Grand rounds presentation

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Primary Lung Tumours In Dogs Louise Martin 23/01/15

Transcript of Grand rounds presentation

1. Primary Lung Tumours In Dogs Louise Martin 23/01/15 2. Pip Budd 8 year old, MN Border Collie History Retching/gagging when exercising Chronic right diaphragmatic hernia discovered and repaired Recurrent pleural effusions since surgery Diagnosis of carcinoma from fluid 3. Investigations In house Haematology and Biochemistry Thoracic and Abdominal Ultrasound Thoracocentesis: Fluid sent for analysis and cytology CT scan of lungs Differential Diagnosis Chronic Inflammation Pulmonary Carcinoma Mesothelioma 4. Pleural Fluid 1 2 3 4 5. Canine Lung Tumours Can be primary or secondary Metastatic lung tumours much more common Primary pulmonary tumours rare in dogs Average age of primary tumour diagnosis 11years No sex or breed predilection 6. Primary Lung Cancers Majority are malignant Carcinoma predominates 85% bronchoalveolar origin in dogs Multiple routes of metastasis 7. Clinical Signs Often none incidental Coughing, dyspnoea, lethargy, anorexia, weight loss, haemoptysis Dull heart and lung sounds due to pleural effusion Increased lung sounds if extensive mass Lameness Hypertrophic osteopathy Neurological Signs - Metastasis 8. Diagnosis As previously mentioned in Pips case Thoracic radiographs Ultrasound guided FNA Bronchoalveolar lavage 9. Surgery > Partial lung lobectomy > Complete lung lobectomy Chemotherapy > Systemic > Intra-pleural Palliative Treatment Treatment 10. Prognosis A number of factors affect the prognosis of dogs with primary pulmonary disease: Clinical signs Metastasis to lymph nodes Tumour well, moderately or poorly differentiated 11. Back to Pip... His owners felt he had been through enough with his previous diaphragmatic hernia surgery so they opted to continue treating him with prednisolone and frusemide and have his chest drained when necessary. Allowing him to have a good quality of life for the time he has left. 12. References RS Brodey, PH Craig. Primary pulmonary neoplasms in the dog: a review of 29 cases J Am Vet Med Assoc, 147 (1965), pp. 16281643 CR Dorn, DO Taylor, FL Frye, et al. Survey of animal neoplasms in Alameda and Contra Costa Counties, California. I. Methodology and description of cases J Natl Cancer Inst, 40 (1968), pp. 295 305 DJ Meuten. Tumors in domestic animals (ed 4)Iowa State University Press, Ames, Iowa (2002) FF Hahn, BA Muggenburg, WC Griffith. Primary lung neoplasia in a beagle colony Vet Pathol, 33 (1996), pp. 633638 JE Moulton, C von Tscharner, R Schneider. Classification of lung carcinomas in the dog and cat Vet Pathol, 18 (1981), pp. 513528 EA McNiel, GK Ogilvie, BE Powers, et al. Evaluation of prognostic factors for dogs with primary lung tumors: 67 cases (1985-1992) J Am Vet Med Assoc, 211 (1997), pp. 14221427 CJ Mehlhaff, CE Leifer, AK Patnaik, et al. Surgical treatment of primary pulmonary neoplasia in 15 dogs J Am Anim Hosp Assoc, 20 (1984), p. 5 GK Ogilvie, WM Haschek, SJ Withrow, et al. Classification of primary lung tumors in dogs: 210 cases (1975-1985) J Am Vet Med Assoc, 195 (1989), pp. 106108 DC Sorjonen, KG Braund, EJ Hoff. Paraplegia and subclinical neuromyopathy associated with a primary lung tumor in a dog J Am Vet Med Assoc, 180 (1982), pp. 12091211 RS Brodey. Hypertrophic osteoarthropathy in the dog: a clinicopathologic survey of 60 cases J Am Vet Med Assoc, 159 (1971), pp. 12421256 VT DeVita, TS Lawrence, SA Rosenberg. DeVita, Hellman, and Rosenberg's cancer: principles & practice of oncology (ed 8)Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia (2008) VJ Poirier, KE Burgess, WM Adams, et al. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia J Vet Intern Med, 18 (2004), pp. 536539 GK Ogilvie, RM Weigel, WM Haschek, et al. Prognostic factors for tumor remission and survival in dogs after surgery for primary lung tumor: 76 cases (1975-1985) AS Moore, C Kirk, A Cardona. Intracavitary cisplatin chemotherapy experience with six dogs J Vet Intern Med, 5 (1991), pp. 227231 Stephen J. Withrow, David M. Vail, Rodney L. Page (2012). Small Animal Clinical Oncology. 5th ed. Missouri: Elsevier. Stephen J. Ettinger, Edward C. Feldman (2010). Textbook of Veterinary Medicine Diseases of the Dog and Cat. 7th ed. Missouri: Elsevier. p1109-1113. 13. Any Questions? Special thanks to Mike in oncology!