Green anticancer-drugs

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  • 1. , -2012

2. 3. , , . , , . 2012 4. , , , , (), . . , , , , , , . , . (review) , , , . , . , , . , , , , . 2012i 5. . , , . , , . , , . , , , , . , , , , . . , , . , . , , . , . , . ii 6. , , . . , , , , , . , , , , , -. , , , , . , . , . , , , . , , C, , , . , , (stress). , , , . , , , , iii 7. , , , , . PowerPoint . www.greenchemistry.gr. iv 8. .i.iiv.....xi1. ....1 1.1 ......2 1.2 ...........2 1.3 & ..........42. , ....7 2.1 ........8 2.2 ......102.2.1 .......12 2.3 ......17 2.4 ....19 2.4.1 ...19 2.4.2 ...20 2.4.3 .......223. ..26 3.1 ...27 3.1.1 ..27 3.1.2 30 3.1.3 .....32 3.2 & ...334. N ...38 4.1 ...39 4.2 ...39v 9. 4.2.1 , ...39 4.2.2 ...41 4.2.3 .....42 4.2.4 & ...44 4.2.5 ..44 4.2.6 45 4.2.7 ....47 4.2.8 .....48 4.2.9 ....48 4.2.10 ..49 4.2.11.494.3 ........50 4.3.1 ..50 4.3.2 ...51 4.3.3 .....51 4.3.4 ....51 4.3.5 , ...52 4.3.6 ..53 4.3.7 ..53 4.3.8 .54 4.3.9 ......54 4.3.10 .54 4.3.11 ....554.4 55 4.4.1 .....55 4.4.2 ..55 4.4.3 , ..56 4.4.4 ....57 4.4.5 ..57 4.4.6 ...58 4.4.7 ...60 vi 10. 4.4.8 62 4.4.9 ..63 4.4.10 63 4.5 ..63 4.5.1 .....64 4.5.2 ....64 4.5.3 ..64 4.5.4 , 65 4.6 (Glivec GleevecTM).67 4.6.1 ....67 4.6.2 .....67 4.6.3 68 4.6.4 ......68 4.6.5 ...69 4.6.6 69 4.6.7 .71 4.6.8 ...71 4.6.9 ..72 4.7 -72 4.7.1 ....72 4.7.2 .73 4.7.3 .73 4.7.4 ..73 4.7.5 ...74 4.7.6 ..75 4.7.8 ..755. , ..76 vii 11. 6. ...81 6.1 ....82 6.2 ( C).83 6.2.1 .....83 6.2.2 ..84 6.2.3 ....85 6.2.4 C..85 6.2.5 ...86 6.2.6 C.86 6.2.7 C..87 6.2.8 ...88 6.2.9 ...88 6.2.10 88 6.2.11 Linus Pauling....89 6.3 ...91 6.3.1 .....91 6.3.2 ......92 6.3.3 ...92 6.3.4 .....92 6.3.5 .......93 6.3.6 ...94 6.3.7 , ...95 6.4 ..95 6.4.1 ...95 6.4.2 ...96 6.4.3 ....96 6.4.4 ..97 6.5 98 6.5.1 ...98 viii 12. 6.5.2 ..996.5.3 ....996.5.4 ........1016.5.5 .........1026.6 (Graviola).1036.6.1 ..1036.6.2 Graviola...1036.6.3 .....1066.7 Laetrile ( B-17) ..1066.8 714-...1086.9 Essiac..1096.10 & ....1116.10.1...1116.10.2 .....1126.10.3 ..1136.10.4 ..1156.10.5 ....1166.10.6.1176.10.7 ....1196.10.8 ...1206.10.9 ......1206.10.10 ....1216.10.11 ...1226.10.12 ......1236.10.13 ()....1246.10.14 ....1256.10.15 ....126 ix 13. 6.10.16 .....128 6.10.17 .....136 6.11 , .....137 6.11.1 ....137 6.11.2 . Budwig....139 6.11.3 . Gerson.....143 6.11.4 .....144 6.12 Lorraine Day..1467. ...149 7.1 ...150 7.2 ...1508. , .1549. ...15710. ..162 10.1 & .....163 10.2 ..169 10.3 & ......171 10.4 .....178 10.5 PowerPoint ..180x 14. , . . , , . . , . , . , , . , . , , , , (stress). , , . xi 15. 1. 1 16. 1. 1.1 . , , . . 1960 , . , . , , , , , , . , .1.2 (Green Chemistry) , . , . , . 2 17. (, , , , ,..) , . , ( 600-700 ) . (, , , , , ,, , , ..). , . , . , (), ., . . 1975, . , , , . . / 3 18. (Green and Sustainable Chemistry), .1.3 & , . , 20 21 , , . . . , . , . , , . (12) . .1. (Prevention): . , , .2. ( ), (Maximizesynthetic methods, Atom Econmy): , , .3. (Less hazardous chemical synthesis): , 4 19. .4. (Designing safer chemicals): , . .5. (Safer solvents and auxiliary substances): . , .6. (Design for energy efficiency): . .7. (Use of renewable feedstocks): (, , , ..).8. (Reduce intermediate derivatives): ( ,-, / ). , .9. . (Catalysis, catalytic reagents): , , .10. (Design products whichdegrade easily): ( ) . .5 20. 11. (Real-time analysisfor pollution prevention): , .12. (Inherently saferchemistry for accident prevention) , , , . . , , , . [1,2] 6 21. 2. 7 22. 2. 2.1 , . , , . 1600 .. , . . . . 460-370 .. (, , ). , , . 1300 .. , . , . , . 15 , . 1628 . 1761 Morgagni . 8 23. . JohnHunter (1728-1793) , . . ( ) , . 19 , Rudolf Virchow. , . , . Virchow , . . 17 18 , . , , . 1779, . 19 20 , , . . , . 1911 Peyton Rous Rockefeller , . , Rous. 9 24. 1968. 1915 , , . , , , . . , , . . [3]2.2 , . , . . 1996925.146 . , , . 400 100.000 . , . , . , , . , . , . , , . 10 25. , , , , , , . . , , , , . . , , . , . , ( -HPV, - HV, C - HCV, - HIV, ..) . , , , , . . , . , , .. . , , , , , , .. , , : ; , . ; , . ; , . 11 26. . , 20% , , 30%. 5% . , , . , . , . [4]2.2.1 . . , . (initiation) . , , . DNA, DNA, . , 12 27. DNA, DNA. , . , (promotion) , , .2.2.2 Watson Crick , DNA, . , , [5]. , DNA, . , DNA [5]. 1948 J.A.Miller , [6], 1960 p450 . 57 CYPs(Cytochrome p450 dependent monoojynases) [7]. CYP 1-3.[8] ( ), DNA, DNA ( 1). DNA , 13 28. DNA. DNA, , , [9]. DNA (excision repair) [10]. DNA DNA , - / 1: .14 29. DNA, , DNA, . ( ) DNA, DNA , , [11]. . , stress [12], , . . , (). (). , ( ) (). : 1. , . in vitro 50 ( Hayflick). 2. , , . . , 15 30. . , , . , . ; , , , , , , , . , , . , . (proto-ogogenes) (tumor suppressor) . , . . , , , . , DNA . , , . , . , . , , , , , , , , ( C ). 16 31. . , , (stress) [13].2.3 . . . : 1. 20% . , 17%. . , , , , . . 2. 40% 60% . Non-Hodgkin , . ( ), . . 3. 60% 80% . , , . ( ). , . 17 32. , . , , . . . 4. 80% : , . , , , . 24%. . CA13-5 . . . . , , . DNA, (). , . [13].18 33. 2.4 2.4.1 2007 , 20.000 . 7,6 . , ,