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. . ~lUu ot ?rOJ.•On4 Stuq of \he~laboU am ot d-J,7aergta J.ctd

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I "' it.udht ot \he mata'boliam o! ~lt•.trt~!_o_ao1d -cU.ethj'lMI4-(I.SD)

ue ooaapUdated 11-,-\he faot th&\ 'h• etten he doni~ la llliaogJ"a

quuUUea. !~Df:_lM.:.~lecmle v~\!\ rtalO&eU.n--~r dt!Lttable-hotoplt __ -~~-.•

. 11 there u.r Ukelthood oto"'\&1il1~..1~t~\1~q:~tn~ relaUn17 tl~ort

per1odt. B7 coAbinhg -~n_r&lmetbodt of t.aa1r~-· dt~~Uont_can._b.t _________ . __.:. __ !

Mde a.e \o \h~ tate ot~\a ltit&e\_-zohouie or~:oe'rtai:l rr~euh ot u. 'r:"'lt &vproaoh requln • _ tne _coordliiatid -'..Of~_ot_a_ te_p~~t_1•x:n uAt1:J.C n.-p,rtt

.· sec\iont below ta whlclCtA,! . .OUnHii-of~\htf1nt r~r ot the ,pro,pu

a.re duorib.!4 in broad tern••

., 3znth1!s1!- 91 tSDa.ttr-rWij]tcl c~spw.n;it.-... -n~ e:'l,.:utcal natur'

of \l11 co:opound. ll&ku 1\ a dU'ficUlt-~o:ne tO '4'oi'k -wnh. , taowled.ge of the~------ -·

lllttaboltu ot L:lD ·rvq bi g.iinede1th~s•byetudha ot-Udtt 'llOllculi! luitablJ

~

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. -- ----- ---- ~--

• .,. ,.

ot qtergio acldh.it not 71l-been oompletelymeatabl1ihed_vork_v1ll ~

carried torvard dmultaneoueir on the pi_ep&Z&\-io-n -ot t&if:ed mohoulea _

and oa the total 17!1theR11.

8enial-1sotoP!•_ .. '1Q_l6'_;rJ>~~'' ~~~ p9ui)le t~•-tor ua! in the ·

LSD molecule. Jaalocazlion..,__(carbon 14) _1\ndJ;riUwa (h11i.r_oge~_3l-u!~~1-~-. ·-·-·· _

u:cepUon.al interest be caul• thei$ h'O -eiement ~- iii&ka -q.p ~a luge ~!-ot .

the rAOlecule. :Soth can~ oli--ta1nad-:...V.Uli fe-ry h1.gh--.-pec1t1o_e.cthU7

and therefore U1_be-=ablet,_ripp:lf __ ~_o:o-1ent ri4lo~t1vit7 ao tha\

micrograJll q..1ant.s. Uel cu 'tii- t-rae-.4-S.nthe 'boq. ReaY7-~1troge_n_ (Dit.rogen 1.5)

hat m.a.n)' advan\Sl;ea;--hoveverJ e.a a ri~ __ eleilient •-~~~hee111ng_U 1At,o lh_e_ -

molecule will biJ-u~_ezc•p~1'--d11foun--teah .. tl --- ------ ------ -

The atnthet,icLch:emic&;! p~ogi'_aa~_i_! '-l.l!_diJ>-__-_!}1_8 -direct ion_ of Dr • _ .. ·--

--- 1-

--------

in chemht17 eomin& a ·-a tr~~~-- .. -

oint. .a~. ------~- _ -(!he budget tor th~~:&Jll~h_eUC[ pro&t&r!_._!ote.lt $7000 and 11

dlseoTer vhat the 'tioqdoes wlth-LSD. The-pe-rcentSiu ot a dose of Lb"D

retained in mAD7-othe:r or&&nl and thsuea ot the- 'bodt will 'be ~:tearued.

al terationa arft induced 'b7 the __ ll\e\abolio a.othit7 orr cella in the eentra.l --· •· -... ; ....

. ' .. ---_-_~"=' ==· -ZZ=:--.• ~ ..... -----

. ...

11 a,dadnhhred, a· cu.roh vilr~-m&t.e _tor !ra€11-:-entsot': the_mole<r..UI_Md. ______ _

then U poedble & _ba.aic_:_b.Oq ot-tntoru\iol:Cvill be dft:'ftiJlOped. fi~U\ ~\""'ht=·~·~~~~~~

!le\a.bolhm of l.Jaergic acid, perhatlt b7 chemJul_ etu.dlu-ot ulihd moleculi•·--=-=----~=i .•

1Uc:rotechn1-rlea w_ch-u=~11!' chroutog:r~hf &q pron to .be i~~portut_! __ ,_ ~ .. ~--~~

Tbe ute ot hittologtcAl rMJ9&U.tom2h• shoul~ 'beinvifn1ga..1~_ .. n __ ~eJL~-~~~~-- ____ _ of \he ab111tr ot \Ma_::aolecule __ toprod.\i.~J~-~~1A~gp~J\1o•l1ke-diiorgwaa-

- -

-·

·,1 the Det&bol1o--J.tl'OQ'M ~ul-be __ ~lid~o,J.t_b:y Dr;~ .. l... -------- -- ------ -- - -- ' •

-In-ph&rwieoloa.~ Pr. ~~ I .... •••1•- .. of fh.e.nacoloa. 'tr:ULlli avaUable( tllf . J _1~-b~ln~-to- \he_pfifPltiJtjJ_~~~~­

broad training arn1 a IB ex~r1ence in ~hs-::£1\8-~~lOQ'~ot the ceotnl-

and peripheral ns'nou-a=qatu~--:-:-- Dr._-_.-~

ot B1oz;h.7t1oa (.?hArmacolog); vho hat bee1t active in traee,.-rssu.rc.~ot·hue­

- 11--to asaiit--vi\h-tn• biophtdeal~;arte ot_th8_1nnlii ... _

£A t1 on: this 1'i'JJ:'F 1 nTo lYe __ lp::~c 1 il--:ij_Otin t_e r.e_ t oi ~ t r1 t iW!l AAd _for _otu• b{ln _14. __ ~,.....,.,... . .,.._~-·-

liE Hi• $.<;110; ap:pP.rat'.la, $5000; e~~nau. ~2o_oo; t.ravel.-- $SOO;­i

eont1n~ency, $2000.

~'he over·All 'bl.1~1!t-h u.ua$2S,SQQ .,.-."'=---"

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- · 2. Die &bOft aubpx'OJeeta~\ ~ n&MHh procna .. _--. _ c - ot Dl'. tinane~ ~ ~. ~ the period -" - ·· -"' ~ 22. October 195J. :t.brouib J1 Ootobc'. 19SS. . .· .

l3 ' baa ·r.questtd·\bltlliftl'aiV to -·· .·. · ...,. Ala1\•to th4a a lN1lfl1i8Z1 · ot ~~ nceim trca_\be _________ _ · 1\u:d.. · £tao, thq l"eqUUted tht ot mr ~- twxts nctd'ftel 1mUr & &nmt. tz.oa. u. ~

49 Title to arrr pmaaur1t *lU!JMilt ,SNHbued b7 f\mds pntad the trnJ:nre.t t7 shall 't>. retaJDid b7. the ti!l!nrait7 1n UG\t ot bigb6r·. OltJbM4 n.t.u.

s. I\ \U ~ ~-that. ~ta.tioD &Dd account.Jnc tw U&ftl upcaes which are ~iabv.rable bf_the Uni.Teraif.7

. . • aball. crmtOI'Il with t.ha acaptecl practicH ot tba\ InsUt.tiUoa,.

6. It wa agr~ -~~-=._~n~~-report~ Htlecting ttle. prog:rus or the 1'Ut&t'Ch prograa ahall be ~tted at. -~- . a~table int.cYal.a. _ _ ___ _

Diatl-ibution I . ~ Orig & 2 - T.SS/r::J

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31 October 19'-4

...

SubproJect 17 expires on 31 October 1954. J.a the

wrk h4.s .uot.7et been completed, an sxten.!io11 ot one

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CERTIFICATE --- --March 31, 1954

Thil 1s=-to C4!rtity that I have toiay received. Cashier's check No. mi944487 UILJI.JII ILL ·;.. E •r•1n _the- sm.g\ln~ ot <¥ 7 . oo. ,

-·

Ma.reh 31, 1954-- -----

Thb is to certify that I have today received

1cash1e~·~check No. :.U39442.l'l- •r WI Ui!lliil•s - E ill flsin the amount of $l9,700.Q9. i

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SUBJECT:

MEMORANDUM REC~I~

I hereby acknowledge receipt of ttle following:

*' W/.£# Ti-i;: P..:·-1:.:'JNT Qf' $.J/.:Z4;1D

.•_

MAR 31 1954 ·

- Phue retvrn~~- eloned copy (In) of thh receipt SIG~ATUR£ ~F RECIPIENT

------------To ~I /1-.-~ . FOIII!I NO. Sl• Ill MAR lUI

•

DATE RECEIVED

•

•

-- • .. . .

~ i'OAI CUU, r.I:IAES Dm8IClf . ·­c- ••• - - - --. _ .. - ·': ·-. m··· . -~-cm.o.r •••• ------~-<::~

2 •. - 'l'hl-ttro ~ e~ W• ~~-~ate~,--172.00 ·.m ft'fNHa\ \1w ~ expenttt?~ \o. be llC4o ~ wa

·· · -- --:-- --Subpro.!~t. x,- u-nqueatedl-w-retOftll. tb:G\ t1lAt ut \h1a Sub•- -·

----- ------

JMj.n bit clccN4. __ _ • _ _

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Atto.cl=atnts: Izr10lee f 2 • ~pr\')Jeot. 17 CerUfteatioM

·-· '~- A ~ ~-m,bt~(l9 Me:reb 1~>

smr:u ·oC'l!t.lD Ch!o!'

ct:andc&l. Pbiaica, 'l'3tl

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lor aervice&- rendered -1D-<WD.1lDCtion·vtth ~ ~jeet 17 ~ Detail&\ bTee.kdatm and receipta on f1l.e 1n m/cn;- - - -- - --- ---- - .•

···~·····.$19,448.00

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JlpAJClal Statemenj for \he ts~ ProJtot

Saluitt

P•l"'l&lmm.t %qulpent

KahrWe a.u4 S11pplh• -

ConUJi&enclet

Dr. ·1 If r- C

total ExpendltN!l

z,o,,.:n. 1,921.:25

137.09

'fotal' bUd

9_,ooo.oo ,.ooo.oo a,ooo.oo

soo.oo 2,550.00

. ~50.00 2,000.QO

1 1 1~-·" 719QO.OO·

'%,012.50 -

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6.966.'S .

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l.e6a.91 500.~

1,.550.00

5,86,.69 -

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FROM: lud&'at/!SS: l ' '

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SU 8J ECT: TwO Che~1 i ; i I ! ~ . I

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I he\eby atfowledge ~eceipt of, th·e following: I a.et #f¢3)382 in the 1110unt .oo an4 cbeolc #KLlS36l 1D the amount . ot $371&.00 ll&de pqablt to Wf'lllllt tor Imtice #l Subprojeo\---. 17, PJ-o~o\ XKUL'lRl.. .• ~ ·'~ . -~

\ ,·\' c. \

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TG ---~---'''·'-:--·-· ----~------- j:, FORM NO. se.et ~' liAR 19U ,

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• Novembe r 2, 1953

.•

This isoto certify_ that~ I have~ today received C:lshier' s check No. 1-1135383 of · ····

E - in the a1noutit ot $374~00~

November 2, 1953

. .,

This is to certify that I have today received Cashier's check -no. :t-n35382 of

. E - · J Q. in the arrou;·"t or $9,3

•

\1-10

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~ JQ. 1 tw SU~Jeot.17 or Pl'O;cct ~JL!BA 111 at~.

- ri ia ftql.Witei tba' ~nt be :dad• 'b'J tw ca~er••·~ la tbt. ___ .... ·-

~t.a Ot f?,J~.oo wd .. m.oo_~ eut to aaWJDIII,._ • . 'l'be· ~C.'~

-. ~k& :~ ·--- a.~t··tc;·e~~ --~-~iii'~~~ ot-H~~ · .-:·. • • . . a ... ~· . ._

TO: TSSjCD

FRoM: .. Budget/TSS --~

- - SUB"ECT: Two Cheeks

- -..... - .~ . . . . . ~· ...

~· .

•

MEMORANDUM RECEIPT

I hereby acknowledge receipt of the following:

• ... .....__. ..

... - •• l' - ••

2 No1'emher 1953 OAT£

.I

· Check IM13S382 ·1n the -amount or $9 ,3.50.00 and cheek #Ml3S38J· ill the am•)unt -~ -. or $374,00 made-pay4ble to 5$-] •.. as p.-ment tor Invilice ll Subprojec~

171

Project MKULTRA. - - ( -···-· · · - :. ·1- .••

c ·<,

Pleas• ret11rn~~-- algud copy(i .. ) of till a receipt •

To~~~ FORM MO. U·U MAll ltd

DATE RECE!VfD ·

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~~~tmt.U 10!1& ~' mtAZC! .. PI'Il3ICI ~ .. --.-- . ·.. . .

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n t• ~ thn~~ bau.i• 'by-tvo cuhiel'•t oh4teu-ln the.

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SD:.JUDta or ~,350.00 ·:w .$374.00 D*tft Out . ... :. . . .. ~-- ;- c- --~

ol'Mn ~oitM·b. .~ ~-cht.t;· ~~~lsi/~ o:fice · -- - -~·· ... -·--

_·- no~ '1..1~1" tbA.i; 30 ce~·l' 1953~:' ~ ·~ ... ---- - ~ , . . ~ - -·

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---- -- 17.\Dier Pl'Ojeot XJrol.TRA-Vhich YU dul1. awrov.l Bftd tbQt_tbo- projoc~ - _ la l;le11W1 oan'iocl_~ 1A ~CC~ __ ?S.~_the_ookmmo~ t..o tci ~------- - ~ dated 3 ~1'11.19531 tbG rot ~rwd1a toW/A elated 13 A)l~l1953J ---- - _. AM the 001 ·~ to tbt 00/A dAted 19 .. v"U9' 1953•

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(~) ·"It. ta bert'b7 efl'tit1•<1 ~~' ~. acope ot ~ ~ ot _0\lb~NJ4Io._ 17 ot ~Jeot- ~«'JL'll'.A-b&U be«f &pproJed..

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INVOICE

.·

For Services •••••••••• •• •• ••• •• ••• ••• ••. _ $9,724.00-

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ProJw\ ~'""U, ~Joot 1.7

~r tM autbofl.tJ Sl"fJlte<J..ta. t~ ~-- dated 13· APtU 1953

. f:'aa tbe OOI_to._ta:..OO/A) 801 ~ turtbe.r llllt~\7 ~«\ 1n ~h•

' -aaln°r~ bttd lT_AJrU 1953 troll the ntJ_/A .frO the CQIJ1.1"0Wt-Cft ~~- ~-~

· MlbJMt1 'TJTJJp..ir'.;..S Pto.lect 1tiJJL?.U", -.1 the ~ date! 19 JuM

-- -1953, ~ tbl·.oot \0 the DD/A ~ tbl autbarit.1 t.o cover fboal

Yul" 1954, s-.m,roJeo\ 17 b&:J ~ ~~ -~ $29,1.72.00 ot ~

~ ProJeot. lmlL!!A f\D.U ~ twil ®1.JQ.te4 to cove-r the .

PRCGVJC ~fii"'.JJJ: A1fll --------·----·--- ·· .l.PP!tO\i.ll M OatJGA'1l02 ~~:~~-----:---~---------------- -·-·· 0?1'\i"MDSt

- ......... --

_1}~tel_-______ _

D1at:r1wt1cm: /v!.iM!I~ • Orl~. 31 2 . ;:uo. aaa'¥• 1 aos. M. • 1 ~33/aui~~t • 1 (4~2502·10)~ T?~J/F.e.'liatey ... 1 · .. • ?'~J/r::J .. :1 ·; ...... ,:~A~.;~~~; .... " .... ),> .• ,,. .. ,. .......... """~..,.. ..

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uaclllt&lf -A

Date I -----·-·-· ---

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SUBJECT:.·

' DRAFt' ... - A . . . 22 October 1953

1. The scope ot this nnareb program is intended _to_cover vork to 'be done Yith LSD-w·rela.ted compounds by ---C.. _:; c - ••• at . . ., . . . . tor th~ period ending 3.1-october-!954~ -- -- n m --

- Tbe proJect v111·oe ~led--::tllrougl:i na•sJll781 :::; U EJ&t~r -'B "i:) _ cut:;0ut ana_ cover purposes,_'1.1le_proposal ti~ r ••• D tdiN -c D - < 3 I 1. I [ .M.B!Iill• is att~hed to this memorandum. _

2. The general object of thiS project is aimed at_elucidation _____ -~----- of the site and- mP.eh" .\tam of _-aotionof LSD by the use· of isotopically tagged mo-lecutet-. --'.:'<'- least tbree · me.jol' adVantages Will accrue from -_- - ·--

-such knovle<lie~--c;'ii·atj' such data should greatly facilitate the_--~- - -­development of a suitable antidote-tor ~c:;Df in addition, they should make it possible_ to design nev compounds having like but even more bizarre activities; and finally; ~lndamental-knovledge of the psycho· therapeutia action of' drugs Vill"oe made-available fOY tuture development.

C.... ·---+- 3· bis-availa'ble to hilii-at-- a highly competent grOl..'P of sc1entiats of 1nternat1on~l reputstion encompassing the fields of physical and_orgacic chemistry_ in addition to_those ~-

. of medicine and psychology. Replans-to use-t}lese people as informal consultants in the vork. ·

4. The funds for this prpj~~! ~tne].ygfL$7 1000.00 f'or the sjnthetic vork on tagsed LSD, $181 500.00 tor the' metabolic studies on· such-- -compounds,. $2,550.oo:.(ot.]•he \.~ ·and $1,122.00 for a. 4~ service charge o;y·· - e, Therefore, the total cost of this inves Y1 $29,172.00 for the period. end1ng~3l::oetober=l9;4.

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PROGRAM APPROVED AND--=-ccc_:_=--::_:::_ --::::-___ ;ecce- -.--

RroOMMENDED: __ _

Date=----~------

- . .

• APPROVED:

- . . .

)~~;x ~;.· :'. :~--~-~~.' . ·.~ : :- • . ~. .

-. APPROVED FOR OM.IGATION ___ QF FUNDS:

Date:

Original Onl-1 - Pi"Oj4ict- MKULTRA;:"SUoproject 17

. ~ . . . .

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-c S.OloiM }'lt&M tlad u ou.\1U. of a ~:pot~ duq of ~ •uboU. aa of

~~gte A4d4 PU~lu14. tM• nUt. la ·~·a &eMftl·tmaa 'bot'4lu• - all ot u tMl Uaa\ •• ve •1*' \be lawa\t&&Uoa ve w~A U.ke to !aw otll'

0~$4tlftt 1a pural t..r.a• n~_\bm IA_t.pflclf\o f)UI• · U' l'·lS ~ANJ1\ .... · -·'- C ~-to 100. _Ill' . _.,,d'Ue ou' a 4at&tle-4 1\&~~S r1f 'M tltt•\ n.,e ~\ be .

ll IJ>1rl.t to \aU v1tli. u.- a14 oS I>re • Ja- ·ua 1 .. 0&1' ·~- ~a 61\aUet\ c:<- C. 4..tmpU!4 ~~ Uw t17t\ ·~nmc\_w ¥0ll14 lU._to .so 1a \M ~~t\Aboll" ~· -

0~:- .:.t;'-~rl4a\ q_UithD la \M ~ of 1fs$:fB{C &-o~l 1M QAt.ti.\1l.\i'Nie to ~· have aq II.VA-0•\l-oat as- \,'1-poo}'le va mp•.vn.~-. tG ol' ~-Mds• Uwl\ ~~~ ~ u'ue•W ta oollaboft.\UC Wl\h •• •' le&a\ t-:1 u. e:z--tat o~ :rr~ndt~ _

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PROPCSED BUOOETS

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Graduate Expenses

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- Apparatus _ _ __ ),ooo -- . Expenses- _ :- , - - -- -, 2,000 ··:-, Tr-.vel __ ___ - )00

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:'$25,500 plus allol·lallce ror university overhead

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4, · It 1a requested that. act.ion 'be t.aken .. in this m.:J.t.ter aa soo.a u pos3ible anu th.-'\t, t.ho comp-l4i~e<Lf'onl_be _returned to CO/T$.<s. ·

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