Global Excellence in Action Graduate School of Interdisciplinary New Science

Toyo University

Graduate School of Interdisciplinary New Science Toyo University

2100, Kujirai, Kawagoe, Saitama 350-8585, Japan Tel: +81 49 239 1313 Fax: +81 49 231 5117 E-mail: fusion@toyo.jp

URL: http://www.toyo.ac.jp/site/english-glns/

Course of Bio-Nano Science Fusion Graduate School of Interdisciplinary New Science Toyo University

Outline of the Graduate School of Interdisciplinary New Science The Graduate School of Interdisciplinary New Science, Toyo University, was opened in 2007 based

on the advanced bio-nano science and technology research carried out at the Bio-Nano Electronics

Research Centre, which was established in 1996. State-of-the-art facilities and equipment such as

nanotechnology super clean rooms, biotechnology clean rooms, transmission electron

microscopes, scanning electron microscopes, scanning probe microscopes and all sorts of

spectroscopic analysers are installed at the Bio-Nano Electronics Research Centre. The main aim of

the Graduate School is to educate and create advanced researchers in the fields of

nanoscience/nanotechnology, bioscience/biotechnology and bio-nano fusion science/technology

from an international point of view. The Graduate School provides a unique curriculum such as

“Workshops on advanced equipment” and “Web educational programmes” as well as advanced

lectures. The Graduate School also organises and holds international symposia, seminars and

workshops for young researchers. The students carry out advanced research in collaboration with

the Bio-Nano Electronics Research Centre, and overseas partner universities and research

institutes. The Graduate School confers the Master and Doctoral Degrees of Bio-Nano Science

Fusion on successful students.

Admission policy The Graduate School of Interdisciplinary New Science accepts motivated Master and Doctoral

Course students from all over the world and creates internationally advanced researchers in the

fields of bioscience, nanotechnology and bio-nano fusion science and technology, the latter being

one of the most important subjects in the 21st

Century. An enquiring spirit of study on advanced

subjects, an adventurous spirit for cutting-edge research areas, and high English communication

skills; i.e., writing, reading, discussion and presentations, are required.

Educational policy All the educational courses; i.e., lectures, seminars, workshops, performance of research and

preparation of scientific papers, theses and presentations, are given in English. The courses do not

focus on only enumeration and memorisation of facts and the solutions to simple ready-made

problems. In the classes, students are encouraged to discuss and give their own ideas and opinions

on important scientific, technological, political, economical and social issues. Each student

eventually writes and presents a thesis in English for her/his Master or Doctoral degree.

Doctoral double degree programmes The Graduate School of Interdisciplinary New Science provides “Doctoral Double Degree

Programmes” in collaboration with the following partner universities;

Université Pierre et Marie Curie (Paris 6), Paris, France

Université de Nantes, Nantes, France

Doctoral degrees are conferred on successful students from both Toyo University and one of the

above universities.

Supervisors

Tatsuro Hanajiri Design and fabrication of nanoscale electron devices I am currently studying the physics of nanoscale electron devices and am interested in its application to nanoelectronics. I have studied the electric properties of thin SOI films and the structures of SOI MOSFETs with decanano scale gates. I propose fully inverted (FI) SOI MOSFETs with ultra-thin SOI films and novel fully depleted (FD) SOI MOSFETs.

Hisao Morimoto Self-organisation/nonlinear dynamics of nano/micro materials I am interested in self-organisations, phase transitions, and non-linear dynamics of nano/micro materials disperse systems such as suspensions, in which nano/micro particles, carbon nanotubes, fullerenes or biological cells are dispersed. I am also interested in bio-nano fusion technologies utilising the above phenomena induced in nano/micro materials disperse systems.

Global Excellence in Action Graduate School of Interdisciplinary New Science

Toyo University

Visiting professors

Daniel Morse UCSB

Sir John Walker University of Cambridge

Régine Perzynski Université Paris 6

Nicole Grobert University of Oxford

Raymond Whitby Nazarbayev University

Leonid Kalachev University of Montana

Yoshio Bando NIMS

Toru Kobayashi JAMSTEC

Shigeru Deguchi JAMSTEC

P.V. Mohanan Sree Chitra Tirunal

Institute for Medical Sciences and Technology

Sakthi Kumar Bio-nano fusion/nanotechnology/ biomaterials I am interested in the research work based on fusion of different science fields, namely physics, chemistry and biotechnology. I focus on research themes such as (a) Nano drug delivery, aptamer (DNA and RNA based)

sensors and bio/chemical sensors. (b) Carbon nanotubes, nano particles and quantum dots

for solar cell applications and plasma processing thin films.

Yoshikata Nakajima Nanotechnology/Nanomaterials Bio-nano fusion I am interested in advanced materials for future electron devices such as silicon-on-insulator (SOI) wafers, silicon-on-quartz (SOQ) and silicon nano dots, and micro-particles and biological cells dispersed in solution. My study also focuses on the design and fabrication of high-resolution bio-nano analytical systems utilising the advanced materials.

Takashi Uchida Growth and application of carbon-based nanostructures I am interested in the research work related to carbon-based nanostructures such as carbon nanotubes, carbon nanowalls and endohedral fullerenes. I focus on research themes such as (a) Equipment development-chemical vapour deposition systems, electron cyclotron resonance ion source. (b) Growth-carbon nanotubes, carbon nanowalls, endohedral fullerenes.

Toru Mizuki Bio-nano fusion/Biotechnology I am interested in the interactions between biomolecules such as protein, peptide and DNA, and nano/micro materials such as CNTs, fullerenes and magnetic materials. I am currently focusing on bio-nano fusion research such as analysis of the function of proteins immobilised on nano/micro materials and acceleration of the enzyme activity using a rotational magnetic field.

Toru Maekawa Self-organisation/self-assembly in nano/micro systems I am very much interested in pattern formations, synchronisation and chaos created via self-organisation/self-assembly, which are induced in nano/micro systems. Fluctuations, surface effects and quantum effects, in particular, become significant on nanometre scales, which makes nano systems completely different from our macroscopic world.

Course of Bio-Nano Science Fusion Graduate School of Interdisciplinary New Science Toyo University

Curriculum (Master Course)

Year Type Title Credits

1

Lectures

Introduction to bio-nano science fusion 2

English for science and technology 2

Fundamental mathematics 2

Fundamental physics 2

Fundamental chemistry 2

Fundamental biotechnology 2

Extremophiles 2

Nanoelectronics 2

Nano materials 2

Bio materials and nanotechnology 2

Microbiology 2

Bio nano science 2

Advanced nano science and nanotechnology 2

Workshops

Workshop on advanced equipment I 2

Workshop on advanced equipment II 2

Workshop on advanced equipment III 2

Workshop on advanced equipment IV 2

Web programme Web education I 2

Research Bio-nano science fusion seminar I and II 4

Bio-nano science fusion research I and II 4

2

Web programme Web education II 2

Research Bio-nano science fusion seminar III and IV 4

Bio-nano science fusion research III and IV 4

Web educational programmes: GEOSET TOYO The Graduate School of Interdisciplinary New Science produces, in collaboration with Florida State

University, web educational programmes named “Global Educational Outreach for Science,

Engineering and Technology, Toyo University” abbreviated to “GEOSET TOYO”. Students also

participate in the production of GEOSET TOYO programmes. Some typical programmes are listed

below;

Type Programmes Level

Lecture + ppt + video

Fundamental science: Classical mechanics (Outline, philosophy, history)

Undergraduate (UG) Graduate (Grad)

Lecture + ppt + video

Fundamental science: Classical mechanics (Experimental verification)

UG, Grad

Lecture + ppt + video

Fundamental science: Electromagnetism (Outline, philosophy, history)

UG, Grad

Lecture + ppt Fundamental science: Electromagnetism

(Maxwell equation) UG, Grad, PD

Experiment + ppt + video

Observation of nanostructures by electron microscopes

UG, Grad, PD

Experiment + ppt + video

Observation of nanostructures by scanning probe microscopes

UG, Grad, PD

Seminar + ppt + video

Room temperature growth of compound semiconductors learning from sea creatures

Professor Daniel Morse

UG, Grad, PD, Researchers (R)

Seminar + ppt + video

Sir Harry Kroto’s International Seminar for Young Scientists

UG, Grad, PD, R

Video Introduction to California NanoSystems

Facilities and equipment UG, Grad, PD, R

Video Visit to the Royal Society

Great scientists UG, Grad, PD, R

Video Sir Harry Kroto’s Seminar for Junior Students Primary, Junior-high and

High School

Global Excellence in Action Graduate School of Interdisciplinary New Science

Toyo University

Facilities and equipment State-of-the-art facilities and equipment are installed at the Bio-Nano Electronics Research Centre,

which Master and Doctoral Course students can use for their research. A unique course such as

“Workshops on advanced equipment” is specially designed for Master Course students.

Nanostructures Processing Room Lithography Room Nanoelectronics Super Clean Rooms

Transmission Electron Microscope Scanning Electron Microscopes

Superconducting Quantum Interference Device Scanning Probe Microscope

Ultra Fast Liquid Chromatography X-ray Photoelectron Spectroscopy System

Course of Bio-Nano Science Fusion Graduate School of Interdisciplinary New Science Toyo University

Events The Graduate School organises and holds international symposia, seminars and workshops for the

students both overseas and in Japan. The students also present their latest results at international

symposia and seminars. International Symposia on Bioscience and Nanotechnology

International Seminars for Young Scientists (overseas)

International Seminars for Young Scientists (Kawagoe Campus)

Global Excellence in Action Graduate School of Interdisciplinary New Science

Toyo University

Sir Harry Kroto’s Seminars for Young Scientists (Kawagoe Campus)

Recent publications S. Syama, C.P. Aby, T. Maekawa, D.S. Kumar and P.V. Mohanan, Nano-bio compatibility of PEGylated reduced graphene oxide on mesenchymal stem cells, 2D Mater. 4, 025066 (2017). DOI: 10.1088/2053-1583/aa65c2 S. Raveendran, A. Sen, T. Maekawa and D.S. Kumar, Ultra-fast microwave aided synthesis of gold nanocages and structural maneuver studies, Nano Res. 10, 1078-1091 (2017). DOI: 10.1007/s12274-016-1368-3 S. Balasubramanian, G.A. Ravindran, R. Romero-Aburto, T. Mitcham, K.A. Mitchel, Y. Nagaoka, R.R. Bouchard, P.M. Ajayan, T. Maekawa and D.S. Kumar, Highly versatile SPIONs encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents, Biomater. Sci. 5, 432-443 (2017). DOI: 10.1039/c6bm00621c H. Shimoshige, Y. Nakajima, H. Kobayashi, K Yanagisawa, Y. Nagaoka, S. Shimamura, T. Mizuki, A. Inoue and T. Maekawa, Formation of core-shell nanoparticles composed of magnetite and samarium oxide in Magnetospirillum magneticum strain RSS-1, PLoS One 12, e017093 (2017). DOI: 10.1371/journal.pone.0170932 M. Suzuki, H. Hayashi, T. Mizuki, T. Maekawa and H. Morimoto, Efficient DNA ligation by selective heating of DNA ligase with a radio frequency alternating magnetic field, Biochem. Biophys. Rep. 8, 360–364 (2016). DOI: 10.1016/j.bbrep.2016.10.006 A.C. Poulose, S. Veeranarayanan, M.S. Mohamed, R.R. Aburto, T. Mitcham, R.R. Bouchard, P.M. Ajayan, Y. Sakamoto, T. Maekawa and D.S. Kumar, Multifunctional Cu2-xTe nanocubes mediated combination therapy for multi-drug resistant MDA MB 453, Sci. Rep. 6, 35961 (2016). DOI: 10.1038/srep35961 Y. Hayasaki, T. Hasumura, T. Fukuda, Y. Nagaoka, T. Ukai, S. Iwai, T. Uchida and T. Maekawa, Synthesis of magnetic alloy-filling carbon nanoparticles in super-critical benzene irradiated with an ultraviolet laser, Heliyon 2, e00171 (2016). DOI: 10.1016/j.heliyon.2016.e00171 A.K. Rochani, B. Sivakumar, R.G. Aswathy, S. Raveendran, A. Borah, Y. Nagaoka, Y. Nakajima, T. Maekawa and D.S. Kumar, Dual mode of cancer cell destruction for pancreatic cancer therapy using Hsp90 inhibitor loaded polymeric nano magnetic formulation, Int. J. Pharm. 511, 648-658 (2016). DOI: 10.1016/j.ijpharm.2016.07.048 V.A. Kumar, Y. Nakajima, T. Uchida, T. Hanajiri and T. Maekawa, Synthesis of nanoparticles composed of silver and silver chloride for a plasmonic photocatalyst using an extract from needles of Pinus densiflora, Mater. Lett. 176, 169-172 (2016). DOI: 10.1016/j.matlet.2016.04.077 M.S. Mohamed, A.C. Poulose, S. Veeranarayanan, Rebeca R.A., Trevor M., Y. Suzuki, Y. Sakamoto, P. M. Ajayan, R.R. Bouchard, Y. Yoshida, T. Maekawa and D.S. Kumar, Plasmonic fluorescent CdSe/Cu2S hybrid nanocrystals for multichannel imaging and cancer directed photothermal therapy, Nanoscale 8, 7876-7888 (2016). DOI: 10.1039/c5nr05225d A.K. Rochani, R.G. Aswathy, A. Borah, T. Maekawa and D.S. Kumar, Heat shock protein 90 targeted nano anticancer therapy, J. Pharm. Sci. 105, 1454-1466 (2016). DOI: 10.1016/j.xphs.2015.10.007 V.A. Kumar, T. Uchida, T. Mizuki, Y. Nakajima, Y. Katsube, T. Hanajiri and T. Maekawa, Synthesis of nanoparticles composed of silver and silver chloride for a plasmonic photocatalyst using an extract from a weed Solidago altissima (goldenrod), Adv. Nat. Sci.: Nanosci. Nanotechnol. 7, 015002 (2016). DOI: 10.1088/2043-6262/7/1/015002

Course of Bio-Nano Science Fusion Graduate School of Interdisciplinary New Science Toyo University

Awards and prizes ✓ Best Poster Award S. Raveendran, N. Chauhan, V. Palaninathan, T. Maekawa and D.S. Kumar, Cancer therapy based on shape dependent biocompatible gold hybrid nanostructures, The 9

th International Conference on Surfaces, Coatings and

Nanostructured Materials (NANOSMAT 2014) (2014), Dublin, Ireland.

✓ IUPAC Young Researcher Award S. Veeranarayanan, M.S. Mohamed, A.C. Poulose, N. Hirosawa, Y. Sakamoto, Y. Yoshida, T. Maekawa and D.S Kumar, Synergistic targeting of cancer and associated angiogenesis In vivo using triple-targeted drug loaded silica nanoformulations for theragnosticst, International Conference on Frontiers of Polymers and Advanced Materials (ICFPAM-2013) (2013), Auckland, New Zealand.

✓ IUPAC Young Researcher Award M.S. Mohamed, S. Veeranarayanan, A.C. Poulose, Y. Nagaoka, Y. Yoshida, T. Maekawa and D.S Kumar, Fe3O4 core-silica shell nanoclusters based multimodal treatment strategy for drug resistant breast cancers, International Conference on Frontiers of Polymers and Advanced Materials (ICFPAM-2013) (2013), Auckland, New Zealand.

✓ Prnka Prize S. Veeranarayanan, A.C. Poulose, M.S. Mohamed, Y. Nagaoka, S. Kashiwada, Y. Yoshida, T. Maekawa and D.S. Kumar, Nanoformulation facilitated disruption of vasculogenesis: Approach towards neo-angiogenic treatment, Nanocon 2012, C13 (2012), Brno, Czech Republic.

Highlighted papers ✓ ACS Editors’ Choice, American Chemical Society A. Baliyan, Y. Nakajima, T. Fukuda, T. Uchida, T. Hanajiri and T. Maekawa, Synthesis of an ultradense forest of vertically aligned triple-walled carbon nanotubes of uniform diameter and length using hollow catalytic nanoparticles, J. Am. Chem. Soc. 136, 1047-1053 (2014). DOI: 10.1021/ja410794p

✓ Spotlights on Recent JACS Publications, American Chemical Society A. Baliyan, Y. Nakajima, T. Fukuda, T. Uchida, T. Hanajiri and T. Maekawa, Hollow Spheres Lend Control to Carbon Nanotube Growth, J. Am. Chem. Soc. 136, 1157 (2014). DOI: 10.1021/ja500664b

✓ Institute of Physics S. Veeranarayanan, A.C. Poulose, S. Mohamed, A. Aravind, Y. Nagaoka, Y. Yoshida, T. Maekawa and D.S. Kumar, FITC labeled silica nanoparticles as efficient cell tags: Uptake and photostability study in endothelial cells, J. Fluoresc. 22, 537–548 (2012). DOI: 10.1007/s10895-011-0991-3

Graduate School of Interdisciplinary New Science Education and Student Affairs Section, Kawagoe Campus, Toyo University

2100, Kujirai, Kawagoe, Saitama 350-8585, Japan Tel: +81-49-239-1313, Fax: +81-49-231-5117, E-mail: fusion@toyo.jp URL: http://www.toyo.ac.jp/site/english-glns/

Bio-Nano Electronics Research Centre, Toyo University Research Promotion Section

2100, Kujirai, Kawagoe, Saitama 350-8585, Japan Tel: +81-49-239-1375, Fax: +81-49-234-2502, E-mail: bnel@toyo.jp URL: http://www.toyo.ac.jp/site/bionano/

Enquiries concerning the graduate school

Enquiries concerning research projects

Secretariat of the Bio-Nano Electronics Research Centre, Toyo University

Secretariat of the Graduate School of Interdisciplinary New Science, Toyo University

Akiko Tanaka Mikiko Koizumi Hiroshi Akasu Minako Hardy Koichi Nishina

Keiko Itamochi Katsumi Funato Narutoshi Fukushima

Takuzo Kakimori Eri Nagatsuka