Graves’ disease Department of Internal Medicine № 2.
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Transcript of Graves’ disease Department of Internal Medicine № 2.
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Graves’ disease
Department of Internal Medicine № 2
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Hyperthyroidism (thyrotoxicosis) Toxic diffuse goiter.
Grave’s disease - is the condition resulting from the effect of excessive amounts of thyroid hormones on body tissues.
Thyrotoxicosis is a main syndromeEnlargment of thyroid gland
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Etiology and predisposing factors
• Defect of T lymphocytes suppressors
Genetic predisposition, conferred by genes close proximity to the major histocompatibility complex (HLA DR3, B8)
Autoimmune disorders, which can be provoked by:
• insolation;• stress;• acute infections;• hormone disbalance
(pregnancy and others)
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PathogenesisInsufficiency of T suppressors
Increasing function of B lymphocyte
Toxic influence of lymfocytes
Secretion of thyroid – stimulating immunoglobulin (TSI)
The thyroid
Secretion of T4, T3
Thyrotoxicosis
Pathologic changes in different organs and systems
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Clinical manifestations
The clinical presentation may be dramatic or subtle.
Dysfunction of - the nervous system - the cardiovascular system - the gastrointestinal system- the pulmonary system- the endocrine organs- katabolic syndrome- ectodermal changes
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Degrees of thyroid gland enlargement(WHO, 1986, 1994)
0-we can’t see or palpate thyroid gland;
IA- we can palpate but can’t see; IB- thyroid gland can be seen when patient put head back;
II –thyroid gland can be seen in normal position of the head.
III – thyroid gland can be seen from the distance of 5 meters or more
0 –goiter is absent
1- we can palpate but can’t see
2 – thyroid gland can be palpated and seen
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Degrees of severity
Mild Moderate Severe
Heart beat under 100 100 - 120 over 120
Weight loss
less than 10 %
10 – 20 % more than 20 %
Changes from organs and systems
rare - ophthalmopathy
- signs of heart failure І – ІІ А
-ophthalmopathy
-dystrophic changes from inner organs
-thyroid storm
Work capacity
normal decreased patients cant work
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Treatment
I. 1. Antithyroid drugs.
2. Drugs to ameliorate thyroid hormone effects .
II. 131I - therapy
III. Surgery.
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Thyroid storm Thyroid storm is a life- threatening emergency
requiring prompt and specific treatment.In is characterized by abrupt onset of more severe symptoms of thyrotoxicosis, with some exacerbated symptoms and signs atypical of uncomplicated Graves disease:
• fever;• marked weakness and muscle wasting;• extreme restlessness with wide emotional swings;• confusion; • psychosis or even coma;• hepatomegaly with mild jaundice;• the patient may present with cardiovascular collapse
or shock.
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Thyroid storm results from:- untreated or inadequately treated thyrotoxicosisIt may be precipitated by:
• infection;• trauma• surgery;• embolism;• diabetic acidosis;• fright;• toxemia of pregnancy;• labor;• discontinuance of antithyroid medication;• radiation thyroiditis.
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Treatment of thyroid storm- Iodine-30 drops Lugol’s solution/day orally in 30g 4 divided
doses; or 1 to 2 gr. sodium iodide slowly by i/v drip- Propylthiouracil (merkazolil) - 900 to 1200 mg/day orally or by
gastric tube.- Propranolol - 160mg/day orally in 4 divided doses; or 1mg
slowly i/v g 4h under careful monitoring; a rate of administration should not exceed 1mg/min; a repeat 1mg dose may be given after 2 min i/v glucose solutions .
- Correction of dehydration and electrolyte imbalance cooling blanket for hypertermia.
- Digitalis if necessary. - Treatment of underlying disease such as infection.- Corticosteroids-100 to 300mg hydrocortisone/day i/v.- Iodine in pharmacological doses inhibits the release of T3 to T4
within hours and inhibits the organification of iodine, a transitory effect lasting from a few days to a week (”escape phenomenon”.)