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Introduction to brain parcellation
Sarah GenonCognitive Neuroinformatics Lab
#BrainBFT
Brain parcellation
From histology
To multimodal MRI
#BrainBFT
Eickhoff, Yeo & Genon, 2018, Nat. Rev. Neurosci.
#BrainBFT
Connectivity-based parcellation (CBP)
Neuroimaging scanner
Connectivity
#BrainBFT
Type of
connecti
vity
Functional Co-plasticity Structural
(white matter)
Data Task-based fMRI Resting state fMRI Anatomical MRI Diffusion MRI
Approach Task-based:
Activation during
task
Resting-state:
Signal fluctuations at rest
Morphometry-
based:
Structural co-
variation in the
population
Diffusion-based:
Estimation of fiber
direction
Main
method
Meta-Analytic
Connectivity
Modeling (MACM)
Cross-timepoint correlation
in signal fluctuations
(RSFC)
Correlation of
local GM across
subjects (SC)
Probabilistic diffusion
tractography
(PDT)
0
1
study c
study a
study b
time
voxel A
voxel B
0
1
time
time
How to estimate connectivity ?
Eickhoff, Yeo & Genon, 2018, Nat. Rev. Neurosci.
VBM-es' mated' ssuevalues
VBM-estimated tissue value
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CBP: how ?
1) Region of Interest:
Dorsal Premotor Cortex:
Interface between prefrontal and primary motor
Genon et al., 2017, Cerebral Cortex
2) Connectivity matrix
3) Clustering/factorization
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Reordered similarity matrix
Convergence between connectivity modalities
study c
study a
study b
Genon et al., 2017, Cerebral Cortex
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CBPtools for different connectivity modalities:
Reuter et al., submitted Poster # T580
#BrainBFT
CBPtools for different connectivity modalities:
Reuter et al., submitted Poster # T580
#BrainBFT
CBPtools for different connectivity modalities:
Reuter et al., submitted Poster # T580
#BrainBFT
Local microstructure VS
large-scale functional integration
Local microstructure Connectivity markers
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Local microstructure Connectivity markers
Local microstructure VS
large-scale functional integration
Poster # T561
#BrainBFT
Local microstructure
Ding & Van Hoesen, 2015
Lateral medial
Connectivity markers
Local microstructure VS
large-scale functional integration
Poster # T561
#BrainBFT
study
cstudy
a
study
b
2k
3k
Plachti et al., in press, Cerebral Cortex
Local microstructure VS
large-scale functional integration
Poster # T561
#BrainBFT
Amunts et al., 2006 Plachti et al., in press
anterior
posterior
mediallateral
Local microstructure Connectivity markers
#BrainBFT
Local microstructure VS
large-scale functional integration
Poster # T561
study
cstudy
a
study
b
2k
3k
VBM-es' mated' ssuevalues
Plachti et al., in press, Cerebral Cortex
Local microstructure and
large-scale functional integration
Poster # T561
VBM-es' mated' ssuevalues
#BrainBFT
Take home messages
Brain parcellation
= a very wide set of methods to identify brain regions and/or networks
From histology to MRI-based connectivity
To understand or to represent brain organization and data
Convergence and divergence between mapping features
CBPtool as a user-friendly tool for connectivity-based parcellation to
• Examine replicability across samples
• Examine convergence across connectivity features
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THANK YOU
CASIA Beijing
Lingzhong Fan
Düsseldorf
Katrin Amunts
Svenja Caspers
Holger Schwender
@fzj_inm7
Simon Eickhoff
Cognitive Neuroinformatics Lab
WashU
Aris Sotiras
#BrainBFT
#BrainBFT
#BrainBFT