HCC: Proposals for biomarkers and imaging surveillance AFPL3% DCP 2013

8/14/2019 HCC: Proposals for biomarkers and imaging surveillance AFPL3% DCP 2013

1/29

@BB> fmdkorigrs oej mkoame

survgmhhoebg

Vdfgrt A. Ams` KJRgemdr Kgjmboh Jmrgbtdr Rt Ndsgp`s Kgjmboh Bgetg\`dgemx

Bhmemboh \rdcgssdr dc Kgjmbmeg> Wemvgrsmty dc Egvoj


2/29

BDM

Jr Ams` `os rgbgmvgj `dedrormuk oejbdesuhtmea cggs crdk Qoid Jmoaoedstmbs


3/29

Ms Rurvgmhhoebg Qdrt`w`mhgoej `dw

kdjmcy wmt` dur CJO opprdvgj fmdkor

@dw jd wg jgcmegwdrt`w`mhg4

Mkprdvgkget me survmvoh dc 2 kdet`s Y?[

Rurvgmhhoebg bdesmjgrgj bdst-gccgbtmvg mc mt ob`mgvgs 2-k

mkprdvgkget me survmvoh ot o bdst dc 8 $7


4/29

Gccgbt dc Rurvgmhhoebg de Dutb Vgtrdspgbtmvg oeohysms dc potmgets wmt` bmrr`dsms oej @BB (E ; 63=)

Rtoejorj-dc-borg survgmhhoebg (e ; ?16)

Whtrosduej dr dt`gr ofjdkmeoh mkoamea ? tmkg/ygor

Rufstoejorj survgmhhoebg (e ; :0)

Hobi dc ofjdkmeoh mkoamea wmt`me ? ygor dc boebgr jmoaedsms

Ofsgebg dc survgmhhoebg (e ; 7=)

Dutbdkgs, %Rtoejorj-dc-Borg

Rurvgmhhoebg(e ; ?16)

Rufstoejorj

Rurvgmhhoebg

(e ; :0)Ofsgebg

Rurvgmhho

(e ; 7=

@BB Jx ot stoags ?/6 3= 27 ?0Hmvgr troesphoetotmde 26 ?2 1Kgoe 2-ygor survmvoh :


5/29

Rukkory> @BB survgmhhoe Whtrosduej ms t`g dehy rgbdkkgejgj kdj

Ed VBZ td prdvg BZ dr KVM ms gccgbtmvg cdr survgmhhoebg

Bdst gccgbtmvgegss oeohysms> Whtrosduej ms t

bdst gccgbtmvg survgmhhoebg kgt`djFut

Whtrosduej quohmty boe vory, sgesmtmvmty ovg~3


6/29


7/29

Eotmdeoh survgy me t`g WR

_ugstmdeeomrg :12 OORHJ p`ysmbmoe kg

B`ohosoem, E. gt oh. Ok N Aostrdgetgrdh


8/29

@BB Rurvgmhhoebg Rurvgy> WB G-komh mevmtotmde sget cdr o frmgc ghgbtrdemb survgy t

AM/`gpotdhday prdvmjgrs me t`g Wemtgj Rtotgs \ort M> 613/6:07 OORHJ kgkfgrs (??.?%)

2< gxbhujgj (mebdkphgtg, edt sggmea ojuht potmgets)

6:3 wgrg oeohyzgj 12 aostrdgetgrdhdamsts (2


9/29

Vgsuhts> OORHJ kgkfgrs 663 (=6%) drjgr @BB survgmhhoebg cdr bmrr`dtmb

6?? (=2%) usg uhtrosduej (WR) me sdkg bopobmty

=0 (:2%) usg ohh 2 mkoamea kdjohmtmgs (WR/BZ/KV

0< (27%) gxbhusmvghy usg WR wmt` fmdkorigr

?3: (12%) gxbhusmvghy usg OC\ ohdea wmt` mkoamea

?0 (0%) usg 6 dr kdrg fmdkorigrs (OC\, OC\ H2%,wmt` mkoamea

:2 (?=%) jd edt usg oey fmdkorigrs, dehy mkoame

?=1 (01%) usg 3 kdet`s metgrvoh

Nds`m, Ided, Ams` gt


10/29

Vgsuhts> OORHJ kgkfgrs

\rdvmjgrs ot troesphoet bgetgrs (ZB) (e; ?:6) k

td usg ohh 2 mkoamea kdjohmtmgs (p8


11/29

Whtrosduej _uohmty Rtujy W

\rghmkmeory Vgsuhts Gxbghhget ?2/?7: (0.:%)

Addj ::/?7: (60.3%)

Comr ::/?7: (60.3%)

\ddr 72/?7: (2:.:%)

Me oeohysms> oey prgjmbtmvg cobtdrs cdr pddr quohmty uhtrosduej4 (FKM, prgsgebg/sgvgrmtbmrr`dsms, robg, oag, agejgr gtb)

Ided, Nds`m, Rmr


12/29

Gd j


13/29

\rdpdsgj Ohadrmt`k

Hmvgr Whtrosduej

\rdtdbdh cdr

sbrggemea oejsurvgmhhoebg

q3kdet`s

Qmt` OC\H2%/JB\

@BB sgruk

fmdkorigrs

\ddr/Comrquohmty WR

Addj/Gxbghhget

quohmty WR

@F\ GdvmstKVM x ?

WR

survgmhhoebg

q3 kdet`s

Gk

J

Gd j

: dr

@BB

WR q3

kdet`s

E

Fy

fm

Ega KV

Ofeh

WR


14/29

\urpdsg Zd cmej `dw koey WR gxoks org

gxbghhget/addj/comr/pddr quohmty Zd cmej t`g prgjmbtdrs dc WR quohmty

Zd cmej t`g sgesmtmvmty dc WR vs @F\ Gdvmst KVM quohmty ms pddr

Zd cmej t`g bdst gccgbtmvgegss dc WR vs Gd-KVM(kdjghmea)

Gxphdrg utmhmty dc usmea OC\H2% oej JB\ td kdmkoamea kdjohmty usgj


15/29

Bdsts cdr mkoamea

Oejgrssde I, gt oh. Bhme Aostrdgetgrdhday oej @gpotdhday> 6 bdetmeugj

OC\H2% 81

JB\ 8 2

\hoe>

Bdetmeug fmdkorigr ossgsskget gvgry 2 kde WR ohtgreotmea wmt` KV wmt` gdvmst gvgry 3 k

Mc OC\H2% dr JB\ rmsg fy 6


18/29

Bosg 6

:7 yd Smgteokgsg koe wmt` o iedwe @t`g hgct hdfg dc t`g hmvgr fy BZ, WR oej f

ot 2.2 bk

@FS JEO +, trgotkget eomvg

OC\ 82 ea/kH


19/29

Bosg 6> bdetmeugj

\hoe Drjgr @BB fmdkorigr poegh

Orroeag ZOBG cdhhdwgj fy Ruragry


20/29

Bosg 6> bdetmeugj

\hoe @BB fmdkorigr poegh

OC\H2%81

JB\ 6


21/29

Bosg 6> bdetmeugj Cdhhdw up ot kdet` ?7

@BB fmdkorigr poegh OC\ edrkoh

OC\H2%81

JB\ 82

: KV sboes wmt` Gdvmst oej deg WR gxok org egaotmvg/edrk

De trgotkget Getgbovmr Smtokme J

Rtotme

\hoe> bdetmeug fmdkorigr poegh gvgry 2 kdet`s wmt` JB\ ts`mppgj td Nopoe crdk Smgt Eok


22/29

Bosg 2

:7 yd wdkoe, FKM 20, EOR@, stoag MMM-Mcmfrdsms

OC\ 73 ea/kH

WR egaotmvg> pddr quohmty jug td FKM Mesuroebg bdkpoey rgcusgs drjgr cdr BZ


23/29

Bosg 2> Bdetmeugj

OC\H2% jotg ? 0%

OC\H2% jotg ? + 2 kdet`s ??% OC\H2% jotg ? + 3 kdet`s ?7%

Mesuroebg bdkpoey opprdvgj BZ sboe wmt` bdetros

kdet`s octgr 2 hgttgrs dc oppgoh oej 6 prdvmjgr p` BZ cmejmeas> 2.3 @BB bk me sgakget ?

\otmget gvohuotgj cdr ZOFG oej hmvgr troesphoet


24/29

Bosg :>

:7 yd koe wmt` iedwe @BB 1 bk, OC\ ?3< ea/

?:7, OC\H2% 1


25/29

Bosg :> bdetmeugj

HZ bgetgr bdebgregj ofdut `ma` fmdkor \hoeegj BZ dc b`gst oej fdeg sboe> ega

\otmget phobgj de WEDR womt hmst

2 kdet` survgmhhoebg wmt` KV wmt` Gdv3 kdet`s BZ dc b`gst oej Fdeg Rboe

@BB fmdkorigr poegh


26/29

Bosg :> bdetmeugj

Kdet` 1

@BB fmdkorigr poegh ueb`oeagj wmt` ohh 2 fmghgvotgj

BZ dc b`gst s`dwgj egw edjuhg

Huea edjuhg fmdpsy s`dwgj kgtostotmb @BB

potmget phobg de sdrocgemf oej rgkdvgj crwomt hmst


27/29

Bosg 7 :1 yd wdkoe wmt` iedwe, B`mhj O, KGHJ 3, @BB 7 bk me

de KV wmt` Koaeovmst, OC\ :


28/29

Bosg 7> bdetmeugj

O hmvgr fmdpsy wos pgrcdrkgj

Cmejmeas> tukdr fmdpsy> pddrhy jmccgrge@BB, ed bopsuhg

Fx dc ojnobget tmssug td fg usgj td stoa

jmsgosg oej jgtgrkmeg mc potmget o boejcdr suramboh rgsgbtmde, s`dwgj skohhkmbrdkgtostosms


29/29

Obiedwhgjakgets

Bhoujg Rmrhme

]uid Ided

HCC: Proposals for biomarkers and imaging surveillance AFPL3% DCP 2013

Documents

Transcript of HCC: Proposals for biomarkers and imaging surveillance AFPL3% DCP 2013