5,349 1.4x 7.7x 1.3x 7.6x

Mean: 12.8% 26.9% $2,326 1.4x 7.5x 1.4x 7.8x

Company NameEquity

Mkt. Value Total DebtCash and

Equiv.

Total Ent.

Value

Lastest Twelve Months (LTM) LTM

PeriodLastest

FYE DateForward Estimate TEV/ LTM Multiples TEV/ Fwd Multiples

11

Provider-Based Services

Page 13: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

12

M&A Detail

September 2012

Announced U.S.

Healthcare &

Life Sciences

M&A

Enterprise Enterprise Value / LTM Private Equity

Announced Target Seller Buyer Value ($mm) Sales EBITDA EBIT Involvement

8/31/2012 Promise Hospital of San Antonio, Inc. Promise Healthcare, Inc. Post Acute Medical LLC - - - - No

8/31/2012 ConnectYourCare, LLC Express Scripts Holding Company

(NasdaqGS:ESRX)

ABS Capital Partners - - - - Yes

8/31/2012 180 Medical, Inc. Cortec Group ConvaTec Inc. - - - - Yes

8/31/2012 Kryptiq Corporation Voyager Capital; Shelter Capital

Partners

SureScripts-RxHub, LLC - - - - No

8/30/2012 Honesdale Volunteer Ambulance Corps Inc. - Wayne Ambulance, Inc. - - - - No

8/30/2012 Park Nicollet Health Services - HealthPartners, Inc. - - - - No

8/30/2012 Elevation Pharmaceuticals, Inc. Canaan Partners; Care Capital, LLC;

TPG Growth

Sunovion Pharmaceuticals Inc. $430.0 - - - Yes

8/29/2012 Accugenix, Inc. - Charles River Laboratories

International, Inc. (NYSE:CRL)

$17.0 - - - No

8/28/2012 Timberline Knolls, LLC - TK Behavioral, LLC $67.8 2.1x - - No

8/28/2012 Lower Bucks Hospital - Prime Healthcare Services, Inc. - - - - No

8/28/2012 Drug Safety Alliance, Inc. - United Drug plc (ISE:UN6A) $28.0 - - - No

8/28/2012 SynopiaRX LLC - United Drug plc (ISE:UN6A) $12.0 - - - No

8/28/2012 SBSI NUTRACEUTICALS, INC. - EnerBrite Technologies Group, Inc.

(OTCPK:ETGG)

- - - - No

8/27/2012 Alliance Urgent Care, LLC - Capital Group Holdings, Inc.

(OTCPK:CGHC)

$0.4 - - - No

8/27/2012 Axial Biotech, Inc., ScoliScore Adolescent

Idiopathic Scoliosis Prognostic Test

Axial Biotech, Inc. Transgenomic Inc. (OTCPK:TBIO) $4.4 - - - No

8/27/2012 Ascender Software, LLC National Healthcare Services, Inc. Community Care Health Network, Inc. - - - - No

8/27/2012 Recovery Works Drug And Alcohol

Rehabilitation Center LLC

- Pinnacle Treatment Centers, Inc. - - - - No

8/27/2012 Robert Horry Center for Sports and Physical

Rehabilitation

- University General Health System, Inc.

(OTCPK:UGHS)

- - - - No

8/24/2012 Computer Vision Systems Laboratories Corp.

(OTCPK:CVSL)

- Happenings Communications Group,

Inc.

- - - - No

8/24/2012 Putnam Acres Care Center Putnam County Ohio Trilogy Health Services, LLC - - - - No

8/23/2012 OrthoHelix Surgical Designs, Inc. River Cities Capital Funds; Mutual

Capital Partners LLC

Tornier, Inc. $155.0 - - - Yes

8/23/2012 Eaton Scientific Systems Ltd. - Pristine Solutions Inc. $3.8 - - - No

8/23/2012 Xanodyne Pharmaceuticals, Inc., All Rights to

Roxicodone New Drug Application

Xanodyne Pharmaceuticals, Inc. Mallinckrodt, LLC - - - - No

8/22/2012 Elko Diagnostic Imaging LLC - PHC-Elko, Inc. - - - - No

8/22/2012 CareCounsel, LLC - Stanford Hospital & Clinics - - - - No

8/21/2012 Sunrise Senior Living Inc. (NYSE:SRZ) BlackRock, Inc. Health Care REIT, Inc. (NYSE:HCN) $1,413.9 2.2x 14.5x 25.9x Yes

8/21/2012 DiagnosisONE, Inc. Edison Venture Fund Alere Inc. (NYSE:ALR) - - - - Yes

8/21/2012 Kanner, Shteiman LLC - Metcare of Florida, Inc. - - - - No

8/21/2012 Penrith Corporation - Siemens Healthcare - - - - No

8/21/2012 Aperio Technologies, Inc. Galen Partners; Advanced

Technology Ventures

Leica Microsystems GmbH - - - - Yes

8/21/2012 Sunrise Atrium at Boca Raton RSC Atrium, LLC Health Care REIT, Inc. (NYSE:HCN) $31.5 - - - No

8/20/2012 IntegraCare Holdings, Inc. Flexpoint Ford, LLC Kindred Healthcare Inc. (NYSE:KND) $75.0 1.1x 8.3x - Yes

8/20/2012 SCD Enterprises, LLC - Creative Edge Nutrition, Inc. - - - - No

8/20/2012 Advocat Inc., Nursing Center in Arkansas Advocat Inc. (NasdaqCM:AVCA) - - - - - No

8/20/2012 Mercy Hospital, Portland, Maine Catholic Health East Steward Health Care System, LLC - - - - No

8/20/2012 RSC Ashford Court LLC, Ashford Court

Assisted Living at 1700 The Greens Way

RSC Ashford Court LLC Health Care REIT, Inc. (NYSE:HCN) $21.5 - - - No

8/20/2012 Med-Trans Corporation TJ Holding Company, Inc. - - - - - No

8/20/2012 L&S Associates, Inc. - Human Arc Corporation - - - - No

8/19/2012 Coventry Health Care Inc. (NYSE:CVH) - Aetna Inc. (NYSE:AET) $5,795.5 0.4x 6.3x 7.3x No

8/17/2012 Bristol-Myers Squibb Company, Assets and

Certain Liabilities Related to FV-100

Bristol-Myers Squibb Company

(NYSE:BMY)

Synergy Pharmaceuticals, Inc.

(NasdaqCM:SGYP)

$1.0 - - - No

8/17/2012 Avid Health, Inc. - Church & Dwight Co. Inc.

(NYSE:CHD)

$650.0 2.8x 11.2x - No

8/17/2012 XAM | MAX - The Outsource Group, Inc. - - - - No

8/17/2012 Workers’ Implantable Network, Surgical Implant

Business

Workers' Implantable Network Orchid Medical, Inc. - - - - No

8/17/2012 Orthodontic Design & Production, Inc. - G&H Wire Company, Inc. - - - - No

8/16/2012 St. Jude Medical, Inc., Venture Wire Control

Catheter

St. Jude Medical Inc. (NYSE:STJ) Vascular Solutions Inc.

(NasdaqGS:VASC)

$3.0 - - - No

8/16/2012 TRS Behavioral Care, Inc. - Elements Behavioral Health, Inc. - - - - No

8/16/2012 Meta Health Technology, Inc. - Streamline Health, Inc. $16.0 - - - No

8/15/2012 ExcellaDerm Corporation - DermaMed Solutions, LLC - - - - No

8/15/2012 Kinetic Concepts, Inc., Therapeutic Support

Systems Business

Kinetic Concepts Inc. ArjoHuntleigh AB - - 5.7x - No

8/15/2012 TTC LLC - IMS Health Incorporated - - - - No

8/14/2012 Senior Living Campus in Silverdale, Washington - National Health Investors Inc.

(NYSE:NHI)

$25.2 - - - No

8/14/2012 Delphi Healthcare Partners, Inc. - Team Health Holdings, Inc.

(NYSE:TMH)

- - - - No

8/14/2012 Four Independent Pharmacies in Central New

York and Vermont

- Kinney Drugs, Inc. - - - - No

Page 14: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

13

M&A Detail

September 2012

Announced U.S.

Healthcare &

Life Sciences

M&A

(Continued)

Turner Bredrup Managing Director

[email protected]

+1 (804) 915-0110

Cheairs Porter Managing Director

[email protected]

+1 (804) 915-0130

James Clark Managing Director

[email protected]

+1 (804) 915-0119

Todd Morris Managing Director

[email protected]

+1 (415) 217-3412

Geoff Smith Director

[email protected]

+1 (804) 915-0195

Andy Dixon Vice President

[email protected]

+1 (415) 217-3419

Contacts

Whit Knier Vice President

[email protected]

+1 (804) 932-1321

Enterprise Enterprise Value / LTM Private Equity

Announced Target Seller Buyer Value ($mm) Sales EBITDA EBIT Involvement

Paul Hepper Vice President

[email protected]

+1 (804) 932-1326

Andy Hewlett Vice President

[email protected]

+1 (415) 217-3427

8/13/2012 Expression Analysis, Inc. - Quintiles Global Laboratories - - - - No

8/13/2012 First Dental Health - Principal Financial Group Inc.

(NYSE:PFG)

- - - - No

8/13/2012 FTMI Operator, LLC - Shefaor Development LLC $13.0 - - - No

8/10/2012 Pier Pharmaceuticals, Inc. Origin Ventures; IllinoisVENTURES,

LLC

Cortex Pharmaceuticals Inc.

(OTCPK:CORX)

$4.1 - - - No

8/10/2012 United Rehab Specialists, Inc., Complex

Rehabilitation Technology Segment

United Rehab Specialists, Inc. ATG Rehab Inc. - - - - No

8/9/2012 Georgetown Healthcare & Rehab, Inc. Winyah Nursing Home, Inc. AdCare Property Holdings, LLC $4.2 - - - No

8/9/2012 Athol Memorial Hospital - Heywood Hospital - - - - No

8/9/2012 Eagle Healthcare, Inc., Ten Rehabilitation Eagle Healthcare, Inc. Prestige Care, Inc. - - - - No

8/8/2012 AllianceCare, Inc. Capital Resource Partners; Cardinal

Partners; GE Equity; Three Arch

Partners; SV Life Sciences Advisers

LLP;

Caresouth Homecare Professionals,

Inc.

- - - - Yes

8/8/2012 Health & Safety Institute The Riverside Company - - - - - Yes

8/8/2012 Classic Pharmaceuticals LLC - Aphena Pharma Solutions, Inc. - - - - No

8/7/2012 InterDent, Inc. Levine Leichtman Capital Partners;

Saratoga Investment Corp.

H.I.G. Capital, LLC - - - - Yes

8/6/2012 Strategic Healthcare Group LLC - Mediware Information Systems Inc.

(NasdaqCM:MEDW)

$8.0 - - - No

8/5/2012 Cardiocore Lab, Inc. Maryland Department of Business

and Economic Development,

Investment Arm

CardioNet, Inc. (NasdaqGM:BEAT) $23.5 - - - No

8/5/2012 Brighton Bay Wells Fargo & Company

(NYSE:WFC)

The Carlyle Group LP

(NasdaqGS:CG)

$19.0 - - - Yes

8/3/2012 Maroland, LLC and 800 HomeCare LLC - Heritage Home Healthcare Services, - - - - No

8/3/2012 Two Skilled Nursing Facilities located in the

Portland, Oregon Metropolitan

Sheridan Care Center LLC; Fernhill

LLC

Cornerstone Healthcare Partners, LLC $8.6 - - - No

8/3/2012 OAD Orthopaedics, Ltd. and DuPage

Orthopaedic Surgery Center, LLC

- CDH-Delnor Health System, Inc. - - - - No

8/3/2012 IOS Technologies, Inc. - Glidewell Laboratories, Inc. - - - - No

8/2/2012 Octagon Research Solutions, Inc. Edison Venture Fund; Ticonderoga

Capital Inc.; Milestone Venture

Partners

Accenture plc (NYSE:ACN) - - - - No

8/2/2012 Wholesale Alliance TPS, LLC Wholesale Alliance, LLC MedTrak Services, LLC - - - - No

8/2/2012 Leprechaun, LLC - Examination Management Services, - - - - No

8/1/2012 Nutrition Consultants LLC - Granite Harbor Business Development

LLC

- - - - No

8/1/2012 MFR Healthcare Solutions, Inc. - MFR Solutions, Inc. - - - - No

8/1/2012 Lipomics Technologies, Inc. - Metabolon, Inc. - - - - No

8/1/2012 Allcare Medical Inc., Complex Rehab

Technology Business

Allcare Medical Inc. ATG Rehab Inc. - - - - No

8/1/2012 Vista Healthcare Center and Discovery Care

Centre and Owyhee Health & Rehabilitation

Center

- The Ensign Group, Inc.

(NasdaqGS:ENSG)

- - - - No

8/1/2012 Children's Dental Center - Children's Hospital Of Wisconsin, Inc. - - - - No

8/1/2012 Reglera, LLC - Dohmen Investment Group, LLC - - - - Yes

8/1/2012 Heritage Arms, LLC - HRC Investors Corp. $5.0 - - - Yes

8/1/2012 Washington Adult Day Services Association - LeadingAge Washington - - - - No

8/1/2012 The Surgical Group of Lancaster General Health - Lancaster General Medical Group Inc. - - - - No

8/1/2012 Milford VNA Milford Regional Medical Center, SALMON Hospice Care LLC - - - - No

8/1/2012 NanoBioMagnetics, Inc. - SWR&D, Inc. - - - - No

8/1/2012 West Escondido Healthcare LLC - The Flagstone Group, Inc. - - - - No

Page 15: Healthcare & Life Sciences Industry Update...08/22/12 08/22/12 Wright Medical Group Inc WMGI Convertible $300.0 08/09/12 08/06/12 Exelixis Inc EXEL Convertible 287.5 08/07/12 08/07/12

14

Sources:

Capital IQ.

Thomson Financial.

S&P.

Reuters.

Bloomberg.

Irving Levin Associates.

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