Group Meeting Problems - 2021/07/03
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Transcript of Group Meeting Problems - 2021/07/03
Group Meeting Problems - 2021/07/03
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J. Gui et al., J. Am. Chem. Soc., 140, 9413 (2018)
AcO STol
H
MeMe
O
H H
(PhO)2OPO1) m-CPBA EtOAc, 0 ºC
2) O-methylquinine toluene, 130 ºC
54% (2 steps)
MeMe
O
H
AcO
H
Group Meeting Problems - 2021/07/10
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G. Evano et al., J. Am. Chem. Soc., 136, 12528 (2014)
TfOH/DCM(0.8:1)
0℃
74%
NTs NH
H
Ts
M. D. Levin et al., Nature, 593, 223 (2021)
Group Meeting Problems - 2021/07/17
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F3C
N
O
OBnOO
NC
H
NSO
tBu
NC
OAc
TMS Pd(Ph3P)4 THF, rt 73%
2) HCl/dioxane Et2O 59%
THF, 45 °C
71%
1)
Group Meeting Problems - 2021/07/17
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T. Sato, N. Chida et al., Org. Lett., 23, 3058 (2021)
N
O TMS
Et
IrCl(CO)(PPh3)2 (0.5 mol%)(Me2HSi)2O (1.5 eq)
MS3A, toluene, 40 °C; NEt
O
(1.5 eq)
O
H
H
Cl2CHCO2H (1.0 eq), i-PrOH (2.0 eq)
Group Meeting Problems - 2021/07/24
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G. G. Faura et al., J. Org. Chem., ASAPDOI: 10.1021/acs.joc.1c00826
OTFE
O
N2
O
N
MeN
Me
Me
OH
O OTFE
O
TFEO
O
NMe
Me
OMe
Me
OMe
Rh2(esp)2(0.5 mol%)
CH2Cl2, reflux
57%
Me
OMe
Cu(hfacac)2(10 mol%)
CH2Cl2, reflux
80%
F3C CF3
O O
Cu
RhRh
OO OO
Me
Me
Me
Me
O
OO
O
Me
MeMe
Me
Rh2(esp)2
Cu(hfacac)2
